{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:26:10Z","timestamp":1762673170877},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2002,2,1]]},"DOI":"10.1038\/sj.leu.2402367","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:45:33Z","timestamp":1031251533000},"page":"244-253","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line"],"prefix":"10.1038","volume":"16","author":[{"given":"SP","family":"Srinivasa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PD","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2002,2,7]]},"reference":[{"key":"BF2402367_CR1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","volume":"80","author":"CJ Marshall","year":"1995","unstructured":"Marshall CJ . Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation Cell 1995 80: 179\u2013185","journal-title":"Cell"},{"key":"BF2402367_CR2","doi-asserted-by":"publisher","first-page":"6087","DOI":"10.1038\/sj.onc.1203129","volume":"18","author":"H Ichijo","year":"1999","unstructured":"Ichijo H . From receptors to stress-activated MAP kinases Oncogene 1999 18: 6087\u20136093","journal-title":"Oncogene"},{"key":"BF2402367_CR3","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.4049\/jimmunol.164.6.3018","volume":"164","author":"M Caivano","year":"2000","unstructured":"Caivano M, Cohen P . Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages J Immunol 2000 164: 3018\u20133025","journal-title":"J Immunol"},{"key":"BF2402367_CR4","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.4049\/jimmunol.163.8.4527","volume":"163","author":"JP Lian","year":"1999","unstructured":"Lian JP, Huang R, Robinson D, Badwey JA . Activation of p90RSK and cAMP response element binding protein in stimulated neutrophils: novel effects of the pyridinyl imidazole SB 203580 on activation of the extracellular signal-regulated kinase cascade J Immunol 1999 163: 4527\u20134536","journal-title":"J Immunol"},{"key":"BF2402367_CR5","doi-asserted-by":"publisher","first-page":"4629","DOI":"10.1002\/j.1460-2075.1996.tb00840.x","volume":"15","author":"Y Tan","year":"1996","unstructured":"Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb MJ . FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 EMBO J 1996 15: 4629\u20134642","journal-title":"EMBO J"},{"key":"BF2402367_CR6","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1002\/j.1460-2075.1995.tb07167.x","volume":"14","author":"C Livingstone","year":"1995","unstructured":"Livingstone C, Patel G, Jones N . ATF-2 contains a phosphorylation-dependent transcriptional activation domain EMBO J 1995 14: 1785\u20131797","journal-title":"EMBO J"},{"key":"BF2402367_CR7","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1128\/MCB.17.3.1170","volume":"17","author":"O Rausch","year":"1997","unstructured":"Rausch O, Marshall CJ . Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK\/SAPK mitogen-activated protein kinase pathway Mol Cell Biol 1997 17: 1170\u20131179","journal-title":"Mol Cell Biol"},{"key":"BF2402367_CR8","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/0092-8674(94)90380-8","volume":"76","author":"B Derijard","year":"1994","unstructured":"Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ . JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain Cell 1994 76: 1025\u20131037","journal-title":"Cell"},{"key":"BF2402367_CR9","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/00062752-199603030-00004","volume":"3","author":"SM Aronica","year":"1996","unstructured":"Aronica SM, Broxmeyer HE . Advances in understanding the postreceptor mechanisms of action of GM- CSF, G-CSF, and Steel factor Curr Opin Hematol 1996 3: 185\u2013190","journal-title":"Curr Opin Hematol"},{"key":"BF2402367_CR10","doi-asserted-by":"publisher","first-page":"3296","DOI":"10.1074\/jbc.272.6.3296","volume":"272","author":"IN Foltz","year":"1997","unstructured":"Foltz IN, Lee JC, Young PR, Schrader JW . Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway J Biol Chem 1997 272: 3296\u20133301","journal-title":"J Biol Chem"},{"key":"BF2402367_CR11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1182\/blood.V93.1.341","volume":"93","author":"K Suzuki","year":"1999","unstructured":"Suzuki K, Hino M, Hato F, Tatsumi N, Kitagawa S . Cytokine-specific activation of distinct mitogen-activated protein kinase subtype cascades in human neutrophils stimulated by granulocyte colony-stimulating factor, granulocyte\u2013macrophage colony-stimulating factor, and tumor necrosis factor-alpha Blood 1999 93: 341\u2013349","journal-title":"Blood"},{"key":"BF2402367_CR12","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1182\/blood.V89.9.3092","volume":"89","author":"IN Foltz","year":"1997","unstructured":"Foltz