{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T09:26:49Z","timestamp":1776936409602,"version":"3.51.4"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"56","license":[{"start":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T00:00:00Z","timestamp":1197244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T00:00:00Z","timestamp":1197244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2007,12,10]]},"DOI":"10.1038\/sj.onc.1210880","type":"journal-article","created":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T08:05:16Z","timestamp":1197273916000},"page":"7749-7758","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":231,"title":["ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks"],"prefix":"10.1038","volume":"26","author":[{"given":"M F","family":"Lavin","sequence":"first","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,12,10]]},"reference":[{"key":"BF1210880_CR1","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.1038\/sj.onc.1209426","volume":"25","author":"KE Adams","year":"2006","unstructured":"Adams KE, Medhurst AL, Dart DA, Lakin ND . (2006). Recruitment of ATR to sites of ionizing radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene 25: 3894\u20133904.","journal-title":"Oncogene"},{"key":"BF1210880_CR2","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.dnarep.2006.05.029","volume":"5","author":"S Agarwal","year":"2006","unstructured":"Agarwal S, Tafel AA, Kanaar R . (2006). DNA double-strand break and chromosome translocations. DNA Repair 5: 1075\u20131081.","journal-title":"DNA Repair"},{"key":"BF1210880_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1101\/gad.1176004","volume":"18","author":"A Ali","year":"2004","unstructured":"Ali A, Zhang J, Bao S, Liu I, Otterness D, Dean NM et al. (2004). Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev 18: 249\u2013254.","journal-title":"Genes Dev"},{"key":"BF1210880_CR4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nature01368","volume":"421","author":"CJ Bakkenist","year":"2003","unstructured":"Bakkenist CJ, Kastan MB . (2003). DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421: 499\u2013506.","journal-title":"Nature"},{"key":"BF1210880_CR5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1083\/jcb.200510130","volume":"173","author":"S Bekker-Jensen","year":"2006","unstructured":"Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J et al. (2006). Spatial organisation of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 173: 195\u2013206.","journal-title":"J Cell Biol"},{"key":"BF1210880_CR6","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/ncb1599","volume":"9","author":"E Berkovich","year":"2007","unstructured":"Berkovich E, Monnat Jr RJ, Kastan MB . (2007). Roles of ATM and Nbs1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 9: 683\u2013690.","journal-title":"Nat Cell Biol"},{"key":"BF1210880_CR7","doi-asserted-by":"publisher","first-page":"6610","DOI":"10.1093\/emboj\/cdg630","volume":"22","author":"CT Carson","year":"2003","unstructured":"Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD . (2003). The Mre11 complex is required for ATM activation and the G2\/M checkpoint. EMBO J 22: 6610\u20136620.","journal-title":"EMBO J"},{"key":"BF1210880_CR8","doi-asserted-by":"publisher","first-page":"38813","DOI":"10.1074\/jbc.M404294200","volume":"279","author":"K Cerosaletti","year":"2004","unstructured":"Cerosaletti K, Concannon P . (2004). Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. J Biol Chem 279: 38813\u201338819.","journal-title":"J Biol Chem"},{"key":"BF1210880_CR9","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1128\/MCB.26.5.1691-1699.2006","volume":"26","author":"K Cerosaletti","year":"2006","unstructured":"Cerosaletti K, Wright J, Concannon P . (2006). Active role for nibrin in the kinetics of Atm activation. Mol Cell Biol 26: 1691\u20131699.","journal-title":"Mol Cell Biol"},{"key":"BF1210880_CR10","doi-asserted-by":"publisher","first-page":"E110","DOI":"10.1371\/journal.pbio.0020110","volume":"2","author":"V Costanzo","year":"2004","unstructured":"Costanzo V, Paull T, Gottesman M, Gautier J . (2004). Mre11 assembles linear DNA fragments into DNA damage signalling complexes. PLoS Biol 2: E110.","journal-title":"PLoS Biol"},{"key":"BF1210880_CR11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S1097-2765(01)00294-5","volume":"8","author":"V Costanzo","year":"2001","unstructured":"Costanzo V, Robertson K, Bibikova M, Kim E, Grieco D, Gottesman M et al. (2001). Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol Cell 8: 137\u2013147.","journal-title":"Mol Cell"},{"key":"BF1210880_CR12","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S1097-2765(00)00063-0","volume":"6","author":"V Costanzo","year":"2000","unstructured":"Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, Gottesman M et al. (2000). Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol Cell 6: 649\u2013659.","journal-title":"Mol Cell"},{"key":"BF1210880_CR13","first-page":"317","volume":"3","author":"D D\u2019Amours","year":"2002","unstructured":"D\u2019Amours D, Jackson SP . (2002). The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Mol Cell Biol 3: 317\u2013327.","journal-title":"Mol Cell Biol"},{"key":"BF1210880_CR14","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/S1097-2765(01)00381-1","volume":"8","author":"M De Jager","year":"2001","unstructured":"De Jager M, van Noort J, van Gent DC, Dekker C, Kanaar R, Wyman C . (2001). Human Rad50\/Mre11 is a flexible complex that can tether DNA ends. Mol Cell 8: 1129\u20131135.","journal-title":"Mol Cell"},{"key":"BF1210880_CR15","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/ncb1270","volume":"7","author":"S Difilippantonio","year":"2005","unstructured":"Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F et al. (2005). Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol 7: 675\u2013685.","journal-title":"Nat Cell Biol"},{"key":"BF1210880_CR16","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1084\/jem.20070319","volume":"204","author":"S Difilippantonio","year":"2007","unstructured":"Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L et al. (2007). Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med 204: 1003\u20131011.","journal-title":"J Exp Med"},{"key":"BF1210880_CR17","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/(SICI)1521-1878(199908)21:8<649::AID-BIES4>3.0.CO;2-O","volume":"21","author":"M Digweed","year":"1999","unstructured":"Digweed M, Reis A, Sperling K . (1999). Nijmegen breakage syndrome: consequences of defective DNA double strand break repair. BioEssays 21: 649\u2013656.","journal-title":"BioEssays"},{"key":"BF1210880_CR18","doi-asserted-by":"publisher","first-page":"19513","DOI":"10.1074\/jbc.274.28.19513","volume":"274","author":"Z Dong","year":"1999","unstructured":"Dong Z, Zhong Q, Chen PL . (1999). The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage. J Biol Chem 274: 19513\u201319516.","journal-title":"J Biol Chem"},{"key":"BF1210880_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0065-2776(04)86002-4","volume":"86","author":"DD Dudley","year":"2005","unstructured":"Dudley DD, Chaudhuri J, Bassing CH, Atl FW . (2005). Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol 86: 43\u2013112.","journal-title":"Adv Immunol"},{"key":"BF1210880_CR20","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nsmb1090","volume":"13","author":"A Dupre","year":"2006","unstructured":"Dupre A, Boyer-Chatenet L, Gautier J . (2006). Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol 13: 451\u2013457.","journal-title":"Nat Struct Mol Biol"},{"key":"BF1210880_CR21","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nature03442","volume":"434","author":"J Falck","year":"2005","unstructured":"Falck J, Coates J, Jackson SP . (2005). Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434: 605\u2013611.","journal-title":"Nature"},{"key":"BF1210880_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0921-8777(99)00006-3","volume":"434","author":"C Featherstone","year":"1999","unstructured":"Featherstone C, Jackson SP . (1999). Ku, a DNA repair protein with multiple cellular functions? Mutat Res 434: 3\u201315.","journal-title":"Mutat Res"},{"key":"BF1210880_CR23","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1080\/095530097143266","volume":"72","author":"N Foray","year":"1997","unstructured":"Foray N, Priestley A, Alsbeih G, Badie C, Capulas EP et al. (1997). Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. Int J Radiat Biol 72: 271\u2013283.","journal-title":"Int J Radiat Biol"},{"key":"BF1210880_CR24","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/75508","volume":"25","author":"M Gatei","year":"2000","unstructured":"Gatei M, Young D, Cerosaletti KM, Desai-Mehta K, Spring K, Kozlov S et al. (2000). ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet 25: 115\u2013119.","journal-title":"Nat Genet"},{"key":"BF1210880_CR25","first-page":"4881","volume":"60","author":"PM Girard","year":"2000","unstructured":"Girard PM, Foray N, Stumm M, Waugh A, Riballo E et al. (2000). Radiosensitivity in Nijmegen breakage syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects. Cancer Res 60: 4881\u20134888.","journal-title":"Cancer Res"},{"key":"BF1210880_CR26","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1038\/sj.emboj.7600455","volume":"23","author":"AA Goodarzi","year":"2004","unstructured":"Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB et al. (2004). Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. EMBO J 23: 4451\u20134461.","journal-title":"EMBO J"},{"key":"BF1210880_CR27","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1095\/biolreprod.103.024950","volume":"70","author":"G Hamer","year":"2004","unstructured":"Hamer G, Kal HB, Westphal CH, Ashley T, de Rooij DG . (2004). Ataxia telangiectasia mutated expression and activation in the testis. Biol Reprod 70: 1206\u20131212.","journal-title":"Biol Reprod"},{"key":"BF1210880_CR28","doi-asserted-by":"publisher","first-page":"9152","DOI":"10.1158\/0008-5472.CAN-04-2727","volume":"64","author":"I Hickson","year":"2004","unstructured":"Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI et al. (2004). Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 64: 9152\u20139159.","journal-title":"Cancer Res"},{"key":"BF1210880_CR29","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nature00922","volume":"418","author":"KP Hopfner","year":"2002","unstructured":"Hopfner KP, Craig L, Moncalian G, Zinkel RA, Usui T, Owen BA et al. (2002). The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature 418: 562\u2013566.","journal-title":"Nature"},{"key":"BF1210880_CR30","doi-asserted-by":"publisher","first-page":"15741","DOI":"10.1074\/jbc.M513172200","volume":"281","author":"X Jiang","year":"2006","unstructured":"Jiang X, Sun Y, Chen S, Roy K, Price BD . (2006). The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem 281: 15741\u201315746.","journal-title":"J Biol Chem"},{"key":"BF1210880_CR31","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1101\/gad.1200304","volume":"18","author":"R Kitagawa","year":"2004","unstructured":"Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB . (2004). Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 18: 1423\u20131438.","journal-title":"Genes Dev"},{"key":"BF1210880_CR32","doi-asserted-by":"publisher","first-page":"9309","DOI":"10.1074\/jbc.M300003200","volume":"278","author":"S Kozlov","year":"2003","unstructured":"Kozlov S, Gueven N, Keating K, Ramsay J, Lavin MF . (2003). ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation. J Biol Chem 278: 9309\u20139317.","journal-title":"J Biol Chem"},{"key":"BF1210880_CR33","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1038\/sj.emboj.7601231","volume":"25","author":"SV Kozlov","year":"2006","unstructured":"Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF . (2006). Involvement of novel autophosphorylation sites in ATM activation. EMBO J 25: 3504\u20133514.","journal-title":"EMBO J"},{"key":"BF1210880_CR34","doi-asserted-by":"publisher","first-page":"5927","DOI":"10.1038\/sj.onc.1206691","volume":"22","author":"DR Krause","year":"2003","unstructured":"Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou B, Nigg EA et al. (2003). Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene 22: 5927\u20135937.","journal-title":"Oncogene"},{"key":"BF1210880_CR35","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1126\/science.1091496","volume":"304","author":"JH Lee","year":"2004","unstructured":"Lee JH, Paull TT . (2004). Direct activation of the ATM protein kinase by the Mre11\/Rad50\/Nbs1 complex. Science 304: 93\u201396.","journal-title":"Science"},{"key":"BF1210880_CR36","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1126\/science.1108297","volume":"308","author":"JH Lee","year":"2005","unstructured":"Lee JH, Paull TT . (2005). ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308: 551\u2013554.","journal-title":"Science"},{"key":"BF1210880_CR37","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/35007091","volume":"404","author":"DS Lim","year":"2000","unstructured":"Lim DS, Kim ST, Xu B, Maser RS, Lin JH et al. (2000). ATM phosphorylates p95\/Nbs1 in an S-phase checkpoint pathway. Nature 404: 613\u2013617.","journal-title":"Nature"},{"key":"BF1210880_CR38","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.cell.2007.05.052","volume":"129","author":"R Linding","year":"2007","unstructured":"Linding R, Jensen LJ, Ostheimer GJ, van Vugt MA, J\u00f8rgensen C, Miron IM et al. (2007). Systematic discovery on in vivo phosphorylation networks. Cell 129: 1415\u20131426.","journal-title":"Cell"},{"key":"BF1210880_CR39","doi-asserted-by":"publisher","first-page":"R994","DOI":"10.1016\/j.cub.2004.11.020","volume":"14","author":"M