{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:12:27Z","timestamp":1779235947714,"version":"3.51.4"},"reference-count":130,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T00:00:00Z","timestamp":1202256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T00:00:00Z","timestamp":1202256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2008,2,6]]},"DOI":"10.1038\/sj.emboj.7601977","type":"journal-article","created":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T08:04:04Z","timestamp":1202285044000},"page":"471-481","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":377,"title":["Messenger RNA regulation: to translate or to degrade"],"prefix":"10.1038","volume":"27","author":[{"given":"Ann\u2010Bin","family":"Shyu","sequence":"first","affiliation":[]},{"given":"Miles F","family":"Wilkinson","sequence":"additional","affiliation":[]},{"given":"Ambro","family":"van Hoof","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,2,6]]},"reference":[{"key":"BFEMBJ7601977_CR1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V Ambros","year":"2004","unstructured":"Ambros V (2004) The functions of animal microRNAs. Nature 431: 350\u2013355","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature03060","volume":"432","author":"N Amrani","year":"2004","unstructured":"Amrani N, Ganesan R, Kervestin S, Mangus DA, Ghosh S, Jacobson A (2004) A faux 3\u2032\u2010UTR promotes aberrant termination and triggers nonsense\u2010mediated mRNA decay. Nature 432: 112\u2013118","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrm1942","volume":"7","author":"N Amrani","year":"2006","unstructured":"Amrani N, Sachs MS, Jacobson A (2006) Early nonsense: mRNA decay solves a translational problem. Nat Rev Mol Cell Biol 7: 415\u2013425","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ7601977_CR4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1261\/rna.2340405","volume":"11","author":"MA Andrei","year":"2005","unstructured":"Andrei MA, IIngelfinger D, Heintzmann R, Achsel T, Rivera\u2010Pomar R, Luhrmann R (2005) A role for eIF4E and eIF4E\u2010transporter in targeting mRNPs to mammalian processing bodies. RNA 11: 717\u2013727","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR5","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1365-313X.2006.02802.x","volume":"47","author":"L Arciga\u2010Reyes","year":"2006","unstructured":"Arciga\u2010Reyes L, Wootton L, Kieffer M, Davies B (2006) UPF1 is required for nonsense\u2010mediated mRNA decay (NMD) and RNAi in Arabidopsis. Plant J 47: 480\u2013489","journal-title":"Plant J"},{"key":"BFEMBJ7601977_CR6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0378-1119(01)00414-0","volume":"268","author":"R Aronoff","year":"2001","unstructured":"Aronoff R, Baran R, Hodgkin J (2001) Molecular identification of smg\u20104, required for mRNA surveillance in C. elegans. Gene 268: 153\u2013164","journal-title":"Gene"},{"key":"BFEMBJ7601977_CR7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cell.2005.07.031","volume":"122","author":"S Bagga","year":"2005","unstructured":"Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, Eachus R, Pasquinelli AE (2005) Regulation by let\u20107 and lin\u20104 miRNAs results in target mRNA degradation. Cell 122: 553\u2013563","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR8","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1261\/rna.92706","volume":"12","author":"KE Baker","year":"2006","unstructured":"Baker KE, Parker R (2006) Conventional 3\u2032 end formation is not required for NMD substrate recognition in Saccharomyces cerevisiae. RNA 12: 1441\u20131445","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281\u2013297","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nrg1328","volume":"5","author":"DP Bartel","year":"2004","unstructured":"Bartel DP, Chen CZ (2004) Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 5: 396\u2013400","journal-title":"Nat Rev Genet"},{"key":"BFEMBJ7601977_CR11","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/sj.emboj.7601588","volume":"26","author":"I Behm\u2010Ansmant","year":"2007","unstructured":"Behm\u2010Ansmant I, Gatfield D, Rehwinkel J, Hilgers V, Izaurralde E (2007) A conserved role for cytoplasmic poly(A)\u2010binding protein 1 (PABPC1) in nonsense\u2010mediated mRNA decay. EMBO J 26: 1591\u20131601","journal-title":"EMBO J"},{"key":"BFEMBJ7601977_CR12","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1101\/gad.1424106","volume":"20","author":"I Behm\u2010Ansmant","year":"2006","unstructured":"Behm\u2010Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P, Izaurralde E (2006) mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev 20: 1885\u20131898","journal-title":"Genes Dev"},{"key":"BFEMBJ7601977_CR13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/35053110","volume":"409","author":"E Bernstein","year":"2001","unstructured":"Bernstein E, Caudy AA, Hammond SM, Hannon GJ (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409: 363\u2013366","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR14","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1017\/S1355838200000546","volume":"6","author":"A Bhattacharya","year":"2000","unstructured":"Bhattacharya A, Czaplinski K, Trifillis P, He F, Jacobson A, Peltz SW (2000) Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense\u2010mediated mRNA decay. RNA 6: 1226\u20131235","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR15","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2006.04.031","volume":"125","author":"SN Bhattacharyya","year":"2006","unstructured":"Bhattacharyya SN, Habermacher R, Martine U, Closs EI, Filipowicz W (2006) Relief of microRNA\u2010mediated translation repression in human cells subjected to stress. Cell 125: 1111\u20131124","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.molcel.2007.07.014","volume":"27","author":"F Bleichert","year":"2007","unstructured":"Bleichert F, Baserga SJ (2007) The long