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Med."],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the critical early stages of an emerging pandemic, limited availability of pathogen-specific testing can severely inhibit individualized risk screening and pandemic tracking. Standard clinical laboratory tests offer a widely available complementary data source for first-line risk screening and pandemic surveillance. Here, we propose an integrated framework for developing clinical-laboratory indicators for novel pandemics that combines population-level and individual-level analyses. We apply this framework to 7,520,834 clinical laboratory tests recorded over five years and find clinical-lab-test combinations that are strongly associated with SARS-CoV-2 PCR test results and Multisystem Inflammatory Syndrome in Children (MIS-C) diagnoses: Interleukin-related tests (e.g. IL4, IL10) were most strongly associated with SARS-CoV-2 infection and MIS-C, while other more widely available tests (ferritin, D-dimer, fibrinogen, alanine transaminase, and C-reactive protein) also had strong associations. When novel pandemics emerge, this framework can be used to identify specific combinations of clinical laboratory tests for public health tracking and first-line individualized risk screening.<\/jats:p>","DOI":"10.1038\/s41746-021-00547-9","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T11:04:47Z","timestamp":1642676687000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An integrated framework for identifying clinical-laboratory indicators for novel pandemics: COVID-19 and MIS-C"],"prefix":"10.1038","volume":"5","author":[{"given":"Adam D.","family":"Nahari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth F.","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane W.","family":"Newburger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-5523","authenticated-orcid":false,"given":"Ben Y.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"547_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jaci.2020.05.012","volume":"146","author":"S Ward","year":"2020","unstructured":"Ward, S., Lindsley, A., Courter, J. & Assa\u2019ad, A. 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