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However, although anandamide\u2010evoked relaxation was inhibited by either charybdotoxin (ChTX) or iberiotoxin, inhibition of the relaxation to EDHF required a combination of ChTX and apamin. The relaxations induced by either anandamide or EDHF were not inhibited by the cannabinoid receptor (CB<jats:sub>1<\/jats:sub>) antagonist SRI41716A, or mimicked by selective CB<jats:sub>1<\/jats:sub> agonists. Thus, anandamide appears to cause smooth muscle relaxation via a CB<jats:sub>1<\/jats:sub> receptor\u2010independent mechanism and cannabinoid receptor activation apparently does not contribute to EDHF\u2010mediated relaxation in this resistance artery.<\/jats:p><jats:p> <jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>121<\/jats:bold>, 1509\u20131511; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701361\">10.1038\/sj.bjp.0701361<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701361","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T17:13:48Z","timestamp":1156526028000},"page":"1509-1511","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries"],"prefix":"10.1111","volume":"121","author":[{"given":"F","family":"Plane","sequence":"first","affiliation":[]},{"given":"M","family":"Holland","sequence":"additional","affiliation":[]},{"given":"G. 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