Lisby","year":"2004","unstructured":"Lisby M, Rothstein R . (2004). DNA repair: keeping it together. Curr Biol 14: R994\u2013R996.","journal-title":"Curr Biol"},{"key":"BF1210880_CR40","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.0105-2896.2004.00170.x","volume":"200","author":"F Livak","year":"2004","unstructured":"Livak F . (2004). In vitro and in vivo studies on the generation of the primary T-cell receptor repertoire. Immunol Rev 200: 23\u201335.","journal-title":"Immunol Rev"},{"key":"BF1210880_CR41","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.molcel.2005.11.025","volume":"21","author":"Z Lou","year":"2006","unstructured":"Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A et al. (2006). MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 21: 187\u2013200.","journal-title":"Mol Cell"},{"key":"BF1210880_CR42","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.dnarep.2006.01.006","volume":"5","author":"J Lukas","year":"2006","unstructured":"Lukas J, Bohr VA, Halazonetis TD . (2006). Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium. DNA Repair 5: 591\u2013601.","journal-title":"DNA Repair"},{"key":"BF1210880_CR43","doi-asserted-by":"publisher","first-page":"6087","DOI":"10.1128\/MCB.17.10.6087","volume":"17","author":"RS Maser","year":"1997","unstructured":"Maser RS, Monsen KJ, Nelms BE, Petrini JH . (1997). hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol 17: 6087\u20136096.","journal-title":"Mol Cell Biol"},{"key":"BF1210880_CR44","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1126\/science.1140321","volume":"316","author":"S Matsouka","year":"2007","unstructured":"Matsouka S, Ballif BA, Smogorzewska A, McDonald III ER, Hurov KE, Luo J et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160\u20131166.","journal-title":"Science"},{"key":"BF1210880_CR45","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ymeth.2005.03.010","volume":"36","author":"KJ McManus","year":"2005","unstructured":"McManus KJ, Hendzel MJ . (2005). Using quantitative imaging microscopy to define the target substrate specificities of histone post-translational-modifying enzymes. Methods 36: 351\u2013361.","journal-title":"Methods"},{"key":"BF1210880_CR46","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.0105-2896.2004.00162.x","volume":"200","author":"K Meek","year":"2004","unstructured":"Meek K, Gupta S, Ramsden DA, Lees-Miller SP . (2004). The DNA-dependent protein kinase: the director at the end. Immunol Rev 200: 132\u2013141.","journal-title":"Immunol Rev"},{"key":"BF1210880_CR47","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1128\/MCB.21.1.281-288.2001","volume":"21","author":"OK Mirzoeva","year":"2001","unstructured":"Mirzoeva OK, Petrini JH . (2001). DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol 21: 281\u2013288.","journal-title":"Mol Cell Biol"},{"key":"BF1210880_CR48","first-page":"207","volume":"1","author":"OK Mirzoeva","year":"2003","unstructured":"Mirzoeva OK, Petrini JH . (2003). DNA replication-dependent nuclear dynamics of the Mre11 complex. Mol Cancer Res 1: 207\u2013218.","journal-title":"Mol Cancer Res"},{"key":"BF1210880_CR49","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/nature03927","volume":"437","author":"F Moreno-Herrero","year":"2005","unstructured":"Moreno-Herrero F, de Jager M, Dekker NH, Kanaar R, Wyman C, Dekker C . (2005). Mesoscale conformational changes in the DNA-repair complex Rad50\/Mre11\/Nbs1 upon binding DNA. Nature 437: 440\u2013443.","journal-title":"Nature"},{"key":"BF1210880_CR50","doi-asserted-by":"publisher","first-page":"9346","DOI":"10.1074\/jbc.M513265200","volume":"281","author":"JS Myers","year":"2006","unstructured":"Myers JS, Cortez D . (2006). Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 281: 9346\u20139350.","journal-title":"J Biol Chem"},{"key":"BF1210880_CR51","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/978-1-4615-5355-7_5","volume":"452","author":"K Nelms","year":"1998","unstructured":"Nelms K, Huang H, Ryan J, Keegan A, Paul WE . (1998). Interleukin-4 receptor signalling mechanisms and their biological significance. Adv Exp Med Biol 452: 37\u201343.","journal-title":"Adv Exp Med Biol"},{"key":"BF1210880_CR52","doi-asserted-by":"publisher","first-page":"10017","DOI":"10.1073\/pnas.0602436103","volume":"103","author":"KE Orii","year":"2006","unstructured":"Orii KE, Lee Y, Kondo N, McKinnon PJ . (2006). Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci USA 103: 10017\u201310022.