{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:00:19Z","timestamp":1767999619478,"version":"3.49.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2005,9,21]]},"DOI":"10.1038\/sj.emboj.7600799","type":"journal-article","created":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T08:03:59Z","timestamp":1125561839000},"page":"3235-3246","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Phosphorylation of EEA1 by p38 MAP kinase regulates \u03bc opioid receptor endocytosis"],"prefix":"10.1038","volume":"24","author":[{"given":"Ga\u00ebtane","family":"Mac\u00e9","sequence":"first","affiliation":[]},{"given":"Marta","family":"Miaczynska","sequence":"additional","affiliation":[]},{"given":"Marino","family":"Zerial","sequence":"additional","affiliation":[]},{"given":"Angel R","family":"Nebreda","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"BFEMBJ7600799_CR1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1097-2765(05)00014-6","volume":"6","author":"S Adams","year":"2000","unstructured":"Adams S, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR (2000) Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 6: 109\u2013116","journal-title":"Mol Cell"},{"key":"BFEMBJ7600799_CR2","doi-asserted-by":"crossref","first-page":"40641","DOI":"10.1074\/jbc.M007835200","volume":"275","author":"G Alonso","year":"2000","unstructured":"Alonso G, Ambrosino C, Jones M, Nebreda AR (2000) Differential activation of p38 mitogen\u2010activated protein kinase isoforms depending on signal strength. J Biol Chem 275: 40641\u201340648","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1128\/MCB.23.1.370-381.2003","volume":"23","author":"C Ambrosino","year":"2003","unstructured":"Ambrosino C, Mace G, Galban S, Fritsch C, Vintersten K, Black E, Gorospe M, Nebreda AR (2003) Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen\u2010activated protein kinase. Mol Cell Biol 23: 370\u2013381","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7600799_CR4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/bj3380539","volume":"338","author":"J Callaghan","year":"1999","unstructured":"Callaghan J, Simonsen A, Gaullier JM, Toh BH, Stenmark H (1999) The endosome fusion regulator early\u2010endosomal autoantigen 1 (EEA1) is a dimer. Biochem J 338: 539\u2013543","journal-title":"Biochem J"},{"key":"BFEMBJ7600799_CR5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1097-2765(01)00189-7","volume":"7","author":"V Cavalli","year":"2001","unstructured":"Cavalli V, Vilbois F, Corti M, Marcote M, Tamura K, Karin M, Arkinstall J, Gruenberg J (2001) The stress induced MAP kinase p38 regulates endocytic trafficking via GDI:Rab5 complex. Mol Cell 7: 421\u2013432","journal-title":"Mol Cell"},{"key":"BFEMBJ7600799_CR6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/17618","volume":"397","author":"S Christoforidis","year":"1999","unstructured":"Christoforidis S, McBride HM, Burgoyne RD, Zerial M (1999) The Rab5 effector EEA1 is a core component of endosome docking. Nature 397: 621\u2013625","journal-title":"Nature"},{"key":"BFEMBJ7600799_CR7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/12075","volume":"1","author":"S Christoforidis","year":"1999","unstructured":"Christoforidis S, Miaczynska M, Ashman K, Wilm M, Zhao L, Yip SC, Waterfield MD, Backer JM, Zerial M (1999) Phosphatidylinositol\u20103\u2010OH kinases are Rab5 effectors. Nat Cell Biol 1: 249\u2013252","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ7600799_CR8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/ncb744","volume":"4","author":"S de Renzis","year":"2002","unstructured":"de Renzis S, Sonnichsen B, Zerial M (2002) Divalent Rab effectors regulate the sub\u2010compartmental organization and sorting of early endosomes. Nat Cell Biol 4: 124\u2013133","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ7600799_CR9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S1097-2765(01)00385-9","volume":"8","author":"JJ Dumas","year":"2001","unstructured":"Dumas JJ, Merithew E, Sudharshan E, Rajamani D, Hayes S, Lawe D, Corvera S, Lambright DG (2001) Multivalent endosome targeting by homodimeric EEA1. Mol Cell 8: 947\u2013958","journal-title":"Mol