IN, Schrader JW . Activation of the stress-activated protein kinases by multiple hematopoietic growth factors with the exception of interleukin-4 Blood 1997 89: 3092\u20133096","journal-title":"Blood"},{"key":"BF2402367_CR13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.leu.2401657","volume":"14","author":"JA McCubrey","year":"2000","unstructured":"McCubrey JA, May WS, Duronio V, Mufson A . Serine\/threonine phosphorylation in cytokine signal transduction Leukemia 2000 14: 9\u201321","journal-title":"Leukemia"},{"key":"BF2402367_CR14","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/sj.leu.2401493","volume":"13","author":"WL Blalock","year":"1999","unstructured":"Blalock WL, Weinstein-Oppenheimer C, Chang F, Hoyle PE, Wang XY, Algate PA, Franklin RA, Oberhaus SM, Steelman LS, McCubrey JA . Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs Leukemia 1999 13: 1109\u20131166","journal-title":"Leukemia"},{"key":"BF2402367_CR15","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1038\/sj.leu.2402167","volume":"15","author":"JA McCubrey","year":"2001","unstructured":"McCubrey JA, Blalock WL, Saleh O, Pearce M, Burrows C, Steelman LS, Lee JT, Franklin RA, Oberhaus SM, Moye PW, Doshi PD, McKearn JP . Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells Leukemia 2001 15: 1203\u20131216","journal-title":"Leukemia"},{"key":"BF2402367_CR16","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/jlb.65.3.372","volume":"65","author":"S Zhang","year":"1999","unstructured":"Zhang S, Mantel C, Broxmeyer HE . Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3\/Flt3 cells J Leukoc Biol 1999 65: 372\u2013380","journal-title":"J Leukoc Biol"},{"key":"BF2402367_CR17","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1074\/jbc.274.7.4096","volume":"274","author":"O Rausch","year":"1999","unstructured":"Rausch O, Marshall CJ . Cooperation of p38 and extracellular signal-regulated kinase mitogen- activated protein kinase pathways during granulocyte colony-stimulating factor-induced hemopoietic cell proliferation J Biol Chem 1999 274: 4096\u20134105","journal-title":"J Biol Chem"},{"key":"BF2402367_CR18","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1182\/blood.V88.6.2004.bloodjournal8862004","volume":"88","author":"K Brasel","year":"1996","unstructured":"Brasel K, McKenna HJ, Morrissey PJ, Charrier K, Morris AE, Lee CC, Williams DE, Lyman SD . Hematologic effects of flt3 ligand in vivo in mice Blood 1996 88: 2004\u20132012","journal-title":"Blood"},{"key":"BF2402367_CR19","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1182\/blood.V78.11.2791.bloodjournal78112791","volume":"78","author":"GD Demetri","year":"1991","unstructured":"Demetri GD, Griffin JD . Granulocyte colony-stimulating factor and its receptor Blood 1991 78: 2791\u20132808","journal-title":"Blood"},{"key":"BF2402367_CR20","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511663376","volume-title":"The Hematopoietic Colony-stimulating Factor: From Biology to Clinical Applications","author":"D Metcalf","year":"1995","unstructured":"Metcalf D, Nicola NA . The Hematopoietic Colony-stimulating Factor: From Biology to Clinical Applications Cambridge: Cambridge University Press 1995"},{"key":"BF2402367_CR21","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1182\/blood.V90.9.3781","volume":"90","author":"K Brasel","year":"1997","unstructured":"Brasel K, McKenna HJ, Charrier K, Morrissey PJ, Williams DE, Lyman SD . Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice Blood 1997 90: 3781\u20133788","journal-title":"Blood"},{"key":"BF2402367_CR22","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1182\/blood.V92.9.3177","volume":"92","author":"M Neipp","year":"1998","unstructured":"Neipp M, Zorina T, Domenick MA, Exner BG, Ildstad ST . Effect of FLT3 ligand and granulocyte colony-stimulating factor on expansion and mobilization of facilitating cells and hematopoietic stem cells in mice: kinetics and repopulating potential Blood 1998 92: 3177\u20133188","journal-title":"Blood"},{"key":"BF2402367_CR23","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1182\/blood.V90.2.620","volume":"90","author":"T Papayannopoulou","year":"1997","unstructured":"Papayannopoulou T, Nakamoto B, Andrews RG, Lyman SD, Lee MY . In vivo effects of Flt3\/Flk2 ligand on mobilization of hematopoietic progenitors in primates and potent synergistic enhancement with granulocyte colony-stimulating factor Blood 1997 90: 620\u2013629","journal-title":"Blood"},{"key":"BF2402367_CR24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0301-472X(98)00022-8","volume":"27","author":"M Pless","year":"1999","unstructured":"Pless M, Wodnar-Filipowicz