{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:39:12Z","timestamp":1779345552106,"version":"3.51.4"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2002,4,25]],"date-time":"2002-04-25T00:00:00Z","timestamp":1019692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1038\/sj.cdd.4400998","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:24:06Z","timestamp":1031250246000},"page":"505-512","source":"Crossref","is-referenced-by-count":604,"title":["Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins"],"prefix":"10.1038","volume":"9","author":[{"given":"H","family":"Puthalakath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Strasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2002,4,25]]},"reference":[{"key":"BF4400998_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.biochem.69.1.217","volume":"69","author":"A Strasser","year":"2000","unstructured":"Strasser A, O'Connor L, Dixit VM . 2000 Apoptosis signaling Annu. Rev. Biochem. 69: 217\u2013245","journal-title":"Annu. Rev. Biochem."},{"key":"BF4400998_CR2","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","volume":"281","author":"A Ashkenazi","year":"1998","unstructured":"Ashkenazi A, Dixit VM . 1998 Death receptors: signaling and modulation Science 281: 1305\u20131308","journal-title":"Science"},{"key":"BF4400998_CR3","doi-asserted-by":"publisher","first-page":"6136","DOI":"10.1002\/j.1460-2075.1995.tb00304.x","volume":"14","author":"A Strasser","year":"1995","unstructured":"Strasser A, Harris AW, Huang DCS, Krammer PH, Cory S . 1995 Bcl-2 and Fas\/APO-1 regulate distinct pathways to lymphocyte apoptosis EMBO J. 14: 6136\u20136147","journal-title":"EMBO J."},{"key":"BF4400998_CR4","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/emboj\/17.3.706","volume":"17","author":"K Newton","year":"1998","unstructured":"Newton K, Harris AW, Bath ML, Smith KGC, Strasser A . 1998 A dominant interfering mutant of FADD\/Mort1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes EMBO J. 17: 706\u2013718","journal-title":"EMBO J."},{"key":"BF4400998_CR5","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S1074-7613(00)80609-3","volume":"9","author":"EE Varfolomeev","year":"1998","unstructured":"Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P, Wallach D . 1998 Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas\/Apo1, and DR3 and is lethal prenatally Immunity 9: 267\u2013276","journal-title":"Immunity"},{"key":"BF4400998_CR6","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1084\/jem.191.10.1709","volume":"191","author":"M Haraguchi","year":"2000","unstructured":"Haraguchi M, Torii S, Matsuzawa S, Xie Z, Kitada S, Krajewski S, Yoshida H, Mak TW, Reed JC . 2000 Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2 J. Exp. Med. 191: 1709\u20131720","journal-title":"J. Exp. Med."},{"key":"BF4400998_CR7","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S0092-8674(00)80849-1","volume":"101","author":"K Li","year":"2000","unstructured":"Li K, Li Y, Shelton JM, Richardson JA, Spencer E, Chen ZJ, Wang X, Williams RS . 2000 Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis Cell 101: 389\u2013399","journal-title":"Cell"},{"key":"BF4400998_CR8","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","volume":"281","author":"JM Adams","year":"1998","unstructured":"Adams JM, Cory S . 1998 The Bcl-2 protein family: arbiters of cell survival Science 281: 1322\u20131326","journal-title":"Science"},{"key":"BF4400998_CR9","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","volume":"13","author":"A Gross","year":"1999","unstructured":"Gross A, McDonnell JM, Korsmeyer SJ . 1999 Bcl-2 family members and the mitochondria in apoptosis Genes Dev. 13: 1899\u20131911","journal-title":"Genes Dev."},{"key":"BF4400998_CR10","first-page":"411","volume":"5","author":"T Lithgow","year":"1994","unstructured":"Lithgow T, van Driel R, Bertram JF, Strasser A . 1994 The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum and the outer mitochondrial membrane Cell Growth Differ. 5: 411\u2013417","journal-title":"Cell Growth Differ."},{"key":"BF4400998_CR11","first-page":"5501","volume":"54","author":"S Krajewski","year":"1994","unstructured":"Krajewski S, Krajewska M, Shabaik A, Wang HG, Irie S, Fong L, Reed JC . 1994 Immunohistochemical analysis of in vivo patterns of Bcl-X expression Cancer Res. 54: 5501\u20135507","journal-title":"Cancer Res."