{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:40:08Z","timestamp":1775076008716,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2001,3,22]],"date-time":"2001-03-22T00:00:00Z","timestamp":985219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,3,22]],"date-time":"2001-03-22T00:00:00Z","timestamp":985219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2001,3,22]]},"DOI":"10.1038\/sj.onc.1204175","type":"journal-article","created":{"date-parts":[[2002,9,20]],"date-time":"2002-09-20T18:49:11Z","timestamp":1032547751000},"page":"1509-1518","source":"Crossref","is-referenced-by-count":302,"title":["Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours"],"prefix":"10.1038","volume":"20","author":[{"given":"Angelo","family":"Agathanggelou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Honorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donia P","family":"Macartney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alonso","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Dallol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Rader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Fullwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline A","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Hosoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael I","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D","family":"Minna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eamonn R","family":"Maher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farida","family":"Latif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF1204175_CR1","unstructured":"Burbee D, Forgacs E, Z\u00f6chbauer-M\u00fcller S, Shivakuma L, Fong K, Gao B, Randle D, Virmani A, Bader S, Sekido Y, Latif F, Milchgrub S, Gazdar AF, Lerman MI, Zabarovsky E, White M, Minna JD . 2001 J. Natl. Cancer Inst In press"},{"key":"BF1204175_CR2","doi-asserted-by":"crossref","unstructured":"Cairns P, Polascik TJ, Eby Y, Tokino K, Califano J, Merlo A, Mao L, Herath J, Jenkins R, Westra W, Rutter JL, Buckler A, Gabrielson E, Tockman M, Cho ER, Hedrick L, Bova GS, Isaac W, Koch W, Scwab D, Sidransky D . 1995 Nature Genetics 11: 210\u2013212","DOI":"10.1038\/ng1095-210"},{"key":"BF1204175_CR3","doi-asserted-by":"crossref","unstructured":"Clifford SC, Prowse AH, Affara NA, Buys CH, Maher ER . 1998 Genes Chromo. Cancer 22: 200\u2013209","DOI":"10.1002\/(SICI)1098-2264(199807)22:3<200::AID-GCC5>3.0.CO;2-#"},{"key":"BF1204175_CR4","doi-asserted-by":"crossref","unstructured":"Crossey PA, Richards FM, Foster K, Green JS, Prowse A, Latif F, Lerman MI, Zbar B, Affara NA, Ferguson-Smith MA, Maher ER . 1994 Hum. Mol. Genet. 3: 1303\u20131308","DOI":"10.1093\/hmg\/3.8.1303"},{"key":"BF1204175_CR5","doi-asserted-by":"crossref","unstructured":"Dammann R, Li C, Yoon JH, Chin PL, Bates S, Pfeifer GP . 2000 Nat Genet. 25: 315\u2013319","DOI":"10.1038\/77083"},{"key":"BF1204175_CR6","doi-asserted-by":"crossref","unstructured":"Elston CW, Ellis IO . 1991 Histopathology 19: 403\u2013410","DOI":"10.1111\/j.1365-2559.1991.tb00229.x"},{"key":"BF1204175_CR7","doi-asserted-by":"crossref","unstructured":"Foster K, Osborne RJ, Huddart RA, Affara NA, Ferguson-Smith MA, Maher ER . 1995 Eur. J. Cancer 31A: 2392\u20132395","DOI":"10.1016\/0959-8049(95)00437-8"},{"key":"BF1204175_CR8","unstructured":"Fullwood P, Marchini S, Rader JS, Martinez A, Macartney D, Broggini M, Morelli C, Barbanti-Brodano G, Maher ER, Latif F . 1999 Cancer Res. 59: 4662\u20134667"},{"key":"BF1204175_CR9","doi-asserted-by":"crossref","unstructured":"Gnarra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, Liu S, Chen F, Duh FM, Lubensky I, Duan D, Florence C, Pazzatti R, Walther MM, Bander NH, Grossman HB, Brauch H, Pomer S, Brooks JD, Isaac WB, Lerman MI, Zbar B, Linehan WM . 1994 Nat Genet. 7: 85\u201390","DOI":"10.1038\/ng0594-85"},{"key":"BF1204175_CR10","doi-asserted-by":"crossref","unstructured":"Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB . 1996 Proc. Natl Acad. Sci. USA 93: 9821\u20139826","DOI":"10.1073\/pnas.93.18.9821"},{"key":"BF1204175_CR11","doi-asserted-by":"crossref","unstructured":"Hosoe S, Shigedo Y, Ueno K, Tachibana I, Osaki T, Tanio Y, Kawase I, Yamakawa K, Nakamura Y, Kishimoto T . 1994 Lung Cancer 10: 297\u2013305","DOI":"10.1016\/0169-5002(94)90659-9"},{"key":"BF1204175_CR12","doi-asserted-by":"crossref","unstructured":"Kaelin Jr WG, Maher ER . 1998 Trends Genet. 14: 423\u2013426","DOI":"10.1016\/S0168-9525(98)01558-3"},{"key":"BF1204175_CR13","doi-asserted-by":"crossref","unstructured":"Kim ST, Lim DS, Canman CE, Kastan MB . 1999 Biol Chem. 274: 37538\u201337543","DOI":"10.1074\/jbc.274.53.37538"},{"key":"BF1204175_CR14","doi-asserted-by":"crossref","unstructured":"Knudson Jr AG . 