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Chest computed tomography has been found to support diagnostics and disease monitoring. A standardized approach to generate, collect, analyze, and share clinical and imaging information in the highest quality possible is urgently needed. We developed systematic, computer-assisted and context-guided electronic data capture on the FDA-approved mint Lesion<jats:sup>TM<\/jats:sup> software platform to enable cloud-based data collection and real-time analysis. The acquisition and annotation include radiological findings and radiomics performed directly on primary imaging data together with information from the patient history and clinical data. As proof of concept, anonymized data of 283 patients with either suspected or confirmed SARS-CoV-2 infection from eight European medical centers were aggregated in data analysis dashboards. Aggregated data were compared to key findings of landmark research literature. This concept has been chosen for use in the national COVID-19 response of the radiological departments of all university hospitals in Germany.<\/jats:p>","DOI":"10.1038\/s41746-021-00439-y","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T10:06:33Z","timestamp":1618221993000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A reporting and analysis framework for structured evaluation of COVID-19 clinical and imaging data"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-3527","authenticated-orcid":false,"given":"Gabriel 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M.B. serves as chief executive officer of Mint Medical. H.G.K. is an indirect shareholder of Mint Medical. T. Penzkofer was supported by Berlin Institute of Health (Clinician Scientist Grant, Platform Grant) and reports research agreements (no personal payments or connection with submitted work) with AGO, Aprea AB, ARCAGY-GINECO, Astellas Pharma Global Inc. (APGD), Astra Zeneca, Clovis Oncology, Inc., Dohme Corp, Holaira, Incyte Corporation, Karyopharm, Lion Biotechnologies, Inc., MedImmune, Merck Sharp, Millennium Pharmaceuticals, Inc., Morphotec Inc., NovoCure Ltd., PharmaMar S.A. and PharmaMar USA, Inc., Roche, Siemens Healthineers, and TESARO Inc. The remaining authors declare no competing interests. The COVID-19 Mint EDC was free of license-royalty charges for noncommercial research activity, clinical usage, and dissemination of data on the COVID-19 pandemic collected and analyzed on the mint Lesion<sup>TM<\/sup> software platform. Mint Medical GmbH does not permit any commercial usage of the collected data and derivative results. All data will remain the property of the participating institutions. Every participating institution may grant and revoke access to its own data for other institutions or general open access at any time.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}