{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:44:38Z","timestamp":1781837078614,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3164,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Honey bees are perhaps the most versatile models to study the cellular and pharmacological basis underlying behaviours ranging from learning and memory to sociobiology. For both aspects octopamine (OA) is known to play a vital role.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The neuronal octopamine receptor of the honey bee shares pharmacological similarities with the neuronal octopamine receptor of the locust. Both, agonists and antagonists known to have high affinities for the locust neuronal octopamine receptor have also high affinities for the bee neuronal octopamine receptor.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The distribution of receptors is more or less congruent between locusts and bees. Optic lobes and especially the mushroom bodies are areas of greatest octopamine receptor expression in both species, which mirrors the physiological significance of octopamine in the insect nervous system.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The neuronal octopamine receptor of insects served as a model to study the pharmacological similarity of homologous receptors from distantly related species, because bees and locusts are separated by at least 330 million years of evolution.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>130<\/jats:bold>, 587\u2013594; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703338\">10.1038\/sj.bjp.0703338<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703338","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:54:37Z","timestamp":1106945677000},"page":"587-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Octopamine receptors in the honey bee and locust nervous system: pharmacological similarities between homologous receptors of distantly related species"],"prefix":"10.1111","volume":"130","author":[{"given":"Joern","family":"Degen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gewecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Roeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.6.2739"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/337033a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00006366"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00605015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197757"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01929916"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013853"},{"key":"e_1_2_7_9_1","first-page":"499","volume-title":"Comprehensive Insect Physiol","author":"EVANS P.D.","year":"1985"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.51.2.293"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.10.6201"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/366059a0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1101\/lm.5.1.146","article-title":"Multiple sites of associative odor learning as revealed by local brain microinjections of octopamine in honeybees","volume":"5","author":"HAMMER M.","year":"1998","journal-title":"Learning Memory"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-10-03650.1998"},{"key":"e_1_2_7_15_1","first-page":"57","article-title":"Generation of behaviour: the orchestration hypothesis","author":"HOYLE G.","year":"1986","journal-title":"Feedback and motor control in invertebrates and vertebrates"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00197758","article-title":"The modulatory effects of serotonin and octopamine in the visual system of the honey bee (Apis mellifera L.). 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