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Med."],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>People of reproductive age have unmet needs related to deficiencies in fertility literacy. Here, we aimed to investigate whether providing fertility-related information via a smartphone application could improve fertility treatment-related literacy in participants. We performed a randomized control-group pretest posttest study and recruited participants between June 18 and 25, 2020. Participants\u2019 fertility treatment-related literacy was assessed with a pretest that comprised of 28 questions and participants were allocated with stratified randomization to either intervention group or control group. The intervention comprised a one-week smartphone application-based provision of information on fertility-related information and the control group received general information about women\u2019s healthcare. Effectiveness of intervention was assessed using a posttest. A total of 4137 participants were administered the questionnaire and pretest, among which 3765 participants (91.0 %) responded and were randomly allocated into either the intervention group (<jats:italic>N<\/jats:italic>\u2009=\u20091883) or the control group (<jats:italic>N<\/jats:italic>\u2009=\u20091882). A significantly higher posttest mean score was observed for the intervention group compared to the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.0017). We also observed that posttest scores were significantly improved compared to pretest scores in both the intervention and control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). When examining by specific test question, the proportion answering correctly increased at posttest compared to pretest for both intervention and control groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Furthermore, the intervention group showed a greater mean difference between posttest and pretest scores than the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In conclusion, educational intervention using a smartphone application contributed to enhancing fertility treatment-related literacy.<\/jats:p>","DOI":"10.1038\/s41746-021-00530-4","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T17:53:32Z","timestamp":1638294812000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Smartphone application improves fertility treatment-related literacy in a large-scale virtual randomized controlled trial in Japan"],"prefix":"10.1038","volume":"4","author":[{"given":"Ryo","family":"Yokomizo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akari","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Nasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaya","family":"Hine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin Y.","family":"Urayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikou","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0485-6653","authenticated-orcid":false,"given":"Akihiro","family":"Umezawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"530_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","volume":"62","author":"M Vander Borght","year":"2018","unstructured":"Vander Borght, M. & Wyns, C. 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