{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:31:19Z","timestamp":1778761879625,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2000,8,1]]},"DOI":"10.1038\/sj.leu.2401829","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T18:36:40Z","timestamp":1031164600000},"page":"1483-1489","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Mantle cell lymphoma proliferates upon IL-10 in the CD40 system"],"prefix":"10.1038","volume":"14","author":[{"given":"HPJ","family":"Visser","sequence":"first","affiliation":[]},{"given":"M","family":"Tewis","sequence":"additional","affiliation":[]},{"given":"R","family":"Willemze","sequence":"additional","affiliation":[]},{"given":"JC","family":"Kluin-Nelemans","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2000,8,4]]},"reference":[{"key":"BF2401829_CR1","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1182\/blood.V83.10.2829.2829","volume":"83","author":"F Berger","year":"1994","unstructured":"Berger F, Felman P, Sonet A, Salles G, Bastion Y, Bryon PA, Coiffier B . Nonfollicular small B cell lymphomas: a heterogeneous group of patients with distinct clinical features Blood 1994 83: 2829\u20132835","journal-title":"Blood"},{"key":"BF2401829_CR2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1182\/blood.V84.2.403.403","volume":"84","author":"M Hummel","year":"1994","unstructured":"Hummel M, Tamaru J, Kalvelage B, Stein H . Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle Blood 1994 84: 403\u2013407","journal-title":"Blood"},{"key":"BF2401829_CR3","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/00000478-199207000-00001","volume":"16","author":"PM Banks","year":"1992","unstructured":"Banks PM, Chan J, Cleary ML, Delsol G, De Wolf-Peeters C, Gatter K, Grogan TM, Harris NL, Isaacson PG, Jaffe ES, Mason D, Pileri S, Ralfkiaer E, Stein H, Warnke RA . Mantle cell lymphoma: a proposal for unification of morphologic, immunologic and molecular data Am J Surg Pathol 1992 16: 637\u2013640","journal-title":"Am J Surg Pathol"},{"key":"BF2401829_CR4","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1200\/JCO.1993.11.4.802","volume":"11","author":"RA Shivdasani","year":"1993","unstructured":"Shivdasani RA, Hess JL, Skarin AT, Pinkus GS . Intermediate lymphocytic lymphoma: clinical and pathologic features of a recently characterized subtype of non-Hodgkin's lymphoma J Clin Oncol 1993 11: 802\u2013811","journal-title":"J Clin Oncol"},{"key":"BF2401829_CR5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/A:1008207005567","volume":"8","author":"CJ De Boer","year":"1997","unstructured":"De Boer CJ, Vaandrager JW, van Krieken JH, Kluin PM, Schuuring E . Bcl-1\/cyclin D1 in malignant lymphoma Ann Oncol 1997 8: (Suppl 2) 109\u2013117","journal-title":"Ann Oncol"},{"key":"BF2401829_CR6","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.6610211","volume":"224","author":"Y Tsujimoto","year":"1984","unstructured":"Tsujimoto Y, Yunis J, Onorato-Showe L, Erikson J, Nowell PC, Croce CM . Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation Science 1984 224: 1403\u20131406","journal-title":"Science"},{"key":"BF2401829_CR7","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1182\/blood.V69.6.1617.1617","volume":"69","author":"DD Weisenburger","year":"1987","unstructured":"Weisenburger DD, Sanger WG, Armitage JO, Purtilo DT . Intermediate lymphocytic lymphoma: immunophenotypic and cytogenetic findings Blood 1987 69: 1617\u20131621","journal-title":"Blood"},{"key":"BF2401829_CR8","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1093\/annonc\/5.suppl_1.S71","volume":"5","author":"ME Williams","year":"1994","unstructured":"Williams ME, Swerdlow SH . Cyclin D1 overexpression in non-Hodgkin's lymphoma with chromosome 11 bcl-1 rearrangement Ann Oncol 1994 5: (Suppl.1) S71\u2013S73","journal-title":"Ann Oncol"},{"key":"BF2401829_CR9","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1365-2141.1994.tb04830.x","volume":"86","author":"K Oka","year":"1994","unstructured":"Oka K, Ohno T, Kita K, Yamaguchi M, Takakura N, Nishii K, Miwa H, Shirakawa S . PRAD1 gene over-expression in mantle-cell lymphoma but not in other low-grade B-cell lymphomas, including extranodal lymphoma Br J Haematol 1994 86: 786\u2013791","journal-title":"Br