unwinding road of RNA helicases. Mol Cell 27: 339\u2013352","journal-title":"Mol Cell"},{"key":"BFEMBJ7601977_CR17","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/jmbi.1995.0438","volume":"251","author":"B Bonetti","year":"1995","unstructured":"Bonetti B, Fu L, Moon J, Bedwell DM (1995) The efficiency of translation termination is determined by a synergistic interplay between upstream and downstream sequences in Saccharomyces cerevisiae. J Mol Biol 251: 334\u2013345","journal-title":"J Mol Biol"},{"key":"BFEMBJ7601977_CR18","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.1115791","volume":"310","author":"M Brengues","year":"2005","unstructured":"Brengues M, Teixeira D, Parker R (2005) Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies. Science 310: 486\u2013489","journal-title":"Science"},{"key":"BFEMBJ7601977_CR19","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1017\/S1355838299981359","volume":"5","author":"S Brogna","year":"1999","unstructured":"Brogna S (1999) Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3\u2032 end processing of the corresponding pre\u2010mRNA. RNA 5: 562\u2013573","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR20","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1093\/nar\/18.21.6339","volume":"18","author":"CM Brown","year":"1990","unstructured":"Brown CM, Stockwell PA, Trotman CNA, Tate WP (1990) Sequence analysis suggests that tetra\u2010nucleotides signal the termination of protein synthesis in eukaryotes. Nucleic Acids Res 18: 6339\u20136345","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ7601977_CR21","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nsmb1081","volume":"13","author":"M Buhler","year":"2006","unstructured":"Buhler M, Steiner S, Mohn F, Paillusson A, Muhlemann O (2006) EJC\u2010independent degradation of nonsense immunoglobulin\u2010mu mRNA depends on 3\u2032 UTR length. Nat Struct Mol Biol 13: 462\u2013464","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBJ7601977_CR22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0092-8674(03)00353-2","volume":"113","author":"D Cao","year":"2003","unstructured":"Cao D, Parker R (2003) Computational modeling and experimental analysis of nonsense\u2010mediated decay in yeast. Cell 113: 533\u2013545","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR23","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/sj.emboj.7601628","volume":"26","author":"WK Chan","year":"2007","unstructured":"Chan WK, Huang L, Gudikote JP, Chang YF, Imam JS, MacLean II JA, Wilkinson MF (2007) An alternative branch of the nonsense\u2010mediated decay pathway. EMBO J 26: 1820\u20131830","journal-title":"EMBO J"},{"key":"BFEMBJ7601977_CR24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.biochem.76.050106.093909","volume":"76","author":"Y\u2010F Chang","year":"2007","unstructured":"Chang Y\u2010F, Imam JS, Wilkinson MF (2007) The nonsense\u2010mediated decay RNA surveillance pathway. Ann Rev Biochem 76: 51\u201374","journal-title":"Ann Rev Biochem"},{"key":"BFEMBJ7601977_CR25","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1128\/MCB.23.14.4805-4813.2003","volume":"23","author":"C\u2010YA Chen","year":"2003","unstructured":"Chen C\u2010YA, Shyu A\u2010B (2003) Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense\u2010mediated decay pathway. Mol Cell Biol 23: 4805\u20134813","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601977_CR26","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1261\/rna.663507","volume":"13","author":"C\u2010YA Chen","year":"2007","unstructured":"Chen C\u2010YA, Yamashita Y, Chang T\u2010C, Yamashita A, Zhu W, Zhong Z, Shyu A\u2010B (2007) Versatile applications of transcriptional pulsing to study mRNA turnover in mammalian cells. RNA 13: 1775\u20131786","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR27","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nature05841","volume":"447","author":"TP Chendrimada","year":"2007","unstructured":"Chendrimada TP, Finn KJ, Ji X, Baillat D, Gregory RI, Liebhaber SA, Pasquinelli AE, Shiekhattar R (2007) MicroRNA silencing through RISC recruitment of eIF6. Nature 447: 823\u2013828","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR28","doi-asserted-by":"crossref","first-page":"e210","DOI":"10.1371\/journal.pbio.0040210","volume":"4","author":"CY Chu","year":"2006","unstructured":"Chu CY, Rana TM (2006) Translation repression in human cells by microRNA\u2010induced gene silencing requires RCK\/p54. PLoS Biol 4: e210","journal-title":"PLoS Biol"},{"key":"BFEMBJ7601977_CR29","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1101\/gad.12.20.3226","volume":"12","author":"JM Coller","year":"1998","unstructured":"Coller JM, Gray NK, Wickens MP (1998) mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation. Genes Dev 12: 3226\u20133235","journal-title":"Genes Dev"},{"key":"BFEMBJ7601977_CR30","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/genetics\/95.4.833","volume":"95","author":"MR Culbertson","year":"1980","unstructured":"Culbertson MR, Underbrink KM, Fink GR (1980) Frameshift suppression in Saccharomyces cerevisiae. II. Genetic properties of group II suppressors. Genetics 95: 833\u2013853","journal-title":"Genetics"},{"key":"BFEMBJ7601977_CR31","first-page":"610","volume":"1","author":"K Czaplinski","year":"1995","unstructured":"Czaplinski K, Weng Y, Hagan KW, Peltz SW (1995) Purification and characterization of the Upf1 protein: a factor involved in translation and mRNA degradation. RNA 1: 610\u2013623","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/jmbi.1997.1013","volume":"269","author":"JA Deardorff","year":"1997","unstructured":"Deardorff JA, Sachs AB (1997) Differential effects of aromatic and charged residue substitutions in the RNA binding domains of the yeast poly(A)\u2010binding protein. J Mol Biol 269: 67\u201381","journal-title":"J Mol Biol"},{"key":"BFEMBJ7601977_CR33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrm760","volume":"3","author":"G