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We successfully obtained EHR data for all patients at both hospitals, as well as from ten additional health systems, which were successfully aggregated with pharmacy data obtained for patients using CVS or Walgreens pharmacies; personal digital device data from activity monitors, digital weight scales, and single-lead ECGs, and patient-reported outcome measure data obtained through surveys to assess post-procedure recovery and disease-specific symptoms. A patient-centered health-data-sharing platform successfully aggregated data from multiple sources.<\/jats:p>","DOI":"10.1038\/s41746-020-0265-z","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T06:03:19Z","timestamp":1587362599000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Aggregating multiple real-world data sources using a patient-centered health-data-sharing platform"],"prefix":"10.1038","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-2032","authenticated-orcid":false,"given":"Sanket S.","family":"Dhruva","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9218-3320","authenticated-orcid":false,"given":"Joseph S.","family":"Ross","sequence":"additional","affiliation":[]},{"given":"Joseph G.","family":"Akar","sequence":"additional","affiliation":[]},{"given":"Brittany","family":"Caldwell","sequence":"additional","affiliation":[]},{"given":"Karla","family":"Childers","sequence":"additional","affiliation":[]},{"given":"Wing","family":"Chow","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-3151","authenticated-orcid":false,"given":"Laura","family":"Ciaccio","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-7780","authenticated-orcid":false,"given":"Paul","family":"Coplan","sequence":"additional","affiliation":[]},{"given":"Jun","family":"Dong","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-3351","authenticated-orcid":false,"given":"Hayley J.","family":"Dykhoff","sequence":"additional","affiliation":[]},{"given":"Stephen","family":"Johnston","sequence":"additional","affiliation":[]},{"given":"Todd","family":"Kellogg","sequence":"additional","affiliation":[]},{"given":"Cynthia","family":"Long","sequence":"additional","affiliation":[]},{"given":"Peter A.","family":"Noseworthy","sequence":"additional","affiliation":[]},{"given":"Kurt","family":"Roberts","sequence":"additional","affiliation":[]},{"given":"Anindita","family":"Saha","sequence":"additional","affiliation":[]},{"given":"Andrew","family":"Yoo","sequence":"additional","affiliation":[]},{"given":"Nilay D.","family":"Shah","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"265_CR1","unstructured":"Food and Drug Administration. 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J.S.R. formerly received research support through Yale University from Medtronic, Inc. and the Food and Drug Administration (FDA) to develop methods for postmarket surveillance of medical devices (U01FD004585), from the Centers of Medicare and Medicaid Services (CMS) to develop and maintain performance measures that are used for public reporting (HHSM-500-2013-13018I), and from the Blue Cross Blue Shield Association to better understand medical technology evaluation; J.S.R. currently receives research support through Yale University from Johnson and Johnson to develop methods of clinical trial data sharing, from the Medical Device Innovation Consortium as part of the National Evaluation System for Health Technology (NEST), from the Agency for Healthcare Research and Quality (R01HS022882), from the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH) (R01HS025164), and from the Laura and John Arnold Foundation to establish the Good Pharma Scorecard at Bioethics International and to establish the Collaboration for Research Integrity and Transparency (CRIT) at Yale. In the past 36 months, N.D.S. has received research from the Centers of Medicare and Medicaid Innovation under the Transforming Clinical Practice Initiative (TCPI), from the Agency for Healthcare Research and Quality (R01HS025164; R01HS025402; 1U19HS024075; R03HS025517), from the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH) (R56HL130496; R01HL131535), National Science Foundation, and from the Patient-Centered Outcomes Research Institute (PCORI) to develop a Clinical Data Research Network (LHSNet). P.C., A.Y., S.J., and K.C. are employees and stockholders of Johnson & Johnson; W.C. is an employee of Janssen Scientific Affairs, LLC, and a stockholder of Johnson & Johnson.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"60"}}