{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:57:01Z","timestamp":1769835421612,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T00:00:00Z","timestamp":1179792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1038\/sj.bjc.6603808","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T15:49:29Z","timestamp":1179935369000},"page":"1783-1787","source":"Crossref","is-referenced-by-count":153,"title":["Desmosomes: a role in cancer?"],"prefix":"10.1038","volume":"96","author":[{"given":"M","family":"Chidgey","sequence":"first","affiliation":[]},{"given":"C","family":"Dawson","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,5,22]]},"reference":[{"key":"BF6603808_CR1","doi-asserted-by":"publisher","first-page":"6384","DOI":"10.1073\/pnas.92.14.6384","volume":"92","author":"H Aberle","year":"1995","unstructured":"Aberle H, Bierkamp C, Torchard D, Serova O, Wagner T, Natt E, Wirsching J, Heidkamper C, Montagna M, Lynch HT, Lenoir GM, Scherer G, Feunteun J, Kemler R (1995) The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Proc Natl Acad Sci USA 92: 6384\u20136388","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6603808_CR2","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.febslet.2007.03.026","volume":"581","author":"K Aigner","year":"2007","unstructured":"Aigner K, Descovich L, Mikula M, Sultan A, Dampier B, Bonne S, van Roy F, Mikulits W, Schreiber M, Brabletz T, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A (2007) The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. FEBS Lett 581: 1617\u20131624","journal-title":"FEBS Lett"},{"key":"BF6603808_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/path.1821","volume":"207","author":"K Biedermann","year":"2005","unstructured":"Biedermann K, Vogelsang H, Becker I, Plaschke S, Siewert JR, Hofler H, Keller G (2005) Desmoglein 2 is expressed abnormally rather than mutated in familial and sporadic gastric cancer. J Pathol 207: 199\u2013206","journal-title":"J Pathol"},{"key":"BF6603808_CR4","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1242\/jcs.03392","volume":"120","author":"D Brennan","year":"2007","unstructured":"Brennan D, Hu Y, Joubeh S, Choi YW, Whitaker-Menezes D, O'Brien T, Uitto J, Rodeck U, Mahoney MG (2007) Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes. J Cell Sci 120: 758\u2013771","journal-title":"J Cell Sci"},{"key":"BF6603808_CR5","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1002\/ijc.20634","volume":"113","author":"D Canes","year":"2005","unstructured":"Canes D, Chiang GJ, Billmeyer BR, Austin CA, Kosakowski M, Rieger-Christ KM, Libertino JA, Summerhayes IC (2005) Histone deacetylase inhibitors upregulate plakoglobin expression in bladder carcinoma cells and display antineoplastic activity in vitro and in vivo. Int J Cancer 113: 841\u2013848","journal-title":"Int J Cancer"},{"key":"BF6603808_CR6","doi-asserted-by":"publisher","first-page":"10512","DOI":"10.1074\/jbc.M108765200","volume":"277","author":"X Chen","year":"2002","unstructured":"Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ (2002) Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and \u03b2-catenin signaling. J Biol Chem 277: 10512\u201310522","journal-title":"J Biol Chem"},{"key":"BF6603808_CR7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/sj.onc.1209802","volume":"26","author":"YJ Chen","year":"2007","unstructured":"Chen YJ, Chang JT, Lee L, Wang HM, Liao CT, Chiu CC, Chen PJ, Cheng AJ (2007) DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. Oncogene 26: 467\u2013476","journal-title":"Oncogene"},{"key":"BF6603808_CR8","first-page":"1179","volume":"17","author":"M Chidgey","year":"2002","unstructured":"Chidgey M (2002) Desmosomes and disease: an update. Histol Histopathol 17: 1179\u20131192","journal-title":"Histol Histopathol"},{"key":"BF6603808_CR9","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1101\/gad.227502","volume":"16","author":"ME Conacci-Sorrell","year":"2002","unstructured":"Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, Feinstein E, Einat P, Ben-Ze'ev A (2002) Nr-CAM is a target gene of the \u03b2-catenin\/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev 16: 2058\u20132072","journal-title":"Genes