Dreyfuss","year":"2003","unstructured":"Dreyfuss G, Kim VN, Kataoka N (2003) Messenger\u2010RNA\u2010binding proteins and the messages they carry. Nat Rev Mol Cell Biol 3: 195\u2013205","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ7601977_CR34","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrm1129","volume":"4","author":"DM Dykxhoorn","year":"2003","unstructured":"Dykxhoorn DM, Novina CD, Sharp PA (2003) Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol 4: 457\u2013467","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ7601977_CR35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm2080","volume":"8","author":"A Eulalio","year":"2007","unstructured":"Eulalio A, Behm\u2010Ansmant I, Izaurralde E (2007a) P bodies: at the crossroads of post\u2010transcriptional pathways. Nat Rev Mol Cell Biol 8: 9\u201322","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ7601977_CR36","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1128\/MCB.00128-07","volume":"27","author":"A Eulalio","year":"2007","unstructured":"Eulalio A, Behm\u2010Ansmant I, Schweizer D, Izaurralde E (2007b) P\u2010body formation is a consequence, not the cause, of RNA\u2010mediated gene silencing. Mol Cell Biol 27: 3970\u20133981","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601977_CR37","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1101\/gad.443107","volume":"21","author":"A Eulalio","year":"2007","unstructured":"Eulalio A, Rehwinkel J, Stricker M, Huntzinger E, Yang S\u2010F, Doerks T, Dorner S, Bork P, Boutros M, Izaurralde E (2007c) Target\u2010specific requirements for enhancers of decapping in miRNA\u2010mediated gene silencing. Genes Dev 21: 2558\u20132570","journal-title":"Genes Dev"},{"key":"BFEMBJ7601977_CR38","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1091\/mbc.01-11-0544","volume":"13","author":"T Eystathioy","year":"2002","unstructured":"Eystathioy T, Chan EKL, Tenenbaum SA, Keene JD, Griffith K, Fritzler MJ (2002) A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol Biol Cell 13: 1338\u20131351","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ7601977_CR39","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/hmg\/8.10.1893","volume":"8","author":"PA Frischmeyer","year":"1999","unstructured":"Frischmeyer PA, Dietz HC (1999) Nonsense\u2010mediated mRNA decay in health and disease. Hum Mol Genet 8: 1893\u20131900","journal-title":"Hum Mol Genet"},{"key":"BFEMBJ7601977_CR40","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature02559","volume":"429","author":"D Gatfield","year":"2004","unstructured":"Gatfield D, Izaurralde E (2004) Nonsense\u2010mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature 429: 575\u2013578","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR41","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1093\/emboj\/cdg371","volume":"22","author":"D Gatfield","year":"2003","unstructured":"Gatfield D, Unterholzner L, Ciccarelli FD, Bork P, Izaurralde E (2003) Nonsense\u2010mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J 22: 3960\u20133970","journal-title":"EMBO J"},{"key":"BFEMBJ7601977_CR42","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1097-2765(03)00142-4","volume":"11","author":"K Gehring","year":"2003","unstructured":"Gehring K, Neu\u2010Yilik G, Schell T, Hentze MW, Kulozik AE (2003) Y14 and hUpf3b form an NMD\u2010activating complex. Mol Cell 11: 939\u2013949","journal-title":"Mol Cell"},{"key":"BFEMBJ7601977_CR43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molcel.2005.08.012","volume":"20","author":"NH Gehring","year":"2005","unstructured":"Gehring NH, Kunz JB, Neu\u2010Yilik G, Breit S, Viegas MH, Hentze MW, Kulozik AE (2005) Exon\u2010junction complex components specify distinct routes of nonsense\u2010mediated mRNA decay with differential cofactor requirements. Mol Cell 20: 65\u201375","journal-title":"Mol Cell"},{"key":"BFEMBJ7601977_CR44","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.biochem.68.1.913","volume":"68","author":"A\u2010C Gingras","year":"1999","unstructured":"Gingras A\u2010C, Raught B, Sonenberg N (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68: 913\u2013963","journal-title":"Annu Rev Biochem"},{"key":"BFEMBJ7601977_CR45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.1122689","volume":"312","author":"AJ Giraldez","year":"2006","unstructured":"Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, Inoue K, Enright AJ, Schier AF (2006) Zebrafish MiR\u2010430 promotes deadenylation and clearance of maternal mRNAs. Science 312: 75\u201379","journal-title":"Science"},{"key":"BFEMBJ7601977_CR46","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1097-2765(00)80443-8","volume":"5","author":"CI Gonzalez","year":"2000","unstructured":"Gonzalez CI, Ruiz\u2010Echevarria MJ, Vasudevan S, Henry MF, Peltz MF (2000) The yeast hnRNP\u2010like protein Hrp1\/Nab4 marks a transcript for nonsense\u2010mediated mRNA decay. Mol Cell 5: 489\u2013499","journal-title":"Mol Cell"},{"key":"BFEMBJ7601977_CR47","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1006\/excr.1994.1104","volume":"211","author":"M G\u00f6rlach","year":"1994","unstructured":"G\u00f6rlach M, Burd CG, Dreyfuss G (1994) The mRNA poly(A)\u2010binding protein: localization, abundance, and RNA\u2010binding specificity. Exp Cell Res 211: 400\u2013407","journal-title":"Exp Cell Res"},{"key":"BFEMBJ7601977_CR48","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.cellbio.14.1.399","volume":"14","author":"NK Gray","year":"1998","unstructured":"Gray NK, Wickens M (1998) Control of translation initiation in animals. Annu Rev Cell Dev Biol 14: 399\u2013458","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFEMBJ7601977_CR49","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/418244a","volume":"418","author":"GJ Hannon","year":"2002","unstructured":"Hannon GJ (2002) RNA interference. Nature 418: 