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Med."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The increasing need for mental health support and a shortage of therapists have led to the development of the eXtended-reality Artificial Intelligence Assistant (XAIA). This platform combines spatial computing, virtual reality (VR), and artificial intelligence (AI) to provide immersive mental health support. Utilizing GPT-4 for AI-driven therapy, XAIA engaged participants with mild-to-moderate anxiety or depression in biophilic VR environments. Speaking with an AI therapy avatar in VR was considered acceptable, helpful, and safe, with participants observed to engage genuinely with the program. However, some still favored human interaction and identified shortcomings with using a digital VR therapist. The study provides initial evidence of the acceptability and safety of AI psychotherapy via spatial computing, warranting further research on technical enhancements and clinical impact.<\/jats:p>","DOI":"10.1038\/s41746-024-01011-0","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T03:02:06Z","timestamp":1706238126000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Feasibility of combining spatial computing and AI for mental health support in anxiety and depression"],"prefix":"10.1038","volume":"7","author":[{"given":"Brennan M. 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After initial funding VRx Health was formed for the purpose of commercializing Cedars-Sinai VR technology. Authors B.M.R.S. and O.L. are co-founders of VRx Health. At the time of acceptance, VRx Health did not own the license to XAIA. The XAIA technology was exclusively licensed from Cedars-Sinai to VRx Health on 23<sup>rd<\/sup> January 2024, after acceptance of this manuscript for publication. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22"}}