{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:52:24Z","timestamp":1776844344575,"version":"3.51.2"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T00:00:00Z","timestamp":1193702400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1038\/sj.bjc.6604054","type":"journal-article","created":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T11:44:14Z","timestamp":1193744654000},"page":"1690-1695","source":"Crossref","is-referenced-by-count":215,"title":["Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer"],"prefix":"10.1038","volume":"97","author":[{"given":"R K","family":"Nam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Sugar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L H","family":"Klotz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L-Y","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Stanimirovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Encioiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Loblaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Trachtenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Narod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Seth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,10,30]]},"reference":[{"key":"BF6604054_CR1","first-page":"1686","volume":"61","author":"DE Afar","year":"2001","unstructured":"Afar DE, Vivanco I, Hubert RS, Kuo J, Chen E, Saffran DC, Raitano AB, Jakobovits A (2001) Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. Cancer Res 61: 1686\u20131692","journal-title":"Cancer Res"},{"key":"BF6604054_CR2","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1001\/jama.280.11.975","volume":"280","author":"PC Albertsen","year":"1998","unstructured":"Albertsen PC, Hanley JA, Gleason DF, Barry MJ (1998) Competing risk analysis of men aged 55\u201374 years at diagnosis managed conservatively for clinically localized prostate cancer. JAMA 280: 975\u2013980","journal-title":"JAMA"},{"key":"BF6604054_CR3","doi-asserted-by":"crossref","unstructured":"Attard G, Clark J, Ambroisine L, Fisher G, Kovacs G, Flohr P, Berney D, Foster CS, Fletcher A, Gerald WL, Moller H, Reuter V, De Bono JS, Scardino P, Cuzick J, Cooper CS (2007) Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. Oncogene 2007 July 16; [Epub ahead of print]","DOI":"10.1038\/sj.onc.1210640"},{"key":"BF6604054_CR4","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1002\/1097-0142(20010615)91:12<2302::AID-CNCR1262>3.0.CO;2-P","volume":"91","author":"MJ Barry","year":"2001","unstructured":"Barry MJ, Albertsen PC, Bagshaw MA, Blute ML, Cox R, Middleton RG, Gleason DF, Zinke H, Bergstralh EJ, Jacobsen SJ (2001) Outcomes for men with clinically nonmetastatic prostate carcinoma managed with radical prostatectomy, external beam radiotherapy, or expectant management. Cancer 91: 2302\u20132314","journal-title":"Cancer"},{"key":"BF6604054_CR5","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1056\/NEJMoa043739","volume":"352","author":"A Bill-Axelson","year":"2005","unstructured":"Bill-Axelson A, Holmberg L, Ruutu M, Haggman M, Andersson SO, Bratell S, Spangberg A, Busch C, Nordling S, Garmo H, Palmgren J, Adami HO, Norlen BJ, Johansson JE (2005) Radical prostatectomy vs watchful waiting in early prostate cancer. N Engl J Med 352: 1977\u20131984","journal-title":"N Engl J Med"},{"key":"BF6604054_CR6","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1038\/sj.onc.1210070","volume":"26","author":"J Clark","year":"2007","unstructured":"Clark J, Merson S, Jhavar S, Flohr P, Edwards S, Foster CS, Eeles R, Martin FL, Phillips DH, Crundwell M, Christmas T, Thompson A, Fisher C, Kovacs G, Cooper CS (2007) Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. Oncogene 26: 2667\u20132673","journal-title":"Oncogene"},{"key":"BF6604054_CR7","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1093\/jnci\/djg043","volume":"95","author":"AV D'Amico","year":"2003","unstructured":"D'Amico AV, Moul JW, Carroll PR, Sun L, Lubeck D, Chen MH (2003) Surrogate end point for prostate cancer-specific mortality after radical prostatectomy or radiation therapy. J Natl Cancer Inst 95: 1376\u20131383","journal-title":"J Natl Cancer Inst"},{"key":"BF6604054_CR8","doi-asserted-by":"publisher","first-page":"4596","DOI":"10.1038\/sj.onc.1210237","volume":"26","author":"F