244\u2013251","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR50","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1101\/gad.9.4.437","volume":"9","author":"F He","year":"1995","unstructured":"He F, Jacobson A (1995) Identification of a novel component of the nonsense\u2010mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9: 437\u2013454","journal-title":"Genes Dev"},{"key":"BFEMBJ7601977_CR51","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1017\/S1355838299990519","volume":"5","author":"P Hilleren","year":"1999","unstructured":"Hilleren P, Parker R (1999) mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization? RNA 5: 711\u2013719","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR52","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/genetics\/123.2.301","volume":"123","author":"J Hodgkin","year":"1989","unstructured":"Hodgkin J, Papp A, Pulak R, Ambros V, Anderson P (1989) A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics 123: 301\u2013313","journal-title":"Genetics"},{"key":"BFEMBJ7601977_CR53","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/ng1403","volume":"36","author":"JA Holbrook","year":"2004","unstructured":"Holbrook JA, Neu\u2010Yilik G, Hentze MW, Kulozik AE (2004) Nonsense\u2010mediated decay approaches the clinic. Nat Genet 36: 801\u2013808","journal-title":"Nat Genet"},{"key":"BFEMBJ7601977_CR54","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1365-313X.2005.02473.x","volume":"43","author":"K Hori","year":"2005","unstructured":"Hori K, Watanabe Y (2005) UPF3 suppresses aberrant spliced mRNA in Arabidopsis. Plant J 43: 530\u2013540","journal-title":"Plant J"},{"key":"BFEMBJ7601977_CR55","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1017\/S1355838202021726","volume":"8","author":"D Ingelfinger","year":"2002","unstructured":"Ingelfinger D, Arndt\u2010Jovin DJ, Luhrmann R, Achsel T (2002) The human LSm1\u20107 proteins colocalize with the mRNA\u2010degrading enzymes Dcp1\/2 and Xrnl in distinct cytoplasmic foci. RNA 8: 1489\u20131501","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR56","doi-asserted-by":"crossref","first-page":"re1","DOI":"10.1126\/stke.3672007re1","volume":"2007","author":"RJ Jackson","year":"2007","unstructured":"Jackson RJ, Standart N (2007) How do microRNAs regulate gene expression? Sci STKE 2007: re1","journal-title":"Sci STKE"},{"key":"BFEMBJ7601977_CR57","series-title":"Tanslational Control","first-page":"451","volume-title":"Poly(A) metabolism and translation: the colsed\u2010loop model","author":"A Jacobson","year":"1996","unstructured":"Jacobson A (1996) Poly(A) metabolism and translation: the colsed\u2010loop model. In Tanslational Control, Hershey JWB, Mathews MB, Sonenberg N (eds), pp 451\u2013480. Plainview: Cold Spring Harbor Laboratory Press"},{"key":"BFEMBJ7601977_CR58","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/ncb1334","volume":"8","author":"A Jakymiw","year":"2005","unstructured":"Jakymiw A, Lian S, Eystathioy T, Li S, Satoh M, Hamel JC, Fritzler MJ, Chan EK (2005) Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol 8: 1267\u20131274","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ7601977_CR59","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1093\/nar\/gkl410","volume":"34","author":"E Jankowsky","year":"2006","unstructured":"Jankowsky E, Bowers H (2006) Remodeling of ribonucleoprotein complexes with DExH\/D RNA helicases. Nucleic Acids Res 34: 4181\u20134188","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ7601977_CR60","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1128\/MCB.00410-07","volume":"27","author":"L Johns","year":"2007","unstructured":"Johns L, Grimson A, Kuchma SL, Newman CL, Anderson P (2007) Caenorhabditis elegans SMG\u20102 selectively marks mRNAs containing premature translation termination codons. Mol Cell Biol 27: 5630\u20135638","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601977_CR61","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1101\/sqb.2001.66.293","volume":"66","author":"A Kahvejian","year":"2001","unstructured":"Kahvejian A, Roy G, Sonenberg N (2001) The mRNA closed\u2010loop model: the function of PABP and PABP\u2010interacting proteins in mRNA translation. Cold Spring Harb Symp Quant Biol 66: 293\u2013300","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"BFEMBJ7601977_CR62","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/gad.1389006","volume":"20","author":"I Kashima","year":"2006","unstructured":"Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G, Ohno S (2006) Binding of a novel SMG\u20101\u2013Upf1\u2013eRF1\u2013eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense\u2010mediated mRNA decay. Genes Dev 20: 355\u2013367","journal-title":"Genes Dev"},{"key":"BFEMBJ7601977_CR63","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0076-6879(07)31005-7","volume":"431","author":"N Kedersha","year":"2007","unstructured":"Kedersha N, Anderson P (2007) Mammalian stress granules and processing bodies. Methods Enzymol 431: 61\u201381","journal-title":"Methods Enzymol"},{"key":"BFEMBJ7601977_CR64","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1261\/rna.5147804","volume":"10","author":"KM Keeling","year":"2004","unstructured":"Keeling KM, Lanier J, Du M, Salas\u2010Marco JOE, Gao LIN, Kaenjak\u2010Angeletti A, Bedwell DM (2004) Leaky termination at premature stop codons antagonizes nonsense\u2010mediated mRNA decay in S. cerevisiae. RNA 10: 691\u2013703","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR65","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1093\/emboj\/20.8.2062","volume":"20","author":"VN Kim","year":"2001","unstructured":"Kim VN, Yong J, Kataoka N, Abel L, Diem MD, Dreyfuss G (2001) The Y14 protein communicates to the cytoplasm the position of exon\u2013exon junctions. EMBO J 20: 2062\u20132068","journal-title":"EMBO J"},{"key":"BFEMBJ7601977_CR66","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cell.2004.11.050","volume":"120","author":"YK