{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:16:05Z","timestamp":1773270965491,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T00:00:00Z","timestamp":1087948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T00:00:00Z","timestamp":1087948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2004,12,1]]},"DOI":"10.1038\/sj.ejcn.1602020","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T14:54:27Z","timestamp":1088002467000},"page":"1635-1642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women"],"prefix":"10.1038","volume":"58","author":[{"given":"M J L","family":"Bonorden","sequence":"first","affiliation":[]},{"given":"K A","family":"Greany","sequence":"additional","affiliation":[]},{"given":"K E","family":"Wangen","sequence":"additional","affiliation":[]},{"given":"W R","family":"Phipps","sequence":"additional","affiliation":[]},{"given":"J","family":"Feirtag","sequence":"additional","affiliation":[]},{"given":"H","family":"Adlercreutz","sequence":"additional","affiliation":[]},{"given":"M S","family":"Kurzer","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2004,6,23]]},"reference":[{"key":"BF1602020_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/ajcn\/49.3.433","volume":"49","author":"H Adlercreutz","year":"1989","unstructured":"Adlercreutz H, Hamalainen E, Gorbach SL, Goldin BR, Woods MN & Dwyer JT (1989): Diet and plasma androgens in postmenopausal vegetarian and omnivorous women and postmenopausal women with breast cancer. Am. J. Clin. Nutr. 49, 433\u2013442.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1602020_CR2","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1093\/ajcn\/54.6.1093","volume":"54","author":"H Adlercreutz","year":"1991","unstructured":"Adlercreutz H, Honjo H, Higashi A, Fotsis T, Hamalainen E, Hasegawa T & Okada H (1991): Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am. J. Clin. Nutr. 54, 1093\u20131100.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1602020_CR3","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/0024-3205(87)90086-5","volume":"40","author":"KE Anderson","year":"1987","unstructured":"Anderson KE, Rosner W, Khan MS, New MI, Pang SY, Wissel PS & Kappas A (1987): Diet\u2013hormone interactions: protein\/carbohydrate ratio alters reciprocally the plasma levels of testosterone and cortisol and their respective binding globulins in man. Life Sci. 40, 1761\u20131768.","journal-title":"Life Sci."},{"key":"BF1602020_CR4","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1111\/j.1348-0421.1992.tb02071.x","volume":"36","author":"Y Benno","year":"1992","unstructured":"Benno Y & Mitsuoka T (1992): Impact of Bifidobacterium longum on human fecal microflora. Microbiol. Immunol. 36, 683\u2013694.","journal-title":"Microbiol. Immunol."},{"key":"BF1602020_CR5","doi-asserted-by":"publisher","first-page":"399S","DOI":"10.1093\/ajcn\/73.2.399s","volume":"73","author":"A Bezkorovainy","year":"2001","unstructured":"Bezkorovainy A (2001): Probiotics: determinants of survival and growth in the gut. Am. J. Clin. Nutr. 73, 399S\u2013405S.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1602020_CR6","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1093\/ajcn\/49.5.752","volume":"49","author":"SJ Bhathena","year":"1989","unstructured":"Bhathena SJ, Berlin E, Judd J, Nair PP, Kennedy BW, Jones J, Smith PM, Jones Y, Taylor PR & Campbell WS (1989): Hormones regulating lipid and carbohydrate metabolism in premenopausal women: modulation by dietary lipids. Am. J. Clin. Nutr. 49, 752\u2013757.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1602020_CR7","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1093\/oxfordjournals.aje.a114416","volume":"124","author":"G Block","year":"1986","unstructured":"Block G, Hartmann AM, Dresser CM, Carroll MD, Gannon J & Gardner L (1986): A data-based approach to diet questionnaire design and testing. Am. J. Epidemiol 124, 453\u2013469.","journal-title":"Am. J. Epidemiol"},{"key":"BF1602020_CR8","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0960-0760(03)00071-2","volume":"84","author":"E Brouwers","year":"2003","unstructured":"Brouwers E, L'Homme R, Al-Maharik N, Lapcik O, Hampl R, Wahala K, Mikola H & Adlercreutz H (2003): Time-resolved fluoroimmunoassay for equol in plasma and urine. J. Steroid Biochem. Mol. Biol. 84, 577\u2013588.","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"BF1602020_CR9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/ajcn\/60.3.333","volume":"60","author":"A Cassidy","year":"1994","unstructured":"Cassidy A, Bingham S & Setchell KD (1994): Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am. J. Clin. Nutr. 60, 333\u2013340.