},{"key":"BF4400998_CR12","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/sj.cdd.4400835","volume":"8","author":"LA O'Reilly","year":"2001","unstructured":"O'Reilly LA, Print C, Hausmann G, Moriishi K, Cory S, Huang DCS, Strasser A . 2001 Tissue expression and subcellular localization of the pro-survival molecule Bcl-w Cell Death Differ. 8: 486\u2013494","journal-title":"Cell Death Differ."},{"key":"BF4400998_CR13","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","volume":"281","author":"DR Green","year":"1998","unstructured":"Green DR, Reed JC . 1998 Mitochondria and apoptosis Science 281: 1309\u20131311","journal-title":"Science"},{"key":"BF4400998_CR14","doi-asserted-by":"publisher","first-page":"9683","DOI":"10.1073\/pnas.96.17.9683","volume":"96","author":"K Moriishi","year":"1999","unstructured":"Moriishi K, Huang DCS, Cory S, Adams JM . 1999 Bcl-2 family members do not inhibit apoptosis by binding the caspase-activator Apaf-1 Proc. Natl. Acad. Sci. USA. 96: 9683\u20139688","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"BF4400998_CR15","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1083\/jcb.149.3.623","volume":"149","author":"G Hausmann","year":"2000","unstructured":"Hausmann G, O'Reilly LA, van Driel R, Beaumont JG, Strasser A, Adams JM, Huang DCS . 2000 Pro-apoptotic apoptosis protease-activating Factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-xL J. Cell Biol. 149: 623\u2013634","journal-title":"J. Cell Biol."},{"key":"BF4400998_CR16","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0092-8674(00)00167-7","volume":"103","author":"M Suzuki","year":"2000","unstructured":"Suzuki M, Youle RJ, Tjandra N . 2000 Structure of Bax: coregulation of dimer formation and intracellular localization Cell 103: 645\u2013654","journal-title":"Cell"},{"key":"BF4400998_CR17","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0092-8674(00)00187-2","volume":"103","author":"DCS Huang","year":"2000","unstructured":"Huang DCS, Strasser A . 2000 BH3-only proteins \u2013 essential initiators of apoptotic cell death Cell 103: 839\u2013842","journal-title":"Cell"},{"key":"BF4400998_CR18","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1101\/gad.10.22.2859","volume":"10","author":"K Wang","year":"1996","unstructured":"Wang K, Yin X-M, Chao DT, Milliman CL, Korsmeyer SJ . 1996 BID: a novel BH3 domain-only death agonist Genes Dev. 10: 2859\u20132869","journal-title":"Genes Dev."},{"key":"BF4400998_CR19","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0092-8674(00)81182-4","volume":"93","author":"B Conradt","year":"1998","unstructured":"Conradt B, Horvitz HR . 1998 The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9 Cell 93: 519\u2013529","journal-title":"Cell"},{"key":"BF4400998_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S0092-8674(00)81961-3","volume":"98","author":"B Conradt","year":"1999","unstructured":"Conradt B, Horvitz HR . 1999 The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene Cell 98: 317\u2013327","journal-title":"Cell"},{"key":"BF4400998_CR21","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1146\/annurev.cb.07.110191.003311","volume":"7","author":"RE Ellis","year":"1991","unstructured":"Ellis RE, Yuan J, Horvitz HR . 1991 Mechanisms and functions of cell death Annu. Rev. Cell Biol. 7: 663\u2013698","journal-title":"Annu. Rev. Cell Biol."},{"key":"BF4400998_CR22","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S1097-2765(00)80438-4","volume":"5","author":"A Gartner","year":"2000","unstructured":"Gartner A, Milstein S, Ahmed S, Hodgkin J, Hengartner MO . 2000 A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans Mol. Cell 5: 435\u2013443","journal-title":"Mol. Cell"},{"key":"BF4400998_CR23","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1126\/science.286.5445.1735","volume":"286","author":"P Bouillet","year":"1999","unstructured":"Bouillet P, Metcalf D, Huang DCS, Tarlinton DM, Kay TWH, K\u00f6ntgen F, Adams JM, Strasser A . 1999 Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity Science 286: 1735\u20131738","journal-title":"Science"},{"key":"BF4400998_CR24","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/23730","volume":"400","author":"X-M Yin","year":"1999","unstructured":"Yin X-M, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ . 1999 Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis Nature 400: 886\u2013891","journal-title":"Nature"},{"key":"BF4400998_CR25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/sj.onc.1200848","volume":"14","author":"DCS Huang","year":"1997","unstructured":"Huang DCS, Cory S, Strasser A . 