Kim","year":"2005","unstructured":"Kim YK, Furic L, Desgroseillers L, Maquat LE (2005) Mammalian Staufen1 recruits Upf1 to specific mRNA 3\u2032UTRs so as to elicit mRNA decay. Cell 120: 195\u2013208","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR67","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.cell.2007.05.016","volume":"129","author":"M Kiriakidou","year":"2007","unstructured":"Kiriakidou M, Tan GS, Lamprinaki S, De Planell\u2010Saguer M, Nelson PT, Mourelatos Z (2007) An mRNA m7G cap binding\u2010like motif within human Ago2 represses translation. Cell 129: 1141\u20131151","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR68","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/jmbi.1996.0065","volume":"256","author":"U Kuhn","year":"1996","unstructured":"Kuhn U, Pieler T (1996) Xenopus poly(A) binding protein: functional domains in RNA binding and protein\u2013protein interaction. J Mol Biol 256: 20\u201330","journal-title":"J Mol Biol"},{"key":"BFEMBJ7601977_CR69","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1093\/emboj\/20.17.4987","volume":"20","author":"H Le Hir","year":"2001","unstructured":"Le Hir H, Gatfield D, Izaurralde E, Moore MJ (2001) The exon\u2013exon junction complex provides a binding platform for factors involved in mRNA export and nonsense\u2010mediated mRNA decay. EMBO J 20: 4987\u20134997","journal-title":"EMBO J"},{"key":"BFEMBJ7601977_CR70","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1101\/gad.14.9.1098","volume":"14","author":"H Le Hir","year":"2000","unstructured":"Le Hir H, Moore MJ, Maquat LE (2000) Pre\u2010mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon\u2013exon junctions. Genes Dev 14: 1098\u20131108","journal-title":"Genes Dev"},{"key":"BFEMBJ7601977_CR71","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1128\/JVI.78.10.5139-5146.2004","volume":"78","author":"JJ LeBlanc","year":"2004","unstructured":"LeBlanc JJ, Beemon KL (2004) Unspliced rous sarcoma virus genomic RNAs are translated and subjected to nonsense\u2010mediated mRNA decay before packaging. J Virol 78: 5139\u20135146","journal-title":"J Virol"},{"key":"BFEMBJ7601977_CR72","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1101\/sqb.2006.71.041","volume":"71","author":"Y Lee","year":"2006","unstructured":"Lee Y, Han J, Yeom KH, Jin H, Kim VN (2006) Drosha in primary MicroRNA processing. Cold Spring Harb Symp Quant Biol 71: 51\u201357","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"BFEMBJ7601977_CR73","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120: 15\u201320","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR74","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","volume":"115","author":"BP Lewis","year":"2003","unstructured":"Lewis BP, Shih IH, Jones\u2010Rhoades MW, Bartel DP, Burge CB (2003) Prediction of mammalian microRNA targets. Cell 115: 787\u2013798","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR75","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1126\/science.1080372","volume":"299","author":"LP Lim","year":"2003","unstructured":"Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (2003) Vertebrate miRNA genes. Science 299: 1540","journal-title":"Science"},{"key":"BFEMBJ7601977_CR76","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","volume":"433","author":"LP Lim","year":"2005","unstructured":"Lim LP, Lau NC, Garrett\u2010Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769\u2013773","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR77","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/ncb1333","volume":"7","author":"J Liu","year":"2005","unstructured":"Liu J, Rivas FV, Wohlschlegel J, Yates III JR, Parker R, Hannon GJ (2005a) A role for the P\u2010body component GW182 in microRNA function. Nat Cell Biol 7: 1261\u20131266","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ7601977_CR78","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/ncb1274","volume":"7","author":"J Liu","year":"2005","unstructured":"Liu J, Valencia\u2010Sanchez MA, Hannon GJ, Parker R (2005b) MicroRNA\u2010dependent localization of targeted mRNAs to mammalian P\u2010bodies. Nat Cell Biol 7: 719\u2013723","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ7601977_CR79","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1101\/gad.417707","volume":"21","author":"D Longman","year":"2007","unstructured":"Longman D, Plasterk RHA, Johnstone IL, Caceres JF (2007) Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Genes Dev 21: 1075\u20131085","journal-title":"Genes Dev"},{"key":"BFEMBJ7601977_CR80","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1073\/pnas.76.10.5134","volume":"76","author":"R Losson","year":"1979","unstructured":"Losson R, Lacroute F (1979) Interference of nonsense mutations with eukaryotic messenger RNA stability. Proc Natl Acad Sci USA 76: 5134\u20135137","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601977_CR81","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1126\/science.1062786","volume":"293","author":"J Lykke\u2010Andersen","year":"2001","unstructured":"Lykke\u2010Andersen J, Shu MD, Steitz JA (2001) Communication of the position of exon\u2013exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science 293: 1836\u20131839","journal-title":"Science"},{"key":"BFEMBJ7601977_CR82","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/gb-2003-4-11-233","volume":"4","author":"DA Mangus","year":"2003","unstructured":"Mangus DA, Evans MC, Jacobson A (2003) Poly(A)\u2010binding proteins: multifunctional scaffolds for the post\u2010transcriptional control of gene expression. Genome Biol 4: 233 http:\/\/genomebiology.com\/2003\/2004\/2007\/2223","journal-title":"Genome Biol"},{"key":"BFEMBJ7601977_CR83","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm1310","volume":"5","author":"LE Maquat","year":"2004","unstructured":"Maquat LE (2004) Nonsense mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol 5: 