Dev"},{"key":"BF6603808_CR10","doi-asserted-by":"publisher","first-page":"7102","DOI":"10.1158\/0008-5472.CAN-04-1877","volume":"65","author":"C Furukawa","year":"2005","unstructured":"Furukawa C, Daigo Y, Ishikawa N, Kato T, Ito T, Tsuchiya E, Sone S, Nakamura Y (2005) Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. Cancer Res 65: 7102\u20137110","journal-title":"Cancer Res"},{"key":"BF6603808_CR11","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1172\/JCI27751","volume":"116","author":"E Garcia-Gras","year":"2006","unstructured":"Garcia-Gras E, Lombardi R, Giocondo MJ, Willerson JT, Schneider MD, Khoury DS, Marian AJ (2006) Suppression of canonical Wnt\/\u03b2-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest 116: 2012\u20132021","journal-title":"J Clin Invest"},{"key":"BF6603808_CR12","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrm1356","volume":"5","author":"S Getsios","year":"2004","unstructured":"Getsios S, Huen AC, Green KJ (2004) Working out the strength and flexibility of desmosomes. Nat Rev Mol Cell Biol 5: 271\u2013281","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BF6603808_CR13","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/bies.20238","volume":"27","author":"T Gomez del Pulgar","year":"2005","unstructured":"Gomez del Pulgar T, Benitah SA, Valeron PF, Espina C, Lacal JC (2005) Rho GTPase expression in tumourigenesis: evidence for a significant link. Bioessays 27: 602\u2013613","journal-title":"Bioessays"},{"key":"BF6603808_CR14","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1083\/jcb.153.5.1049","volume":"153","author":"CJ Gottardi","year":"2001","unstructured":"Gottardi CJ, Wong E, Gumbiner BM (2001) E-cadherin suppresses cellular transformation by inhibiting \u03b2-catenin signaling in an adhesion-independent manner. J Cell Biol 153: 1049\u20131060","journal-title":"J Cell Biol"},{"key":"BF6603808_CR15","doi-asserted-by":"publisher","first-page":"10905","DOI":"10.1074\/jbc.275.15.10905","volume":"275","author":"S Hakimelahi","year":"2000","unstructured":"Hakimelahi S, Parker HR, Gilchrist AJ, Barry M, Li Z, Bleackley RC, Pasdar M (2000) Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2. J Biol Chem 275: 10905\u201310911","journal-title":"J Biol Chem"},{"key":"BF6603808_CR16","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1128\/MCB.25.3.969-978.2005","volume":"25","author":"MJ Hardman","year":"2005","unstructured":"Hardman MJ, Liu K, Avilion AA, Merritt A, Brennan K, Garrod DR, Byrne C (2005) Desmosomal cadherin misexpression alters \u03b2-catenin stability and epidermal differentiation. Mol Cell Biol 25: 969\u2013978","journal-title":"Mol Cell Biol"},{"key":"BF6603808_CR17","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1242\/jcs.00275","volume":"116","author":"M Hatzfeld","year":"2003","unstructured":"Hatzfeld M, Green KJ, Sauter H (2003) Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. J Cell Sci 116: 1219\u20131233","journal-title":"J Cell Sci"},{"key":"BF6603808_CR18","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/sj.ejhg.5200605","volume":"9","author":"DM Hunt","year":"2001","unstructured":"Hunt DM, Rickman L, Whittock NV, Eady RA, Simrak D, Dopping-Hepenstal PJ, Stevens HP, Armstrong DK, Hennies HC, Kuster W, Hughes AE, Arnemann J, Leigh IM, McGrath JA, Kelsell DP, Buxton RS (2001) Spectrum of dominant mutations in the desmosomal cadherin desmoglein 1, causing the skin disease striate palmoplantar keratoderma. Eur J Hum Genet 9: 197\u2013203","journal-title":"Eur J Hum Genet"},{"key":"BF6603808_CR19","doi-asserted-by":"publisher","first-page":"4522","DOI":"10.1073\/pnas.92.10.4522","volume":"92","author":"A Karnovsky","year":"1995","unstructured":"Karnovsky A, Klymkowsky MW (1995) Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin. Proc Natl Acad Sci USA 92: 4522\u20134526","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6603808_CR20","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/sj.bjc.6603453","volume":"95","author":"K Khan","year":"2006","unstructured":"Khan K, Hardy R, Haq A, Ogunbiyi O, Morton D, Chidgey M (2006) Desmocollin switching in colorectal cancer. Br J Cancer 95: 1367\u20131370","journal-title":"Br J Cancer"},{"key":"BF6603808_CR21","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1101\/gad.14.11.1319","volume":"14","author":"FT