1997 Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death Oncogene 14: 405\u2013414","journal-title":"Oncogene"},{"key":"BF4400998_CR26","doi-asserted-by":"publisher","first-page":"14871","DOI":"10.1073\/pnas.96.26.14871","volume":"96","author":"DC Huang","year":"1999","unstructured":"Huang DC, Hahne M, Schroeter M, Frei K, Fontana A, Villunger A, Newton K, Tschopp J, Strasser A . 1999 Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-xL Proc. Natl. Acad. Sci. USA. 96: 14871\u201314876","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"BF4400998_CR27","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1084\/jem.192.5.647","volume":"192","author":"A Villunger","year":"2000","unstructured":"Villunger A, O'Reilly LA, Holler N, Adams JM, Strasser A . 2000 Fas ligand, Bcl-2, G-CSF and p38 MAPK: regulators of distinct cell death and survival pathways in granulocytes J. Exp. Med. 192: 647\u2013657","journal-title":"J. Exp. Med."},{"key":"BF4400998_CR28","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/S1097-2765(00)00136-2","volume":"6","author":"T Lindsten","year":"2000","unstructured":"Lindsten T, Ross AJ, King A, Zong W, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR, Thompson CB . 2000 The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues Mol. Cell 6: 1389\u20131399","journal-title":"Mol. Cell"},{"key":"BF4400998_CR29","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1101\/gad.897601","volume":"15","author":"WX Zong","year":"2001","unstructured":"Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB . 2001 BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak Genes Dev. 15: 1481\u20131486","journal-title":"Genes Dev."},{"key":"BF4400998_CR30","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S1097-2765(01)00320-3","volume":"8","author":"EH Cheng","year":"2001","unstructured":"Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ . 2001 Bcl-2, bcl-x(l) sequester bh3 domain-only molecules preventing bax- and bak-mediated mitochondrial apoptosis Mol. Cell 8: 705\u2013711","journal-title":"Mol. Cell"},{"key":"BF4400998_CR31","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/381335a0","volume":"381","author":"SW Muchmore","year":"1996","unstructured":"Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong S-L, Ng S-C, Fesik SW . 1996 X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death Nature 381: 335\u2013341","journal-title":"Nature"},{"key":"BF4400998_CR32","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/369318a0","volume":"369","author":"MO Hengartner","year":"1994","unstructured":"Hengartner MO, Horvitz HR . 1994 Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2 Nature 369: 318\u2013320","journal-title":"Nature"},{"key":"BF4400998_CR33","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/382545a0","volume":"382","author":"MM Metzstein","year":"1996","unstructured":"Metzstein MM, Hengartner MO, Tsung N, Ellis RE, Horvitz HR . 1996 Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2 Nature 382: 545\u2013547","journal-title":"Nature"},{"key":"BF4400998_CR34","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S1097-2765(00)80333-0","volume":"4","author":"MM Metzstein","year":"1999","unstructured":"Metzstein MM, Horvitz HR . 1999 The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein Mol. Cell 4: 309\u2013319","journal-title":"Mol. Cell"},{"key":"BF4400998_CR35","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1093\/emboj\/16.7.1686","volume":"16","author":"N Inohara","year":"1997","unstructured":"Inohara N, Ding L, Chen S, N\u00fa\u00f1ez G . 1997 Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL EMBO J. 16: 1686\u20131694","journal-title":"EMBO J."},{"key":"BF4400998_CR36","doi-asserted-by":"publisher","first-page":"18842","DOI":"10.1074\/jbc.272.30.18842","volume":"272","author":"K Imaizumi","year":"1997","unstructured":"Imaizumi K, Tsuda M, Imai Y, Wanaka A, Takagi T, Tohyama M . 1997 Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death J. Biol. Chem. 272: 18842\u201318848","journal-title":"J. Biol. Chem."},{"key":"BF4400998_CR37","doi-asserted-by":"publisher","first-page":"7975","DOI":"10.1074\/jbc.274.12.7975","volume":"274","author":"K Imaizumi","year":"1999","unstructured":"Imaizumi K, Morihara T, Mori Y, Katayama T, Tsuda M, Furuyama T, Wanaka A, Takeda M, Tohyama M . 