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We sought to determine whether there were common patterns of disease progression that could aid in the design and analysis of clinical trials. We developed an approach based on a mixture of Gaussian processes to identify clusters of patients sharing similar disease progression patterns, modeling their average trajectories and the variability in each cluster. We show that ALS progression is frequently nonlinear, with periods of stable disease preceded or followed by rapid decline. We also show that our approach can be extended to Alzheimer\u2019s and Parkinson\u2019s diseases. Our results advance the characterization of disease progression of ALS and provide a flexible modeling approach that can be applied to other progressive diseases.<\/jats:p>","DOI":"10.1038\/s43588-022-00299-w","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T12:23:02Z","timestamp":1662639782000},"page":"605-616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal 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