{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:23:23Z","timestamp":1772936603571,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["www.embopress.org"],"crossmark-restriction":false},"short-container-title":["EMBO Reports"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p>\n                    Histone acetylation regulates many chromosome functions, such as gene expression and chromosome segregation. Histone deacetylase inhibitors (HDACIs) induce growth arrest, differentiation and apoptosis of cancer cells\n                    <jats:italic>ex vivo<\/jats:italic>\n                    , as well as\n                    <jats:italic>in vivo<\/jats:italic>\n                    in tumour\u2010bearing animal models, and are now undergoing clinical trials as anti\u2010tumour agents. However, little attention has been paid to how HDACIs function in these biological settings and why different cells respond in different ways. Here, we discuss the consequences of inhibiting histone deacetylases in cycling versus non\u2010cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome.\n                  <\/jats:p>","DOI":"10.1038\/sj.embor.7400441","type":"journal-article","created":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T22:59:48Z","timestamp":1118098788000},"page":"520-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?"],"prefix":"10.1038","volume":"6","author":[{"given":"Angela","family":"Taddei","sequence":"first","affiliation":[{"name":"Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d'Ulm  75248 Paris cedex 05 France"},{"name":"Present address: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66  4058 Basel Switzerland"}]},{"given":"Dani\u00e8le","family":"Roche","sequence":"additional","affiliation":[{"name":"Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d'Ulm  75248 Paris cedex 05 France"}]},{"given":"Wendy A.","family":"Bickmore","sequence":"additional","affiliation":[{"name":"MRC Human Genetics Unit  Crewe Road Edinburgh EH4 2XU UK"}]},{"given":"Genevi\u00e8ve","family":"Almouzni","sequence":"additional","affiliation":[{"name":"Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d'Ulm  75248 Paris cedex 05 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