1999 The cell death-promoting gene DP5, which interacts with the Bcl-2 family, is induced during neuronal apoptosis following exposure to amyloid \u03b2 protein J. Biol. Chem. 274: 7975\u20137981","journal-title":"J. Biol. Chem."},{"key":"BF4400998_CR38","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1126\/science.288.5468.1053","volume":"288","author":"E Oda","year":"2000","unstructured":"Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N . 2000 Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis Science 288: 1053\u20131058","journal-title":"Science"},{"key":"BF4400998_CR39","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S1097-2765(01)00214-3","volume":"7","author":"K Nakano","year":"2001","unstructured":"Nakano K, Wousden KH . 2001 PUMA, a novel proapoptotic gene, is induced by p53 Mol. Cell 7: 683\u2013694","journal-title":"Mol. Cell"},{"key":"BF4400998_CR40","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S1097-2765(01)00213-1","volume":"7","author":"J Yu","year":"2001","unstructured":"Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B . 2001 PUMA induces the rapid apoptosis of colorectal cancer cells Mol. Cell 7: 673\u2013682","journal-title":"Mol. Cell"},{"key":"BF4400998_CR41","doi-asserted-by":"publisher","first-page":"11318","DOI":"10.1073\/pnas.201208798","volume":"98","author":"J Han","year":"2001","unstructured":"Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T . 2001 Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals Proc. Natl. Acad. Sci. USA. 98: 11318\u201311323","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"BF4400998_CR42","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0896-6273(01)00238-0","volume":"29","author":"GV Putcha","year":"2001","unstructured":"Putcha GV, Moulder KL, Golden JP, Bouillet P, Adams JM, Strasser A, Johnson EMJ . 2001 Induction of Bim, a proapoptotic BH3-only Bcl-2 family member, is critical for neuronal apoptosis Neuron 29: 615\u2013628","journal-title":"Neuron"},{"key":"BF4400998_CR43","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0896-6273(01)00239-2","volume":"29","author":"J Whitfield","year":"2001","unstructured":"Whitfield J, Neame SJ, Paquet L, Bernard O, Ham J . 2001 Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release Neuron 29: 629\u2013643","journal-title":"Neuron"},{"key":"BF4400998_CR44","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/S0960-9822(00)00728-4","volume":"10","author":"PF Dijkers","year":"2000","unstructured":"Dijkers PF, Medemadagger RH, Lammers JJ, Koenderman L, Coffer PJ . 2000 Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1 Curr. Biol. 10: 1201\u20131204","journal-title":"Curr. Biol."},{"key":"BF4400998_CR45","doi-asserted-by":"crossref","first-page":"37754","DOI":"10.1074\/jbc.M104073200","volume":"276","author":"CA Harris","year":"2001","unstructured":"Harris CA, Johnson EM Jr . 2001 BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons J. Biol. Chem. 276: 37754\u201337760","journal-title":"J. Biol. Chem."},{"key":"BF4400998_CR46","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1128\/MCB.21.3.854-864.2001","volume":"21","author":"T Shinjyo","year":"2001","unstructured":"Shinjyo T, Kuribara R, Inukai T, Hosoi H, Kinoshita T, Miyajima A, Houghton PJ, Look AT, Ozawa K, Inaba T . 2001 Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors Mol. Cell. Biol. 21: 854\u2013864","journal-title":"Mol. Cell. Biol."},{"key":"BF4400998_CR47","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1046\/j.1471-4159.2001.00294.x","volume":"77","author":"D Bozyczko-Coyne","year":"2001","unstructured":"Bozyczko-Coyne D, O'Kane TM, Wu ZL, Dobrzanski P, Murthy S, Vaught JL, Scott RW . 2001 CEP-1347\/KT-7515, an inhibitor of SAPK\/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis J. Neurochem. 77: 849\u2013863","journal-title":"J. Neurochem."},{"key":"BF4400998_CR48","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/362849a0","volume":"362","author":"AR Clarke","year":"1993","unstructured":"Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH . 1993 Thymocyte apoptosis induced by p53-dependent and independent pathways Nature 362: 849\u2013852","journal-title":"Nature"},{"key":"BF4400998_CR49","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/362847a0","volume":"362","author":"SW Lowe","year":"1993","unstructured":"Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T . 