{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:37:44Z","timestamp":1767155864075,"version":"build-2238731810"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,8,29]],"date-time":"2003-08-29T00:00:00Z","timestamp":1062115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,8,29]],"date-time":"2003-08-29T00:00:00Z","timestamp":1062115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2004,1,1]]},"DOI":"10.1038\/sj.cdd.4401319","type":"journal-article","created":{"date-parts":[[2003,9,12]],"date-time":"2003-09-12T05:28:23Z","timestamp":1063344503000},"page":"61-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death"],"prefix":"10.1038","volume":"11","author":[{"given":"I Moreno","family":"de Albor\u00e1n","sequence":"first","affiliation":[]},{"given":"E","family":"Baena","sequence":"additional","affiliation":[]},{"given":"C","family":"Martinez-A","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2003,8,29]]},"reference":[{"key":"BF4401319_CR1","first-page":"1915","volume":"6","author":"DS Askew","year":"1991","unstructured":"Askew DS, Ashmun RA, Simmons BC and Cleveland JL (1991) Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6: 1915\u20131922","journal-title":"Oncogene"},{"key":"BF4401319_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0092-8674(92)90123-T","volume":"69","author":"GI Evan","year":"1992","unstructured":"Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ and Hancock DC (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119\u2013128","journal-title":"Cell"},{"key":"BF4401319_CR3","first-page":"797","volume":"6","author":"CM Waters","year":"1991","unstructured":"Waters CM, Littlewood TD, Hancock DC, Moore JP and Evan GI (1991) c-myc protein expression in untransformed fibroblasts. Oncogene 6: 797\u2013805","journal-title":"Oncogene"},{"key":"BF4401319_CR4","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1096\/fasebj.12.9.633","volume":"12","author":"LM Facchini","year":"1998","unstructured":"Facchini LM and LZ P (1998) The molecular role of Myc in growth and transformation: recent discoveries lead to new insights. FASEB J 12: 633\u2013651","journal-title":"FASEB J"},{"key":"BF4401319_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/MCB.19.1.1","volume":"19","author":"CV Dang","year":"1999","unstructured":"Dang CV (1999) c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 19: 1\u201311","journal-title":"Mol Cell Biol"},{"key":"BF4401319_CR6","first-page":"75","volume":"2","author":"Ka Zimmerman","year":"1990","unstructured":"Zimmerman Ka and Alt FW (1990) Expression and function of myc family genes. Crit Rev Oncog 2: 75\u201395","journal-title":"Crit Rev Oncog"},{"key":"BF4401319_CR7","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0092-8674(84)90217-4","volume":"36","author":"J Campisi","year":"1984","unstructured":"Campisi J, Gray HE, Pardee AB, Dean M and Sonenshein GE (1984) Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell 36: 241\u2013247","journal-title":"Cell"},{"issue":"Part 2","key":"BF4401319_CR8","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/0092-8674(83)90092-2","volume":"35","author":"K Kelly","year":"1983","unstructured":"Kelly K, Cochran BH, Stiles CD and Leder P (1983) Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35 (Part 2): 603\u2013610","journal-title":"Cell"},{"key":"BF4401319_CR9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1146\/annurev.physiol.60.1.575","volume":"60","author":"EB Thompson","year":"1998","unstructured":"Thompson EB (1998) The many roles of c-Myc in apoptosis. Annu Rev Physiol 60: 575\u2013600","journal-title":"Annu Rev Physiol"},{"key":"BF4401319_CR10","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1126\/science.278.5341.1305","volume":"278","author":"AO Hueber","year":"1997","unstructured":"Hueber AO, Zornig M, Lyon D, Suda T, Nagata S and Evan GI (1997) Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science 278: 1305\u20131309","journal-title":"Science"},{"key":"BF4401319_CR11","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/35037728","volume":"407","author":"PH Krammer","year":"2000","unstructured":"Krammer PH (2000) CD95's deadly mission in the immune system. Nature 407: 789\u2013795","journal-title":"Nature"},{"key":"BF4401319_CR12","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1126\/science.1378649","volume":"257","author":"Y Shi","year":"1992","unstructured":"Shi Y, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP and Green DR (1992) Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257: 212\u2013214","journal-title":"Science"},{"key":"BF4401319_CR13","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/373441a0","volume":"373","author":"T Brunner","year":"1995","unstructured":"Brunner T, Mogil RJ, LaFace D, Yoo NJ, Mahboubi A, Echeverri F, Martin SJ, Force WR L, DH WC and DR G (1995) Cell-autonomous Fas (CD95)\/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373: 