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1602020_CR10","first-page":"815","volume":"11","author":"Q Dai","year":"2002","unstructured":"Dai Q, Franke AA, Jin F, Shu XO, Hebert JR, Custer LJ, Cheng J, Gao YT & Zheng W (2002): Urinary excretion of phytoestrogens and risk of breast cancer among Chinese women in Shanghai. Cancer Epidemiol. Biomarkers Prev. 11, 815\u2013821.","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"BF1602020_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1093\/ajcn\/64.1.25","volume":"64","author":"JF Dorgan","year":"1996","unstructured":"Dorgan JF, Reichman ME, Judd JT, Brown C, Longcope C, Schatzkin A, Forman M, Campbell WS, Franz C, Kahle L & Taylor PR (1996): Relation of energy, fat, and fiber intakes to plasma concentrations of estrogens and androgens in premenopausal women. Am. J. Clin. Nutr. 64, 25\u201331.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1602020_CR12","first-page":"581","volume":"9","author":"AM Duncan","year":"2000","unstructured":"Duncan AM, Merz-Demlow BE, Xu X, Phipps WR & Kurzer MS (2000): Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 9, 581\u2013586.","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"BF1602020_CR13","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/0960-0760(91)90033-2","volume":"39","author":"S Franks","year":"1991","unstructured":"Franks S, Kiddy DS, Hamilton-Fairley D, Bush A, Sharp PS & Reed MJ (1991): The role of nutrition and insulin in the regulation of sex hormone binding globulin. J. Steroid Biochem. Mol. Biol. 39, 835\u2013838.","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"BF1602020_CR14","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","volume":"125","author":"GR Gibson","year":"1995","unstructured":"Gibson GR & Roberfroid MB (1995): Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. Nutr. 125, 1401\u20131412.","journal-title":"J. Nutr."},{"key":"BF1602020_CR15","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1093\/ajcn\/39.5.756","volume":"39","author":"BR Goldin","year":"1984","unstructured":"Goldin BR & Gorbach SL (1984): The effect of milk and lactobacillus feeding on human intestinal bacterial enzyme activity. Am. J. Clin. Nutr. 39, 756\u2013761.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1602020_CR16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-1-4615-2510-3_4","volume":"364","author":"BR Goldin","year":"1994","unstructured":"Goldin BR & Gorbach SL (1994): Hormone studies and the diet and breast cancer connection. Adv. Exp. Med. Biol. 364, 35\u201346.","journal-title":"Adv. Exp. Med. Biol."},{"key":"BF1602020_CR17","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1210\/jcem-63-6-1257","volume":"63","author":"S Grenman","year":"1986","unstructured":"Grenman S, Ronnemaa T, Irjala K, Kaihola HL & Gronroos M (1986): Sex steroid, gonadotropin, cortisol, and prolactin levels in healthy, massively obese women: correlation with abdominal fat cell size and effect of weight reduction. J. Clin. Endocrinol. Metab. 63, 1257\u20131261.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF1602020_CR18","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/0022-4731(83)90117-6","volume":"18","author":"EK H\u00e4m\u00e4l\u00e4inen","year":"1983","unstructured":"H\u00e4m\u00e4l\u00e4inen EK, Adlercreutz H, Puska P & Pietinen P (1983): Decrease of serum total and free testosterone during a low-fat high-fibre diet. J. Steroid Biochem. 18, 369\u2013370.","journal-title":"J. Steroid Biochem."},{"key":"BF1602020_CR19","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1099\/00222615-4-4-451","volume":"4","author":"G Hawksworth","year":"1971","unstructured":"Hawksworth G, Drasar BS & Hill MJ (1971): Intestinal bacteria and the hydrolysis of glycosidic bonds. J. Med. Microbiol. 4, 451\u2013459.","journal-title":"J. Med. Microbiol."