1993 p53 is required for radiation-induced apoptosis in mouse thymocytes Nature 362: 847\u2013849","journal-title":"Nature"},{"key":"BF4400998_CR50","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0092-8674(94)90201-1","volume":"79","author":"A Strasser","year":"1994","unstructured":"Strasser A, Harris AW, Jacks T, Cory S . 1994 DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2 Cell 79: 329\u2013339","journal-title":"Cell"},{"key":"BF4400998_CR51","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/emboj\/17.2.384","volume":"17","author":"L O'Connor","year":"1998","unstructured":"O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DCS . 1998 Bim: a novel member of the Bcl-2 family that promotes apoptosis EMBO J. 17: 384\u2013395","journal-title":"EMBO J."},{"key":"BF4400998_CR52","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0092-8674(00)81382-3","volume":"87","author":"J Zha","year":"1996","unstructured":"Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ . 1996 Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-xL Cell 87: 619\u2013628","journal-title":"Cell"},{"key":"BF4400998_CR53","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1126\/science.278.5338.687","volume":"278","author":"L del Peso","year":"1997","unstructured":"del Peso L, Gonz\u00e1lez-Garcia M, Page C, Herrera R, Nu\u00f1ez G . 1997 Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt Science 278: 687\u2013689","journal-title":"Science"},{"key":"BF4400998_CR54","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0092-8674(00)80405-5","volume":"91","author":"SR Datta","year":"1997","unstructured":"Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME . 1997 Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 91: 231\u2013241","journal-title":"Cell"},{"key":"BF4400998_CR55","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S1097-2765(00)80469-4","volume":"3","author":"H Harada","year":"1999","unstructured":"Harada H, Becknell B, Wilm M, Mann M, Huang LJ, Taylor SS, Scott JD, Korsmeyer SJ . 1999 Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A Mol. Cell 3: 413\u2013422","journal-title":"Mol. Cell"},{"key":"BF4400998_CR56","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0092-8674(00)81383-5","volume":"87","author":"H-G Wang","year":"1996","unstructured":"Wang H-G, Rapp UR, Reed JC . 1996 Bcl-2 targets the protein kinase Raf-1 to mitochondria Cell 87: 629\u2013638","journal-title":"Cell"},{"key":"BF4400998_CR57","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S1097-2765(05)00012-2","volume":"6","author":"SR Datta","year":"2000","unstructured":"Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME . 2000 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation Mol. Cell 6: 41\u201351","journal-title":"Mol. Cell"},{"key":"BF4400998_CR58","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1126\/science.284.5412.339","volume":"284","author":"H-G Wang","year":"1999","unstructured":"Wang H-G, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC . 1999 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD Science 284: 339\u2013343","journal-title":"Science"},{"key":"BF4400998_CR59","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.1074\/jbc.M008983200","volume":"276","author":"S Verma","year":"2001","unstructured":"Verma S, Zhao L, Chinnadurai G . 2001 Phosphorylation of the pro-apoptotic protein bik. mapping of phosphorylation sites and effect on apoptosis J. Biol. Chem. 276: 4671\u20134676","journal-title":"J. Biol. Chem."},{"key":"BF4400998_CR60","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S1097-2765(01)00335-5","volume":"8","author":"S Desagher","year":"2001","unstructured":"Desagher S, Osen-Sand A, Montessuit S, Magnenat E, Vilbois F, Hochmann A, Journot L, Antonsson B, Martinou J . 2001 Phosphorylation of bid by casein kinases i and ii regulates its cleavage by caspase 8 Mol. Cell 8: 601\u2013611","journal-title":"Mol. Cell"},{"key":"BF4400998_CR61","doi-asserted-by":"publisher","first-page":"13119","DOI":"10.1074\/jbc.273.21.13119","volume":"273","author":"MF Santoro","year":"1998","unstructured":"Santoro MF, Annand RR, Robertson MM, Peng YW, Brady MJ, Mankovich JA, Hackett MC, Ghayur T, Walter G, Wong WW, Giegel DA . 1998 Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis J. Biol. Chem. 273: 13119\u201313128","journal-title":"J. Biol. Chem."