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Med."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This perspective introduces MS360\u00b0, a conceptual hybrid care model for the management of multiple sclerosis (MS). It integrates traditional on-site assessments with digital health technologies (DHT) to enable more continuous, personalised, and proactive disease management. Current MS care is often fragmented, limiting timely interventions and patient engagement. MS360\u00b0 addresses these challenges by introducing a digital-first hybrid framework for continuous data collection through remote monitoring, wearable sensors, and telemedicine. This data can be used to dynamically steer structured patient pathways and trigger targeted on-site assessments and interventions such as neurological examinations, imaging, laboratory assessments, and standardised functional tests based on predefined thresholds and patient profiles. The interaction of multidisciplinary teams, structured care pathways and bidirectional data flow enables timely clinical decision-making, stratified patient management and early detection of disease progression. Digital tools can further enhance patient engagement and lifestyle management, promoting adherence and outcomes. New technologies, including artificial intelligence and digital twins, are being discussed as potential future extensions for precision care, workflow optimisation, and risk prediction. 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MP receives honoraria for lecturing and travel expenses for attending meetings from Alexion, ArgenX, Bayer Health Care, Biogen, Hexal, Merck Serono, Neuraxpharm, Novartis, Roche, Sanofi-Aventis, Takeda and Teva. His research is funded by ArgenX, Biogen, Demecan, Hexal, Horizon Merck Serono, Novartis, Roche, Viatris, Taked, TEVA, B. Braun foundation and the Multiple Sclerosis Society North Rhine-Westphalia Regional Association (DMSG).HI received speaker honoraria from Roche and financial support for research activities from Novartis, Teva, Neuraxpharm, Biogen and Alexion.SGM receives honoraria for lecturing, travel expenses and for attending meetings from Academy 2, Argenx, Alexion, Almirall, Amicus Therapeutics Germany, AstraZeneca, Bayer Health Care, Biogen, BioNtech, BMS, Celgene, Datamed, Demecan, Desitin, Diamed, Diaplan, DIU Dresden, DPmed, Gen Medicine and Healthcare products, Genzyme, Hexal AG, IGES, Impulze GmbH, Janssen Cilag, KW Medipoint, MedDay Pharmaceuticals, Medmile, Merck Serono, MICE, Mylan, Neuraxpharm, Neuropoint, Novartis, Novo Nordisk, ONO Pharma, Oxford PharmaGenesis, QuintilesIMS, Roche, Sanofi, Springer Medizin Verlag, STADA, Chugai Pharma, Teva, UCB, Viatris, Wings for Life international and Xcenda. His research is funded by the German Ministry for Education and Research (BMBF), German Federal Institute for Risk Assessment (BfR), German Research Foundation (DFG), Else Kr\u00f6ner Fresenius Foundation, Gemeinsamer Bundesausschuss (G-BA), German Academic Exchange Service, Hertie Foundation, Interdisciplinary Center for Clinical Studies (IZKF) Muenster, German Foundation Neurology, Ministry of Culture and Science of the State of North Rhine-Westphalia, The Daimler and Benz Foundation, Multiple Sclerosis Society North Rhine-Westphalia Regional Association (dmsg), Peek & Cloppenburg D\u00fcsseldorf Foundation, Hempel Foundation for Science, Art and Welfare, German Alzheimer Society e.V. Dementia self-help and Alexion, Almirall, Amicus Therapeutics Germany, Argenx, Bayer Vital GmbH, BGP Products Operations (Viatris Company), Biogen, BMS, Demecan, Diamed, DGM e.v., Fresenius Medical Care, Genzyme, Gesellschaft von Freunden und F\u00f6rderern der Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf e.V., HERZ Burgdorf, Hexal, Janssen, Merck Serono, Novartis, Novo Nordisk Pharma, ONO Pharma, Roche and Teva.TZ declares advisory boards fees from Biogen, BMS, Merck, Novartis, Roche, Sanofi, Neuraxpharm, Viatris and Teva; speaker fees from Almirall, Alexion, Biogen, BMS, Hexal, Novartis, Novo Nordisk, Roche, Sanofi, Sandoz, Teva and Viatris; research support from Biogen, BMS, Novartis, Roche, Sanofi Neuraxpharm and Teva.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"229"}}