Demichelis","year":"2007","unstructured":"Demichelis F, Fall K, Perner S, Andren O, Schmidt F, Setlur SR, Hoshida Y, Mosquera JM, Pawitan Y, Lee C, Adami HO, Mucci LA, Kantoff PW, Andersson SO, Chinnaiyan AM, Johansson JE, Rubin MA (2007) TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene 26: 4596\u20134599","journal-title":"Oncogene"},{"key":"BF6604054_CR9","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/modpathol.3800759","volume":"20","author":"J Lapointe","year":"2007","unstructured":"Lapointe J, Kim YH, Miller MA, Li C, Kaygusuz G, van de Rijn M, Huntsman DG, Brooks JD, Pollack JR (2007) A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis. Mod Pathol 20: 467\u2013473","journal-title":"Mod Pathol"},{"key":"BF6604054_CR10","first-page":"4180","volume":"59","author":"B Lin","year":"1999","unstructured":"Lin B, Ferguson C, White JT, Wang S, Vessella R, True LD, Hood L, Nelson PS (1999) Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res 59: 4180\u20134184","journal-title":"Cancer Res"},{"key":"BF6604054_CR11","doi-asserted-by":"crossref","unstructured":"Liu W, Ewing CM, Chang BL, Li T, Sun J, Turner AR, Dimitrov L, Zhu Y, Sun J, Kim JW, Zheng SL, Isaacs WB, Xu J (2007) Multiple genomic alterations on 21q22 predict various TMPRSS2\/ERG fusion transcripts in human prostate cancers. Genes Chromosomes Cancer","DOI":"10.1002\/gcc.20482"},{"key":"BF6604054_CR12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/path.2154","volume":"212","author":"JM Mosquera","year":"2007","unstructured":"Mosquera JM, Perner S, Demichelis F, Kim R, Hofer M, Mertz K, Paris P, Simko J, Collins C, Bismar T, Chinnaiyan A, Rubin M (2007) Morphological features of TMPRSS2-ERG gene fusion prostate cancer. J Pathol 212: 91\u2013101","journal-title":"J Pathol"},{"key":"BF6604054_CR13","first-page":"1891","volume":"10","author":"RK Nam","year":"2003","unstructured":"Nam RK, Jewett MA, Krahn MD, Robinette MA, Tsihlias J, Toi A, Ho M, Evans A, Sweet J, Trachtenberg J (2003) Delay in surgical therapy for clinically localized prostate cancer and biochemical recurrence after radical prostatectomy. Can J Urol 10: 1891\u20131898","journal-title":"Can J Urol"},{"key":"BF6604054_CR14","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1158\/1535-7163.MCT-06-0080","volume":"6","author":"RK Nam","year":"2007","unstructured":"Nam RK, Sugar L, Wang Z, Yang W, Kitching R, Klotz LH, Venkateswaran V, Narod SA, Seth A (2007) Expression of TMPRSS2 ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression. Cancer Biol Ther 6: e1\u2013e6","journal-title":"Cancer Biol Ther"},{"key":"BF6604054_CR15","doi-asserted-by":"publisher","first-page":"8337","DOI":"10.1158\/0008-5472.CAN-06-1482","volume":"66","author":"S Perner","year":"2006","unstructured":"Perner S, Demichelis F, Beroukhim R, Schmidt FH, Mosquera JM, Setlur S, Tchinda J, Tomlins SA, Hofer MD, Pienta KG, Kuefer R, Vessella R, Sun XW, Meyerson M, Lee C, Sellers WR, Chinnaiyan AM, Rubin MA (2006) TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res 66: 8337\u20138341","journal-title":"Cancer Res"},{"key":"BF6604054_CR16","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1001\/jama.281.17.1591","volume":"281","author":"CR Pound","year":"1999","unstructured":"Pound CR, Partin AW, Eisenberger MA, Chan DW, Pearson JD, Walsh PC (1999) Natural history of progression after PSA elevation following radical prostatectomy. J Am Med Assoc 281: 1591\u20131597","journal-title":"J Am Med Assoc"},{"key":"BF6604054_CR17","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1136\/jcp.2006.043810","volume":"60","author":"AB Rajput","year":"2007","unstructured":"Rajput AB, Miller MA, De Luca A, Boyd N, Leung S, Hurtado-Coll A, Fazli L, Jones EC, Palmer JB, Gleave ME, Cox ME, Huntsman DG (2007) Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers. J Clin Pathol 60: 1238\u20131243","journal-title":"J Clin Pathol"},{"key":"BF6604054_CR18","first-page":"983","volume":"20","author":"AD Seidman","year":"2006","unstructured":"Seidman AD (2006) Systemic treatment of breast cancer. two decades of progress. Oncology (Williston Park) 20: 983\u2013990, discussion 991-2, 997-8.","journal-title":"Oncology (Williston