{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:15:36Z","timestamp":1773677736661,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1999,1,14]],"date-time":"1999-01-14T00:00:00Z","timestamp":916272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1999,1,14]],"date-time":"1999-01-14T00:00:00Z","timestamp":916272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[1999,1,14]]},"DOI":"10.1038\/sj.onc.1202307","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T19:27:53Z","timestamp":1031167673000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":169,"title":["Regulation of Cyclooxygenase-2 pathway by HER2 receptor"],"prefix":"10.1038","volume":"18","author":[{"given":"Ratna","family":"Vadlamudi","sequence":"first","affiliation":[]},{"given":"Mahitosh","family":"Mandal","sequence":"additional","affiliation":[]},{"given":"Liana","family":"Adam","sequence":"additional","affiliation":[]},{"given":"Gideon","family":"Steinbach","sequence":"additional","affiliation":[]},{"given":"John","family":"Mendelsohn","sequence":"additional","affiliation":[]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[1999,1,20]]},"reference":[{"issue":"2","key":"BF1202307_CR1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/ijc.2910590219","volume":"59","author":"Liana Adam","year":"1994","unstructured":"Adam L, Crepin M, Lelong J, Spanakis E and Israel L. . 1994 Int. J. Cancer 59: 262\u2013268.","journal-title":"International Journal of Cancer"},{"key":"BF1202307_CR2","doi-asserted-by":"crossref","unstructured":"Alroy I and Yarden Y. . 1997 FEBS Lett. 410: 83\u201386.","DOI":"10.1016\/S0014-5793(97)00412-2"},{"key":"BF1202307_CR3","unstructured":"Anzano M, Rieman D, Pritchett W, Bowen-Pope D and Grieg R. . 1989 Cancer Res. 49: 2898\u20132904."},{"key":"BF1202307_CR4","unstructured":"Boolbol SK, Dannenberg AJ, Chadburn A, Martucci C, Guo X, Ramonetti JT, Abreu-Goris M, Newmark HL, Lipkin ML, DeCosse JJ and Bertagnolli MM. . 1996 Cancer Res. 56: 2556\u20132560."},{"key":"BF1202307_CR5","doi-asserted-by":"crossref","unstructured":"Brattain MG, Levine AE, Chakrabarty S, Yeoman LC, Willson JKV and Long B. . 1984 Cancer Metast. Rev. 3: 177\u2013191.","DOI":"10.1007\/BF00048384"},{"issue":"13","key":"BF1202307_CR6","doi-asserted-by":"publisher","first-page":"7111","DOI":"10.1074\/jbc.270.13.7111","volume":"270","author":"Kermit L. Carraway","year":"1995","unstructured":"Carraway III KL, Soltoff SP, Diamonti AJ and Cantley LC. . 1995 J. Biol. Chem. 270: 7111\u20137116.","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"BF1202307_CR7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0092-8674(94)90564-9","volume":"78","author":"Kermit L. Carraway","year":"1994","unstructured":"Carraway III KL and Cantley LC. . 1994 Cell 78: 5\u20138.","journal-title":"Cell"},{"key":"BF1202307_CR8","unstructured":"Chiu C, McEntee MF and Whelan J. . 1997 Cancer Res. 57: 4267\u20134273."},{"issue":"9","key":"BF1202307_CR9","doi-asserted-by":"publisher","first-page":"5952","DOI":"10.1074\/jbc.272.9.5952","volume":"272","author":"Qing-Rong Chen","year":"1997","unstructured":"Chen Q, Miyaura C, Higashi S, Murakami M, Kudo I, Saito S, Hiraide T, Shibasaki Y and Suda I. . 1997 J. Biol. Chem. 272: 5952\u20135958.","journal-title":"Journal of Biological Chemistry"},{"issue":"13","key":"BF1202307_CR10","doi-asserted-by":"publisher","first-page":"7620","DOI":"10.1074\/jbc.271.13.7620","volume":"271","author":"Xiaomei Chen","year":"1996","unstructured":"Chen X, Levkowitz G, Tzabart E, Karunagaran D, Lavi S, Ben-Baruch N, Leitner O, Ratzkin BJ, Bacus SS and Yarden Y. . 