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Med."],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Even though hypomimia is a hallmark of Parkinson\u2019s disease (PD), objective and easily interpretable tools to capture the disruption of spontaneous and deliberate facial movements are lacking. This study aimed to develop a fully automatic video-based hypomimia assessment tool and estimate the prevalence and characteristics of hypomimia in de-novo PD patients with relation to clinical and dopamine transporter imaging markers. For this cross-sectional study, video samples of spontaneous speech were collected from 91 de-novo, drug-na\u00efve PD participants and 75 age and sex-matched healthy controls. Twelve facial markers covering areas of forehead, nose root, eyebrows, eyes, lateral canthal areas, cheeks, mouth, and jaw were used to quantitatively describe facial dynamics. All patients were evaluated using Movement Disorder Society-Unified PD Rating Scale and Dopamine Transporter Single-Photon Emission Computed Tomography. Newly developed automated facial analysis tool enabled high-accuracy discrimination between PD and controls with area under the curve of 0.87. The prevalence of hypomimia in de-novo PD cohort was 57%, mainly associated with dysfunction of mouth and jaw movements, and decreased variability in forehead and nose root wrinkles (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Strongest correlation was found between reduction of lower lip movements and nigro-putaminal dopaminergic loss (<jats:italic>r<\/jats:italic>\u2009=\u20090.32, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) as well as limb bradykinesia\/rigidity scores (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.37 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Hypomimia represents a frequent, early marker of motor impairment in PD that can be robustly assessed via automatic video-based analysis. Our results support an association between striatal dopaminergic deficit and hypomimia in PD.<\/jats:p>","DOI":"10.1038\/s41746-022-00642-5","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T12:03:46Z","timestamp":1658145826000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Automated video-based assessment of facial bradykinesia in de-novo Parkinson\u2019s disease"],"prefix":"10.1038","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-4029","authenticated-orcid":false,"given":"Michal","family":"Novotny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Tykalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Ruzickova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-9661","authenticated-orcid":false,"given":"Evzen","family":"Ruzicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Dusek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-3054","authenticated-orcid":false,"given":"Jan","family":"Rusz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"642_CR1","doi-asserted-by":"crossref","unstructured":"Gowers, W. 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