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Med."],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multidimensional integrative data analysis of digital phenotyping is crucial for elucidating the pathologies of multifactorial and heterogeneous diseases, such as the dry eye (DE). This crowdsourced cross-sectional study explored a novel smartphone-based digital phenotyping strategy to stratify and visualize the heterogenous DE symptoms into distinct subgroups. Multidimensional integrative data were collected from 3,593 participants between November 2016 and September 2019. Dimension reduction via Uniform Manifold Approximation and Projection stratified the collected data into seven clusters of symptomatic DE. Symptom profiles and risk factors in each cluster were identified by hierarchical heatmaps and multivariate logistic regressions. Stratified DE subgroups were visualized by chord diagrams, co-occurrence networks, and Circos plot analyses to improve interpretability. 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(Tokyo, Japan) and Medical Logue, Inc. (Tokyo, Japan). Y.O. and T.I. are the owners of InnoJin, Inc., Tokyo, Japan for developing DryEyeRhytm. T.I. reported receiving grants from Johnson & Johnson Vision Care, SEED Co., Ltd, Novartis Pharma K.K., and Kowa Company, Ltd. outside the submitted work, as well as personal fees from Santen Pharmaceutical Co., Ltd., and InnoJin, Inc. A.M. reported receiving grants from Johnson & Johnson Vision Care and Santen Pharmaceutical Co., Ltd. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"171"}}