{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:47:03Z","timestamp":1789001223787,"version":"build-2803163510"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1038\/ajg.2010.216","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T14:35:21Z","timestamp":1274798121000},"page":"2186-2194","source":"Crossref","is-referenced-by-count":339,"title":["Baseline Ductopenia and Treatment Response Predict Long-Term Histological Progression in Primary Biliary Cirrhosis"],"prefix":"10.14309","volume":"105","author":[{"given":"Teru","family":"Kumagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Guindi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Arenovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Abdalian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Coltescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny E","family":"Heathcote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon M","family":"Hirschfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20210210","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis.","volume":"353","author":"Kaplan","year":"2005","journal-title":"N Engl J Med"},{"key":"R2-14-20210210","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/hep.510230108","article-title":"Time course of histological progression in primary biliary cirrhosis.","volume":"23","author":"Locke","year":"1996","journal-title":"Hepatology"},{"key":"R3-14-20210210","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1053\/gast.1996.v110.pm8613058","article-title":"Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis.","volume":"110","author":"Lindor","year":"1996","journal-title":"Gastroenterology"},{"key":"R4-14-20210210","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1056\/NEJM199105303242204","article-title":"A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group.","volume":"324","author":"Poupon","year":"1991","journal-title":"N Engl J Med"},{"key":"R5-14-20210210","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/0016-5085(94)90021-3","article-title":"Ursodeoxycholic acid in the treatment of primary biliary cirrhosis.","volume":"106","author":"Lindor","year":"1994","journal-title":"Gastroenterology"},{"key":"R6-14-20210210","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/hep.1840190512","article-title":"The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis.","volume":"19","author":"Heathcote","year":"1994","journal-title":"Hepatology"},{"key":"R7-14-20210210","first-page":"759","article-title":"A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis.","volume":"22","author":"Combes","year":"1995","journal-title":"Hepatology"},{"key":"R8-14-20210210","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0016-5085(97)70183-5","article-title":"Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis.","volume":"113","author":"Poupon","year":"1997","journal-title":"Gastroenterology"},{"key":"R9-14-20210210","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1053\/j.gastro.2008.07.019","article-title":"Portal hypertension and primary biliary cirrhosis: effect of long-term ursodeoxycholic acid treatment.","volume":"135","author":"Huet","year":"2008","journal-title":"Gastroenterology"},{"key":"R10-14-20210210","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0168-8278(03)00192-2","article-title":"Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis.","volume":"39","author":"Poupon","year":"2003","journal-title":"J Hepatol"},{"key":"R11-14-20210210","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","article-title":"Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid.","volume":"130","author":"Pares","year":"2006","journal-title":"Gastroenterology"},{"key":"R12-14-20210210","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.22428","article-title":"Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis.","volume":"48","author":"Corpechot","year":"2008","journal-title":"Hepatology"},{"key":"R13-14-20210210","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/gast.2002.31880","article-title":"Primary biliary cirrhosis: incidence and predictive factors of cirrhosis development in ursodiol-treated patients.","volume":"122","author":"Corpechot","year":"2002","journal-title":"Gastroenterology"},{"key":"R14-14-20210210","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/j.gastro.2004.11.009","article-title":"The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis.","volume":"128","author":"Corpechot","year":"2005","journal-title":"Gastroenterology"},{"key":"R15-14-20210210","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1053\/he.2000.5984","article-title":"Management of primary biliary cirrhosis. The American Association for the Study of Liver Diseases practice guidelines.","volume":"31","author":"Heathcote","year":"2000","journal-title":"Hepatology"},{"key":"R16-14-20210210","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.510280203","article-title":"Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: clinical features and response to therapy.","volume":"28","author":"Chazouilleres","year":"1998","journal-title":"Hepatology"},{"key":"R17-14-20210210","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/hep.1840200120","article-title":"Primary biliary cirrhosis: prediction of short-term survival based on repeated patient visits.","volume":"20","author":"Murtaugh","year":"1994","journal-title":"Hepatology"},{"key":"R18-14-20210210","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2559.2006.02537.x","article-title":"Proposal of a new staging and grading system of the liver for primary biliary cirrhosis.","volume":"49","author":"Hiramatsu","year":"2006","journal-title":"Histopathology"},{"key":"R19-14-20210210","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0168-8278(88)80482-3","article-title":"Idiopathic adulthood ductopenia. A cause of chronic cholestatic liver disease and biliary cirrhosis.","volume":"7","author":"Ludwig","year":"1988","journal-title":"J Hepatol"},{"key":"R20-14-20210210","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/hep.22458","article-title":"Surveillance for hepatocellular carcinoma in patients with primary biliary cirrhosis.","volume":"48","author":"Silveira","year":"2008","journal-title":"Hepatology"},{"key":"R21-14-20210210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.1840100102","article-title":"Prognosis in primary biliary cirrhosis: model for decision making.","volume":"10","author":"Dickson","year":"1989","journal-title":"Hepatology"},{"key":"R22-14-20210210","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/MEG.0b013e328277594a","article-title":"Incidence, prevalence and clinical course of primary biliary cirrhosis in a Spanish community.","volume":"19","author":"Pla","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R23-14-20210210","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1053\/j.gastro.2009.01.003","article-title":", for the Dutch PBC study group. Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid.","volume":"136","author":"Kuiper","year":"2009","journal-title":"Gastroenterology"},{"key":"R24-14-20210210","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/0016-5085(85)90001-0","article-title":"Sequential and diagnostic features in primary biliary cirrhosis based on serial histologic study in 209 patients.","volume":"88","author":"Portmann","year":"1985","journal-title":"Gastroenterology"},{"key":"R25-14-20210210","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0016-5085(99)70351-3","article-title":"Oral budesonide and ursodeoxycholic acid for treatment of primary biliary cirrhosis: results of a prospective double-blind trial.","volume":"117","author":"Leuschner","year":"1999","journal-title":"Gastroenterology"},{"key":"R26-14-20210210","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jhep.2005.10.017","article-title":"Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome.","volume":"44","author":"Chazouilleres","year":"2006","journal-title":"J Hepatol"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2010216.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2010216","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2010216.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201010000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:34:02Z","timestamp":1786541642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201010000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2010.216","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}