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Q.C., H.Q.L., Y.F.L. and W.L.W. have filed patent application (no. 202210091553.7) relating to rotamer-free protein seuqence design in the name of University of Science and Technology of China. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}