{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:07:40Z","timestamp":1772136460900,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Digit. Med."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Telerehabilitation is emerging as a promising digital method for delivering rehabilitation to Parkinson\u2019s Disease (PD) patients, especially in the early stages to promote brain resilience. This study explores how cognitive reserve (CR), the brain\u2019s ability to withstand aging and disease, impacts the effectiveness of telerehabilitation. It specifically examines the influence of lifelong cognitive activities on the relationship between neural reserve and improved functional abilities following rehabilitation. In the study, 42 PD patients underwent a 4-month neuromotor telerehabilitation program. CR proxies were assessed using the Cognitive Reserve Index questionnaire (CRIq), brain changes via 3T-MRI, and functional response through changes in the 6-Minute Walk Distance (6MWD). Participants were divided into responders (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200923) and non-responders (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919) based on their 6MWD improvement. A multiple regression model was run to test significant predictors of 6MWD after treatment in each group. The results revealed a significant correlation between 6MWD and CRIq scores, but only among responders. Notably, the CRIq Leisure-Time sub-index, along with baseline 6MWD, were predictors of post-treatment 6MWD. These findings highlight CR\u2019s role in enhancing the benefits of telerehabilitation on PD patients\u2019 neuromotor functions. Clinically, these results suggest that neurologists and clinicians should consider patients\u2019 lifestyles and cognitive engagement as important factors in predicting and enhancing the outcomes of telerehabilitation. The study underscores the potential of CR as both a predictor and booster of telerehabilitation\u2019s effects, advocating for a personalized approach to PD treatment that takes into account individual CR levels.\n                  <\/jats:p>","DOI":"10.1038\/s41746-024-01113-9","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T08:02:01Z","timestamp":1714982521000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring cognitive reserve\u2019s influence: unveiling the dynamics of digital telerehabilitation in Parkinson\u2019s Disease Resilience"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0849-3984","authenticated-orcid":false,"given":"Sara","family":"Isernia","sequence":"first","affiliation":[]},{"given":"Sonia","family":"Di Tella","sequence":"additional","affiliation":[]},{"given":"Federica","family":"Rossetto","sequence":"additional","affiliation":[]},{"given":"Francesca","family":"Borgnis","sequence":"additional","affiliation":[]},{"given":"Olivia","family":"Realdon","sequence":"additional","affiliation":[]},{"given":"Monia","family":"Cabinio","sequence":"additional","affiliation":[]},{"given":"Chiara","family":"Pagliari","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-7562","authenticated-orcid":false,"given":"Alessandro","family":"Torchio","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0216-8205","authenticated-orcid":false,"given":"Anna","family":"Castagna","sequence":"additional","affiliation":[]},{"given":"Valeria","family":"Blasi","sequence":"additional","affiliation":[]},{"given":"Maria Caterina","family":"Silveri","sequence":"additional","affiliation":[]},{"given":"Francesca","family":"Baglio","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"1113_CR1","doi-asserted-by":"publisher","first-page":"618330","DOI":"10.3389\/fneur.2020.618330","volume":"11","author":"S Di Tella","year":"2020","unstructured":"Di Tella, S. et al. A multidimensional virtual reality neurorehabilitation approach to improve functional memory: who is the ideal candidate? Front Neurol. 