Kolligs","year":"2000","unstructured":"Kolligs FT, Kolligs B, Hajra KM, Hu G, Tani M, Cho KR, Fearon ER (2000) Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of \u03b2-catenin. Genes Dev 14: 1319\u20131331","journal-title":"Genes Dev"},{"key":"BF6603808_CR22","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1242\/jcs.02888","volume":"119","author":"MD Kottke","year":"2006","unstructured":"Kottke MD, Delva E, Kowalczyk AP (2006) The desmosome: cell science lessons from human diseases. J Cell Sci 119: 797\u2013806","journal-title":"J Cell Sci"},{"key":"BF6603808_CR23","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.yexcr.2005.11.007","volume":"312","author":"F Kuphal","year":"2006","unstructured":"Kuphal F, Behrens J (2006) E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts. Exp Cell Res 312: 457\u2013467","journal-title":"Exp Cell Res"},{"key":"BF6603808_CR24","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1034\/j.1600-0560.2003.00122.x","volume":"30","author":"H Kurzen","year":"2003","unstructured":"Kurzen H, Munzing I, Hartschuh W (2003) Expression of desmosomal proteins in squamous cell carcinomas of the skin. J Cutan Pathol 30: 621\u2013630","journal-title":"J Cutan Pathol"},{"key":"BF6603808_CR25","first-page":"103","volume":"21","author":"F Li","year":"2006","unstructured":"Li F, Chong ZZ, Maiese K (2006) Winding through the WNT pathway during cellular development and demise. Histol Histopathol 21: 103\u2013124","journal-title":"Histol Histopathol"},{"key":"BF6603808_CR26","doi-asserted-by":"publisher","first-page":"37191","DOI":"10.1074\/jbc.M405123200","volume":"279","author":"JH Lorch","year":"2004","unstructured":"Lorch JH, Klessner J, Park JK, Getsios S, Wu YL, Stack MS, Green KJ (2004) Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells. J Biol Chem 279: 37191\u201337200","journal-title":"J Biol Chem"},{"key":"BF6603808_CR27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1006\/dbio.1997.8550","volume":"185","author":"JM Merriam","year":"1997","unstructured":"Merriam JM, Rubenstein AB, Klymkowsky MW (1997) Cytoplasmically anchored plakoglobin induces a WNT-like phenotype in Xenopus. Dev Biol 185: 67\u201381","journal-title":"Dev Biol"},{"key":"BF6603808_CR28","doi-asserted-by":"publisher","first-page":"5846","DOI":"10.1128\/MCB.22.16.5846-5858.2002","volume":"22","author":"AJ Merritt","year":"2002","unstructured":"Merritt AJ, Berika MY, Zhai W, Kirk SE, Ji B, Hardman MJ, Garrod DR (2002) Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation. Mol Cell Biol 22: 5846\u20135858","journal-title":"Mol Cell Biol"},{"key":"BF6603808_CR29","doi-asserted-by":"publisher","first-page":"7391","DOI":"10.1128\/MCB.23.20.7391-7402.2003","volume":"23","author":"S Miravet","year":"2003","unstructured":"Miravet S, Piedra J, Castano J, Raurell I, Franci C, Dunach M, Garcia de Herreros A (2003) Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates \u03b2-catenin-mediated transcription. Mol Cell Biol 23: 7391\u20137402","journal-title":"Mol Cell Biol"},{"key":"BF6603808_CR30","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1074\/jbc.M110248200","volume":"277","author":"S Miravet","year":"2002","unstructured":"Miravet S, Piedra J, Miro F, Itarte E, Garcia de Herreros A, Dunach M (2002) The transcriptional factor Tcf-4 contains different binding sites for \u03b2-catenin and plakoglobin. J Biol Chem 277: 1884\u20131891","journal-title":"J Biol Chem"},{"key":"BF6603808_CR31","doi-asserted-by":"publisher","first-page":"R669","DOI":"10.1186\/bcr1273","volume":"7","author":"MM Oshiro","year":"2005","unstructured":"Oshiro MM, Kim CJ, Wozniak RJ, Junk DJ, Munoz-Rodriguez JL, Burr JA, Fitzgerald M, Pawar SC, Cress AE, Domann FE, Futscher BW (2005) Epigenetic silencing of DSC3 is a common event in human breast cancer. Breast Cancer Res 7: R669\u2013R680","journal-title":"Breast Cancer Res"},{"key":"BF6603808_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/(SICI)1097-0169(1998)40:1<87::AID-CM8>3.0.CO;2-C","volume":"40","author":"HR Parker","year":"1998","unstructured":"Parker HR, Li Z, Sheinin H, Lauzon G, Pasdar M (1998) Plakoglobin induces desmosome formation and epidermoid phenotype in N-cadherin-expressing squamous carcinoma cells deficient