1996 J. Biol. Chem. 271: 7620\u20137629.","journal-title":"Journal of Biological Chemistry"},{"key":"BF1202307_CR11","doi-asserted-by":"crossref","unstructured":"Ciardiello F, Kim N, Saeki T, Dono R, Persico MG, Plowman GD, Garrigues J, Radke S, Todaro GJ and Salomon DS. . 1991 Proc. Natl. Acad. Sci. USA 88: 7792\u20137796.","DOI":"10.1073\/pnas.88.17.7792"},{"key":"BF1202307_CR12","doi-asserted-by":"crossref","unstructured":"Coffey RJ, Hawkey CJ, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland SC, DuBois RN, Jetton TL and Morrow JD. . 1997 Proc. Natl. Acad. Sci. USA 94: 657\u2013662.","DOI":"10.1073\/pnas.94.2.657"},{"key":"BF1202307_CR13","unstructured":"Coffey R, Goustin A, Soderquiat S, Shipley G, Wolfshohl J, Carpenter G and Moses H. . 1987 Cancer Res. 47: 4590\u20134594."},{"issue":"4","key":"BF1202307_CR14","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1053\/gast.1996.v110.pm8613017","volume":"110","author":"RN DuBois","year":"1996","unstructured":"DuBois RN, Radhika A, Reddy BS and Entingh AJ. . 1996 Gastroenterology 110: 1259\u20131262.","journal-title":"Gastroenterology"},{"issue":"2","key":"BF1202307_CR15","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1172\/JCI116998","volume":"93","author":"R N DuBois","year":"1994","unstructured":"DuBois RN, Awad J, Morrow J, Roberts II LJ and Bishop PR. . 1994 J. Clin. Invest. 93: 493\u2013498.","journal-title":"Journal of Clinical Investigation"},{"issue":"4","key":"BF1202307_CR16","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/0016-5085(94)90246-1","volume":"107","author":"Charles E. Eberhart","year":"1994","unstructured":"Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S and DuBois RN. . 1994 Gastroenterology 107: 1183\u20131188.","journal-title":"Gastroenterology"},{"key":"BF1202307_CR17","doi-asserted-by":"crossref","unstructured":"Fanger BO, Stephens JE and Staros JV. . 1989 FASEB J. 3: 71\u201375.","DOI":"10.1096\/fasebj.3.1.2783412"},{"key":"BF1202307_CR18","unstructured":"Granstrom E and Kindahl H. . 1978 Adv. Prostagland. Thromb. Res. 5: 119."},{"key":"BF1202307_CR19","doi-asserted-by":"crossref","unstructured":"Graus-Porta D, Beerli RR, Daly JM and Hynes NE. . 1997 EMBO J. 16: 1647\u20131655.","DOI":"10.1093\/emboj\/16.7.1647"},{"key":"BF1202307_CR20","doi-asserted-by":"crossref","unstructured":"Guy PM, Platko JV, Cantley LC, Cerione RA and Carraway III KL. . 1994 Proc. Natl. Acad. Sci. USA 91: 8132\u20138136.","DOI":"10.1073\/pnas.91.17.8132"},{"issue":"41","key":"BF1202307_CR21","doi-asserted-by":"publisher","first-page":"24604","DOI":"10.1074\/jbc.270.41.24604","volume":"270","author":"Thomas Horan","year":"1995","unstructured":"Horan T, Wen J, Arakawa T, Liu NL, Brankow D, Hu S, Ratzkin B and Philo JS. . 1995 J. Biol. Chem. 270: 24604\u201324608.","journal-title":"Journal of Biological Chemistry"},{"key":"BF1202307_CR22","doi-asserted-by":"crossref","unstructured":"Hynes NC and Stern DF. . 1994 Biochim. Biophys. Acta. 1198: 165\u2013184.","DOI":"10.1016\/0304-419X(94)90012-4"},{"issue":"4","key":"BF1202307_CR23","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/S0016-5085(97)70120-3","volume":"112","author":"S Kapitanovic","year":"1997","unstructured":"Kapitanovic S, Radosevic S, Kapitanovic M, Andelinovic S, Ferencic Z, Tavassoli M, Primorac D, Sonicki Z, Spaventi S, Pavelic K and Spaventi R. . 1997 Gastroenterology 112: 1103\u20131113.","journal-title":"Gastroenterology"},{"issue":"4842","key":"BF1202307_CR24","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1126\/science.2829358","volume":"239","author":"M. Keating","year":"1988","unstructured":"Keating MT and Williams LT. . 