11, 618330 (2020).","journal-title":"Front Neurol."},{"key":"1113_CR2","doi-asserted-by":"publisher","first-page":"735508","DOI":"10.3389\/fnagi.2021.735508","volume":"13","author":"S Di Tella","year":"2021","unstructured":"Di Tella, S. et al. Neuroimaging biomarkers predicting the efficacy of multimodal rehabilitative intervention in the alzheimer\u2019s dementia continuum pathology. Front Aging Neurosci. 13, 735508 (2021).","journal-title":"Front Aging Neurosci."},{"key":"1113_CR3","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1016\/j.neuropsychologia.2009.03.004","volume":"47","author":"Y Stern","year":"2009","unstructured":"Stern, Y. Cognitive reserve. Neuropsychologia 47, 2015\u20132028 (2009).","journal-title":"Neuropsychologia"},{"key":"1113_CR4","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/MRR.0000000000000175","volume":"39","author":"DG Fortune","year":"2016","unstructured":"Fortune, D. G., Walsh, R. S. & Richards, H. L. Cognitive reserve and preinjury educational attainment: effects on outcome of community-based rehabilitation for longer-term individuals with acquired brain injury. Int. J. Rehabil. Res. 39, 234\u2013239 (2016).","journal-title":"Int. J. Rehabil. Res."},{"key":"1113_CR5","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1007\/s10072-021-05123-3","volume":"42","author":"I Imbimbo","year":"2021","unstructured":"Imbimbo, I. et al. Parkinson\u2019s disease and virtual reality rehabilitation: cognitive reserve influences the walking and balance outcome. Neurol. Sci. 42, 4615\u20134621 (2021).","journal-title":"Neurol. Sci."},{"key":"1113_CR6","doi-asserted-by":"publisher","first-page":"554","DOI":"10.23736\/S1973-9087.17.04837-7","volume":"54","author":"G Piccinini","year":"2018","unstructured":"Piccinini, G. et al. The impact of cognitive reserve on the effectiveness of balance rehabilitation in Parkinson\u2019s disease. Eur. J. Phys. Rehabil. Med 54, 554\u2013559 (2018).","journal-title":"Eur. J. Phys. Rehabil. Med"},{"key":"1113_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10339-011-0410-3","volume":"13","author":"G Liberati","year":"2012","unstructured":"Liberati, G., Raffone, A. & Olivetti Belardinelli, M. Cognitive reserve and its implications for rehabilitation and Alzheimer\u2019s disease. Cogn. Process 13, 1\u201312 (2012).","journal-title":"Cogn. Process"},{"key":"1113_CR8","first-page":"7389658","volume":"2022","author":"L Pezzi","year":"2022","unstructured":"Pezzi, L. et al. How cognitive reserve should influence rehabilitation choices using virtual reality in Parkinson\u2019s disease. Parkinsons Dis. 2022, 7389658 (2022).","journal-title":"Parkinsons Dis."},{"key":"1113_CR9","doi-asserted-by":"publisher","first-page":"E18","DOI":"10.1097\/HTR.0000000000000325","volume":"33","author":"KA Steward","year":"2018","unstructured":"Steward, K. A. et al. The role of cognitive reserve in recovery from traumatic brain injury. J. Head. Trauma Rehabil. 33, E18\u2013e27 (2018).","journal-title":"J. Head. Trauma Rehabil."},{"key":"1113_CR10","doi-asserted-by":"publisher","first-page":"1266314","DOI":"10.3389\/fpsyg.2023.1266314","volume":"14","author":"S Bernini","year":"2023","unstructured":"Bernini, S. et al. In person versus remote cognitive rehabilitation in patients with subjective cognitive decline or neurocognitive disorders: what factors drive patient\u2019s preference? Front Psychol. 14, 1266314 (2023).","journal-title":"Front Psychol."},{"key":"1113_CR11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neurobiolaging.2022.10.015","volume":"124","author":"Y Stern","year":"2023","unstructured":"Stern, Y. et al. A framework for concepts of reserve and resilience in aging. Neurobiol. Aging 124, 100\u2013103 (2023).","journal-title":"Neurobiol. Aging"},{"key":"1113_CR12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/mds.25292","volume":"28","author":"SL Kowal","year":"2013","unstructured":"Kowal, S. L., Dall, T. M., Chakrabarti, R., Storm, M. V. & Jain, A. The current and projected economic burden of Parkinson\u2019s disease in the United States. Mov. Disord. 