Cell"},{"key":"BFEMBJ7600799_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(24)01478-9","volume":"53","author":"S Ferguson","year":"2001","unstructured":"Ferguson S (2001) Evolving concepts in G protein coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol rev 53: 1\u201324","journal-title":"Pharmacol rev"},{"key":"BFEMBJ7600799_CR11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0896-6273(01)00517-7","volume":"32","author":"AK Finn","year":"2001","unstructured":"Finn AK, Whistler JL (2001) Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal. Neuron 32: 829\u2013839","journal-title":"Neuron"},{"key":"BFEMBJ7600799_CR12","doi-asserted-by":"crossref","first-page":"46961","DOI":"10.1074\/jbc.M305225200","volume":"278","author":"RA Fratti","year":"2003","unstructured":"Fratti RA, Chua J, Deretic V (2003) Induction of p38 mitogen\u2010activated protein kinase reduces early endosome autoantigen 1 (EEA1) recruitment to phagosomal membranes. J Biol Chem 278: 46961\u201346967","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR13","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1074\/jbc.M310503200","volume":"279","author":"A Hayakawa","year":"2004","unstructured":"Hayakawa A, Hayes SJ, Lawe DC, Sudharshan E, Tuft R, Fogarty K, Lambright D, Corvera S (2004) Structural basis for endosomal targeting by FYVE domains. J Biol Chem 279: 5958\u20135966, Epub 2003 Oct 5931","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0092-8674(02)00613-X","volume":"108","author":"L He","year":"2002","unstructured":"He L, Fong J, von Zastrow M, Whistler JL (2002) Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell 108: 271\u2013282","journal-title":"Cell"},{"key":"BFEMBJ7600799_CR15","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0092-8674(00)80380-3","volume":"90","author":"H Horiuchi","year":"1997","unstructured":"Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M (1997) A novel Rab5 GDP\/GTP exchange factor complexed to Rabaptin\u20105 links nucleotide exchange to effector recruitment and function. Cell 90: 1149\u20131159","journal-title":"Cell"},{"key":"BFEMBJ7600799_CR16","doi-asserted-by":"crossref","first-page":"12286","DOI":"10.1074\/jbc.M312868200","volume":"279","author":"CC Huang","year":"2004","unstructured":"Huang CC, You JL, Wu MY, Hsu KS (2004) Rap1\u2010induced p38 mitogen\u2010activated protein kinase activation facilitates AMPA receptor trafficking via the GDI:Rab5 complex: potential role in (S)\u20103,5\u2010dihydroxyphenylglycine\u2010induced long\u2010term depression. J Biol Chem 279: 12286\u201312292","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1124\/mol.53.3.377","volume":"53","author":"DE Keith","year":"1998","unstructured":"Keith DE, Anton B, Murray SR, Zaki PA, Chu PC, Lissin DV, Monteillet\u2010Agius G, Stewart PL, Evans CJ, von Zastrow M (1998) mu\u2010Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain. Mol Pharmacol 53: 377\u2013384","journal-title":"Mol Pharmacol"},{"key":"BFEMBJ7600799_CR18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-6147(98)01279-6","volume":"20","author":"BL Kieffer","year":"1999","unstructured":"Kieffer BL (1999) Opioids: first lessons from knockout mice. Trends Pharmacol Sci 20: 19\u201326","journal-title":"Trends Pharmacol Sci"},{"key":"BFEMBJ7600799_CR19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(02)00666-9","volume":"108","author":"BL Kieffer","year":"2002","unstructured":"Kieffer BL, Evans CJ (2002) Opioid tolerance\u2014in search of the holy grail. Cell 108: 587\u2013590","journal-title":"Cell"},{"key":"BFEMBJ7600799_CR20","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1074\/jbc.M309007200","volume":"279","author":"TG Kutateladze","year":"2004","unstructured":"Kutateladze TG, Capelluto DG, Ferguson CG, Cheever ML, Kutateladze AG, Prestwich GD, Overduin M (2004) Multivalent mechanism of membrane insertion by the FYVE domain. J Biol Chem 279: 3050\u20133057","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/35042605","volume":"408","author":"L Lanzetti","year":"2000","unstructured":"Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (2000) The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature 408: 