J Haematol"},{"key":"BF2401829_CR10","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1182\/blood.V84.8.2726.2726","volume":"84","author":"F Bosch","year":"1994","unstructured":"Bosch F, Jares P, Campo E, Lopez-Guillermo A, Piris MA, Villamor N, Tassies D, Jaffe ES, Montserrat E, Rozman C, Cardesa A . PRAD-1\/Cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma Blood 1994 84: 2726\u20132732","journal-title":"Blood"},{"key":"BF2401829_CR11","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/sj.onc.1201320","volume":"15","author":"CJ De Boer","year":"1997","unstructured":"De Boer CJ, Vaandrager JW, van Krieken JH, Holmes Z, Kluin PM, Schuuring E . Visualisation of mono-allelic chromosomal aberrations 3\u2032 and 5\u2032 of the cyclin D1 gene in mantle cell lymphoma using DNA fiber fluorescence in situ hybridization Oncogene 1997 15: 1599\u20131603","journal-title":"Oncogene"},{"key":"BF2401829_CR12","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1182\/blood.V86.7.2715.2715","volume":"86","author":"CJ De Boer","year":"1995","unstructured":"De Boer CJ, Schuuring E, Dreef E, Peters G, Bartek J, Kluin PM, van Krieken JH . Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma Blood 1995 86: 2715\u20132723","journal-title":"Blood"},{"key":"BF2401829_CR13","first-page":"5499","volume":"56","author":"N Voorzanger","year":"1996","unstructured":"Voorzanger N, Touitou R, Garcia E, Delecluse H-J, Rousset F, Joab I, Favrot MC, Blay J-Y . Interleukin (IL)-10 and IL6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors Cancer Res 1996 56: 5499\u20135505","journal-title":"Cancer Res"},{"key":"BF2401829_CR14","first-page":"488","volume":"10","author":"EV Planken","year":"1996","unstructured":"Planken EV, Dijkstra NH, Willemze R, Kluin-Nelemans JC . Proliferation of B cell malignancies in all stages of differentiation upon stimulation in the \u2018CD40 system\u2019 Leukemia 1996 10: 488\u2013493","journal-title":"Leukemia"},{"key":"BF2401829_CR15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.1702555","volume":"251","author":"J Banchereau","year":"1991","unstructured":"Banchereau J, de Paoli P, Vall\u00e9 A, Garcia E, Rousset F . Long-term human B cell lines dependent on interleukin-4 and antibody to CD40 Science 1991 251: 70\u201372","journal-title":"Science"},{"key":"BF2401829_CR16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/10428199109103373","volume":"5","author":"T Defrance","year":"1991","unstructured":"Defrance T, Fluckiger A-C, Rossi J-F, Rousset F, Banchereau J . In vitro activation of B-CLL cells Leuk Lymphoma 1991 5: (Suppl) 13\u201319","journal-title":"Leuk Lymphoma"},{"key":"BF2401829_CR17","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1182\/blood.V80.12.3173.3173","volume":"80","author":"AC Fluckiger","year":"1992","unstructured":"Fluckiger AC, Rossi J-F, Bussel A, Bryon P, Banchereau J, Defrance T . Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors Blood 1992 80: 3173\u20133181","journal-title":"Blood"},{"key":"BF2401829_CR18","first-page":"40","volume":"80","author":"DH Crawford","year":"1993","unstructured":"Crawford DH, Catovsky D . In vitro activation of leukemic B cells by interleukin-4 and antibodies to CD40 Immunology 1993 80: 40\u201344","journal-title":"Immunology"},{"key":"BF2401829_CR19","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V82.6.1848.1848","volume":"82","author":"PWM Johnson","year":"1993","unstructured":"Johnson PWM, Watt SM, Betts DR, Davies D, Jordan S, Norton AJ, Lister TA . Isolated follicular lymphoma cells are resistant to apoptosis and can be grown in vitro in the CD40\/stromal cell system Blood 1993 82: 1848\u20131857","journal-title":"Blood"},{"key":"BF2401829_CR20","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1182\/blood.V88.4.1177.bloodjournal8841177","volume":"88","author":"JW Vaandrager","year":"1996","unstructured":"Vaandrager JW, Schuuring E, Zwikstra E, de Boer CJ, Kleiverda KK, van Krieken JM, Kluin-Nelemans JC, van Ommen G-JB, Raap AK, Kluin PM . Direct visualisation of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization Blood 1996 88: 1177\u20131182","journal-title":"Blood"},{"key":"BF2401829_CR21","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","volume":"84","author":"NL