1971 Proc. Natl Acad. Sci. USA 68: 820\u2013823","DOI":"10.1073\/pnas.68.4.820"},{"key":"BF1204175_CR15","doi-asserted-by":"crossref","unstructured":"Knudson AG . 1996 J. Cancer Res. Clin. Oncol. 122: 135\u2013140","DOI":"10.1007\/BF01366952"},{"key":"BF1204175_CR16","doi-asserted-by":"crossref","unstructured":"Kok K, Naylor SL, Buys CH . 1997 Adv. Cancer Res. 71: 27\u201392","DOI":"10.1016\/S0065-230X(08)60096-2"},{"key":"BF1204175_CR17","doi-asserted-by":"crossref","unstructured":"Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Li H, Wei M, Chen F, Glenn G, Choyke P, Walther MM, Weng Y, Duan D-SR, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Smith MA, Le Paslier D, Chumakov I, Cohen D, Chinault AC, Maher ER, Linehan WM, Zbar B, Lerman MI . 1993 Science 260: 1317\u20131320","DOI":"10.1126\/science.8493574"},{"key":"BF1204175_CR18","doi-asserted-by":"crossref","unstructured":"Latif F, Tory K, Modi WS, Graziano SL, Gamble G, Douglas J, Heppell-Parton AC, Rabbitts PH., Zbar B, Lerman MI . 1992 Genes Chrom. Cancer 5: 119\u2013127","DOI":"10.1002\/gcc.2870050205"},{"key":"BF1204175_CR19","unstructured":"Lerman MI, Minna JD for the International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium . 2000 Cancer Res. 60: 6116\u20136133"},{"key":"BF1204175_CR20","doi-asserted-by":"crossref","unstructured":"Partridge M, Emilion G, Pateromichelakis S, Phillips E, Langdon J . 1999 Int. J. Cancer. 83: 318\u2013325","DOI":"10.1002\/(SICI)1097-0215(19991029)83:3<318::AID-IJC6>3.0.CO;2-V"},{"key":"BF1204175_CR21","doi-asserted-by":"crossref","unstructured":"Rabbitts P, Bergh J, Douglas J, Collins F, Waters J . 1990 Genes Chrom. Cancer 2: 231\u2013238","DOI":"10.1002\/gcc.2870020312"},{"key":"BF1204175_CR22","unstructured":"Reed AL, Califano J, Cairns P, Westra WH, Jones RM, Koch W, Ahrendt S, Eby Y, Sewell D, Nawroz H, Bartek J, Sidransky D . 1996 Cancer Res. 56: 3630\u20133633"},{"key":"BF1204175_CR23","doi-asserted-by":"crossref","unstructured":"Sekido Y, Ahmadian M, Wistuba II, Latif F, Bader S, Wei MH, Duh FM, Gazdar AF, Lerman MI, Minna JD . 1998 Oncogene 16: 3151\u20133157","DOI":"10.1038\/sj.onc.1201858"},{"key":"BF1204175_CR24","unstructured":"Sekido Y, Bader S, Latif F, Gnarra JR, Gazdar AF, Linehan WM, Zbar B, Lerman MI, Minna JD . 1994 Oncogene 9: 1599\u20131604"},{"key":"BF1204175_CR25","doi-asserted-by":"crossref","unstructured":"Shaw JA, Walsh T, Chappell SA, Carey N, Johnson K, Walker RA . 1996 Br. J. Cancer 73: 1393\u20131397","DOI":"10.1038\/bjc.1996.264"},{"key":"BF1204175_CR26","doi-asserted-by":"crossref","unstructured":"Sundaresan V, Chung G, Heppell-Parton A, Xiong J, Grundy C, Roberts I, James L, Cahn A, Bench A, Douglas J, Minna MI, Sekido Y, Lerman MI, Latif F, Bergh J, Li H, Lowe N, Ogilvie D, Rabbitts P . 1998 Oncogene 17: 1723\u20131729","DOI":"10.1038\/sj.onc.1202103"},{"key":"BF1204175_CR27","doi-asserted-by":"crossref","unstructured":"Vavvas D, Li X, Avruch J, Zhang XF . 1998 J. Biol. Chem. 273: 5439\u20135442","DOI":"10.1074\/jbc.273.10.5439"},{"key":"BF1204175_CR28","doi-asserted-by":"crossref","unstructured":"Virmani AK, Fong KM, Kodagoda D, McIntire D, Hung J, Tonk V, Minna JD, Gazdar AF . 1998 Genes Chrom. Cancer 21: 308\u2013319","DOI":"10.1002\/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2"},{"key":"BF1204175_CR29","unstructured":"Vos M.D, Ellis CA, Bell A, Birrer MJ, Clark GJ . 2000 J. Biol. Chem in press"},{"key":"BF1204175_CR30","unstructured":"Wei MH, Latif F, Bader S, Kashuba V, Chen JY, Duh FM, Sekido Y, Lee CC, Geil L, Kuzmin I, Zabarovsky E, Klein G, Zbar B, Minna JD, Lerman MI . 1996 Cancer Res. 56: 1487\u20131492"},{"key":"BF1204175_CR31","doi-asserted-by":"crossref","unstructured":"Wistuba II, Behrens C, Milchgrub S, Bryant D, Hung J, Minna JD, Gazdar AF . 1999 Oncogene 18: 643\u2013650","DOI":"10.1038\/sj.onc.1202349"},{"key":"BF1204175_CR32","unstructured":"Wistuba II, Behrens C, Virmani AK, Mele G, Milchgrub S, Girard L, Fondon III JW, Garner HR, McKay B, Latif F, Lerman MI, Lam S, Gazdar AF, Minna JD . 2000 Cancer Res. 60: 1949\u20131960"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1204175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1204175","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1204175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T02:16:43Z","timestamp":1647915403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1204175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,22]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,3,22]]}},"alternative-id":["BF1204175"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1204175","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,22]]}}}