{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:53:46Z","timestamp":1776232426169,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T00:00:00Z","timestamp":1103500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T00:00:00Z","timestamp":1103500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2005,2,17]]},"DOI":"10.1038\/sj.onc.1208304","type":"journal-article","created":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T11:26:23Z","timestamp":1103541983000},"page":"1477-1480","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":422,"title":["PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas"],"prefix":"10.1038","volume":"24","author":[{"given":"Jong Woo","family":"Lee","sequence":"first","affiliation":[]},{"given":"Young Hwa","family":"Soung","sequence":"additional","affiliation":[]},{"given":"Su Young","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Hae Woo","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Won Sang","family":"Park","sequence":"additional","affiliation":[]},{"given":"Suk Woo","family":"Nam","sequence":"additional","affiliation":[]},{"given":"Sang Ho","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Jung Young","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Nam Jin","family":"Yoo","sequence":"additional","affiliation":[]},{"given":"Sug Hyung","family":"Lee","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2004,12,20]]},"reference":[{"key":"BF1208304_CR1","doi-asserted-by":"crossref","unstructured":"Arteaga CL, Moulder SL and Yakes FM . (2002). Semin. Oncol., 29, 4\u201310.","DOI":"10.1016\/S0093-7754(02)70121-8"},{"key":"BF1208304_CR2","doi-asserted-by":"crossref","unstructured":"Bellacosa A, de Feo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, Wan M, Dubeau L, Scambia G, Masciullo V, Ferrandina G, Benedetti Panici P, Mancuso S, Neri G and Testa JR . (1995). Int. J. Cancer, 64, 280\u2013285.","DOI":"10.1002\/ijc.2910640412"},{"key":"BF1208304_CR3","doi-asserted-by":"crossref","unstructured":"Benistant C, Chapuis H and Roche S . (2000). Oncogene, 19, 5083\u20135090.","DOI":"10.1038\/sj.onc.1203871"},{"key":"BF1208304_CR4","doi-asserted-by":"crossref","unstructured":"Bogomoletz WV . (1984). Am. J. Surg. Pathol., 8, 381\u2013391.","DOI":"10.1097\/00000478-198405000-00007"},{"key":"BF1208304_CR5","doi-asserted-by":"crossref","unstructured":"Cantley LC . (2002). Science, 296, 1655\u20131657.","DOI":"10.1126\/science.296.5573.1655"},{"key":"BF1208304_CR6","doi-asserted-by":"crossref","unstructured":"Cantley LC and Neel BG . (1999). Proc. Natl. Acad. Sci. USA, 96, 4240\u20134245.","DOI":"10.1073\/pnas.96.8.4240"},{"key":"BF1208304_CR7","doi-asserted-by":"crossref","unstructured":"Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R and Talpaz M . (2001). N. Engl. J. Med., 344, 1038\u20131042.","DOI":"10.1056\/NEJM200104053441402"},{"key":"BF1208304_CR8","doi-asserted-by":"crossref","unstructured":"Edmondson HA and Steiner PE . (1954). Cancer, 7, 462\u2013503.","DOI":"10.1002\/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E"},{"key":"BF1208304_CR9","doi-asserted-by":"crossref","unstructured":"International Working Party (1995). Hepatology, 22, 983\u2013993.","DOI":"10.1016\/0270-9139(95)90324-0"},{"key":"BF1208304_CR10","doi-asserted-by":"crossref","unstructured":"Kim HS, Lee JW, Soung YH, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ, Jeong SW, Nam SW, Kim SH, Lee JY, Yoo NJ and Lee SH . (2003). Gastroenterology, 125, 708\u2013715.","DOI":"10.1016\/S0016-5085(03)01059-X"},{"key":"BF1208304_CR11","doi-asserted-by":"crossref","unstructured":"Lee JY, Dong SM, Kim SY, Yoo NJ, Lee SH and Park WS . (1998). Virchows Arch., 433, 305\u2013309.","DOI":"10.1007\/s004280050253"},{"key":"BF1208304_CR12","doi-asserted-by":"crossref","unstructured":"Luo J, Manning BD and Cantley LC . (2003). Cancer Cell, 4, 257\u2013262.","DOI":"10.1016\/S1535-6108(03)00248-4"},{"key":"BF1208304_CR13","doi-asserted-by":"crossref","unstructured":"Phillips WA, St Clair F, Munday AD, Thomas RJ and Mitchell CA . (1998). Cancer, 83, 41\u201347.","DOI":"10.1002\/(SICI)1097-0142(19980701)83:1<41::AID-CNCR6>3.0.CO;2-H"},{"key":"BF1208304_CR14","doi-asserted-by":"crossref","unstructured":"Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B and Velculescu VE . (2004). Science, 304, 554.","DOI":"10.1126\/science.1096502"},{"key":"BF1208304_CR15","doi-asserted-by":"crossref","unstructured":"Shay JW, Wright WE and Werbin H . (1993). Breast Cancer Res. Treat., 25, 83\u201394.","DOI":"10.1007\/BF00662404"},{"key":"BF1208304_CR16","doi-asserted-by":"crossref","unstructured":"Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB and Gray JW . (1999). Nat. Genet., 21, 99\u2013102.","DOI":"10.1038\/5042"},{"key":"BF1208304_CR17","doi-asserted-by":"crossref","unstructured":"Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F and Hawkins PT . (1997). Science, 277, 567\u2013570.","DOI":"10.1126\/science.277.5325.567"},{"key":"BF1208304_CR18","doi-asserted-by":"crossref","unstructured":"Ueki K, Algenstaedt P, Mauvais-Jarvis F and Kahn CR . (2000). Mol. Cell. Biol., 20, 8035\u20138046.","DOI":"10.1128\/MCB.20.21.8035-8046.2000"},{"key":"BF1208304_CR19","doi-asserted-by":"crossref","unstructured":"Vanhaesebroeck B and Alessi DR . (2000). Biochem. J., 346 (Part 3), 561\u2013576.","DOI":"10.1042\/bj3460561"},{"key":"BF1208304_CR20","doi-asserted-by":"crossref","unstructured":"Vivanco I and Sawyers CL . (2002). Nat. Rev. Cancer, 2, 489\u2013501.","DOI":"10.1038\/nrc839"},{"key":"BF1208304_CR21","unstructured":"Wakeling AE, Guy SP, Woodburn JR, Ashton SE, Curry BJ, Barker AJ and Gibson KH . (2002). Cancer Res., 62, 5749\u20135754."},{"key":"BF1208304_CR22","doi-asserted-by":"crossref","unstructured":"Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X, Jiang C, Coppola D, Nicosia V and Cheng JQ . (2000). Oncogene, 19, 2324\u20132330.","DOI":"10.1038\/sj.onc.1203598"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1208304.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1208304","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1208304.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T08:45:35Z","timestamp":1647938735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1208304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,20]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,2,17]]}},"alternative-id":["BF1208304"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1208304","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,20]]},"assertion":[{"value":"6 July 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2004","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2004","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2004","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}