A, John L, Baldomero H, Lyman SD, Nissen C, Gratwohl A . Synergy of growth factors during mobilization of peripheral blood precursor cells with recombinant human Flt3-ligand and granulocyte colony-stimulating factor in rabbits Exp Hematol 1999 27: 155\u2013161","journal-title":"Exp Hematol"},{"key":"BF2402367_CR25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0301-472X(00)00616-0","volume":"29","author":"PR Streeter","year":"2001","unstructured":"Streeter PR, Minster NI, Kahn LE, Hood WF, Vickery LE, Thurman TL, Monahan JB, Welply JK, McKearn JP, Woulfe SL . Progenipoietins. Biological characterization of a family of dual agonists of fetal liver tyrosine kinase-3 and the granulocyte colony-stimulating factor receptor Exp Hematol 2001 29: 41\u201350","journal-title":"Exp Hematol"},{"key":"BF2402367_CR26","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/sj.leu.2400633","volume":"11","author":"HG Drexler","year":"1997","unstructured":"Drexler HG, Zaborski M, Quentmeier H . Cytokine response profiles of human myeloid factor-dependent leukemia cell lines Leukemia 1997 11: 701\u2013708","journal-title":"Leukemia"},{"key":"BF2402367_CR27","first-page":"261","volume":"10","author":"U Dehmel","year":"1996","unstructured":"Dehmel U, Zaborski M, Meierhoff G, Rosnet O, Birnbaum D, Ludwig WD, Quentmeier H, Drexler HG . Effects of FLT3 ligand on human leukemia cells. I. Proliferative response of myeloid leukemia cells Leukemia 1996 10: 261\u2013270","journal-title":"Leukemia"},{"key":"BF2402367_CR28","doi-asserted-by":"publisher","first-page":"5288","DOI":"10.1002\/j.1460-2075.1995.tb00213.x","volume":"14","author":"A Yoshikawa","year":"1995","unstructured":"Yoshikawa A, Murakami H, Nagata S . Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor EMBO J 1995 14: 5288\u20135296","journal-title":"EMBO J"},{"key":"BF2402367_CR29","doi-asserted-by":"publisher","first-page":"27489","DOI":"10.1074\/jbc.270.46.27489","volume":"270","author":"DR Alessi","year":"1995","unstructured":"Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR . PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo J Biol Chem 1995 270: 27489\u201327494","journal-title":"J Biol Chem"},{"key":"BF2402367_CR30","first-page":"161","volume":"99","author":"A Cuenda","year":"2000","unstructured":"Cuenda A, Alessi DR . Use of kinase inhibitors to dissect signaling pathways Meth Mol Biol 2000 99: 161\u2013175","journal-title":"Meth Mol Biol"},{"key":"BF2402367_CR31","doi-asserted-by":"publisher","first-page":"25273","DOI":"10.1074\/jbc.274.36.25273","volume":"274","author":"C Li","year":"1999","unstructured":"Li C, Hu Y, Mayr M, Xu Q . Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by Ras\/Rac-MAPK pathways J Biol Chem 1999 274: 25273\u201325280","journal-title":"J Biol Chem"},{"key":"BF2402367_CR32","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1182\/blood.V85.10.2747.bloodjournal85102747","volume":"85","author":"S Hudak","year":"1995","unstructured":"Hudak S, Hunte B, Culpepper J, Menon S, Hannum C, Thompson-Snipes L, Rennick D . FLT3\/FLK2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units Blood 1995 85: 2747\u20132755","journal-title":"Blood"},{"key":"BF2402367_CR33","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1084\/jem.181.4.1357","volume":"181","author":"SE Jacobsen","year":"1995","unstructured":"Jacobsen SE, Okkenhaug C, Myklebust J, Veiby OP, Lyman SD . The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors J Exp Med 1995 181: 1357\u20131363","journal-title":"J Exp Med"},{"key":"BF2402367_CR34","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1182\/blood.V85.7.1762.bloodjournal8571762","volume":"85","author":"F Hirayama","year":"1995","unstructured":"Hirayama F, Lyman SD, Clark SC, Ogawa M . The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors Blood 1995 85: 1762\u20131768","journal-title":"Blood"},{"key":"BF2402367_CR35","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1023\/A:1007520311457","volume":"25","author":"N Tindberg","year":"2000","unstructured":"Tindberg N, Porsmyr-Palmertz M, Simi A . Contribution of MAP kinase pathways to the activation of ATF-2 in human neuroblastoma cells Neurochem Res 2000 25: 527\u2013531","journal-title":"Neurochem Res"},{"key":"BF2402367_CR36","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1038\/sj.leu.2401967","volume":"14","author":"RA Franklin","year":"2000","unstructured":"Franklin RA, McCubrey JA . Kinases: positive and negative regulators of apoptosis Leukemia 2000 14: 2019\u20132034","journal-title":"Leukemia"},{"key":"BF2402367_CR37","doi-asserted-by":"publisher","first-page":"15023","DOI":"10.1074\/jbc.272.23.15023","volume":"272","author":"JB