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Med."],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the availability of hepatitis B virus (HBV) and hepatitis C virus (HCV) testing in primary care, testing rates in China remain low. Social media is an inexpensive means of disseminating information and could facilitate hepatitis testing promotion. We evaluated the capacity of digitally crowdsourced materials to promote HBV\/HCV testing uptake via a randomized controlled trial (identifier: ChiCTR1900025771), which enrolled 750 Chinese primary care patients. We randomized patients (1:1) to receive crowdsourced HBV\/HCV promotion materials through social media or facility-based care without promotional materials for four weeks. Exposure to all intervention materials was associated with increased odds of HBV (aOR\u2009=\u20091.79, 95% CI: 1.09\u20133.00) and HCV (aOR\u2009=\u20091.95, 95% CI: 1.29\u20132.99) testing compared to facility-based care. There was a significant reduction in hepatitis stigma among intervention group participants (HBV slope: \u22120.15, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05; and HCV slope: \u22120.13, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Digitally crowdsourced promotion messages could enhance hepatitis testing uptake and should be considered in hepatitis reduction strategies.<\/jats:p><jats:p>Trial registration: Chinese Clinical Trial Registry (ChiCTR1900025771) on September 9, 2019. Available from: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\/showproj.aspx?proj=42788\">http:\/\/www.chictr.org.cn\/showproj.aspx?proj=42788<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/s41746-022-00645-2","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T10:03:15Z","timestamp":1658224995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A randomized controlled trial enhancing viral hepatitis testing in primary care via digital crowdsourced intervention"],"prefix":"10.1038","volume":"5","author":[{"given":"William C. 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W.K. Seto received speaker\u2019s fees from AstraZeneca and Mylan, is an advisory board member of Abbott, is an advisory board member and received speaker\u2019s fees from AbbVie, and is an advisory board member, received speaker\u2019s fees and researching funding from Gilead Sciences. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The institutional review board of the Hong Kong University Shenzhen Hospital (HKU-SZH) approved the study (Ref no: hkuszh201888). All participants provided written informed consent that highlighted their right to opt-out of the study at any point prior to participation in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"95"}}