374\u2013377","journal-title":"Nature"},{"key":"BFEMBJ7600799_CR22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev.pharmtox.40.1.389","volume":"40","author":"PY Law","year":"2000","unstructured":"Law PY, Wong YH, Loh HH (2000) Molecular mechanisms and regulation of opioid receptor signaling. Annu Rev Pharmacol Toxicol 40: 389\u2013430","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"BFEMBJ7600799_CR23","doi-asserted-by":"crossref","first-page":"8611","DOI":"10.1074\/jbc.M109239200","volume":"277","author":"DC Lawe","year":"2002","unstructured":"Lawe DC, Chawla A, Merithew E, Dumas J, Carrington W, Fogarty K, Lifshitz L, Tuft R, Lambright D, Corvera S (2002) Sequential roles for phosphatidylinositol 3\u2010phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem 277: 8611\u20138617","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR24","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1091\/mbc.e02-09-0591","volume":"14","author":"DC Lawe","year":"2003","unstructured":"Lawe DC, Sitouah N, Hayes S, Chawla A, Virbasius JV, Tuft R, Fogarty K, Lifshitz L, Lambright D, Corvera S (2003) Essential role of Ca2+\/calmodulin in Early Endosome Antigen\u20101 localization. Mol Biol Cell 14: 2935\u20132945","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ7600799_CR25","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1124\/mol.60.5.1064","volume":"60","author":"J Li","year":"2001","unstructured":"Li J, Chen C, Huang P, Liu\u2010Chen LY (2001) Inverse agonist up\u2010regulates the constitutively active D3.49(164)Q mutant of the rat mu\u2010opioid receptor by stabilizing the structure and blocking constitutive internalization and down\u2010regulation. Mol Pharmacol 60: 1064\u20131075","journal-title":"Mol Pharmacol"},{"key":"BFEMBJ7600799_CR26","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1046\/j.0953-816x.2001.01731.x","volume":"14","author":"W Ma","year":"2001","unstructured":"Ma W, Zheng WH, Powell K, Jhamandas K, Quirion R (2001) Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study. Eur J Neurosci 14: 1091\u20131104","journal-title":"Eur J Neurosci"},{"key":"BFEMBJ7600799_CR27","doi-asserted-by":"crossref","first-page":"20079","DOI":"10.1074\/jbc.274.29.20079","volume":"274","author":"G Mac\u00e9","year":"1999","unstructured":"Mac\u00e9 G, Blanpied C, Emorine LJ, Druet P, Dietrich G (1999) Morphine\u2010like activity of natural human IgG autoantibodies is because of binding to the first and third extracellular loops of the mu\u2010opioid receptor. J Biol Chem 274: 20079\u201320082","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR28","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/383819a0","volume":"383","author":"HWD Matthes","year":"1996","unstructured":"Matthes HWD, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, Le Meur M, Doll\u00e9 P, Tzavara E, Hanoune J, Roques BP, Kieffer BL (1996) Loss of morphine\u2010induced analgesia, reward effect and withdrawal symptoms in mice lacking the \u03bc\u2010opioid\u2010receptor gene. Nature 383: 819\u2013823","journal-title":"Nature"},{"key":"BFEMBJ7600799_CR29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0092-8674(00)81966-2","volume":"98","author":"HM McBride","year":"1999","unstructured":"McBride HM, Rybin V, Murphy C, Giner A, Teasdale R, Zerial M (1999) Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13. Cell 98: 377\u2013386","journal-title":"Cell"},{"key":"BFEMBJ7600799_CR30","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0960-9822(07)00351-X","volume":"8","author":"IG Mills","year":"1998","unstructured":"Mills IG, Jones AT, Clague MJ (1998) Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes. Curr Biol 8: 881\u2013884","journal-title":"Curr Biol"},{"key":"BFEMBJ7600799_CR31","doi-asserted-by":"crossref","first-page":"13503","DOI":"10.1074\/jbc.270.22.13503","volume":"270","author":"FT Mu","year":"1995","unstructured":"Mu FT, Callaghan JM, Steele\u2010Mortimer O, Stenmark H, Parton RG, Campbell PL, McCluskey J, Yeo JP, Tock EP, Toh BH (1995) EEA1, an early endosome\u2010associated protein. EEA1 is a conserved alpha\u2010helical peripheral membrane protein flanked by cysteine \u2018fingers\u2019 