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A growing body of evidence indicates that cognitive, behavioral, sensory, and motor changes may precede clinical manifestations of AD by several years. Existing tests designed to diagnose neurodegenerative diseases, while well-validated, are often less effective in detecting deviations from normal cognitive decline trajectory in the earliest stages of the disease. In the quest for gold standards for AD assessment, there is a growing interest in the identification of readily accessible digital biomarkers, which harness advances in consumer grade mobile and wearable technologies. Topics examined include a review of existing early clinical manifestations of AD and a path to the respective sensor and mobile\/wearable device usage to acquire domain-centric data towards objective, high frequency and passive digital phenotyping.<\/jats:p>","DOI":"10.1038\/s41746-019-0084-2","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T11:03:38Z","timestamp":1550747018000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":402,"title":["Digital biomarkers for Alzheimer\u2019s disease: the mobile\/wearable devices opportunity"],"prefix":"10.1038","volume":"2","author":[{"given":"Lampros C.","family":"Kourtis","sequence":"first","affiliation":[]},{"given":"Oliver B.","family":"Regele","sequence":"additional","affiliation":[]},{"given":"Justin M.","family":"Wright","sequence":"additional","affiliation":[]},{"given":"Graham B.","family":"Jones","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"key":"84_CR1","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","volume":"84","author":"R Sperling","year":"2014","unstructured":"Sperling, R., Mormino, E. & Johnson, K. 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