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210880_CR53","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/S1097-2765(00)80097-0","volume":"1","author":"TT Paull","year":"1998","unstructured":"Paull TT, Gellert M . (1998). The 3 to 5 exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks. Mol Cell 1: 969\u2013979.","journal-title":"Mol Cell"},{"key":"BF1210880_CR54","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1101\/gad.13.10.1276","volume":"13","author":"TT Paull","year":"1999","unstructured":"Paull TT, Gellert M . (1999). Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11\/Rad50 complex. Genes Dev 13: 1276\u20131288.","journal-title":"Genes Dev"},{"key":"BF1210880_CR55","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.dnarep.2007.02.015","volume":"6","author":"RD Paulsen","year":"2007","unstructured":"Paulsen RD, Cimprich KA . (2007). The ATR pathway: fine-tuning the fork. DNA Repair 6: 953\u2013966.","journal-title":"DNA Repair"},{"key":"BF1210880_CR56","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature05112","volume":"443","author":"M Pellegrini","year":"2006","unstructured":"Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L et al. (2006). Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature 443: 222\u2013225.","journal-title":"Nature"},{"key":"BF1210880_CR57","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1158\/1541-7786.203.2.4","volume":"2","author":"JT Powers","year":"2004","unstructured":"Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG . (2004). E2F1 uses the ATM signalling pathway to induce p53 and Chk2 phosphorylation and apoptosis. Mol Cancer Res 2: 203\u2013214.","journal-title":"Mol Cancer Res"},{"key":"BF1210880_CR58","doi-asserted-by":"publisher","first-page":"31124","DOI":"10.1074\/jbc.M103866200","volume":"276","author":"E Riballo","year":"2001","unstructured":"Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA et al. (2001). Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity. J Biol Chem 276: 31124\u201333132.","journal-title":"J Biol Chem"},{"key":"BF1210880_CR59","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.molcel.2004.10.029","volume":"16","author":"E Riballo","year":"2004","unstructured":"Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ et al. (2004). A pathway of double-strand break rejoining dependent upon ATM, Artemis and proteins locating to gamma-H2AX foci. Mol Cell 16: 715\u2013724.","journal-title":"Mol Cell"},{"key":"BF1210880_CR60","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/sj.emboj.7600914","volume":"25","author":"A Rodrigue","year":"2006","unstructured":"Rodrigue A, Lafrance M, Gauthier MC, McDonald D, Hendzel M, West SC et al. (2006). Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J 25: 222\u2013231.","journal-title":"EMBO J"},{"key":"BF1210880_CR61","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1080\/13556210412331292596","volume":"9","author":"KC Schroff","year":"2004","unstructured":"Schroff KC, Cowen MS, Koch S, Spanagel R . (2004). Strain-specific responses of inbred mice to ethanol following food shortage. Addict Biol 9: 265\u2013271.","journal-title":"Addict Biol"},{"key":"BF1210880_CR62","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/35020123","volume":"406","author":"X Shen","year":"2000","unstructured":"Shen X, Mizuguchi G, Hamiche A, Wu C . (2000). A chromatin remodelling complex involved in transcription and DNA processing. Nature 406: 541\u2013544.","journal-title":"Nature"},{"key":"BF1210880_CR63","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.tibs.2006.05.004","volume":"31","author":"Y Shiloh","year":"2006","unstructured":"Shiloh Y . (2006). The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci 31: 402\u2013410.","journal-title":"Trends Biochem Sci"},{"key":"BF1210880_CR64","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/nature00863","volume":"418","author":"TH Stracker","year":"2002","unstructured":"Stracker TH, Carson CT, Weitzman MD . (2002). Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature 418: 348\u2013352.","journal-title":"Nature"},{"key":"BF1210880_CR65","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nature05740","volume":"447","author":"TH Stracker","year":"2007","unstructured":"Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH . (2007). The carboxy terminus of NBS1 is required for induction of apoptosis by the Mre11 complex. Nature 447: 218\u2013221.","journal-title":"Nature"},{"key":"BF1210880_CR66","doi-asserted-by":"publisher","first-page":"13182","DOI":"10.1073\/pnas.0504211102","volume":"102","author":"Y Sun","year":"2005","unstructured":"Sun Y, Jiang X, Chen S, Fernandes N, Price BD . (2005). A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci USA 102: 13182\u201313187.