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This work provides a powerful, externally validated, and explainable AI framework to augment clinical judgment, with strong potential to reduce diagnostic delays and improve outcomes for these devastating infections.<\/jats:p>","DOI":"10.1038\/s41746-026-02686-3","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:43:17Z","timestamp":1777444997000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Explainable machine learning differentiates necrotizing fasciitis and osteomyelitis via routine blood biomarkers"],"prefix":"10.1038","volume":"9","author":[{"given":"Parhat","family":"Yasin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubaidanmu","family":"Aizezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasen","family":"Yimit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alimujiang","family":"Yusufu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoujun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haopeng","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"2686_CR1","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/TA.0000000000002636","volume":"89","author":"DL Horn","year":"2020","unstructured":"Horn, D. 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