Park)"},{"key":"BF6604054_CR19","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1016\/j.ejca.2005.08.013","volume":"41","author":"A Seth","year":"2005","unstructured":"Seth A, Watson DK (2005) ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 41: 2462\u20132478","journal-title":"Eur J Cancer"},{"key":"BF6604054_CR20","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/gcc.20329","volume":"45","author":"MJ Soller","year":"2006","unstructured":"Soller MJ, Isaksson M, Elfving P, Soller W, Lundgren R, Panagopoulos I (2006) Confirmation of the high frequency of the TMPRSS2\/ERG fusion gene in prostate cancer. Genes Chromosomes Cancer 45: 717\u2013719","journal-title":"Genes Chromosomes Cancer"},{"key":"BF6604054_CR21","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1126\/science.1117679","volume":"310","author":"SA Tomlins","year":"2005","unstructured":"Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA, Chinnaiyan AM (2005) Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310: 644\u2013648","journal-title":"Science"},{"key":"BF6604054_CR22","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/(SICI)1097-0215(19961021)69:5<357::AID-IJC1>3.0.CO;2-4","volume":"69","author":"H Tu","year":"1996","unstructured":"Tu H, Jacobs SC, Borkowski A, Kyprianou N (1996) Incidence of apoptosis and cell proliferation in prostate cancer: relationship with TGF-beta1 and bcl-2 expression. Int J Cancer 69: 357\u2013363","journal-title":"Int J Cancer"},{"key":"BF6604054_CR23","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/modpathol.3800903","volume":"20","author":"JJ Tu","year":"2007","unstructured":"Tu JJ, Rohan S, Kao J, Kitabayashi N, Mathew S, Chen YT (2007) Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues. Mod Pathol 20: 921\u2013928","journal-title":"Mod Pathol"},{"key":"BF6604054_CR24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1464-410X.1994.tb16601.x","volume":"152","author":"PC Walsh","year":"1994","unstructured":"Walsh PC (1994) Results of conservative management of clinically localized prostate cancer. J Urol 152: 255\u2013256","journal-title":"J Urol"},{"key":"BF6604054_CR25","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1016\/S0022-5347(17)32396-0","volume":"152","author":"PC Walsh","year":"1994","unstructured":"Walsh PC, Partin AW, Epstein JI (1994) Cancer control and quality of life following anatomical radical retropubic prostatectomy: results at 10 years. J Urol 152: 1831\u20131836","journal-title":"J Urol"},{"key":"BF6604054_CR26","doi-asserted-by":"publisher","first-page":"8347","DOI":"10.1158\/0008-5472.CAN-06-1966","volume":"66","author":"J Wang","year":"2006","unstructured":"Wang J, Cai Y, Ren C, Ittmann M (2006) Expression of variant TMPRSS2\/ERG fusion messenger RNAs is associated with aggressive prostate cancer. Cancer Res 66: 8347\u20138351","journal-title":"Cancer Res"},{"key":"BF6604054_CR27","first-page":"751","volume-title":"Encyclopedia of Cancer","author":"DK Watson","year":"2002","unstructured":"Watson DK, Li R, Sementchenko VI, Mavrothalassitis G, Seth A (2002) ETS family of transcription factors. In: Bertino JR (ed) Encyclopedia of Cancer, vol. 2, pp 751\u2013758. Academic Press: Elsevier Inc., Massachusetts, USA."},{"key":"BF6604054_CR28","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1200\/JCO.1994.12.11.2254","volume":"12","author":"H Zincke","year":"1994","unstructured":"Zincke H, Bergstralh EJ, Blute ML, Myers RP, Barrett DM, Lieber MM, Martin SK, Oesterling JE (1994) Radical prostatectomy for clinically localized prostate cancer: long-term results of 1143 patients from a single institution. J Clin Oncol 12: 2254\u20132263","journal-title":"J Clin Oncol"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6604054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6604054","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6604054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:29:43Z","timestamp":1684412983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6604054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,30]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["BF6604054"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6604054","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,30]]}}}