89\u201399","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ7601977_CR84","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0092-8674(81)90396-2","volume":"27","author":"LE Maquat","year":"1981","unstructured":"Maquat LE, Kinniburgh AJ, Rachmilewitz EA, Ross J (1981) Unstable beta\u2010globin mRNA in mRNA\u2010deficient beta o thalassemia. Cell 27: 543\u2013553","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR85","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nsmb1174","volume":"13","author":"PA Maroney","year":"2006","unstructured":"Maroney PA, Yu Y, Fisher J, Nilsen TW (2006) Evidence that microRNAs are associated with translating messenger RNAs in human cells. Nat Struct Mol Biol 13: 1102\u20131107","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBJ7601977_CR86","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1126\/science.1146067","volume":"317","author":"G Mathonnet","year":"2007","unstructured":"Mathonnet G, Fabian MR, Svitkin YV, Parsyan A, Huck L, Murata T, Biffo S, Merrick WC, Darzynkiewicz E, Pillai RS, Filipowicz W, Duchaine TF, Sonenberg N (2007) MicroRNA inhibition of translation initiation in vitro by targeting the cap\u2010binding complex eIF4F. Science 317: 1764\u20131767","journal-title":"Science"},{"key":"BFEMBJ7601977_CR87","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1073\/pnas.92.12.5431","volume":"92","author":"KK McCaughan","year":"1995","unstructured":"McCaughan KK, Brown CM, Dalphin ME, Berry MJ, Tate WP (1995) Translational termination efficiency in mammals is influenced by the base following the stop codon. Proc Natl Acad Sci USA 92: 5431\u20135435","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601977_CR88","series-title":"Mol Cell","volume-title":"Nonsense\u2010mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail","author":"S Meaux","year":"2008","unstructured":"Meaux S, van Hoof A, Baker KE (2008) Nonsense\u2010mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail. Mol Cell (in press)"},{"key":"BFEMBJ7601977_CR89","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.cub.2005.10.048","volume":"15","author":"G Meister","year":"2005","unstructured":"Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Luhrmann R, Tuschl T (2005) Identificiation of novel argonaute\u2010associated proteins. Curr Biol 15: 2149\u20132155","journal-title":"Curr Biol"},{"key":"BFEMBJ7601977_CR90","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.1074428","volume":"298","author":"JT Mendell","year":"2002","unstructured":"Mendell JT, ap Rhys CM, Dietz HC (2002) Separable roles for rent1\/hUpf1 in altered splicing and decay of nonsense transcripts. Science 298: 419\u2013422","journal-title":"Science"},{"key":"BFEMBJ7601977_CR91","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.cub.2006.08.086","volume":"16","author":"Y Mishima","year":"2006","unstructured":"Mishima Y, Giraldez AJ, Takeda Y, Fujiwara T, Sakamoto H, Schier AF, Inoue K (2006) Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR\u2010430. Curr Biol 16: 2135\u20132142","journal-title":"Curr Biol"},{"key":"BFEMBJ7601977_CR92","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S1097-2765(03)00190-4","volume":"11","author":"P Mitchell","year":"2003","unstructured":"Mitchell P, Tollervey D (2003) An NMD pathway in yeast involving accelerated deadenylation and exosome\u2010mediated 3\u2032 \u2192 5\u2032 degradation. Mol Cell 11: 1405\u20131413","journal-title":"Mol Cell"},{"key":"BFEMBJ7601977_CR93","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1126\/science.1111443","volume":"309","author":"MJ Moore","year":"2005","unstructured":"Moore MJ (2005) From birth to death: the complex lives of eukaryotic mRNAs. Science 309: 1514\u20131518","journal-title":"Science"},{"key":"BFEMBJ7601977_CR94","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/370578a0","volume":"370","author":"D Muhlrad","year":"1994","unstructured":"Muhlrad D, Parker R (1994) Premature translational termination triggers mRNA decapping. Nature 370: 578\u2013581","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR95","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1091\/mbc.10.11.3971","volume":"10","author":"D Muhlrad","year":"1999","unstructured":"Muhlrad D, Parker R (1999) Recognition of yeast mRNAs as \u2018nonsense containing\u2019 leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping. Mol Biol Cell 10: 3971\u20133978","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ7601977_CR96","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0968-0004(98)01208-0","volume":"23","author":"E Nagy","year":"1998","unstructured":"Nagy E, Maquat LE (1998) A rule for termination\u2010codon position within intron\u2010containing genes: when nonsense affects RNA abundance. Trends Biochem Sci 23: 198\u2013199","journal-title":"Trends Biochem Sci"},{"key":"BFEMBJ7601977_CR97","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1261\/rna.5181104","volume":"10","author":"PT Nelson","year":"2004","unstructured":"Nelson PT, Hatzigeorgiou AG, Mourelatos Z (2004) miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA 10: 387\u2013394","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR98","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/emboj\/20.3.532","volume":"20","author":"G Neu\u2010Yilik","year":"2001","unstructured":"Neu\u2010Yilik G, Gehring NH, Thermann R, Frede U, Hentze MW, Kulozik AE (2001) Splicing and 3\u2032 end formation in the definition of nonsense\u2010mediated decay\u2010competent human {beta}\u2010globin mRNPs. EMBO J 20: 532\u2013540","journal-title":"EMBO J"},{"key":"BFEMBJ7601977_CR99","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tig.2007.02.011","volume":"23","author":"TW Nilsen","year":"2007","unstructured":"Nilsen TW (2007) Mechanisms of miroRNA\u2010mediated gene regulation in animal cells. Trends Genet 23: 243\u2013249","journal-title":"Trends Genet"},{"key":"BFEMBJ7601977_CR100","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nsmb1173","volume":"13","author":"S