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Cell line panels were established for basic research and drug development, but did not cover the full spectrum of leukemia and lymphoma. Therefore, we now developed a novel panel (LL-100), 100 cell lines covering 22 entities of human leukemia and lymphoma including T-cell, B-cell and myeloid malignancies. Importantly, all cell lines are unequivocally authenticated and assigned to the correct tissue. Cell line samples were proven to be free of mycoplasma and non-inherent virus contamination. Whole exome sequencing and RNA-sequencing of the 100 cell lines were conducted with a uniform methodology to complement existing data on these publicly available cell lines. We show that such comprehensive sequencing data can be used to find lymphoma-subtype-characteristic copy number aberrations, mRNA isoforms, transcription factor activities and expression patterns of NKL homeobox genes. These exemplary studies confirm that the novel LL-100 panel will be useful for understanding the function of oncogenes and tumor suppressor genes and to develop targeted therapies.<\/jats:p>","DOI":"10.1038\/s41598-019-44491-x","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T10:22:43Z","timestamp":1559557363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["The LL-100 panel: 100 cell lines for blood cancer studies"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-3032","authenticated-orcid":false,"given":"Hilmar","family":"Quentmeier","sequence":"first","affiliation":[]},{"given":"Claudia","family":"Pommerenke","sequence":"additional","affiliation":[]},{"given":"Wilhelm G.","family":"Dirks","sequence":"additional","affiliation":[]},{"given":"Sonja","family":"Eberth","sequence":"additional","affiliation":[]},{"given":"Max","family":"Koeppel","sequence":"additional","affiliation":[]},{"given":"Roderick A. 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