1988 Science 239: 914\u2013916.","journal-title":"Science"},{"issue":"2","key":"BF1202307_CR25","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1128\/MCB.11.2.979","volume":"11","author":"R Kumar","year":"1991","unstructured":"Kumar R, Shepard HM and Mendelsohn J. . 1991 Mol. Cell. Biol. 11: 979\u2013986.","journal-title":"Molecular and Cellular Biology"},{"key":"BF1202307_CR26","unstructured":"Kumar R, Mandal M, Ratzkin BJ, Liu N and Lipton A. . 1996 J. Cell. Biochem. 239: 914\u2013916."},{"key":"BF1202307_CR27","doi-asserted-by":"crossref","unstructured":"Kumar R and Atlas I. . 1992 Proc. Natl. Acad. Sci. USA 89: 6599\u20136603.","DOI":"10.1073\/pnas.89.14.6599"},{"key":"BF1202307_CR28","doi-asserted-by":"crossref","unstructured":"Kutchera W, Jones DA, Matsunami N, Groden J, McIntyre TM, Zimmerman GA, White RL and Prescott SM. . 1996 Proc. Natl. Acad. Sci. USA 93: 4816\u20134820.","DOI":"10.1073\/pnas.93.10.4816"},{"key":"BF1202307_CR29","doi-asserted-by":"crossref","unstructured":"Lupu R, Cardillo M, Harris L, Hijazi M and Rosenberg K. . 1995 Cancer Biol. 6: 135\u2013145.","DOI":"10.1006\/scbi.1995.0016"},{"key":"BF1202307_CR30","unstructured":"Mandal M, Adam L, Mendelsohn J and Kumar R. . 1998 Oncogene In Press."},{"issue":"1","key":"BF1202307_CR31","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/carcin\/18.1.229","volume":"18","author":"M Mandal","year":"1997","unstructured":"Mandal M, Wu X and Kumar R. . 1997 Carcinogenesis 18: 229\u2013232.","journal-title":"Carcinogenesis"},{"issue":"48","key":"BF1202307_CR32","doi-asserted-by":"publisher","first-page":"30354","DOI":"10.1074\/jbc.271.48.30354","volume":"271","author":"Mahitosh Mandal","year":"1996","unstructured":"Mandal M, Maggirwar SB, Sharma N, Kaufmann SH, Sun S and Kumar R. . 1996 J. Biol. Chem. 271: 30354\u201330359.","journal-title":"Journal of Biological Chemistry"},{"key":"BF1202307_CR33","doi-asserted-by":"crossref","unstructured":"Martin TE, Barghusen SC, Leser GP and Spear PG. . 1987 J. Cell. Biol. 105: 2069\u20132082.","DOI":"10.1083\/jcb.105.5.2069"},{"issue":"5","key":"BF1202307_CR34","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/S0092-8674(00)81988-1","volume":"87","author":"Masanobu Oshima","year":"1996","unstructured":"Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF and Taketo MM. . 1996 Cell 87: 803\u2013809.","journal-title":"Cell"},{"key":"BF1202307_CR35","doi-asserted-by":"crossref","unstructured":"Pinkas-Kramarski R, Soussan L, Waterman H, Levkowizt G, Alroy I, Klapper L, Lavi S, Seger R, Ratzkin BJ, Sela M and Yarden Y. . 1997 EMBO J. 15: 2452\u20132467.","DOI":"10.1002\/j.1460-2075.1996.tb00603.x"},{"issue":"32","key":"BF1202307_CR36","doi-asserted-by":"publisher","first-page":"19029","DOI":"10.1074\/jbc.271.32.19029","volume":"271","author":"Ronit Pinkas-Kramarski","year":"1996","unstructured":"Pinkas-Kramarski R, Shelly M, Glathe S, Ratzkin BJ and Yarden Y. . 1996 J. Biol. Chem. 271: 19029\u201319032.","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"BF1202307_CR37","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0092-8674(00)81983-2","volume":"87","author":"Stephen M Prescott","year":"1996","unstructured":"Prescott SM and White RL. . 1996 Cell 87: 783\u2013786.","journal-title":"Cell"},{"issue":"3","key":"BF1202307_CR38","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/path.1711700309","volume":"170","author":"Thangarajan Rajkumar","year":"1993","unstructured":"Rajkumar J, Goden CSR, Lemoine NR and Gullick WJ. . 1993 J. Pathol. 