{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:48:49Z","timestamp":1762112929036},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":4114,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The analgesic activity of CP\u2010101,606, an NR2B subunit\u2010selective <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>D<\/jats:sc>\u2010aspartate (NMDA) receptor antagonist, was examined in carrageenan\u2010induced hyperalgesia, capsaicin\u2010 and 4\u03b2\u2010phorbol\u201012\u2010myristate\u201013\u2010acetate (PMA)\u2010induced nociceptive tests in the rat.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CP\u2010101,606 30\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c., at 0.5 and 2.5\u2003h after carrageenan challenge suppressed mechanical hyperalgesia without any apparant alternations in motor coordination or behaviour in the rat.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CP\u2010101,606 also inhibited capsaicin\u2010 and PMA\u2010induced nociceptive responses (licking behaviour) with ED<jats:sub>50<\/jats:sub> values of 7.5 and 5.7\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c., respectively.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest that inhibition of the NR2B subunit of the NMDA receptor is effective <jats:italic>in vivo<\/jats:italic> at modulating nociception and hyperalgesia responses without causing the behavioural side effects often observed with currently available NMDA receptor antagonists.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>122<\/jats:bold>, 809\u2013812; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701445\">10.1038\/sj.bjp.0701445<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701445","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:15:39Z","timestamp":1106939739000},"page":"809-812","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Antinociceptive activity of CP\u2010101,606, an NMDA receptor NR2B subunit antagonist"],"prefix":"10.1111","volume":"122","author":[{"given":"Kana","family":"Taniguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Shinjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank S.","family":"Menniti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nagahisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"475","article-title":"Ifenprodil and SL 82.0715 as cerebral antiischemic agents. 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