{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:57:35Z","timestamp":1778291855786,"version":"3.51.4"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2001,8,29]],"date-time":"2001-08-29T00:00:00Z","timestamp":999043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,8,29]],"date-time":"2001-08-29T00:00:00Z","timestamp":999043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2001,9,1]]},"DOI":"10.1038\/sj.mp.4000876","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T21:19:33Z","timestamp":1032470373000},"page":"586-592","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity"],"prefix":"10.1038","volume":"6","author":[{"given":"A","family":"Serretti","sequence":"first","affiliation":[]},{"given":"R","family":"Zanardi","sequence":"additional","affiliation":[]},{"given":"D","family":"Rossini","sequence":"additional","affiliation":[]},{"given":"C","family":"Cusin","sequence":"additional","affiliation":[]},{"given":"R","family":"Lilli","sequence":"additional","affiliation":[]},{"given":"E","family":"Smeraldi","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2001,8,29]]},"reference":[{"key":"BF4000876_CR1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/0006-3223(94)90642-4","volume":"36","author":"RL O'Reilly","year":"1994","unstructured":"O'Reilly RL, Bouge L, Singh FM . Pharmacogenetic response to antidepressants in a multicase family with affective disorder Biol Psychiatry 1994 36: 467\u2013471","journal-title":"Biol Psychiatry"},{"key":"BF4000876_CR2","doi-asserted-by":"crossref","unstructured":"Pare CMB, Rees L, Sainsbury MJ . Differentiation of two genetically specific types of depression by the response to antidepressant Lancet 1962 1340\u20131343","DOI":"10.1016\/S0140-6736(62)91019-X"},{"key":"BF4000876_CR3","first-page":"p 20","volume-title":"Inpatients Psychiatry Diagnosis and Treatment","author":"LI Sederer","year":"1986","unstructured":"Sederer LI . Depression. In: Sederer LI (ed) Inpatients Psychiatry Diagnosis and Treatment William & Wilkins: Baltimore 1986 p 20"},{"key":"BF4000876_CR4","volume-title":"Anxious Depression: Assessment and Treatment","author":"A Orsini","year":"1987","unstructured":"Orsini A . Antidepressant responses and segregation analyses in affective families. In: Racagni G, Smeraldi E (eds) Anxious Depression: Assessment and Treatment Raven Press: New York 1987"},{"key":"BF4000876_CR5","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1600-0447.1998.tb10117.x","volume":"98","author":"A Serretti","year":"1998","unstructured":"Serretti A, Franchini L, Gasperini M, Rampoldi R, Smeraldi E . Mode of inheritance in mood disorders families according to fluvoxamine response Acta Psychiatr Scand 1998 98: 443\u2013450","journal-title":"Acta Psychiatr Scand"},{"key":"BF4000876_CR6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0022-3956(98)00004-1","volume":"32","author":"L Franchini","year":"1998","unstructured":"Franchini L, Serretti A, Gasperini M, Smeraldi E . Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees J Psychiatr Res 1998 32: 255\u2013259","journal-title":"J Psychiatr Res"},{"key":"BF4000876_CR7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0165-0327(98)00020-2","volume":"50","author":"W Berrettini","year":"1998","unstructured":"Berrettini W . Progress and pitfalls: bipolar molecular linkage studies J Affect Disord 1998 50: 287\u2013297","journal-title":"J Affect Disord"},{"key":"BF4000876_CR8","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1126\/science.274.5292.1527","volume":"274","author":"K Lesch","year":"1996","unstructured":"Lesch K, Bengel D, Heils A, Sabol S, Greenberg B, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science, 1996 274: 1527\u20131530","journal-title":"Science,"},{"key":"BF4000876_CR9","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1046\/j.1471-4159.1996.66062621.x","volume":"66","author":"A Heils","year":"1996","unstructured":"Heils A, Teufel A, Petri S, St\u00f6ber G, Riederer P, Bengel D et al. Allelic variation of human serotonin trasporter gene expression J Neurochem 1996 66: 2621\u20132624","journal-title":"J Neurochem"},{"key":"BF4000876_CR10","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/sj.mp.4000425","volume":"3","author":"E Smeraldi","year":"1998","unstructured":"Smeraldi E, Zanardi R, Benedetti F, Dibella D, Perez J, Catalano M . Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine Mol Psychiatry 1998 3: 508\u2013511","journal-title":"Mol Psychiatry"},{"key":"BF4000876_CR11","unstructured":"Zanardi R, Serretti A, Rossini D, Franchini L, Cusin C. Lattuada E et al. Factors affecting fluvoxamine antidepressant activity: influence of pindolol and 5-HTTLPR in delusional and nondelusional depression Biol Psychiatry (submitted)"},{"key":"BF4000876_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1097\/00004714-200002000-00021","volume":"20","author":"R Zanardi","year":"2000","unstructured":"Zanardi R, Benedetti F, DiBella D, Catalano M, Smeraldi E . Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of serotonin transporter gene J Clin Psychopharmacol 2000 20: 105\u2013107","journal-title":"J Clin Psychopharmacol"},{"key":"BF4000876_CR13","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0893-133X(00)00132-9","volume":"23","author":"BG Pollock","year":"2000","unstructured":"Pollock BG, Ferrell RE, Mulsant BH, Mazumdar S, Miller M, Sweet RA et al. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression Neuropsychopharmacology 2000 23: 587\u2013590","journal-title":"Neuropsychopharmacology"},{"key":"BF4000876_CR14","first-page":"pp?235","volume-title":"Handbook of Psychiatric Genetics","author":"D Comings","year":"1997","unstructured":"Comings D . Polygenic inheritance in psychiatric disorders. In: Blum K, Noble EP (eds) Handbook of Psychiatric Genetics CRC Press: Boca Raton 1997 pp?235\u2013260"},{"key":"BF4000876_CR15","first-page":"222","volume":"46","author":"N Risch","year":"1990","unstructured":"Risch N . Linkage strategies for genetically complex traits: I. Multilocus models Am J Med Gen 1990 46: 222\u2013228","journal-title":"Am J Med Gen"},{"key":"BF4000876_CR16","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/ng1296-371","volume":"14","author":"W Frankel","year":"1996","unstructured":"Frankel W, Schork N . Who's afraid of epistasis? Nat Genet 1996 14: 371\u2013373","journal-title":"Nat Genet"},{"key":"BF4000876_CR17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3109\/00207459208994781","volume":"67","author":"R Sandyk","year":"1992","unstructured":"Sandyk R . L-tryptophan in neuropsychiatric disorders: a review Int J Neurosci 1992 67: 127\u2013144","journal-title":"Int J Neurosci"},{"key":"BF4000876_CR18","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1001\/archpsyc.1976.01770110112012","volume":"33","author":"J Walinder","year":"1976","unstructured":"Walinder J, Skott A, Carlsson A, Nagy A, Bjorn-Erik R . Potentiation of the antidepressant action of clomipramine by tryptophan Arch Gen Psychiatry 1976 33: 1384\u20131389","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000876_CR19","first-page":"241","volume":"16","author":"SN Young","year":"1991","unstructured":"Young SN . Use of tryptophan in combination with other antidepressant treatments: a review J Psychiatry Neurosci 1991 16: 241\u2013246","journal-title":"J Psychiatry Neurosci"},{"key":"BF4000876_CR20","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/S0140-6736(96)07044-4","volume":"349","author":"KA Smith","year":"1997","unstructured":"Smith KA, Fairburn CG, Cowen PJ . Relapse of depression after rapid depletion of tryptophan Lancet 1997 349: 915\u2013919","journal-title":"Lancet"},{"key":"BF4000876_CR21","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.1093\/nar\/18.14.4257","volume":"18","author":"S Boularand","year":"1990","unstructured":"Boularand S, Darmon MC, Ganem Y, Launay JM, Mallet J . Complete coding sequence of human tryptophan hydroxylase Nucleic Acid Res 1990 18: 4257","journal-title":"Nucleic Acid Res"},{"key":"BF4000876_CR22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1159\/000133075","volume":"56","author":"SP Craig","year":"1991","unstructured":"Craig SP, Boularand S, Darmon MC, Mallet J, Craig IW . Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3\u2014p14 by in situ hybridization Cytogenet Cell Genet 1991 56: 157\u2013159","journal-title":"Cytogenet Cell Genet"},{"key":"BF4000876_CR23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0169-328X(96)00304-X","volume":"45","author":"DA Nielsen","year":"1997","unstructured":"Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D . Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7 Brain Res Mol Brain Res 1997 45: 145\u2013148","journal-title":"Brain Res Mol Brain Res"},{"key":"BF4000876_CR24","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/BF02922258","volume":"247","author":"EG Jonsson","year":"1997","unstructured":"Jonsson EG, Goldman D, Spurlock G, Gustavsson JP, Nielsen DA, Linnoila M et al. Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers Eur Arch Psychiatry Clin Neurosci 1997 247: 297\u2013302","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"BF4000876_CR25","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1176\/ajp.156.9.1450","volume":"156","author":"F Benedetti","year":"1999","unstructured":"Benedetti F, Serretti A, Colombo C, Campori E, Barbini B, Di Bella D et al. Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression Am J Psychiatry 1999 156: 1450\u20131452","journal-title":"Am J Psychiatry"},{"key":"BF4000876_CR26","volume-title":"Nature, nurture and affective disorder. In: Royal College of Psychiatrists (ed). The Biology of Affective Disorders","author":"P McGuffin","year":"1986","unstructured":"McGuffin P, Katz R . Nature, nurture and affective disorder. In: Royal College of Psychiatrists (ed). The Biology of Affective Disorders Gaskell Press: London 1986"},{"key":"BF4000876_CR27","first-page":"367","volume":"52","author":"G Winokur","year":"1995","unstructured":"Winokur G, Coryell W, Keller M, Endicott J, Leon A . A family study of manic-depressive (bipolar I) disease Is it a distinct illness separable from primary unipolar depression? Arch Gen Psychiatry 1995 52: 367\u2013373","journal-title":"Is it a distinct illness separable from primary unipolar depression? Arch Gen Psychiatry"},{"key":"BF4000876_CR28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/00001756-200001170-00042","volume":"11","author":"DK Kim","year":"2000","unstructured":"Kim DK, Lim SW, Lee S, Sohn SE, Kim S, Hahn CG et al. Serotonin transporter gene polymorphism and antidepressant response Neuroreport 2000 11: 215\u2013219","journal-title":"Neuroreport"},{"key":"BF4000876_CR29","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/sj.mp.4000334","volume":"2","author":"H Kunugi","year":"1997","unstructured":"Kunugi H, Hattori M, Kato T, Tatsumi M, Sakai T, Sasaki T et al. Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder Mol Psychiatry 1997 2: 457\u2013462","journal-title":"Mol Psychiatry"},{"key":"BF4000876_CR30","first-page":"1366","volume":"51","author":"DA Nielsen","year":"1992","unstructured":"Nielsen DA, Dean M, Goldman D . Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism Am J Hum Genet 1992 51: 1366\u20131371","journal-title":"Am J Hum Genet"},{"key":"BF4000876_CR31","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1006\/geno.1998.5454","volume":"52","author":"J Gelernter","year":"1998","unstructured":"Gelernter J, Kranzler H, Lacobelle J . Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic factor (CNTF)) Genomics 1998 52: 289\u2013297","journal-title":"Genomics"},{"key":"BF4000876_CR32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000484738","volume":"5","author":"P Gasparini","year":"1997","unstructured":"Gasparini P, Estivill X, Volpini V, Totaro A, Castellvi-Bel S, Govea N et al. Linkage of DFNB1 to non-syndromic neurosensory autosomal-recessive deafness in Mediterranean families Eur J Hum Genet 1997 5: 83\u201388","journal-title":"Eur J Hum Genet"},{"key":"BF4000876_CR33","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1001\/archpsyc.55.1.33","volume":"55","author":"F Bellivier","year":"1998","unstructured":"Bellivier F, Leboyer M, Courtet P, Buresi C, Beaufils B, Samolyk D et al. Association between the tryptophan hydroxylase gene and manic-depressive illness Arch Gen Psychiatry 1998 55: 33\u201337","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000876_CR34","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/sj.mp.4000536","volume":"4","author":"A Frisch","year":"1999","unstructured":"Frisch A, Postilnick D, Rockah R, Michaelovsky E, Postilnick S, Birman E et al. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways Mol Psychiatry 1999 4: 389\u2013392","journal-title":"Mol Psychiatry"},{"key":"BF4000876_CR35","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/(SICI)1096-8628(19980508)81:3<245::AID-AJMG8>3.0.CO;2-V","volume":"81","author":"RA Furlong","year":"1998","unstructured":"Furlong RA, Ho L, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC . No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder Am J Med Gen 1998 81: 245\u2013247","journal-title":"Am J Med Gen"},{"key":"BF4000876_CR36","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1176\/ajp.156.5.774","volume":"156","author":"H Kunugi","year":"1999","unstructured":"Kunugi H, Ishida S, Kato T, Sakai T, Tatsumi M, Hirose T et al. No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients Am J Psychiatry 1999 156: 774\u2013776","journal-title":"Am J Psychiatry"},{"key":"BF4000876_CR37","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1001\/archpsyc.56.1.99","volume":"56","author":"A McQuillin","year":"1999","unstructured":"McQuillin A, Lawrence J, Kalsi G, Gurling H, Curtis D . No allelic association between bipolar affective disorder and the tryptophan hydroxylase gene Arch Gen Psychiatry 1999 56: 99\u2013100","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000876_CR38","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1176\/ajp.156.1.136","volume":"156","author":"JB Vincent","year":"1999","unstructured":"Vincent JB, Masellis M, Lawrence J, Choi V, Gurling HM, Parikh SV et al. Genetic association analysis of serotonin system genes in bipolar affective disorder Am J Psychiatry 1999 156: 136\u2013138","journal-title":"Am J Psychiatry"},{"key":"BF4000876_CR39","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1097\/00001756-199912160-00010","volume":"10","author":"SJ Tsai","year":"1999","unstructured":"Tsai SJ, Hong CJ, Wang YC . Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors Neuroreport 1999 10: 3773\u20133775","journal-title":"Neuroreport"},{"key":"BF4000876_CR40","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/1096-8628(20000612)96:3<310::AID-AJMG15>3.0.CO;2-H","volume":"96","author":"M Rietschel","year":"2000","unstructured":"Rietschel M, Schorr A, Albus M, Franzek E, Kreiner R, Held T et al. Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls Am J Med Genet 2000 96: 310\u2013311","journal-title":"Am J Med Genet"},{"key":"BF4000876_CR41","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s007020050220","volume":"106","author":"H Ishiguro","year":"1999","unstructured":"Ishiguro H, Saito T, Shibuya H, Toru M, Arinami T . The 5\u2032 region of the tryptophan hydroxylase gene: mutation search and association study with alcoholism J Neural Transm 1999 106: 1017\u20131025","journal-title":"J Neural Transm"},{"key":"BF4000876_CR42","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0006-3223(98)00122-X","volume":"45","author":"L Han","year":"1999","unstructured":"Han L, Nielsen DA, Rosenthal NE, Jefferson K, Kaye W, Murphy D et al. No coding variant of tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism Biol Psychiatry 1999 45: 615\u2013619","journal-title":"Biol Psychiatry"},{"key":"BF4000876_CR43","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/sj.mp.4000578","volume":"4","author":"A Rotondo","year":"1999","unstructured":"Rotondo A, Schuebel KE, Bergen AW, Aragon R, Virkkunen M, Linnoila M et al. Identification of four variants in the tryptophan hydroxylase promoter and association to behavior Mol Psychiatry 1999 4: 360\u2013368","journal-title":"Mol Psychiatry"},{"key":"BF4000876_CR44","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0924-977X(00)00071-7","volume":"10","author":"A Frisch","year":"2000","unstructured":"Frisch A, Michaelovsky E, Rockah R, Amir I, Hermesh H, Laor N et al. Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways Eur Neuropsychopharmacol 2000 10: 205\u2013209","journal-title":"Eur Neuropsychopharmacol"},{"key":"BF4000876_CR45","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1001\/archpsyc.1994.03950010034005","volume":"51","author":"DA Nielsen","year":"1994","unstructured":"Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M . Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism Arch Gen Psychiatry 1994 51: 34\u201338","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000876_CR46","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1176\/ajp.154.10.1451","volume":"154","author":"JJ Mann","year":"1997","unstructured":"Mann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J . Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients Am J Psychiatry 1997 154: 1451\u20131453","journal-title":"Am J Psychiatry"},{"key":"BF4000876_CR47","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1001\/archpsyc.1995.03950220056011","volume":"52","author":"M Abbar","year":"1995","unstructured":"Abbar M, Courtet P, Amadeo S, Caer Y, Mallet J, Baldy-Moulinier M et al. Suicidal behaviors and the tryptophan hydroxylase gene Arch Gen Psychiatry 1995 52: 846\u2013849","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000876_CR48","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/00041444-200010010-00003","volume":"10","author":"PJ Bennett","year":"2000","unstructured":"Bennett PJ, McMahon WM, Watabe J, Achilles J, Bacon M, Coon H et al. Tryptophan hydroxylase polymorphisms in suicide victims Psychiatr Genet 2000 10: 13\u201317","journal-title":"Psychiatr Genet"},{"key":"BF4000876_CR49","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1159\/000022942","volume":"50","author":"I Paik","year":"2000","unstructured":"Paik I, Toh K, Kim J, Lee C . TPH gene may be associated with suicidal behavior, but not with schizophrenia in the Korean population Hum Hered 2000 50: 365\u2013369","journal-title":"Hum Hered"},{"key":"BF4000876_CR50","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/00041444-200010010-00004","volume":"10","author":"T Geijer","year":"2000","unstructured":"Geijer T, Frisch A, Persson ML, Wasserman D, Rockah R, Michaelovsky E et al. Search for association between suicide attempt and serotonergic polymorphisms Psychiatr Genet 2000 10: 19\u201326","journal-title":"Psychiatr Genet"},{"key":"BF4000876_CR51","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/S0006-3223(98)00375-8","volume":"45","author":"SB Manuck","year":"1999","unstructured":"Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF . Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene Biol Psychiatry 1999 45: 603\u2013614","journal-title":"Biol Psychiatry"},{"key":"BF4000876_CR52","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1017\/S0033291799002822","volume":"30","author":"J Evans","year":"2000","unstructured":"Evans J, Reeves B, Platt H, Leibenau A, Goldman D, Jefferson K et al. Impulsiveness, serotonin genes and repetition of deliberate self-harm (DSH) Psychol Med 2000 30: 1327\u20131334","journal-title":"Psychol Med"},{"key":"BF4000876_CR53","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"J Cohen","year":"1988","unstructured":"Cohen J . Statistical Power Analysis for the Behavioral Sciences Lawrence Erlbaum Associates: Hillsdale, NJ 1988"},{"key":"BF4000876_CR54","volume-title":"Diagnostic and Statistical Manual of Mental Disorders, 4th edn","author":"Association American Psychiatric","year":"1994","unstructured":"American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders, 4th edn American Psychiatric Association: Washington DC 1994"},{"key":"BF4000876_CR55","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1001\/archpsyc.1982.04290080001001","volume":"39","author":"JF Leckman","year":"1982","unstructured":"Leckman JF, Sholomskas D, Thompson WD, Belanger A, Weissman MM . Best estimate of lifetime psychiatric diagnosis: a methodological study Arch Gen Psychiatry 1982 39: 879\u2013883","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000876_CR56","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","volume":"6","author":"M Hamilton","year":"1967","unstructured":"Hamilton M . Development of a rating scale for primary depressive illness Br J Soc Clin Psychol 1967 6: 278\u2013296","journal-title":"Br J Soc Clin Psychol"},{"key":"BF4000876_CR57","first-page":"37","volume":"87 Suppl 372","author":"P Bech","year":"1993","unstructured":"Bech P, Malt