441\u2013444","journal-title":"Nature"},{"key":"BF4401319_CR14","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/373438a0","volume":"373","author":"J Dhein","year":"1995","unstructured":"Dhein J, Walczak H, Baumler C, Debatin KM and PH K (1995) Autocrine T-cell suicide mediated by APO-1\/. Nature 373: 438\u2013441","journal-title":"Nature"},{"key":"BF4401319_CR15","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/373444a0","volume":"373","author":"ST Ju","year":"1995","unstructured":"Ju ST, Panka DJ, Cui H, Ettinger R, el-Khatib M, Sherr DH, Stanger BZ and Marshak-Rothstein A (1995) Fas(CD95)\/FasL interactions required for programmed cell death after T-cell activation. Nature 373: 444\u2013448","journal-title":"Nature"},{"key":"BF4401319_CR16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1084\/jem.189.2.231","volume":"189","author":"L Genestier","year":"1999","unstructured":"Genestier L, Kasibhatla S, Brunner T and Green DR (1999) Transforming growth factor beta1 inhibits fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc (in process citation). J Exp Med 189: 231\u2013239","journal-title":"J Exp Med"},{"key":"BF4401319_CR17","doi-asserted-by":"publisher","first-page":"9767","DOI":"10.1074\/jbc.275.13.9767","volume":"275","author":"T Brunner","year":"2000","unstructured":"Brunner T, Kasibhatla S, Pinkoski MJ, Frutschi C, Yoo NJ, Echeverri F, Mahboubi A and Green DR (2000) Expression of Fas ligand in activated T cells is regulated by c-Myc. J Biol Chem 275: 9767\u20139772","journal-title":"J Biol Chem"},{"key":"BF4401319_CR18","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.4049\/jimmunol.158.5.1994","volume":"158","author":"GE Sonenshein","year":"1997","unstructured":"Sonenshein GE (1997) Down-modulation of c-myc expression induces apoptosis of B lymphocyte models of tolerance via clonal deletion. J Immunol 158: 1994\u20131997","journal-title":"J Immunol"},{"key":"BF4401319_CR19","doi-asserted-by":"publisher","first-page":"5015","DOI":"10.1128\/MCB.16.9.5015","volume":"16","author":"M Wu","year":"1996","unstructured":"Wu M, Arsura M, Bellas RE, FitzGerald MJ, Lee H, Schauer SL, Sherr DH and Sonenshein GE (1996) Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Mol Cell Biol 16: 5015\u20135025","journal-title":"Mol Cell Biol"},{"key":"BF4401319_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/978-1-4899-0987-9_2","volume":"365","author":"AL DeFranco","year":"1994","unstructured":"DeFranco AL, Mittelstadt PR, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK and Matsuuchi L (1994) Mechanism of B cell antigen receptor function: transmembrane signaling and triggering of apoptosis. Adv Exp Med Biol 365: 9\u201322","journal-title":"Adv Exp Med Biol"},{"key":"BF4401319_CR21","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0092-8674(00)81349-5","volume":"87","author":"JC Rathmell","year":"1996","unstructured":"Rathmell JC, Townsend SE, Xu JC, Flavell RA and CC G (1996) Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. Cell 87: 319\u2013329","journal-title":"Cell"},{"key":"BF4401319_CR22","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/376181a0","volume":"376","author":"JC Rathmell","year":"1995","unstructured":"Rathmell JC, Cooke MP, Ho WY, Grein J, Townsend SE, Davis MM and Goodnow CC (1995) CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature 376: 181\u2013184","journal-title":"Nature"},{"key":"BF4401319_CR23","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/374163a0","volume":"374","author":"TL Rothstein","year":"1995","unstructured":"Rothstein TL, Wang JK, Panka DJ, Foote LC, Wang Z, Stanger B, Cui H, Ju ST and Marshak-Rothstein A (1995) Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor. Nature 374: 163\u2013165","journal-title":"Nature"},{"key":"BF4401319_CR24","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1101\/gad.7.4.671","volume":"7","author":"AC Davis","year":"1993","unstructured":"Davis AC, Wims M, Spotts GD, Hann SR and Bradley A (1993) A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev 7: 671\u2013682","journal-title":"Genes Dev"},{"key":"BF4401319_CR25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S1074-7613(01)00088-7","volume":"14","author":"IM de Alboran","year":"2001","unstructured":"de Alboran IM, O'Hagan RC, Gartner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA and Alt FW (2001) Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity 14: 45\u201355","journal-title":"Immunity"},{"key":"BF4401319_CR26","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1182\/blood.V97.1.324","volume":"97","author":"X Mao","year":"2001","unstructured":"Mao X, Fujiwara Y, Chapdelaine A, Yang H and Orkin SH (2001) Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood 97: 324\u2013326","journal-title":"Blood"},{"key":"BF4401319_CR27","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1101\/gad.5.9.1513","volume":"5","author":"G Friedrich","year":"1991","unstructured":"Friedrich G and Soriano P (1991) Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5: 