170: 271\u2013278.","journal-title":"The Journal of Pathology"},{"key":"BF1202307_CR39","doi-asserted-by":"crossref","unstructured":"Reidel H, Massoglia S, Schlessinger J and Ullrich A. . 1988 Proc. Natl. Acad. Sci. USA 85: 1477\u20131481.","DOI":"10.1073\/pnas.85.5.1477"},{"issue":"3","key":"BF1202307_CR40","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1042\/bj3220757","volume":"322","author":"Susan L. SIERKE","year":"1997","unstructured":"Sierke SL, Cheng K, Kim H and Koland JG. . 1997 Biochem. J. 322: 757\u2013763.","journal-title":"Biochemical Journal"},{"issue":"9","key":"BF1202307_CR41","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1172\/JCI119400","volume":"99","author":"H Sheng","year":"1997","unstructured":"Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD and DuBois RN. . 1997 J. Clin. Invest. 99: 2254\u20132259.","journal-title":"Journal of Clinical Investigation"},{"issue":"52","key":"BF1202307_CR42","doi-asserted-by":"publisher","first-page":"33157","DOI":"10.1074\/jbc.271.52.33157","volume":"271","author":"William L. Smith","year":"1996","unstructured":"Smith WL, Garavito RM and DeWitt DL. . 1996 J. Biol. Chem. 271: 33157\u201333160.","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"BF1202307_CR43","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0092-8674(95)90127-2","volume":"83","author":"Masahiko Tsujii","year":"1995","unstructured":"Tsujii M and DuBois RN. . 1995 Cell 83: 493\u2013501.","journal-title":"Cell"},{"issue":"2","key":"BF1202307_CR44","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0092-8674(90)90801-K","volume":"61","author":"Axel Ullrich","year":"1990","unstructured":"Ullrich A and Schlessinger J. . 1990 Cell 61: 203\u2013212.","journal-title":"Cell"},{"key":"BF1202307_CR45","unstructured":"Untawale S, Zorbas MA, Hodgson CP, Coffey RJ, Gallick GE, North SM, Wildrick DM, Olive M, Blick M, Yeoman LC and Boman BW. . 1993 Cancer Res. 53: 1630\u20131636."},{"key":"BF1202307_CR46","unstructured":"Yang J, Yu Y, Markovic B, Russell PJ and Crowe PJ. . 1997 Anticancer Res. 17: 1023\u20131026."},{"issue":"3","key":"BF1202307_CR47","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/0092-8674(92)90456-M","volume":"69","author":"Duanzhi Wen","year":"1992","unstructured":"Wen D, Peles E, Cupples R, Suggs SF, Bacus SS, Luo Y, Trail G, Hu S, Silbiger R, Levy R, Koski RA, Lu SH and Yarden Y. . 1992 Cell 69: 559\u2013572.","journal-title":"Cell"},{"issue":"7","key":"BF1202307_CR48","doi-asserted-by":"publisher","first-page":"3884","DOI":"10.1074\/jbc.271.7.3884","volume":"271","author":"Ke Zhang","year":"1996","unstructured":"Zhang K, Sun J, Liu N, Wen D, Chang D, Thomason A and Yoshinaga SK. . 1996 J. Biol. Chem. 271: 3884\u20133890.","journal-title":"Journal of Biological Chemistry"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1202307.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1202307","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1202307.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T22:26:30Z","timestamp":1647901590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1202307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1,14]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,1,14]]}},"alternative-id":["BF1202307"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1202307","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1,14]]},"assertion":[{"value":"24 March 1998","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 1998","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 1998","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 1999","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}