{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:05:42Z","timestamp":1768280742435,"version":"3.49.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,10,23]],"date-time":"2003-10-23T00:00:00Z","timestamp":1066867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,10,23]],"date-time":"2003-10-23T00:00:00Z","timestamp":1066867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2004,1,1]]},"DOI":"10.1038\/sj.leu.2403145","type":"journal-article","created":{"date-parts":[[2003,10,23]],"date-time":"2003-10-23T09:27:04Z","timestamp":1066901224000},"page":"103-112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Constitutive NF-\u03baB DNA-binding activity in AML is frequently mediated by a Ras\/PI3-K\/PKB-dependent pathway"],"prefix":"10.1038","volume":"18","author":[{"given":"K U","family":"Birkenkamp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Geugien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Schepers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Westra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H H","family":"Lemmink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Vellenga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,10,23]]},"reference":[{"key":"BF2403145_CR1","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","volume":"14","author":"AS Baldwin Jr","year":"1996","unstructured":"Baldwin Jr AS . The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649\u2013683.","journal-title":"Annu Rev Immunol"},{"key":"BF2403145_CR2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","volume":"16","author":"S Ghosh","year":"1998","unstructured":"Ghosh S, May MJ, Kopp EB . NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16: 225\u2013260.","journal-title":"Annu Rev Immunol"},{"key":"BF2403145_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0065-2776(08)60742-7","volume":"65","author":"PA Baeuerle","year":"1997","unstructured":"Baeuerle PA, Baichwal VR . NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv Immunol 1997; 65: 111\u2013137.","journal-title":"Adv Immunol"},{"key":"BF2403145_CR4","first-page":"M55","volume":"1470","author":"MW Mayo","year":"2000","unstructured":"Mayo MW, Baldwin AS . The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance. Biochim Biophys Acta 2000; 1470: M55\u2013M62.","journal-title":"Biochim Biophys Acta"},{"key":"BF2403145_CR5","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1182\/blood.V98.8.2301","volume":"98","author":"ML Guzman","year":"2001","unstructured":"Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001; 98: 2301\u20132307.","journal-title":"Blood"},{"key":"BF2403145_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-2776(08)60740-3","volume":"65","author":"S Akira","year":"1997","unstructured":"Akira S, Kishimoto T . NF-IL6 and NF-kappa B in cytokine gene regulation. Adv Immunol 1997; 65: 1\u201346.","journal-title":"Adv Immunol"},{"key":"BF2403145_CR7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/0092-8674(95)90506-5","volume":"80","author":"D Thanos","year":"1995","unstructured":"Thanos D, Maniatis T . NF-kappa B: a lesson in family values. Cell 1995; 80: 529\u2013532.","journal-title":"Cell"},{"key":"BF2403145_CR8","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1177\/009127009803801101","volume":"38","author":"JI Lee","year":"1998","unstructured":"Lee JI, Burckart GJ . Nuclear factor kappa B: important transcription factor and therapeutic target. J Clin Pharmacol 1998; 38: 981\u2013993.","journal-title":"J Clin Pharmacol"},{"key":"BF2403145_CR9","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1126\/science.278.5339.818","volume":"278","author":"T Maniatis","year":"1997","unstructured":"Maniatis T . Catalysis by a multiprotein IkappaB kinase complex. Science 1997; 278: 818\u2013819.","journal-title":"Science"},{"key":"BF2403145_CR10","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0092-8674(00)80413-4","volume":"91","author":"I Stancovski","year":"1997","unstructured":"Stancovski I, Baltimore D . NF-kappaB activation: the I kappaB kinase revealed? Cell 1997; 91: 299\u2013302.","journal-title":"Cell"},{"key":"BF2403145_CR11","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0092-8674(00)80406-7","volume":"91","author":"E Zandi","year":"1997","unstructured":"Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M . The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 1997; 91: 243\u2013252.","journal-title":"Cell"},{"key":"BF2403145_CR12","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1038\/sj.leu.2402641","volume":"16","author":"B Baumgartner","year":"2002","unstructured":"Baumgartner B, Weber M, Quirling M, Fischer C, Page S, Adam M et al. Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts. Leukemia 2002; 16: 2062\u20132071.","journal-title":"Leukemia"},{"key":"BF2403145_CR13","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1073\/pnas.080583397","volume":"97","author":"B Baumann","year":"2000","unstructured":"Baumann B, Weber CK, Troppmair J, Whiteside S, Israel A, Rapp UR et al. Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Proc Natl Acad Sci USA 2000; 97: 4615\u20134620.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2403145_CR14","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.4049\/jimmunol.162.8.4893","volume":"162","author":"LM Tuyt","year":"1999","unstructured":"Tuyt LM, Dokter WH, Birkenkamp K, Koopmans SB, Lummen C, Kruijer W et al. Extracellular-regulated kinase 1\/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes. J Immunol 1999; 162: 4893\u20134902.","journal-title":"J Immunol"},{"key":"BF2403145_CR15","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S1043-4682(10)80018-2","volume":"3","author":"D Bar-Sagi","year":"1992","unstructured":"Bar-Sagi D . Mechanisms of signal transduction by Ras. Semin Cell Biol 1992; 3: 93\u201398.","journal-title":"Semin Cell Biol"},{"key":"BF2403145_CR16","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1200\/JCO.1999.17.3.1071","volume":"17","author":"DM Beaupre","year":"1999","unstructured":"Beaupre DM, Kurzrock R . RAS and leukemia: from basic mechanisms to gene-directed therapy. J Clin Oncol 1999; 17: 1071\u20131079.","journal-title":"J Clin Oncol"},{"key":"BF2403145_CR17","first-page":"3074","volume":"93","author":"H Kiyoi","year":"1999","unstructured":"Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood 1999; 93: 3074\u20133080.","journal-title":"Blood"},{"key":"BF2403145_CR18","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/sj.leu.2402460","volume":"16","author":"JT Lee Jr","year":"2002","unstructured":"Lee Jr JT, McCubrey JA . The Raf\/MEK\/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 2002; 16: 486\u2013507.","journal-title":"Leukemia"},{"key":"BF2403145_CR19","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/S0955-0674(98)80149-X","volume":"10","author":"J Downward","year":"1998","unstructured":"Downward J . Mechanisms and consequences of activation of protein kinase B\/Akt. Curr Opin Cell Biol 1998; 10: 262\u2013267.","journal-title":"Curr Opin Cell Biol"},{"key":"BF2403145_CR20","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0962-8924(00)01740-2","volume":"10","author":"JM Shields","year":"2000","unstructured":"Shields JM, Pruitt K, McFall A, Shaub A, Der CJ . Understanding Ras: \u2018it ain't over \u2018til it's over\u2019. Trends Cell Biol 2000; 10: 147\u2013154.","journal-title":"Trends Cell Biol"},{"key":"BF2403145_CR21","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1126\/science.275.5306.1649","volume":"275","author":"K Irani","year":"1997","unstructured":"Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 1997; 275: 1649\u20131652.","journal-title":"Science"},{"key":"BF2403145_CR22","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/sj.leu.2401726","volume":"14","author":"DM O'Gorman","year":"2000","unstructured":"O'Gorman DM, McKenna SL, McGahon AJ, Knox KA, Cotter TG . Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals. Leukemia 2000; 14: 602\u2013611.","journal-title":"Leukemia"},{"key":"BF2403145_CR23","doi-asserted-by":"publisher","first-page":"620","DOI":"10.7326\/0003-4819-103-4-620","volume":"103","author":"JM Bennett","year":"1985","unstructured":"Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French\u2013American\u2013British Cooperative Group. Ann Intern Med 1985; 103: 620\u2013625.","journal-title":"Ann Intern Med"},{"key":"BF2403145_CR24","doi-asserted-by":"publisher","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","volume":"17","author":"E Schreiber","year":"1989","unstructured":"Schreiber E, Matthias P, Muller MM, Schaffner W . Rapid detection of octamer binding proteins with \u2018mini-extracts\u2019, prepared from a small number of cells. Nucleic Acids Res 1989; 17: 6419.","journal-title":"Nucleic Acids Res"},{"key":"BF2403145_CR25","doi-asserted-by":"publisher","first-page":"21847","DOI":"10.1074\/jbc.274.31.21847","volume":"274","author":"L M'Rabet","year":"1999","unstructured":"M'Rabet L, Coffer PJ, Wolthuis RM, Zwartkruis F, Koenderman L, Bos JL . Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils. J Biol Chem 1999; 274: 21847\u201321852.","journal-title":"J Biol Chem"},{"key":"BF2403145_CR26","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1038\/sj.leu.2402317","volume":"15","author":"KU Birkenkamp","year":"2001","unstructured":"Birkenkamp KU, Geugien M, Lemmink HH, Kruijer W, Vellenga E . Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts. Leukemia 2001; 15: 1923\u20131931.","journal-title":"Leukemia"},{"key":"BF2403145_CR27","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1037>3.0.CO;2-F","volume":"29","author":"VM Hayes","year":"2000","unstructured":"Hayes VM, Westra JL, Verlind E, Bleeker W, Plukker JT, Hofstra RM et al. New comprehensive denaturing-gradient-gel-electrophoresis assay for KRAS mutation detection applied to paraffin-embedded tumours. Genes Chromosomes Cancer 2000; 29: 309\u2013314.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403145_CR28","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1182\/blood.V96.12.3907","volume":"96","author":"M Mizuki","year":"2000","unstructured":"Mizuki M, Fenski R, Halfter H, Matsumura I, Schmidt R, Muller C et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood 2000; 96: 3907\u20133914.","journal-title":"Blood"},{"key":"BF2403145_CR29","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/sj.onc.1203354","volume":"19","author":"F Hayakawa","year":"2000","unstructured":"Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 2000; 19: 624\u2013631.","journal-title":"Oncogene"},{"key":"BF2403145_CR30","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0022-2836(03)00313-9","volume":"328","author":"C Lundin","year":"2003","unstructured":"Lundin C, Schultz N, Arnaudeau C, Mohindra A, Hansen LT, Helleday T . RAD51 is involved in repair of damage associated with DNA replication in mammalian cells. J Mol Biol 2003; 328: 521\u2013535.","journal-title":"J Mol Biol"},{"key":"BF2403145_CR31","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/sj.leu.2401447","volume":"13","author":"KU Birkenkamp","year":"1999","unstructured":"Birkenkamp KU, Dokter WH, Esselink MT, Jonk LJ, Kruijer W, Vellenga E . A dual function for p38 MAP kinase in hematopoietic cells: involvement in apoptosis and cell activation. Leukemia 1999; 13: 1037\u20131045.","journal-title":"Leukemia"},{"key":"BF2403145_CR32","doi-asserted-by":"publisher","first-page":"21281","DOI":"10.1074\/jbc.272.34.21281","volume":"272","author":"L Ghoda","year":"1997","unstructured":"Ghoda L, Lin X, Greene WC . The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. J Biol Chem 1997; 272: 21281\u201321288.","journal-title":"J Biol Chem"},{"issue":"Part 1","key":"BF2403145_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj3350001","volume":"335","author":"PJ Coffer","year":"1998","unstructured":"Coffer PJ, Jin J, Woodgett JR . Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 1998; 335 (Part 1): 1\u201313.","journal-title":"Biochem J"},{"key":"BF2403145_CR34","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/43466","volume":"401","author":"ON Ozes","year":"1999","unstructured":"Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB . NF-kappaB activation by tumour necrosis factor requires the Akt serine\u2013threonine kinase. Nature 1999; 401: 82\u201385.","journal-title":"Nature"},{"key":"BF2403145_CR35","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/43474","volume":"401","author":"JA Romashkova","year":"1999","unstructured":"Romashkova JA, Makarov SS . NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999; 401: 86\u201390.","journal-title":"Nature"},{"key":"BF2403145_CR36","doi-asserted-by":"publisher","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","volume":"15","author":"DR Alessi","year":"1996","unstructured":"Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996; 15: 6541\u20136551.","journal-title":"EMBO J"},{"key":"BF2403145_CR37","doi-asserted-by":"publisher","first-page":"24113","DOI":"10.1074\/jbc.272.39.24113","volume":"272","author":"TS Finco","year":"1997","unstructured":"Finco TS, Westwick JK, Norris JL, Beg AA, Der CJ, Baldwin Jr AS . Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation. J Biol Chem 1997; 272: 24113\u201324116.","journal-title":"J Biol Chem"},{"key":"BF2403145_CR38","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1126\/science.274.5288.787","volume":"274","author":"DJ Van Antwerp","year":"1996","unstructured":"Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM . Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 1996; 274: 787\u2013789.","journal-title":"Science"},{"key":"BF2403145_CR39","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1126\/science.274.5288.782","volume":"274","author":"AA Beg","year":"1996","unstructured":"Beg AA, Baltimore D . An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 1996; 274: 782\u2013784.","journal-title":"Science"},{"key":"BF2403145_CR40","doi-asserted-by":"publisher","first-page":"30508","DOI":"10.1074\/jbc.M111330200","volume":"277","author":"GW Reuther","year":"2002","unstructured":"Reuther GW, Lambert QT, Rebhun JF, Caligiuri MA, Quilliam LA, Der CJ . RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. J Biol Chem 2002; 277: 30508\u201330514.","journal-title":"J Biol Chem"},{"key":"BF2403145_CR41","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1172\/JCI12807","volume":"108","author":"M Milella","year":"2001","unstructured":"Milella M, Kornblau SM, Estrov Z, Carter BZ, Lapillonne H, Harris D et al. Therapeutic targeting of the MEK\/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 2001; 108: 851\u2013859.","journal-title":"J Clin Invest"},{"key":"BF2403145_CR42","first-page":"425","volume":"9","author":"WH Dokter","year":"1995","unstructured":"Dokter WH, Tuyt L, Sierdsema SJ, Esselink MT, Vellenga E . The spontaneous expression of interleukin-1 beta and interleukin-6 is associated with spontaneous expression of AP-1 and NF-kappa B transcription factor in acute myeloblastic leukemia cells. Leukemia 1995; 9: 425\u2013432.","journal-title":"Leukemia"},{"key":"BF2403145_CR43","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1182\/blood.V95.12.3765","volume":"95","author":"JJ Schuringa","year":"2000","unstructured":"Schuringa JJ, Wierenga AT, Kruijer W, Vellenga E . Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6. Blood 2000; 95: 3765\u20133770.","journal-title":"Blood"},{"key":"BF2403145_CR44","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1038\/sj.leu.2403106","volume":"17","author":"H Schepers","year":"2003","unstructured":"Schepers H, Geugien M, Eggen BJL, Vellenga E . Constitutive cytoplasmic localization of p21Waf1\/Cip1 affects the apoptotic process in monocytic leukemia. Leukemia 2003; 17: 2113\u20132121.","journal-title":"Leukemia"},{"key":"BF2403145_CR45","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1128\/MCB.21.6.1930-1941.2001","volume":"21","author":"KN Pennington","year":"2001","unstructured":"Pennington KN, Taylor JA, Bren GD, Paya CV . IkappaB kinase-dependent chronic activation of NF-kappaB is necessary for p21(WAF1\/Cip1) inhibition of differentiation-induced apoptosis of monocytes. Mol Cell Biol 2001; 21: 1930\u20131941.","journal-title":"Mol Cell Biol"},{"key":"BF2403145_CR46","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1093\/emboj\/18.5.1223","volume":"18","author":"M Asada","year":"1999","unstructured":"Asada M, Yamada T, Ichijo H, Delia D, Miyazono K, Fukumuro K et al. Apoptosis inhibitory activity of cytoplasmic p21(Cip1\/WAF1) in monocytic differentiation. EMBO J 1999; 18: 1223\u20131234.","journal-title":"EMBO J"},{"key":"BF2403145_CR47","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1038\/sj.leu.2401228","volume":"12","author":"M Asada","year":"1998","unstructured":"Asada M, Yamada T, Fukumuro K, Mizutani S . p21Cip1\/WAF1 is important for differentiation and survival of U937 cells. Leukemia 1998; 12: 1944\u20131950.","journal-title":"Leukemia"},{"key":"BF2403145_CR48","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1126\/science.278.5344.1812","volume":"278","author":"MW Mayo","year":"1997","unstructured":"Mayo MW, Wang CY, Cogswell PC, Rogers-Graham KS, Lowe SW, Der CJ et al. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 1997; 278: 1812\u20131815.","journal-title":"Science"},{"key":"BF2403145_CR49","first-page":"584","volume":"1","author":"E Vellenga","year":"1987","unstructured":"Vellenga E, Ostapovicz D, O'Rourke B, Griffin JD . Effects of recombinant IL-3, GM-CSF, and G-CSF on proliferation of leukemic clonogenic cells in short-term and long-term cultures. Leukemia 1987; 1: 584\u2013589.","journal-title":"Leukemia"},{"key":"BF2403145_CR50","first-page":"479","volume":"10","author":"KU Birkenkamp","year":"1999","unstructured":"Birkenkamp KU, Esselink MT, Kruijer W, Vellenga E . Differential effects of interleukin-3 and interleukin-1 on the proliferation and interleukin-6 protein secretion of acute myeloid leukemic cells; the involvement of ERK, p38 and STAT5. Eur Cytokine Netw 1999; 10: 479\u2013490.","journal-title":"Eur Cytokine Netw"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2403145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403145","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T06:44:50Z","timestamp":1682577890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2403145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,23]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1,1]]}},"alternative-id":["BF2403145"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2403145","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,23]]},"assertion":[{"value":"5 March 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2003","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2003","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}