{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:39:15Z","timestamp":1776166755851,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"32","license":[{"start":{"date-parts":[[2001,7,19]],"date-time":"2001-07-19T00:00:00Z","timestamp":995500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,7,19]],"date-time":"2001-07-19T00:00:00Z","timestamp":995500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2001,7,19]]},"DOI":"10.1038\/sj.onc.1204486","type":"journal-article","created":{"date-parts":[[2002,9,20]],"date-time":"2002-09-20T18:52:33Z","timestamp":1032547953000},"page":"4419-4423","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Oncogenic transformation induced by membrane-targeted Akt2 and Akt3"],"prefix":"10.1038","volume":"20","author":[{"given":"Ines","family":"Mende","sequence":"first","affiliation":[]},{"given":"Scott","family":"Malstrom","sequence":"additional","affiliation":[]},{"given":"Philip N","family":"Tsichlis","sequence":"additional","affiliation":[]},{"given":"Peter K","family":"Vogt","sequence":"additional","affiliation":[]},{"given":"Masahiro","family":"Aoki","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2001,7,19]]},"reference":[{"key":"BF1204486_CR1","doi-asserted-by":"crossref","unstructured":"Abraham KM, Levin SD, Marth JD, Forbush KA, Perlmutter RM . 1991 Proc. Natl. Acad. Sci. USA 88: 3977\u20133981","DOI":"10.1073\/pnas.88.9.3977"},{"key":"BF1204486_CR2","doi-asserted-by":"crossref","unstructured":"Alessi DR, Cohen P . 1998 Curr. Opin. Genet. Dev. 8: 55\u201362","DOI":"10.1016\/S0959-437X(98)80062-2"},{"key":"BF1204486_CR3","doi-asserted-by":"crossref","unstructured":"Alessi DR, Downes CP . 1998 Biochim. Biophys. Acta 1436: 151\u2013164","DOI":"10.1016\/S0005-2760(98)00133-7"},{"key":"BF1204486_CR4","doi-asserted-by":"crossref","unstructured":"Ali IU, Schrimi LM, Dean M . 1999 J. Natl. Cancer Inst. 91: 1922\u20131932","DOI":"10.1093\/jnci\/91.22.1922"},{"key":"BF1204486_CR5","doi-asserted-by":"crossref","unstructured":"Altomare DA, Lyons GE, Mitsuuchi Y, Cheng JQ, Testa JR . 1998 Oncogene 16: 2407\u20132411","DOI":"10.1038\/sj.onc.1201750"},{"key":"BF1204486_CR6","doi-asserted-by":"crossref","unstructured":"Andersson S, Davis DL, Dahlback H, Jornvall H, Russell DW . 1989 J. Biol. Chem. 264: 8222\u20138229","DOI":"10.1016\/S0021-9258(18)83172-6"},{"key":"BF1204486_CR7","doi-asserted-by":"crossref","unstructured":"Aoki M, Batista O, Bellacosa A, Tsichlis P, Vogt PK . 1998 Proc. Natl. Acad. Sci. USA 95: 14950\u201314955","DOI":"10.1073\/pnas.95.25.14950"},{"key":"BF1204486_CR8","doi-asserted-by":"crossref","unstructured":"Aoki M, Blazek E, Vogt PK . 2001 Proc. Natl. Acad. Sci. USA 98: 136\u2013141","DOI":"10.1073\/pnas.98.1.136"},{"key":"BF1204486_CR9","doi-asserted-by":"crossref","unstructured":"Aoki M, Schetter C, Himly M, Batista O, Chang HW, Vogt PK . 2000 J. Biol. Chem. 275: 6267\u20136275","DOI":"10.1074\/jbc.275.9.6267"},{"key":"BF1204486_CR10","doi-asserted-by":"crossref","unstructured":"Bellacosa A, de Feo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, Wan M, Dubeau L, Scambia G, Masciullo V et al . 1995 Int. J. Cancer 64: 280\u2013285","DOI":"10.1002\/ijc.2910640412"},{"key":"BF1204486_CR11","doi-asserted-by":"crossref","unstructured":"Bellacosa A, Testa JR, Staal SP, Tsichlis PN . 1991 Science 254: 274\u2013277","DOI":"10.1126\/science.254.5029.274"},{"key":"BF1204486_CR12","doi-asserted-by":"crossref","unstructured":"Brodbeck D, Cron P, Hemmings BA . 1999 J. Biol. Chem. 274: 9133\u20139136","DOI":"10.1074\/jbc.274.14.9133"},{"key":"BF1204486_CR13","doi-asserted-by":"crossref","unstructured":"Cantley LC, Neel BG . 1999 Proc. Natl. Acad. Sci. USA 96: 4240\u20134245","DOI":"10.1073\/pnas.96.8.4240"},{"key":"BF1204486_CR14","unstructured":"Ceci JD, Kovatch RM, Swing DA, Jones JM, Snow CM, Rosenberg MP, Jenkins NA, Copeland NG, Meisler MH . 