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Med."],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Social interaction deficits are evident in many psychiatric conditions and specifically in autism spectrum disorder (ASD), but hard to assess objectively. We present a digital tool to automatically quantify biomarkers of social interaction deficits: the simulated interaction task (SIT), which entails a standardized 7-min simulated dialog via video and the automated analysis of facial expressions, gaze behavior, and voice characteristics. In a study with 37 adults with ASD without intellectual disability and 43 healthy controls, we show the potential of the tool as a diagnostic instrument and for better description of ASD-associated social phenotypes. Using machine-learning tools, we detected individuals with ASD with an accuracy of 73%, sensitivity of 67%, and specificity of 79%, based on their facial expressions and vocal characteristics alone. Especially reduced social smiling and facial mimicry as well as a higher voice fundamental frequency and harmony-to-noise-ratio were characteristic for individuals with ASD. The time-effective and cost-effective computer-based analysis outperformed a majority vote and performed equal to clinical expert ratings.<\/jats:p>","DOI":"10.1038\/s41746-020-0227-5","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T11:02:41Z","timestamp":1582887761000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Towards the automatic detection of social biomarkers in autism spectrum disorder: introducing the simulated interaction task (SIT)"],"prefix":"10.1038","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-7237","authenticated-orcid":false,"given":"Hanna","family":"Drimalla","sequence":"first","affiliation":[]},{"given":"Tobias","family":"Scheffer","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-7620","authenticated-orcid":false,"given":"Niels","family":"Landwehr","sequence":"additional","affiliation":[]},{"given":"Irina","family":"Baskow","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Roepke","sequence":"additional","affiliation":[]},{"given":"Behnoush","family":"Behnia","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Dziobek","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"227_CR1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neubiorev.2017.11.014","volume":"84","author":"J Cotter","year":"2018","unstructured":"Cotter, J. et al. 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