and contains a calmodulin\u2010binding IQ motif. J Biol Chem 270: 13503\u201313511","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0968-0004(00)01595-4","volume":"25","author":"A Nebreda","year":"2000","unstructured":"Nebreda A, Porras A (2000) p38 MAP kinases: beyond the stress response. Trends Biochem Sci 25: 257\u2013260","journal-title":"Trends Biochem Sci"},{"key":"BFEMBJ7600799_CR33","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1083\/jcb.151.3.601","volume":"151","author":"E Nielsen","year":"2000","unstructured":"Nielsen E, Christoforidis S, Uttenweiler\u2010Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M (2000) Rabenosyn\u20105, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. J Cell Biol 151: 601\u2013612","journal-title":"J Cell Biol"},{"key":"BFEMBJ7600799_CR34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/dbio.2002.0855","volume":"253","author":"JF Nitsche","year":"2003","unstructured":"Nitsche JF, Pintar JE (2003) Opioid receptor\u2010induced GTPgamma35S binding during mouse development. Dev Biol 253: 99\u2013108","journal-title":"Dev Biol"},{"key":"BFEMBJ7600799_CR35","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1073\/pnas.94.14.7326","volume":"94","author":"V Patki","year":"1997","unstructured":"Patki V, Virbasius J, Lane WS, Toh BH, Shpetner HS, Corvera S (1997) Identification of an early endosomal protein regulated by phosphatidylinositol 3\u2010kinase. Proc Natl Acad Sci USA 94: 7326\u20137330","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600799_CR36","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature03571","volume":"436","author":"L Pelkmans","year":"2005","unstructured":"Pelkmans L, Fava E, Grabner H, Hannus M, Habermann B, Krausz E, Zerial M (2005) Genome\u2010wide analysis of human kinases in clathrin\u2010 and caveolae\/raft\u2010mediated endocytosis. Nature 436: 78\u201386","journal-title":"Nature"},{"key":"BFEMBJ7600799_CR37","doi-asserted-by":"crossref","first-page":"17057","DOI":"10.1074\/jbc.270.29.17057","volume":"270","author":"SR Pfeffer","year":"1995","unstructured":"Pfeffer SR, Dirac\u2010Svejstrup AB, Soldati T (1995) Rab GDP dissociation inhibitor: putting rab GTPases in the right place. J Biol Chem 270: 17057\u201317059","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR38","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1091\/mbc.e03-08-0592","volume":"15","author":"A Porras","year":"2004","unstructured":"Porras A, Zuluaga S, Black E, Valladares A, Alvarez AM, Ambrosino C, Benito M, Nebreda AR (2004) p38 alpha mitogen\u2010activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Mol Biol Cell 15: 922\u2013933","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ7600799_CR39","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/383266a0","volume":"383","author":"V Rybin","year":"1996","unstructured":"Rybin V, Ullrich O, Rubino M, Alexandrov K, Simon I, Seabra MC, Goody R, Zerial M (1996) GTPase activity of Rab5 acts as a timer for endocytic membrane fusion. Nature 383: 266\u2013269","journal-title":"Nature"},{"key":"BFEMBJ7600799_CR40","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/S0021-9258(19)39980-6","volume":"265","author":"T Sasaki","year":"1990","unstructured":"Sasaki T, Kikuchi A, Araki S, Hata Y, Isomura M, Kuroda S, Takai Y (1990) Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21\u2010like GTP\u2010binding protein. J Biol Chem 265: 2333\u20132337","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.lfs.2003.09.009","volume":"74","author":"JL Seachrist","year":"2003","unstructured":"Seachrist JL, Ferguson SS (2003) Regulation of G protein\u2010coupled receptor endocytosis and trafficking by Rab GTPases. Life Sci 74: 225\u2013235","journal-title":"Life Sci"},{"key":"BFEMBJ7600799_CR42","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/28879","volume":"394","author":"A Simonsen","year":"1998","unstructured":"Simonsen A, Lippe R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H (1998) EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394: 494\u2013498","journal-title":"Nature"},{"key":"BFEMBJ7600799_CR43","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.4049\/jimmunol.168.8.4025","volume":"168","author":"PC