1991 Oncogene 6: 323\u2013332"},{"key":"BF1204486_CR15","doi-asserted-by":"crossref","unstructured":"Ceci JD, Siracusa LD, Jenkins NA, Copeland NG . 1989 Genomics 5: 699\u2013709","DOI":"10.1016\/0888-7543(89)90111-0"},{"key":"BF1204486_CR16","doi-asserted-by":"crossref","unstructured":"Chan TO, Rittenhouse SE, Tsichlis PN . 1999 Ann. Rev. Biochem. 68: 965\u20131014","DOI":"10.1146\/annurev.biochem.68.1.965"},{"key":"BF1204486_CR17","doi-asserted-by":"crossref","unstructured":"Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK . 1997 Science 276: 1848\u20131850","DOI":"10.1126\/science.276.5320.1848"},{"key":"BF1204486_CR18","doi-asserted-by":"crossref","unstructured":"Cheng JQ, Altomare DA, Klein MA, Lee WC, Kruh GD, Lissy NA, Testa JR . 1997 Oncogene 14: 2793\u20132801","DOI":"10.1038\/sj.onc.1201121"},{"key":"BF1204486_CR19","doi-asserted-by":"crossref","unstructured":"Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR . 1992 Proc. Natl. Acad. Sci. USA 89: 9267\u20139271","DOI":"10.1073\/pnas.89.19.9267"},{"key":"BF1204486_CR20","doi-asserted-by":"crossref","unstructured":"Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK, Testa JR . 1996 Proc. Natl. Acad. Sci. USA 93: 3636\u20133641","DOI":"10.1073\/pnas.93.8.3636"},{"key":"BF1204486_CR21","doi-asserted-by":"crossref","unstructured":"Coffer PJ, Jin J, Woodgett JR . 1998 Biochem. J. 335: 1\u201313","DOI":"10.1042\/bj3350001"},{"key":"BF1204486_CR22","doi-asserted-by":"crossref","unstructured":"Datta SR, Brunet A, Greenberg ME . 1999 Genes Dev. 13: 2905\u20132927","DOI":"10.1101\/gad.13.22.2905"},{"key":"BF1204486_CR23","doi-asserted-by":"crossref","unstructured":"Di Cristofano A, Pandolfi PP . 2000 Cell 100: 387\u2013390","DOI":"10.1016\/S0092-8674(00)80674-1"},{"key":"BF1204486_CR24","doi-asserted-by":"crossref","unstructured":"Dufner A, Andjelkovic M, Burgering BM, Hemmings BA, Thomas G . 1999 Mol. Cell. Biol. 19: 4525\u20134534","DOI":"10.1128\/MCB.19.6.4525"},{"key":"BF1204486_CR25","doi-asserted-by":"crossref","unstructured":"Fruman DA, Meyers RE, Cantley LC . 1998 Ann. Rev. Biochem. 67: 481\u2013507","DOI":"10.1146\/annurev.biochem.67.1.481"},{"key":"BF1204486_CR26","doi-asserted-by":"crossref","unstructured":"Fukui Y, Hanafusa H . 1989 Mol. Cell. Biol. 9: 1651\u20131658","DOI":"10.1128\/mcb.9.4.1651-1658.1989"},{"key":"BF1204486_CR27","doi-asserted-by":"crossref","unstructured":"Hu P, Margolis B, Skolnik EY, Lammers R, Ullrich A, Schlessinger J . 1992 Mol. Cell. Biol. 12: 981\u2013990","DOI":"10.1128\/mcb.12.3.981-990.1992"},{"key":"BF1204486_CR28","doi-asserted-by":"crossref","unstructured":"Hughes SH, Greenhouse JJ, Petropoulos CJ, Sutrave P . 1987 J. Virol. 61: 3004\u20133012","DOI":"10.1128\/jvi.61.10.3004-3012.1987"},{"key":"BF1204486_CR29","doi-asserted-by":"crossref","unstructured":"Konishi H, Kuroda S, Tanaka M, Matsuzaki H, Ono Y, Kameyama K, Haga T, Kikkawa U . 1995 Biochem. Biophys. Res. Commun. 216: 526\u2013534","DOI":"10.1006\/bbrc.1995.2654"},{"key":"BF1204486_CR30","unstructured":"Liu AX, Testa JR, Hamilton TC, Jove R, Nicosia SV, Cheng JQ . 1998 Cancer Res. 58: 2973\u20132977"},{"key":"BF1204486_CR31","doi-asserted-by":"crossref","unstructured":"Maehama T, Dixon JE . 1999 Trends Cell. Biol. 9: 125\u2013128","DOI":"10.1016\/S0962-8924(99)01519-6"},{"key":"BF1204486_CR32","doi-asserted-by":"crossref","unstructured":"Masure S, Haefner B, Wesselink JJ, Hoefnagel E, Mortier E, Verhasselt P, Tuytelaars A, Gordon R, Richardson A . 1999 Eur. J. Biochem. 265: 353\u2013360","DOI":"10.1046\/j.1432-1327.1999.00774.x"},{"key":"BF1204486_CR33","doi-asserted-by":"crossref","unstructured":"Meier R, Alessi DR, Cron P, Andjelkovic M, Hemmings BA . 