Nottrott","year":"2006","unstructured":"Nottrott S, Simard MJ, Richter JD (2006) Human let\u20107a miRNA blocks protein production on actively translating polyribosomes. Nat Struct Mol Biol 13: 1108\u20131114","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBJ7601977_CR101","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1006\/dbio.1999.9523","volume":"216","author":"PH Olsen","year":"1999","unstructured":"Olsen PH, Ambros V (1999) The lin\u20104 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN\u201014 protein synthesis after the initiation of translation. Dev Biol 216: 671\u2013680","journal-title":"Dev Biol"},{"key":"BFEMBJ7601977_CR102","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1128\/MCB.19.9.5943","volume":"19","author":"MF Page","year":"1999","unstructured":"Page MF, Carr B, Anders KR, Grimson A, Anderson P (1999) SMG\u20102 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol Cell Biol 19: 5943\u20135951","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601977_CR103","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nature02351","volume":"427","author":"IM Palacios","year":"2004","unstructured":"Palacios IM, Gatfield D, St Johnston D, Izaurralde E (2004) An eIF4AIII\u2010containing complex required for mRNA localization and nonsense\u2010mediated mRNA decay. Nature 427: 753\u2013757","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR104","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.molcel.2007.02.011","volume":"25","author":"R Parker","year":"2007","unstructured":"Parker R, Sheth U (2007) P bodies and the control of mRNA translation and degradation. Mol Cell 25: 635\u2013646","journal-title":"Mol Cell"},{"key":"BFEMBJ7601977_CR105","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1101\/gad.7.9.1737","volume":"7","author":"SW Peltz","year":"1993","unstructured":"Peltz SW, Brown AH, Jacobson A (1993) mRNA destabilization triggered by premature translational termination depends on at least three cis\u2010acting sequence elements and one trans\u2010acting factor. Genes Dev 7: 1737\u20131754","journal-title":"Genes Dev"},{"key":"BFEMBJ7601977_CR106","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1261\/rna.7131604","volume":"10","author":"RS Pillai","year":"2004","unstructured":"Pillai RS, Artus CG, Filipowicz W (2004) Tethering of human Ago proteins to mRNA mimics the miRNA\u2010mediated repression of protein synthesis. RNA 10: 1518\u20131525","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR107","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tcb.2006.12.007","volume":"17","author":"RS Pillai","year":"2007","unstructured":"Pillai RS, Bhattacharyya SN, Filipowicz W (2007) Repression of protein sysnthesis by miRNAs: how many mechanisms? Trends Cell Biol 17: 118\u2013126","journal-title":"Trends Cell Biol"},{"key":"BFEMBJ7601977_CR108","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1128\/MCB.21.16.5512-5519.2001","volume":"21","author":"KS Rajavel","year":"2001","unstructured":"Rajavel KS, Neufeld EF (2001) Nonsense\u2010mediated decay of human HEXA mRNA. Mol Cell Biol 21: 5512\u20135519","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601977_CR109","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/ng1798","volume":"38","author":"N Rajewsky","year":"2006","unstructured":"Rajewsky N (2006) microRNA target predictions in animals. Nat Genet 38 (Suppl): S8\u2013S13","journal-title":"Nat Genet"},{"key":"BFEMBJ7601977_CR110","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.cell.2005.10.020","volume":"123","author":"TA Rand","year":"2005","unstructured":"Rand TA, Petersen S, Du F, Wang X (2005) Argonaute2 cleaves the anti\u2010guide strand of siRNA during RISC activation. Cell 123: 621\u2013629","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR111","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1261\/rna.2191905","volume":"11","author":"JAN Rehwinkel","year":"2005","unstructured":"Rehwinkel JAN, Behm\u2010Ansmant I, Gatfield D, Izaurralde E (2005) A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA\u2010mediated gene silencing. RNA 11: 1640\u20131647","journal-title":"RNA"},{"key":"BFEMBJ7601977_CR112","series-title":"Translational Control","first-page":"481","volume-title":"Dynamics of poly(A) addition and removal during development","author":"JD Richter","year":"1996","unstructured":"Richter JD (1996) Dynamics of poly(A) addition and removal during development. In Translational Control, Hershey JWB, Mathews MB, Sonenberg N (eds), pp 481\u2013503. Plainview: Cold Spring Harbor Laboratory Press"},{"key":"BFEMBJ7601977_CR113","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1128\/MCB.00286-06","volume":"26","author":"MA Rodriguez\u2010Gabriel","year":"2006","unstructured":"Rodriguez\u2010Gabriel MA, Watt S, Bahler J, Russell P (2006) Upf1, an RNA helicase required for nonsense\u2010mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Mol Cell Biol 26: 6347\u20136356","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601977_CR114","doi-asserted-by":"crossref","first-page":"reviews1006.1","DOI":"10.1186\/gb-2002-3-3-reviews1006","volume":"3","author":"T Schell","year":"2002","unstructured":"Schell T, Kulozik A, Hentze M (2002) Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense\u2010mediated decay pathway. Genome Biol 3: reviews1006.1\u20131006.6","journal-title":"Genome Biol"},{"key":"BFEMBJ7601977_CR115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/dbio.2001.0563","volume":"243","author":"K Seggerson","year":"2002","unstructured":"Seggerson K, Tang L, Moss EG (2002) Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin\u201028 after translation initiation. Dev Biol 243: 215\u2013225","journal-title":"Dev Biol"},{"key":"BFEMBJ7601977_CR116","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1082320","volume":"300","author":"U Sheth","year":"2003","unstructured":"Sheth U, Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300: 805\u2013808","journal-title":"Science"},{"key":"BFEMBJ7601977_CR117","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.cell.2006.04.037","volume":"125","author":"U Sheth","year":"2006","unstructured":"Sheth U, Parker R (2006) Targeting of aberrant mRNAs to cytoplasmic processing bodies. Cell 125: 1095\u20131109","journal-title":"Cell"},{"key":"BFEMBJ7601977_CR118","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.molcel.2006.05.043","volume":"23","author":"EC Small","year":"2006","unstructured":"Small EC, Leggett SR, Winans AA, Staley JP (2006) The EF\u2010G\u2010like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD\/H box ATPase. Mol Cell 23: 389\u2013399","journal-title":"Mol Cell"},{"key":"BFEMBJ7601977_CR119","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/sj.embor.7400572","volume":"7","author":"G Stoecklin","year":"2006","unstructured":"Stoecklin G, Mayo T, Anderson P (2006) ARE\u2010mRNA degradation requires the 5\u2032\u20133\u2032 decay pathway. EMBO Rep 7: 72\u201377","journal-title":"EMBO Rep"},{"key":"BFEMBJ7601977_CR120","doi-asserted-by":"crossref","first-page":"10009","DOI":"10.1073\/pnas.95.17.10009","volume":"95","author":"X Sun","year":"1998","unstructured":"Sun X, Perlick HA, Dietz HC, Maquat LE (1998) A mutated human homologue to yeast Upf1 protein has a dominant\u2010negative effect on the decay of nonsensecontaining mRNAs in mammalian cells. Proc Natl Acad Sci USA 95: 10009\u201310014","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601977_CR121","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nature05878","volume":"447","author":"R Thermann","year":"2007","unstructured":"Thermann R, Hentze MW (2007) Drosophila miR2 induces pseudo\u2010polysomes and inhibits translation initiation. Nature 447: 875\u2013878","journal-title":"Nature"},{"key":"BFEMBJ7601977_CR122","doi-asserted-by":"crossref","first-page":"50286","DOI":"10.1074\/jbc.M203029200","volume":"277","author":"N Uchida","year":"2002","unstructured":"Uchida N, Hoshino S\u2010I, Imataka H, Sonenberg N, Katada T (2002) A novel role of the mammalian GSPT\/eRF3 associating with poly(A)\u2010binding protein in Cap\/poly(A)\u2010dependent translation. J Biol Chem 277: 50286\u201350292","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601977_CR123","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.molcel.2004.10.013","volume":"16","author":"L Unterholzner","year":"2004","unstructured":"Unterholzner L, Izaurralde E (2004) SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell 16: 587\u2013596","journal-title":"Mol Cell"},{"key":"BFEMBJ7601977_CR124","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1046\/j.1365-313x.1996.10030415.x","volume":"10","author":"A van Hoof","year":"1996","unstructured":"van Hoof A, Green PJ (1996) Premature nonsense codons decrease the stability of phytohemagglutinin mRNA in a position\u2010dependent manner. Plant J 10: 415\u2013424","journal-title":"Plant J"},{"key":"BFEMBJ7601977_CR125","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1101\/gad.1566707","volume":"21","author":"M Wakiyama","year":"2007","unstructured":"Wakiyama M, Takimoto K, Ohara O, Yokoyama S (2007) Let\u20107 microRNA\u2010mediated mRNA deadenylation and translational repression in a mammalian cell\u2010free system. Genes Dev 21: 1857\u20131862","journal-title":"Genes Dev"},{"key":"BFEMBJ7601977_CR126","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/embo-reports\/kvf036","volume":"3","author":"J Wang","year":"2002","unstructured":"Wang J, Gudikote JP, Olivas OR, Wilkinson MF (2002) Boundary\u2010independent polar nonsense\u2010mediated decay. EMBO Rep 3: 274\u2013279","journal-title":"EMBO Rep"},{"key":"BFEMBJ7601977_CR127","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1073\/pnas.0510928103","volume":"103","author":"L Wu","year":"2006","unstructured":"Wu L, Fan J, Belasco JG (2006) MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci USA 103: 4034\u20134039","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601977_CR128","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nsmb1016","volume":"12","author":"A Yamashita","year":"2005","unstructured":"Yamashita A, Chang TC, Yamashita Y, Zhu W, Zhong Z, Chen CY, Shyu AB (2005) Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover. Nat Struct Mol Biol 12: 1054\u20131063","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBJ7601977_CR129","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1111444","volume":"309","author":"PD Zamore","year":"2005","unstructured":"Zamore PD, Haley B (2005) Ribo\u2010genome: the big world of small RNAs. Science 309: 1519\u20131524","journal-title":"Science"},{"key":"BFEMBJ7601977_CR130","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1128\/MCB.18.9.5272","volume":"18","author":"J Zhang","year":"1998","unstructured":"Zhang J, Sun X, Qian Y, LaDuca JP, Maquat LE (1998) At least one intron is required for the nonsense\u2010mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation. Mol Cell Biol 18: 5272\u20135283","journal-title":"Mol Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.emboj.7601977","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7601977.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/sj.emboj.7601977","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/sj.emboj.7601977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7601977.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:54:28Z","timestamp":1779234868000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/sj.emboj.7601977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,6]]},"references-count":130,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,2,6]]}},"alternative-id":["BFEMBJ7601977"],"URL":"https:\/\/doi.org\/10.1038\/sj.emboj.7601977","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,6]]},"assertion":[{"value":"10 November 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}