28, 311\u2013318 (2013).","journal-title":"Mov. Disord."},{"key":"1113_CR13","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1093\/aje\/kwq303","volume":"172","author":"AW Willis","year":"2010","unstructured":"Willis, A. W. et al. Metal emissions and urban incident Parkinson disease: a community health study of Medicare beneficiaries by using geographic information systems. Am. J. Epidemiol. 172, 1357\u20131363 (2010).","journal-title":"Am. J. Epidemiol."},{"key":"1113_CR14","doi-asserted-by":"publisher","first-page":"626041","DOI":"10.3389\/fneur.2021.626041","volume":"12","author":"M Meloni","year":"2021","unstructured":"Meloni, M. et al. Functional and cognitive improvement after an intensive inpatient multidisciplinary rehabilitation program in mild to severe Parkinson\u2019s disease: a retrospective and observational study. Front Neurol. 12, 626041 (2021).","journal-title":"Front Neurol."},{"key":"1113_CR15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1515\/revneuro-2021-0064","volume":"33","author":"F Baglio","year":"2022","unstructured":"Baglio, F., Pirastru, A., Bergsland, N., Cazzoli, M. & Tavazzi, E. Neuroplasticity mediated by motor rehabilitation in Parkinson\u2019s disease: a systematic review on structural and functional MRI markers. Rev. Neurosci. 33, 213\u2013226 (2022).","journal-title":"Rev. Neurosci."},{"key":"1113_CR16","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/bs.irn.2017.05.017","volume":"134","author":"N Titova","year":"2017","unstructured":"Titova, N. & Chaudhuri, K. R. Nonmotor Parkinson\u2019s and future directions. Int. Rev. Neurobiol. 134, 1493\u20131505 (2017).","journal-title":"Int. Rev. Neurobiol."},{"key":"1113_CR17","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1212\/WNL.0000000000004355","volume":"89","author":"ME Fullard","year":"2017","unstructured":"Fullard, M. E. et al. Utilization of rehabilitation therapy services in Parkinson disease in the United States. Neurology 89, 1162\u20131169 (2017).","journal-title":"Neurology"},{"key":"1113_CR18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1055\/s-0041-1725133","volume":"41","author":"TD Ellis","year":"2021","unstructured":"Ellis, T. D. et al. Evidence for early and regular physical therapy and exercise in Parkinson\u2019s disease. Semin. Neurol. 41, 189\u2013205 (2021).","journal-title":"Semin. Neurol."},{"key":"1113_CR19","doi-asserted-by":"publisher","unstructured":"Rossetto, F. et al. System Integrated Digital Empowerment and Rehabilitation to promote patient Activation and well-Being (SIDERA^ B): Protocol for a Randomized Crossover Trial on Effectiveness and Implementation. medRxiv https:\/\/doi.org\/10.1101\/2022.04.19.22274012 (2022).","DOI":"10.1101\/2022.04.19.22274012"},{"key":"1113_CR20","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.3389\/fneur.2019.01206","volume":"10","author":"S Isernia","year":"2019","unstructured":"Isernia, S. et al. Efficiency and patient-reported outcome measures from clinic to home: the human empowerment aging and disability program for digital-health rehabilitation. Front Neurol. 10, 1206 (2019).","journal-title":"Front Neurol."},{"key":"1113_CR21","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3389\/fneur.2020.00846","volume":"11","author":"S Isernia","year":"2020","unstructured":"Isernia, S. et al. Effects of an innovative telerehabilitation intervention for people with parkinson\u2019s disease on quality of life, motor, and non-motor abilities. Front Neurol. 11, 846 (2020).","journal-title":"Front Neurol."