Crawley","year":"1997","unstructured":"Crawley JB, Rawlinson L, Lali FV, Page TH, Saklatvala J, Foxwell BM . T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation J Biol Chem 1997 272: 15023\u201315027","journal-title":"J Biol Chem"},{"key":"BF2402367_CR38","doi-asserted-by":"publisher","first-page":"21086","DOI":"10.1074\/jbc.M001281200","volume":"275","author":"RY Liu","year":"2000","unstructured":"Liu RY, Fan C, Liu G, Olashaw NE, Zuckerman KS . Activation of p38 mitogen-activated protein kinase is required for tumor necrosis factor-alpha-supported proliferation of leukemia and lymphoma cell lines J Biol Chem 2000 275: 21086\u201321093","journal-title":"J Biol Chem"},{"key":"BF2402367_CR39","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/S0955-0674(97)80068-3","volume":"9","author":"M Karin","year":"1997","unstructured":"Karin M, Liu Z, Zandi E . AP-1 function and regulation Curr Opin Cell Biol 1997 9: 240\u2013246","journal-title":"Curr Opin Cell Biol"},{"key":"BF2402367_CR40","doi-asserted-by":"publisher","first-page":"8484","DOI":"10.1074\/jbc.M009654200","volume":"276","author":"L Pei","year":"2001","unstructured":"Pei L . Identification of c-myc as a down-stream target for pituitary tumor-transforming gene J Biol Chem 2001 276: 8484\u20138491","journal-title":"J Biol Chem"},{"key":"BF2402367_CR41","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/328445a0","volume":"328","author":"R Heikkila","year":"1987","unstructured":"Heikkila R, Schwab G, Wickstrom E, Loke SL, Pluznik DH, Watt R, Neckers LM . A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1 Nature 1987 328: 445\u2013449","journal-title":"Nature"},{"key":"BF2402367_CR42","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/1040-8428(94)90021-3","volume":"17","author":"M Piechaczyk","year":"1994","unstructured":"Piechaczyk M, Blanchard JM . c-fos proto-oncogene regulation and function Crit Rev Oncol Hematol 1994 17: 93\u2013131","journal-title":"Crit Rev Oncol Hematol"},{"key":"BF2402367_CR43","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/(SICI)1521-1878(199903)21:3<221::AID-BIES6>3.0.CO;2-J","volume":"21","author":"P Lavia","year":"1999","unstructured":"Lavia P, Jansen-Durr P . E2F target genes and cell-cycle checkpoint control Bioessays 1999 21: 221\u2013230","journal-title":"Bioessays"},{"key":"BF2402367_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/MCB.19.1.1","volume":"19","author":"CV Dang","year":"1999","unstructured":"Dang CV . c-Myc target genes involved in cell growth, apoptosis, and metabolism Mol Cell Biol 1999 19: 1\u201311","journal-title":"Mol Cell Biol"},{"key":"BF2402367_CR45","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1182\/blood.V90.6.2282","volume":"90","author":"OJ Borge","year":"1997","unstructured":"Borge OJ, Ramsfjell V, Cui L, Jacobsen SE . Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+ Blood 1997 90: 2282\u20132292","journal-title":"Blood"},{"key":"BF2402367_CR46","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1182\/blood.V92.2.452","volume":"92","author":"T Matsunaga","year":"1998","unstructured":"Matsunaga T, Kato T, Miyazaki H, Ogawa M . Thrombopoietin promotes the survival of murine hematopoietic long-term reconstituting cells: comparison with the effects of FLT3\/FLK-2 ligand and interleukin-6 Blood 1998 92: 452\u2013461","journal-title":"Blood"},{"key":"BF2402367_CR47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3109\/10428199909093728","volume":"33","author":"HG Drexler","year":"1999","unstructured":"Drexler HG, Meyer C, Quentmeier H . Effects of FLT3 ligand on proliferation and survival of myeloid leukemia cells Leuk Lymphoma 1999 33: 83\u201391","journal-title":"Leuk Lymphoma"},{"key":"BF2402367_CR48","doi-asserted-by":"publisher","first-page":"577","DOI":"10.3109\/10428199909058416","volume":"32","author":"C Meyer","year":"1999","unstructured":"Meyer C, Drexler HG . FLT3 ligand inhibits apoptosis and promotes survival of myeloid leukemia cell lines Leuk Lymphoma 1999 32: 577\u2013581","journal-title":"Leuk Lymphoma"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2402367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402367","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T22:11:47Z","timestamp":1682028707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2402367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,1]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2,1]]}},"alternative-id":["BF2402367"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2402367","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2,1]]},"assertion":[{"value":"14 February 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}