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Med."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Physical activity and mobility are critical for healthy aging and predict diverse health outcomes. While wrist-worn accelerometers are widely used to monitor physical activity, estimating gait metrics from wrist data remains challenging. We extend ElderNet, a self-supervised deep-learning model previously validated for walking-bout detection, to estimate gait metrics from wrist accelerometry. Validation involved 819 older adults (Rush-Memory-and-Aging-Project) and 85 individuals with gait impairments (Mobilise-D), from six medical centers. In Mobilise-D, ElderNet achieved an absolute error of 8.82\u2009cm\/s and an intra-class correlation of 0.87 for gait speed, outperforming state-of-the-art methods (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and models using a lower-back sensor. ElderNet outperformed (percentage error;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) competing approaches in estimating cadence and stride length, and better (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) classified mobility disability (AUC\u2009=\u20090.80) than conventional gait or physical activity metrics. These results demonstrate the potential of ElderNet a scalable tool for gait assessment using wrist-worn devices in aging and clinical populations.\n                  <\/jats:p>","DOI":"10.1038\/s41746-026-02528-2","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:45:37Z","timestamp":1773305137000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous assessment of daily-living gait using self-supervised learning of wrist-worn accelerometer data"],"prefix":"10.1038","volume":"9","author":[{"given":"Yonatan E.","family":"Brand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron S.","family":"Buchman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Kluge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Palmerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Cereatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Maetzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrix","family":"Vereijken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison J.","family":"Yarnall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Rochester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Del Din","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Hausdorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Or","family":"Perlman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"2528_CR1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s12877-023-03859-5","volume":"23","author":"EM Reijnierse","year":"2023","unstructured":"Reijnierse, E. 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