Harris","year":"1994","unstructured":"Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller-Hermelink H-K, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA . A revised European\u2013American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group Blood 1994 84: 1361\u20131392","journal-title":"Blood"},{"key":"BF2401829_CR22","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.4049\/jimmunol.152.4.1821","volume":"152","author":"Y Liu","year":"1994","unstructured":"Liu Y, Wei SH-Y, Ho AS-Y, de Waal Malefyt R, Moore KW . Expression cloning and characterization of a human IL-10 receptor J Immunol 1994 152: 1821\u20131829","journal-title":"J Immunol"},{"key":"BF2401829_CR23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1046\/j.1365-2141.1996.d01-1908.x","volume":"95","author":"EV Planken","year":"1996","unstructured":"Planken EV, Dijkstra NH, Bakkus M, Willemze R, Kluin-Nelemans JC . Proliferation of precursor B-lineage acute lymphoblastic leukemia by activating the CD40 antigen Br J Haematol 1996 95: 319\u2013326","journal-title":"Br J Haematol"},{"key":"BF2401829_CR24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/cyto.990090512","volume":"9","author":"LWMM Terstappen","year":"1988","unstructured":"Terstappen LWMM, Shah VO, Conrad MP, Recktenwald D, Loken MR . Discriminating between damaged and intact cells in fixed flowcytometric samples Cytometry 1988 9: 477\u2013484","journal-title":"Cytometry"},{"key":"BF2401829_CR25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0022-1759(94)90236-4","volume":"171","author":"AB Lyons","year":"1994","unstructured":"Lyons AB, Parish CR . Determination of lymphocyte division by flow cytometry J Immunol Meth 1994 171: 131\u2013137","journal-title":"J Immunol Meth"},{"key":"BF2401829_CR26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.184.1.277","volume":"184","author":"PD Hodgkin","year":"1996","unstructured":"Hodgkin PD, Lee J-H, Lyons AB . B cell differentiation and isotype switching is related to division cycle number J Exp Med 1996 184: 277\u2013281","journal-title":"J Exp Med"},{"key":"BF2401829_CR27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1089\/vim.1998.11.221","volume":"11","author":"T Sairenji","year":"1998","unstructured":"Sairenji T, Ohnishi E, Inouye S, Kurata T . Induction of interleukin-10 on activation of Epstein\u2013Barr virus in EBV-infected B-cell lines Viral Immunol 1998 11: 221\u2013231","journal-title":"Viral Immunol"},{"key":"BF2401829_CR28","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<508::AID-IMMU508>3.0.CO;2-I","volume":"28","author":"J Choe","year":"1998","unstructured":"Choe J, Choi YS . IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells Eur J Immunol 1998 28: 508\u2013515","journal-title":"Eur J Immunol"},{"key":"BF2401829_CR29","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1182\/blood.V87.2.717.bloodjournal872717","volume":"87","author":"F Malisan","year":"1996","unstructured":"Malisan F, Fluckiger A-C, Ho S, Guret C, Banchereau J, Martinez-Valdez H . B-chronic lymphocytic leukemias can undergo isotype switching in vivo and can be induced to differentiate and switch in vitro Blood 1996 87: 717\u2013724","journal-title":"Blood"},{"key":"BF2401829_CR30","doi-asserted-by":"crossref","first-page":"4481 (letter)","DOI":"10.1182\/blood.V87.10.4481.bloodjournal87104481","volume":"87","author":"SD Hudnall","year":"1996","unstructured":"Hudnall SD . Further evidence for in vivo isotype switching in B-cell chronic lymphocytic leukemia Blood 1996 87: 4481 (letter)","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2401829.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401829","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401829.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:31:29Z","timestamp":1682037089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2401829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8,1]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8,1]]}},"alternative-id":["BF2401829"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2401829","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8,1]]},"assertion":[{"value":"7 February 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}