1997 J. Biol. Chem. 272: 30491\u201330497","DOI":"10.1074\/jbc.272.48.30491"},{"key":"BF1204486_CR34","doi-asserted-by":"crossref","unstructured":"Miwa W, Yasuda J, Murakami Y, Yashima K, Sugano K, Sekine T, Kono A, Egawa S, Yamaguchi K, Hayashiazaki Y, Sekiya T . 1996 Biochem. Biophys. Res. Commun. 225: 968\u2013974","DOI":"10.1006\/bbrc.1996.1280"},{"key":"BF1204486_CR35","doi-asserted-by":"crossref","unstructured":"Nakatani K, Sakaue H, Thompson DA, Weigel RJ, Roth RA . 1999a Biochem. Biophys. Res. Commun. 257: 906\u2013910","DOI":"10.1006\/bbrc.1999.0559"},{"key":"BF1204486_CR36","doi-asserted-by":"crossref","unstructured":"Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ, Roth RA . 1999b J. Biol. Chem. 274: 21528\u201321532","DOI":"10.1074\/jbc.274.31.21528"},{"key":"BF1204486_CR37","doi-asserted-by":"crossref","unstructured":"Osborn L, Rosenberg MP, Keller SA, Meisler MH . 1987 Mol. Cell. Biol. 7: 326\u2013334","DOI":"10.1128\/MCB.7.1.326"},{"key":"BF1204486_CR38","doi-asserted-by":"crossref","unstructured":"Peles E, Lamprecht R, Ben-Levy R, Tzahar E, Yarden Y . 1992 J. Biol. Chem. 267: 12266\u201312274","DOI":"10.1016\/S0021-9258(19)49834-7"},{"key":"BF1204486_CR39","doi-asserted-by":"crossref","unstructured":"Reith AD, Ellis C, Lyman SD, Anderson DM, Williams DE, Bernstein A, Pawson T . 1991 EMBO J. 10: 2451\u20132459","DOI":"10.1002\/j.1460-2075.1991.tb07784.x"},{"key":"BF1204486_CR40","doi-asserted-by":"crossref","unstructured":"Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J . 1994 Nature 370: 527\u2013532","DOI":"10.1038\/370527a0"},{"key":"BF1204486_CR41","doi-asserted-by":"crossref","unstructured":"Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J . 1996 EMBO J. 15: 2442\u20132451","DOI":"10.1002\/j.1460-2075.1996.tb00602.x"},{"key":"BF1204486_CR42","doi-asserted-by":"crossref","unstructured":"Ruggeri BA, Huang L, Wood M, Cheng JQ, Testa JR . 1998 Mol. Carcinog. 21: 81\u201386","DOI":"10.1002\/(SICI)1098-2744(199802)21:2<81::AID-MC1>3.0.CO;2-R"},{"key":"BF1204486_CR43","doi-asserted-by":"crossref","unstructured":"Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Gray JW . 1999 Nat. Genet. 21: 99\u2013102","DOI":"10.1038\/5042"},{"key":"BF1204486_CR44","doi-asserted-by":"crossref","unstructured":"Shepherd PR, Withers DJ, Siddle K . 1998 Biochem. J. 333: 471\u2013490","DOI":"10.1042\/bj3330471"},{"key":"BF1204486_CR45","doi-asserted-by":"crossref","unstructured":"Siracusa LD, Russell LB, Jenkins NA, Copeland NG . 1987 Genetics 117: 85\u201392","DOI":"10.1093\/genetics\/117.1.85"},{"key":"BF1204486_CR46","doi-asserted-by":"crossref","unstructured":"Staal SP . 1987 Proc. Natl. Aad. Sci. USA 84: 5034\u20135037","DOI":"10.1073\/pnas.84.14.5034"},{"key":"BF1204486_CR47","doi-asserted-by":"crossref","unstructured":"Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM . 1985 Nature 315: 239\u2013242","DOI":"10.1038\/315239a0"},{"key":"BF1204486_CR48","doi-asserted-by":"crossref","unstructured":"Wymann MP, Pirola L . 1998 Biochim. Biophys. Acta 1436: 127\u2013150","DOI":"10.1016\/S0005-2760(98)00139-8"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1204486.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1204486","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1204486.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T23:46:51Z","timestamp":1647906411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1204486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,19]]},"references-count":48,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2001,7,19]]}},"alternative-id":["BF1204486"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1204486","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,19]]},"assertion":[{"value":"29 November 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2001","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}