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Med."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Careful selection of skin lesions that require expert evaluation is important for early skin cancer detection. Yet challenges include lack of cost-effective asymptomatic screening, geographical inequality in access to specialty dermatology, and long wait times due to exam inefficiencies and staff shortages. Machine learning models trained on high-quality dermoscopy photos have been shown to aid clinicians in diagnosing individual, hand-selected skin lesions. In contrast, models designed for triage have been less explored due to limited datasets that represent a broader net of skin lesions. 3D total body photography is an emerging technology used in dermatology to document all apparent skin lesions on a patient for skin cancer monitoring. A multi-institutional and global project collected over 900,000 lesion crops off 3D total body photos for an online grand challenge in machine learning. Here we summarize the results of the competition, \u2018ISIC 2024 \u2013 Skin Cancer Detection with 3D-TBP\u2019, demonstrate superiority of a model that utilized intra-patient context against a prior published approach, and explore clinical plausibility of automated atypical skin lesion triage through an ablation study.<\/jats:p>","DOI":"10.1038\/s41746-025-02070-7","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:41:32Z","timestamp":1763728892000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Automated triage of cancer-suspicious skin lesions with 3D total-body photography"],"prefix":"10.1038","volume":"8","author":[{"given":"Nicholas R.","family":"Kurtansky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura C.","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel C. 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D\u2019Alessandro is an employee of Canfield Scientific, Inc. N. Codella is a Microsoft employee and holds diverse investments in the technology and healthcare sectors. P. Guitera has participated in Advisory Boards for MSD and L\u2019Oreal and received honoraria from Metaoptima PTY and travel support from L\u2019Or\u00e9al. Neither of these is relevant for this paper. A. Halpern receives consultation fees from Canfield Scientific, Inc. A. Navarini and L.V. Maul received a grant from Canfield Scientific, Inc. for physician's salary in a separate study that had no influence on this manuscript. H.P. Soyer is a shareholder of MoleMap NZ Limited and e-derm consult GmbH and undertakes regular teledermatological reporting for both companies. H.P. Soyer is a medical consultant for Canfield Scientific Inc. and a medical advisor for First Derm. V. Rotemberg is a consultant for Inhabit Brands, Inc. and Atria Institute, and receives in-kind support from Kaggle and AWS. The other authors do not declare any competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"708"}}