},{"key":"BF4400998_CR62","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1101\/gad.14.16.2060","volume":"14","author":"MC Wei","year":"2000","unstructured":"Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, Korsmeyer SJ . 2000 tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c Genes Dev. 14: 2060\u20132071","journal-title":"Genes Dev."},{"key":"BF4400998_CR63","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S0092-8674(00)81589-5","volume":"94","author":"X Luo","year":"1998","unstructured":"Luo X, Budlhardjo I, Zou H, Slaughter C, Wang X . 1998 Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors Cell 94: 481\u2013490","journal-title":"Cell"},{"key":"BF4400998_CR64","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S0092-8674(00)81590-1","volume":"94","author":"H Li","year":"1998","unstructured":"Li H, Zhu H, Xu C-J, Yuan J . 1998 Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 94: 491\u2013501","journal-title":"Cell"},{"key":"BF4400998_CR65","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1126\/science.290.5497.1761","volume":"290","author":"J Zha","year":"2000","unstructured":"Zha J, Weiler S, Oh KJ, Wei MC, Korsmeyer SJ . 2000 Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis Science 290: 1761\u20131765","journal-title":"Science"},{"key":"BF4400998_CR66","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1083\/jcb.144.5.891","volume":"144","author":"S Desagher","year":"1999","unstructured":"Desagher S, Osen-Sand A, Nichols A, Eskes R, Montessuit S, Lauper S, Maundrell K, Antonsson B, Martinou J-C . 1999 Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis J. Cell Biol. 144: 891\u2013901","journal-title":"J. Cell Biol."},{"key":"BF4400998_CR67","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S1097-2765(00)80456-6","volume":"3","author":"H Puthalakath","year":"1999","unstructured":"Puthalakath H, Huang DCS, O'Reilly LA, King SM, Strasser A . 1999 The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex Mol. Cell 3: 287\u2013296","journal-title":"Mol. Cell"},{"key":"BF4400998_CR68","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1126\/science.1062257","volume":"293","author":"H Puthalakath","year":"2001","unstructured":"Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DCS, Strasser A . 2001 Bmf: a pro-apoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis Science 293: 1829\u20131832","journal-title":"Science"},{"key":"BF4400998_CR69","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0002-9440(10)64557-9","volume":"157","author":"LA O'Reilly","year":"2000","unstructured":"O'Reilly LA, Cullen L, Visvader J, Lindeman G, Print C, Bath ML, Huang DCS, Strasser A . 2000 The pro-apoptotic BH3-only protein Bim is expressed in hemopoietic, epithelial, neuronal and germ cells Am. J. Path. 157: 449\u2013461","journal-title":"Am. J. Path."},{"key":"BF4400998_CR70","first-page":"973","volume":"12","author":"W Wick","year":"1996","unstructured":"Wick W, Petersen I, Schmutzler RK, Wolfarth B, Lenartz D, Bierhoff E, Hummerich J, Muller DJ, Stangl AP, Schramm J, Wiestler OD, von Deimling A . 1996 Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer Oncogene 12: 973\u2013978","journal-title":"Oncogene"},{"key":"BF4400998_CR71","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/0092-8674(94)90209-7","volume":"77","author":"E Ruoslahti","year":"1994","unstructured":"Ruoslahti E, Reed JC . 1994 Anchorage dependence, integrins, and apoptosis Cell 77: 477\u2013478","journal-title":"Cell"},{"key":"BF4400998_CR72","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S1534-5807(01)00083-1","volume":"1","author":"P Bouillet","year":"2001","unstructured":"Bouillet P, Cory S, Zhang L-C, Strasser A, Adams JM . 2001 Degenerative disorders caused by Bcl-2 deficiency are prevented by loss of its BH3-only antagonist Bim Developmental Cell 1: 645\u2013650","journal-title":"Developmental Cell"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4400998.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4400998","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4400998.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:18:41Z","timestamp":1684369121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4400998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,25]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["BF4400998"],"URL":"https:\/\/doi.org\/10.1038\/sj.cdd.4400998","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,25]]}}}