},{"key":"BF1602020_CR20","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0002-8223(95)00149-2","volume":"95","author":"AM Hutchins","year":"1995","unstructured":"Hutchins AM, Slavin JL & Lampe JW (1995): Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. J. Am. Diet. Assoc. 95, 545\u2013551.","journal-title":"J. Am. Diet. Assoc."},{"key":"BF1602020_CR21","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/S0140-6736(97)01339-1","volume":"350","author":"D Ingram","year":"1997","unstructured":"Ingram D, Sanders K, Kolybaba M & Lopez D (1997): Case\u2013control study of phyto-oestrogens and breast cancer. Lancet 350, 990\u2013994.","journal-title":"Lancet"},{"key":"BF1602020_CR22","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3181\/00379727-208-43829","volume":"208","author":"GE Kelly","year":"1995","unstructured":"Kelly GE, Joannou GE, Reeder AY, Nelson C & Waring MA (1995): The variable metabolic response to dietary isoflavones in humans. Proc. Soc. Exp. Biol. Med. 208, 40\u201343.","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"BF1602020_CR23","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1079\/PNS200068","volume":"60","author":"TJ Key","year":"2001","unstructured":"Key TJ, Allen NE, Verkasalo PK & Banks E (2001): Energy balance and cancer: the role of sex hormones. Proc. Nutr. Soc. 60, 81\u201389.","journal-title":"Proc. Nutr. Soc."},{"key":"BF1602020_CR24","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/0022-4731(83)90225-X","volume":"19","author":"MA Kirschner","year":"1983","unstructured":"Kirschner MA, Samojlik E & Silber D (1983): A comparison of androgen production and clearance in hirsute and obese women. J. Steroid Biochem. 19, 607\u2013614.","journal-title":"J. Steroid Biochem."},{"key":"BF1602020_CR25","first-page":"699","volume":"8","author":"JW Lampe","year":"1999","unstructured":"Lampe JW, Gustafson DR, Hutchins AM, Martini MC, Li S, Wahala K, Grandits GA, Potter JD & Slavin JL (1999): Urinary isoflavonoid and lignan excretion on a Western diet: relation to soy, vegetable, and fruit intake. Cancer Epidemiol. Biomarkers Prev. 8, 699\u2013707.","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"BF1602020_CR26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3181\/00379727-217-44241","volume":"217","author":"JW Lampe","year":"1998","unstructured":"Lampe JW, Karr SC, Hutchins AM & Slavin JL (1998): Urinary equol excretion with a soy challenge: influence of habitual diet. Proc. Soc. Exp. Biol. Med. 217, 335\u2013339.","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"BF1602020_CR27","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1093\/jn\/131.3.740","volume":"131","author":"JW Lampe","year":"2001","unstructured":"Lampe JW, Skor HE, Li S, Wahala K, Howald WN & Chen C (2001): Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women. J. Nutr. 131, 740\u2013744.","journal-title":"J. Nutr."},{"key":"BF1602020_CR28","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/0140-6736(91)92867-2","volume":"337","author":"HP Lee","year":"1991","unstructured":"Lee HP, Gourley L, Duffy SW, Esteve J, Lee J & Day NE (1991): Dietary effects on breast-cancer risk in Singapore. Lancet 337, 1197\u20131200.","journal-title":"Lancet"},{"key":"BF1602020_CR29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1080\/01635589609514485","volume":"26","author":"LJ Lu","year":"1996","unstructured":"Lu LJ, Lin SN, Grady JJ, Nagamani M & Anderson KE (1996): Altered kinetics and extent of urinary daidzein and genistein excretion in women during chronic soya exposure. Nutr. Cancer 26, 289\u2013302.","journal-title":"Nutr. Cancer"},{"key":"BF1602020_CR30","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/ajcn\/52.4.685","volume":"52","author":"P Marteau","year":"1990","unstructured":"Marteau P, Pochart P, Flourie B, Pellier P, Santos L, Desjeux JF & Rambaud JC (1990): Effect of chronic ingestion of a fermented dairy product containing Lactobacillus acidophilus and Bifidobacterium bifidum on metabolic activities of the colonic flora in humans. Am. J. Clin. Nutr. 52, 685\u2013688.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1602020_CR31","first-page":"195","volume":"11","author":"G Maskarinec","year":"2002","unstructured":"Maskarinec G, Williams AE, Inouye JS, Stanczyk FZ & Franke AA (2002): A randomized isoflavone intervention among premenopausal women. Cancer Epidemiol. Biomarkers Prev. 11, 195\u2013201.","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"BF1602020_CR32","doi-asserted-by":"publisher","first-page":"3168","DOI":"10.1093\/jn\/131.10.3168","volume":"132","author":"MS Morton","year":"2002","unstructured":"Morton MS, Arisaka O, Miyake N, Morgan LD & Evans BA (2002): Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. J. Nutr. 132, 3168\u20133171.","journal-title":"J. Nutr."