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210880_CR67","doi-asserted-by":"publisher","first-page":"35458","DOI":"10.1074\/jbc.M105482200","volume":"276","author":"KM Trujillo","year":"2001","unstructured":"Trujillo KM, Sung P . (2001). DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50 Mre11 complex. J Biol Chem 276: 35458\u201335464.","journal-title":"J Biol Chem"},{"key":"BF1210880_CR68","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nature04148","volume":"438","author":"T Tsukuda","year":"2005","unstructured":"Tsukuda T, Fleming AB, Nickoloff JA, Osley MA . (2005). Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae. Nature 438: 379\u2013383.","journal-title":"Nature"},{"key":"BF1210880_CR69","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1016\/j.yexcr.2006.06.013","volume":"312","author":"T Usui","year":"2006","unstructured":"Usui T, Petrini JH, Morales M . (2006). Rad50S alleles of the Mre11 complex: questions answered and questions raised. Exp Cell Res 312: 2694\u20132699.","journal-title":"Exp Cell Res"},{"key":"BF1210880_CR70","doi-asserted-by":"publisher","first-page":"5612","DOI":"10.1093\/emboj\/cdg541","volume":"22","author":"T Uziel","year":"2003","unstructured":"Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittleman L, Shiloh Y . (2003). Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 22: 5612\u20135621.","journal-title":"EMBO J"},{"key":"BF1210880_CR71","doi-asserted-by":"publisher","first-page":"5792","DOI":"10.1038\/sj.onc.1206679","volume":"22","author":"K Valerie","year":"2003","unstructured":"Valerie K, Povirk LF . (2003). Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22: 5792\u20135812.","journal-title":"Oncogene"},{"key":"BF1210880_CR72","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/sj.embor.embor925","volume":"4","author":"M van den Bosch","year":"2003","unstructured":"van den Bosch M, Ronan T, Lowndes BN . (2003). The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep 4: 844\u2013849.","journal-title":"EMBO Rep"},{"key":"BF1210880_CR73","doi-asserted-by":"publisher","first-page":"103","DOI":"10.2307\/3583517","volume":"8","author":"JF Ward","year":"1985","unstructured":"Ward JF . (1985). Biochemistry of DNA lesions. Radiat Res Suppl 8: 103\u2013111.","journal-title":"Radiat Res Suppl"},{"key":"BF1210880_CR74","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1101\/gad.970702","volume":"16","author":"PT Yazdi","year":"2002","unstructured":"Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J . (2002). SMC1 is a downstream effector in the ATM\/NBS1 branch of the human S-phase checkpoint. Genes Dev 16: 571\u2013582.","journal-title":"Genes Dev"},{"key":"BF1210880_CR75","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0300-483X(02)00220-2","volume":"177","author":"SS Yuan","year":"2002","unstructured":"Yuan SS, Chang HL, Hou MF, Chan TF, Kao YH, Wu YC et al. (2002). Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism. Toxicology 177: 123\u2013130.","journal-title":"Toxicology"},{"key":"BF1210880_CR76","doi-asserted-by":"publisher","first-page":"9910","DOI":"10.1128\/MCB.25.22.9910-9919.2005","volume":"25","author":"J Zhang","year":"2005","unstructured":"Zhang J, Bao S, Furumai R, Kucera KS, Ali A, Dean NM et al. (2005). Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Mol Cell Biol 25: 9910\u20139919.","journal-title":"Mol Cell Biol"},{"key":"BF1210880_CR77","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/35044005","volume":"408","author":"BB Zhou","year":"2000","unstructured":"Zhou BB, Elledge SJ . (2000). The DNA damage response: putting checkpoints in perspective. Nature 408: 433\u2013439.","journal-title":"Nature"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1210880.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1210880","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1210880.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T06:44:15Z","timestamp":1684133055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1210880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,10]]},"references-count":77,"journal-issue":{"issue":"56","published-print":{"date-parts":[[2007,12,10]]}},"alternative-id":["BF1210880"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1210880","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,10]]},"assertion":[{"value":"10 December 2007","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}