1513\u20131523","journal-title":"Genes Dev"},{"key":"BF4401319_CR28","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1101\/gad.13.11.1367","volume":"13","author":"P Juin","year":"1999","unstructured":"Juin P, Hueber AO, Littlewood T and Evan G (1999) c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes Dev 13: 1367\u20131381","journal-title":"Genes Dev"},{"key":"BF4401319_CR29","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.4049\/jimmunol.157.7.2749","volume":"157","author":"LC Foote","year":"1996","unstructured":"Foote LC, Howard RG, Marshak-Rothstein A and Rothstein TL (1996) IL-4 induces Fas resistance in B cells. J Immunol 157: 2749\u20132753","journal-title":"J Immunol"},{"key":"BF4401319_CR30","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1084\/jem.187.6.847","volume":"187","author":"LC Foote","year":"1998","unstructured":"Foote LC, Marshak-Rothstein A and Rothstein TL (1998) Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded. J Exp Med 187: 847\u2013853","journal-title":"J Exp Med"},{"key":"BF4401319_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0006-291X(86)90008-2","volume":"135","author":"T Tamaoki","year":"1986","unstructured":"Tamaoki T, Nomoto H, Takahashi I, Kato Y, Morimoto M and Tomita F (1986) Staurosporine, a potent inhibitor of phospholipid\/Ca++ dependent protein kinase. Biochem Biophys Res Commun 135: 397\u2013402","journal-title":"Biochem Biophys Res Commun"},{"key":"BF4401319_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0165-2478(02)00048-2","volume":"83","author":"A Malyguine","year":"2002","unstructured":"Malyguine A, Derby E, Brooks A, Reddy V, Baseler M and Sayers T (2002) Study of diverse mechanisms of cell-mediated cytotoxicity in gene-targeted mice using flow cytometric cytotoxicity assay. Immunol Lett 83: 55\u201359","journal-title":"Immunol Lett"},{"key":"BF4401319_CR33","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/40657","volume":"388","author":"M Irmler","year":"1997","unstructured":"Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE and Tschopp J (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388: 190\u2013195","journal-title":"Nature"},{"key":"BF4401319_CR34","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1002\/eji.1830261225","volume":"26","author":"Y Delneste","year":"1996","unstructured":"Delneste Y, Jeannin P, Sebille E, Aubry JP and Bonnefoy JY (1996) Thiols prevent Fas (CD95)-mediated T cell apoptosis by down-regulating membrane Fas expression. Eur J Immunol 26: 2981\u20132988","journal-title":"Eur J Immunol"},{"key":"BF4401319_CR35","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/375081a0","volume":"375","author":"M Los","year":"1995","unstructured":"Los M, Van de Craen M, Penning LC, Schenk H, Westendorp M, Baeuerle PA, Droge W, Krammer PH, Fiers W and Schulze-Osthoff K (1995) Requirement of an ICE\/CED-3 protease for Fas\/APO-1-mediated apoptosis. Nature 375: 81\u201383","journal-title":"Nature"},{"key":"BF4401319_CR36","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/371346a0","volume":"371","author":"YA Lazebnik","year":"1994","unstructured":"Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG and Earnshaw WC (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346\u2013347","journal-title":"Nature"},{"key":"BF4401319_CR37","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/embo-reports\/kve064","volume":"2","author":"M Vooijs","year":"2001","unstructured":"Vooijs M, Jonkers J and Berns A (2001) A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep 2: 292\u2013297","journal-title":"EMBO Rep"},{"key":"BF4401319_CR38","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1128\/IAI.70.2.812-819.2002","volume":"70","author":"SK Lundy","year":"2002","unstructured":"Lundy SK and Boros DL (2002) Fas ligand-expressing B-1a lymphocytes mediate CD4(+)-T-cell apoptosis during schistosomal infection: induction by interleukin 4 (IL-4) and IL-10. Infect Immun 70: 812\u2013819","journal-title":"Infect Immun"}],"updated-by":[{"DOI":"10.1038\/sj.cdd.4401425","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T00:00:00Z","timestamp":1084924800000}}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4401319.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401319","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401319.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T13:43:26Z","timestamp":1704894206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4401319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,29]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1,1]]}},"alternative-id":["BF4401319"],"URL":"https:\/\/doi.org\/10.1038\/sj.cdd.4401319","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,29]]},"assertion":[{"value":"16 January 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2003","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2003","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2003","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}