},{"key":"BF1602020_CR33","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1210\/jcem-67-3-460","volume":"67","author":"SR Plymate","year":"1988","unstructured":"Plymate SR, Matej LA, Jones RE & Friedl KE (1988): Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin. J. Clin. Endocrinol. Metab. 67, 460\u2013464.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF1602020_CR34","first-page":"257","volume-title":"Dietary Fiber in Health & Disease","author":"AV Rao","year":"1995","unstructured":"Rao AV (1995): Effect of dietary fiber on intestinal microflora and health. In Dietary Fiber in Health & Disease eds D Kritchevsky and C Bonfield, pp 257\u2013266. St. Paul: Eagan Press."},{"key":"BF1602020_CR35","first-page":"2487","volume":"132","author":"M Richelle","year":"2002","unstructured":"Richelle M, Merten-Pridmore S, Bodenstab S, Enslen M & Offord EA (2002): Hydrolysis of isoflavone glycosides to aglycones by beta-glycosidase does not alter plasma and urine isoflavone pharmokinetics in postmenopausal women. J. Nutr. 132, 2487\u20132592.","journal-title":"J. Nutr."},{"key":"BF1602020_CR36","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1042\/bst0270304","volume":"27","author":"I Rowland","year":"1999","unstructured":"Rowland I, Wiseman H, Sanders T, Adlercreutz H & Bowey E (1999): Metabolism of oestrogens and phytoestrogens: role of the gut microflora. Biochem. Soc. Trans. 27, 304\u2013308.","journal-title":"Biochem. Soc. Trans."},{"key":"BF1602020_CR37","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1207\/S15327914NC3601_5","volume":"36","author":"IR Rowland","year":"2000","unstructured":"Rowland IR, Wiseman H, Sanders TA, Adlercreutz H & Bowey EA (2000): Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr. Cancer 36, 27\u201332.","journal-title":"Nutr. Cancer"},{"key":"BF1602020_CR38","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1365-2621.2003.tb05721.x","volume":"68","author":"D Tsangalis","year":"2003","unstructured":"Tsangalis D, Ashton JF, McGill AEJ & Shah NP (2003): Biotransformation of isoflavones by bifidobacteria in fermented soymilk supplemented with D-glucose and L-cysteine. J. Food Sci. 68, 623\u2013631.","journal-title":"J. Food Sci."},{"key":"BF1602020_CR39","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1152\/jappl.1997.82.1.49","volume":"82","author":"JS Volek","year":"1997","unstructured":"Volek JS, Kraemer WJ, Bush JA, Incledon T & Boetes M (1997): Testosterone and cortisol in relationship to dietary nutrients and resistance exercise. J. Appl. Physiol. 82, 49\u201354.","journal-title":"J. Appl. Physiol."},{"key":"BF1602020_CR40","first-page":"901","volume":"5","author":"AH Wu","year":"1996","unstructured":"Wu AH, Ziegler RG, Horn-Ross PL, Nomura AM, West DW, Kolonel LN, Rosenthal JF, Hoover RN & Pike MC (1996): Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol. Biomarkers Prev. 5, 901\u2013906.","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"BF1602020_CR41","first-page":"35","volume":"8","author":"W Zheng","year":"1999","unstructured":"Zheng W, Dai Q, Custer LJ, Shu XO, Wen WQ, Jin F & Franke AA (1999): Urinary excretion of isoflavonoids and the risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 8, 35\u201340.","journal-title":"Cancer Epidemiol. Biomarkers Prev."}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1602020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1602020","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1602020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T17:08:52Z","timestamp":1648228132000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1602020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,23]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12,1]]}},"alternative-id":["BF1602020"],"URL":"https:\/\/doi.org\/10.1038\/sj.ejcn.1602020","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,23]]},"assertion":[{"value":"23 June 2004","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}