U, Dencker S, Ahlfors U, Elgen K, Lewander T et al. Scales for assessment of diagnosis and severity of mental disorders Acta Psychiatr Scand 1993 87 Suppl 372: 37\u201340","journal-title":"Acta Psychiatr Scand"},{"key":"BF4000876_CR58","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0165-0327(92)90075-H","volume":"25","author":"L Bellini","year":"1992","unstructured":"Bellini L, Gatti F, Gasperini M, Smeraldi E . A comparison between delusional and non-delusional depressives J Affect Disord 1992 25: 129\u2013138","journal-title":"J Affect Disord"},{"key":"BF4000876_CR59","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1176\/ajp.154.1.4","volume":"154","author":"CA Sobin","year":"1997","unstructured":"Sobin CA, Sackeim H . Psychomotor symptoms of depression Am J Psychiatry 1997 154: 4\u201317","journal-title":"Am J Psychiatry"},{"key":"BF4000876_CR60","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000119071","volume":"29","author":"A Lucca","year":"1994","unstructured":"Lucca A, Lucini V, Catalano M, Alfano M, Smeraldi E . Plasma tryptophan to large neutral amino acids ratio and therapeutic response to a selective serotonin uptake inhibitor Neuropsychobiology 1994 29: 108\u2013111","journal-title":"Neuropsychobiology"},{"key":"BF4000876_CR61","doi-asserted-by":"publisher","first-page":"5444","DOI":"10.1093\/nar\/19.19.5444","volume":"19","author":"DK Lahiri","year":"1991","unstructured":"Lahiri DK, Nurnberger JIJ . A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies Nucleic Acid Res 1991 19: 5444","journal-title":"Nucleic Acid Res"},{"key":"BF4000876_CR62","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1001\/archpsyc.1993.01820210073009","volume":"50","author":"RD Gibbons","year":"1993","unstructured":"Gibbons RD, Hedeker D, Elkin I, Waternaux C, Kraemer HC, Greenhouse JB et al. Some conceptual and statistical issues in analysis of longitudinal psychiatric data. Application to the NIMH treatment of Depression Collaborative Research Program dataset Arch Gen Psychiatry 1993 50: 739\u2013750","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000876_CR63","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1037\/0022-006X.63.5.841","volume":"63","author":"I Elkin","year":"1995","unstructured":"Elkin I, Gibbons RD, Shea MT, Sotsky SM, Watkins JT, Pilkonis PA et al. Initial severity and differential treatment outcome in the National Institute of Mental Health Treatment of Depression Collaborative Research Program J Consult Clin Psychol 1995 63: 841\u2013847","journal-title":"J Consult Clin Psychol"},{"key":"BF4000876_CR64","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0165-1781(00)00139-6","volume":"94","author":"A Serretti","year":"2000","unstructured":"Serretti A, Lattuada E, Zanardi R, Franchini L, Smeraldi E . Patterns of symptom improvement during antidepressant treatment of delusional depression Psychiatry Res 2000 94: 185\u2013190","journal-title":"Psychiatry Res"},{"key":"BF4000876_CR65","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0169-2607(96)01723-3","volume":"49","author":"D Hedeker","year":"1996","unstructured":"Hedeker D, Gibbons RD . MIXREG: a computer program for mixed-effects regression analysis with autocorrelated errors Comput Methods Programs Biomed 1996 49: 229\u2013252","journal-title":"Comput Methods Programs Biomed"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4000876.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4000876","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4000876.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T17:20:13Z","timestamp":1682356813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4000876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,29]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9,1]]}},"alternative-id":["BF4000876"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4000876","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,29]]},"assertion":[{"value":"18 October 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2000","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2000","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2001","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}