},{"key":"1113_CR22","doi-asserted-by":"publisher","first-page":"S73","DOI":"10.1016\/j.parkreldis.2015.08.031","volume":"22","author":"MS Ekker","year":"2016","unstructured":"Ekker, M. S., Janssen, S., Nonnekes, J., Bloem, B. R. & de Vries, N. M. Neurorehabilitation for Parkinson\u2019s disease: Future perspectives for behavioural adaptation. Parkinsonism Relat. Disord. 22, S73\u2013S77 (2016).","journal-title":"Parkinsonism Relat. Disord."},{"key":"1113_CR23","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1007\/s10072-021-05855-2","volume":"43","author":"S Truijen","year":"2022","unstructured":"Truijen, S. et al. Effect of home-based virtual reality training and telerehabilitation on balance in individuals with Parkinson disease, multiple sclerosis, and stroke: a systematic review and meta-analysis. Neurol. Sci. 43, 2995\u20133006 (2022).","journal-title":"Neurol. Sci."},{"key":"1113_CR24","doi-asserted-by":"publisher","first-page":"7962826","DOI":"10.1155\/2017\/7962826","volume":"2017","author":"M Gandolfi","year":"2017","unstructured":"Gandolfi, M. et al. Virtual reality telerehabilitation for postural instability in Parkinson\u2019s disease: a multicenter, single-blind, randomized, controlled trial. Biomed. Res. Int. 2017, 7962826 (2017).","journal-title":"Biomed. Res. Int."},{"key":"1113_CR25","doi-asserted-by":"publisher","first-page":"627999","DOI":"10.3389\/fneur.2021.627999","volume":"12","author":"C Vellata","year":"2021","unstructured":"Vellata, C. et al. Effectiveness of telerehabilitation on motor impairments, non-motor symptoms and compliance in patients with Parkinson\u2019s disease: a systematic review. Front Neurol. 12, 627999 (2021).","journal-title":"Front Neurol."},{"key":"1113_CR26","doi-asserted-by":"publisher","unstructured":"Di Tella, S. et al. Cognitive Reserve proxies can modulate motor and non-motor basal ganglia circuits in early Parkinson\u2019s Disease. Brain Imaging Behav https:\/\/doi.org\/10.1007\/s11682-023-00829-8 (2023).","DOI":"10.1007\/s11682-023-00829-8"},{"key":"1113_CR27","doi-asserted-by":"publisher","first-page":"1207988","DOI":"10.3389\/fpsyg.2023.1207988","volume":"14","author":"S Di Tella","year":"2023","unstructured":"Di Tella, S., De Marco, M., Baglio, F., Silveri, M. C. & Venneri, A. Resting-state functional connectivity is modulated by cognitive reserve in early Parkinson\u2019s disease. Front Psychol. 14, 1207988 (2023).","journal-title":"Front Psychol."},{"key":"1113_CR28","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1532-5415.2006.00701.x","volume":"54","author":"S Perera","year":"2006","unstructured":"Perera, S., Mody, S. H., Woodman, R. C. & Studenski, S. A. Meaningful change and responsiveness in common physical performance measures in older adults. J. Am. Geriatr. Soc. 54, 743\u2013749 (2006).","journal-title":"J. Am. Geriatr. Soc."},{"key":"1113_CR29","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/jep.12629","volume":"23","author":"RW Bohannon","year":"2017","unstructured":"Bohannon, R. W. & Crouch, R. Minimal clinically important difference for change in 6-minute walk test distance of adults with pathology: a systematic review. J. Eval. Clin. Pr. 23, 377\u2013381 (2017).","journal-title":"J. Eval. Clin. Pr."},{"key":"1113_CR30","doi-asserted-by":"publisher","first-page":"1154481","DOI":"10.3389\/fpubh.2023.1154481","volume":"11","author":"F Rossetto","year":"2023","unstructured":"Rossetto, F. et al. System integrated digital empowering and telerehabilitation to promote patient activation and well-being in chronic disabilities: a usability and acceptability study. Front Public Health 11, 1154481 (2023).","journal-title":"Front Public Health"},{"key":"1113_CR31","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/ene.14090","volume":"27","author":"L Padua","year":"2020","unstructured":"Padua, L. et al. Cognitive reserve as a useful variable to address robotic or conventional upper limb rehabilitation treatment after stroke: a multicentre study of the Fondazione Don Carlo Gnocchi. Eur. J. Neurol. 