in plakoglobin and E-cadherin. Cell Motil Cytoskeleton 40: 87\u2013100","journal-title":"Cell Motil Cytoskeleton"},{"key":"BF6603808_CR33","doi-asserted-by":"publisher","first-page":"7947","DOI":"10.1038\/sj.onc.1208161","volume":"23","author":"AB Reynolds","year":"2004","unstructured":"Reynolds AB, Roczniak-Ferguson A (2004) Emerging roles for p120-catenin in cell adhesion and cancer. Oncogene 23: 7947\u20137956","journal-title":"Oncogene"},{"key":"BF6603808_CR34","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1038\/sj.bjc.6602651","volume":"92","author":"KM Rieger-Christ","year":"2005","unstructured":"Rieger-Christ KM, Ng L, Hanley RS, Durrani O, Ma H, Yee AS, Libertino JA, Summerhayes IC (2005) Restoration of plakoglobin expression in bladder carcinoma cell lines suppresses cell migration and tumorigenic potential. Br J Cancer 92: 2153\u20132159","journal-title":"Br J Cancer"},{"key":"BF6603808_CR35","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1002\/jcp.20188","volume":"202","author":"P Savagner","year":"2005","unstructured":"Savagner P, Kusewitt DF, Carver EA, Magnino F, Choi C, Gridley T, Hudson LG (2005) Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. Cell Physiol 202: 858\u2013866","journal-title":"Cell Physiol"},{"key":"BF6603808_CR36","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1158\/0008-5472.CAN-04-3398","volume":"65","author":"H Shiina","year":"2005","unstructured":"Shiina H, Breault JE, Basset WW, Enokida H, Urakami S, Li LC, Okino ST, Deguchi M, Kaneuchi M, Terashima M, Yoneda T, Shigeno K, Carroll PR, Igawa M, Dahiya R (2005) Functional loss of the \u03b3-catenin gene through epigenetic and genetic pathways in human prostate cancer. Cancer Res 65: 2130\u20132138","journal-title":"Cancer Res"},{"key":"BF6603808_CR37","doi-asserted-by":"publisher","first-page":"8064","DOI":"10.1073\/pnas.95.14.8064","volume":"95","author":"C Tselepis","year":"1998","unstructured":"Tselepis C, Chidgey M, North A, Garrod D (1998) Desmosomal adhesion inhibits invasive behavior. Proc Natl Acad Sci USA 95: 8064\u20138069","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6603808_CR38","doi-asserted-by":"publisher","first-page":"6566","DOI":"10.1093\/nar\/gki965","volume":"33","author":"C Vandewalle","year":"2005","unstructured":"Vandewalle C, Comijn J, De Craene B, Vermassen P, Bruyneel E, Andersen H, Tulchinsky E, Van Roy F, Berx G (2005) SIP1\/ZEB2 induces EMT by repressing genes of different epithelial cell\u2013cell junctions. Nucleic Acids Res 33: 6566\u20136578","journal-title":"Nucleic Acids Res"},{"key":"BF6603808_CR39","doi-asserted-by":"publisher","first-page":"7497","DOI":"10.1038\/sj.onc.1205963","volume":"21","author":"RA Winn","year":"2002","unstructured":"Winn RA, Bremnes RM, Bemis L, Franklin WA, Miller YE, Cool C, Heasley LE (2002) Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth. Oncogene 21: 7497\u20137506","journal-title":"Oncogene"},{"key":"BF6603808_CR40","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1038\/ncb1504","volume":"8","author":"A Wolf","year":"2006","unstructured":"Wolf A, Keil R, Gotzl O, Mun A, Schwarze K, Lederer M, Huttelmaier S, Hatzfeld M (2006) The armadillo protein p0071 regulates Rho signalling during cytokinesis. Nat Cell Biol 8: 1432\u20131440","journal-title":"Nat Cell Biol"},{"key":"BF6603808_CR41","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1016\/j.ejca.2006.03.024","volume":"42","author":"M Yashiro","year":"2006","unstructured":"Yashiro M, Nishioka N, Hirakawa K (2006) Decreased expression of the adhesion molecule desmoglein-2 is associated with diffuse-type gastric carcinoma. Eur J Cancer 42: 2397\u20132403","journal-title":"Eur J Cancer"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6603808.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6603808","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6603808.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:27:33Z","timestamp":1684412853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6603808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,22]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["BF6603808"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6603808","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,22]]}}}