Singhal","year":"2002","unstructured":"Singhal PC, Bhaskaran M, Patel J, Patel K, Kasinath BS, Duraisamy S, Franki N, Reddy K, Kapasi AA (2002) Role of p38 mitogen\u2010activated protein kinase phosphorylation and Fas\u2013Fas ligand interaction in morphine\u2010induced macrophage apoptosis. J Immunol 168: 4025\u20134033","journal-title":"J Immunol"},{"key":"BFEMBJ7600799_CR44","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nature02057","volume":"425","author":"U Sivars","year":"2003","unstructured":"Sivars U, Aivazian D, Pfeffer SR (2003) Yip3 catalyses the dissociation of endosomal Rab\u2013GDI complexes. Nature 425: 856\u2013859","journal-title":"Nature"},{"key":"BFEMBJ7600799_CR45","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-5793(01)03308-7","volume":"513","author":"H Stenmark","year":"2002","unstructured":"Stenmark H, Aasland R, Driscoll PC (2002) The phosphatidylinositol 3\u2010phosphate\u2010binding FYVE finger. FEBS Lett 513: 77\u201384","journal-title":"FEBS Lett"},{"key":"BFEMBJ7600799_CR46","doi-asserted-by":"crossref","first-page":"24048","DOI":"10.1074\/jbc.271.39.24048","volume":"271","author":"H Stenmark","year":"1996","unstructured":"Stenmark H, Aasland R, Toh BH, D'Arrigo A (1996) Endosomal localization of the autoantigen EEA1 is mediated by a zinc\u2010binding FYVE finger. J Biol Chem 271: 24048\u201324054","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600799_CR47","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/j.1460-2075.1994.tb06381.x","volume":"13","author":"H Stenmark","year":"1994","unstructured":"Stenmark H, Parton RG, Steele\u2010Mortimer O, Lutcke A, Gruenberg J, Zerial M (1994) Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J 13: 1287\u20131296","journal-title":"EMBO J"},{"key":"BFEMBJ7600799_CR48","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.1073\/pnas.93.17.9241","volume":"93","author":"C Sternini","year":"1996","unstructured":"Sternini C, Spann M, Anton B, Keith DE, Jr, Bunnett NW, von Zastrow M, Evans C, Brecha NC (1996) Agonist\u2010selective endocytosis of mu opioid receptor by neurons in vivo. Proc Natl Acad Sci USA 93: 9241\u20139246","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600799_CR49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-5793(94)80368-4","volume":"338","author":"JB Wang","year":"1994","unstructured":"Wang JB, Johnson PS, Persico AM, Hawkins AL, Griffin CA, Uhl GR (1994) Human mu opiate receptor\u2014cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett 338: 217\u2013222","journal-title":"FEBS Lett"},{"key":"BFEMBJ7600799_CR50","doi-asserted-by":"crossref","first-page":"9914","DOI":"10.1073\/pnas.95.17.9914","volume":"95","author":"JL Whistler","year":"1998","unstructured":"Whistler JL, von Zastrow M (1998) Morphine\u2010activated opioid receptors elude desensitization by beta\u2010arrestin. Proc Natl Acad Sci USA 95: 9914\u20139919","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600799_CR51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/35052055","volume":"2","author":"M Zerial","year":"2001","unstructured":"Zerial M, McBride H (2001) Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2: 107\u2013117","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.emboj.7600799","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/epdf\/10.1038\/sj.emboj.7600799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/full\/10.1038\/sj.emboj.7600799","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/sj.emboj.7600799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.embopress.org\/doi\/epdf\/10.1038\/sj.emboj.7600799","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:35:01Z","timestamp":1764916501000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1038\/sj.emboj.7600799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,1]]},"references-count":51,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2005,9,21]]}},"alternative-id":["BFEMBJ7600799"],"URL":"https:\/\/doi.org\/10.1038\/sj.emboj.7600799","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,1]]},"assertion":[{"value":"9 March 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}