27, 392\u2013398 (2020).","journal-title":"Eur. J. Neurol."},{"key":"1113_CR32","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3233\/JAD-200264","volume":"77","author":"S Lamballais","year":"2020","unstructured":"Lamballais, S. et al. The risk of dementia in relation to cognitive and brain reserve. J. Alzheimers Dis. 77, 607\u2013618 (2020).","journal-title":"J. Alzheimers Dis."},{"key":"1113_CR33","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3233\/JAD-215122","volume":"85","author":"JL Zijlmans","year":"2022","unstructured":"Zijlmans, J. L., Lamballais, S., Vernooij, M. W., Ikram, M. A. & Luik, A. I. Sociodemographic, lifestyle, physical, and psychosocial determinants of cognitive reserve. J. Alzheimers Dis. 85, 701\u2013713 (2022).","journal-title":"J. Alzheimers Dis."},{"key":"1113_CR34","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1177\/1545968320952799","volume":"34","author":"DLM Radder","year":"2020","unstructured":"Radder, D. L. M. et al. Physiotherapy in Parkinson\u2019s disease: a meta-analysis of present treatment modalities. Neurorehabil. Neural Repair 34, 871\u2013880 (2020).","journal-title":"Neurorehabil. Neural Repair"},{"key":"1113_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01938-3","volume":"20","author":"MS Barnish","year":"2020","unstructured":"Barnish, M. S. & Barran, S. M. A systematic review of active group-based dance, singing, music therapy and theatrical interventions for quality of life, functional communication, speech, motor function and cognitive status in people with Parkinson\u2019s disease. BMC Neurol. 20, 371 (2020).","journal-title":"BMC Neurol."},{"key":"1113_CR36","doi-asserted-by":"publisher","first-page":"e1505","DOI":"10.1111\/hsc.13842","volume":"30","author":"J Salse-Bat\u00e1n","year":"2022","unstructured":"Salse-Bat\u00e1n, J., Sanchez-Lastra, M. A., Suarez-Iglesias, D., Varela, S. & Ay\u00e1n, C. Effects of Nordic walking in people with Parkinson\u2019s disease: A systematic review and meta-analysis. Health Soc. Care Commun. 30, e1505\u2013e1520 (2022).","journal-title":"Health Soc. Care Commun."},{"key":"1113_CR37","doi-asserted-by":"publisher","unstructured":"Bergsland, N. et al. Automated assessment of the substantia nigra pars compacta in Parkinson\u2019s disease: a diffusion tensor imaging study. J. Pers. Med. 11 https:\/\/doi.org\/10.3390\/jpm11111235 (2021).","DOI":"10.3390\/jpm11111235"},{"key":"1113_CR38","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1016\/j.apmr.2021.04.006","volume":"102","author":"C Arienti","year":"2021","unstructured":"Arienti, C. et al. Methodological issues in rehabilitation research: a scoping review. Arch. Phys. Med Rehabil. 102, 1614\u20131622.e1614 (2021).","journal-title":"Arch. Phys. Med Rehabil."},{"key":"1113_CR39","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma, R. B. et al. MDS clinical diagnostic criteria for Parkinson\u2019s disease. Mov. Disord. 30, 1591\u20131601 (2015).","journal-title":"Mov. Disord."},{"key":"1113_CR40","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s10072-014-1995-y","volume":"36","author":"G Santangelo","year":"2015","unstructured":"Santangelo, G. et al. Normative data for the Montreal Cognitive Assessment in an Italian population sample. Neurol. Sci. 36, 585\u2013591 (2015).","journal-title":"Neurol. Sci."},{"key":"1113_CR41","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/mds.20213","volume":"19","author":"CG Goetz","year":"2004","unstructured":"Goetz, C. G. et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov. Disord. 19, 1020\u20131028 (2004).","journal-title":"Mov. Disord."},{"key":"1113_CR42","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1002\/mds.22340","volume":"23","author":"CG Goetz","year":"2008","unstructured":"Goetz, C. G. et al. Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov. Disord. 23, 2129\u20132170 (2008).","journal-title":"Mov. Disord."},{"key":"1113_CR43","first-page":"783","volume":"48","author":"PL Enright","year":"2003","unstructured":"Enright, P. L. The six-minute walk test. Respir. Care 48, 783\u2013785 (2003).","journal-title":"Respir. Care"},{"key":"1113_CR44","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuroimage.2019.01.014","volume":"189","author":"ET Klapwijk","year":"2019","unstructured":"Klapwijk, E. T., van de Kamp, F., van der Meulen, M., Peters, S. & Wierenga, L. M. Qoala-T: A supervised-learning tool for quality control of FreeSurfer segmented MRI data. Neuroimage 189, 116\u2013129 (2019).","journal-title":"Neuroimage"},{"key":"1113_CR45","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl, B. et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33, 341\u2013355 (2002).","journal-title":"Neuron"},{"key":"1113_CR46","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/BF03654795","volume":"24","author":"M Nucci","year":"2012","unstructured":"Nucci, M., Mapelli, D. & Mondini, S. Cognitive Reserve Index questionnaire (CRIq): a new instrument for measuring cognitive reserve. Aging Clin. Exp. Res 24, 218\u2013226 (2012).","journal-title":"Aging Clin. Exp. Res"},{"key":"1113_CR47","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1080\/07853890.2023.2185672","volume":"55","author":"F Rossetto","year":"2023","unstructured":"Rossetto, F. et al. A digital health home intervention for people within the Alzheimer\u2019s disease continuum: results from the Ability-TelerehABILITation pilot randomized controlled trial. Ann. Med 55, 1080\u20131091 (2023).","journal-title":"Ann. Med"},{"key":"1113_CR48","first-page":"205566831989277","volume":"7","author":"B Byrom","year":"2020","unstructured":"Byrom, B., Breedon, P., Tulkki-Wilke, R. & Platko, J. V. Meaningful change: Defining the interpretability of changes in endpoints derived from interactive and mHealth technologies in healthcare and clinical research. J. Rehabil. Assist Technol. Eng. 7, 2055668319892778 (2020).","journal-title":"J. Rehabil. Assist Technol. Eng."},{"key":"1113_CR49","doi-asserted-by":"publisher","unstructured":"Katajapuu, N., Heinonen, A. & Saltychev, M. Minimal clinically important difference and minimal detectable change of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) amongst patients with chronic musculoskeletal pain. Clin. Rehabil. 269215520942573 https:\/\/doi.org\/10.1177\/0269215520942573 (2020).","DOI":"10.1177\/0269215520942573"},{"key":"1113_CR50","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1477-7525-3-36","volume":"3","author":"R Shikiar","year":"2005","unstructured":"Shikiar, R., Harding, G., Leahy, M. & Lennox, R. D. Minimal important difference (MID) of the Dermatology Life Quality Index (DLQI): results from patients with chronic idiopathic urticaria. Health Qual. Life Outcomes 3, 36 (2005).","journal-title":"Health Qual. Life Outcomes"}],"container-title":["npj Digital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41746-024-01113-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41746-024-01113-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41746-024-01113-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T08:08:11Z","timestamp":1714982891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41746-024-01113-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,6]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1113"],"URL":"https:\/\/doi.org\/10.1038\/s41746-024-01113-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3793223\/v1","asserted-by":"object"}]},"ISSN":["2398-6352"],"issn-type":[{"value":"2398-6352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,6]]},"assertion":[{"value":"22 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"116"}}