{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:29:52Z","timestamp":1786544992270,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1038\/ajg.2010.272","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T12:09:27Z","timestamp":1283515767000},"page":"1944-1946","source":"Crossref","is-referenced-by-count":13,"title":["Bringing GERD Management up to PAR-2"],"prefix":"10.14309","volume":"105","author":[{"given":"Rhonda F","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210210","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1111\/j.1572-0241.2006.00723.x","article-title":"The burden of gastrointestinal and liver diseases, 2006.","volume":"101","author":"Shaheen","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"R2-6-20210210","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1111\/j.1572-0241.2001.05260.x","article-title":"The role of pepsin in acid injury to esophageal epithelium.","volume":"96","author":"Tobey","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"R3-6-20210210","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/MCG.0b013e31815d0628","article-title":"Pathophysiology of gastroesophageal reflux disease.","volume":"42","author":"Orlando","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"R4-6-20210210","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0016-5085(70)80004-X","article-title":"Histological consequences of gastroesophageal reflux in man.","volume":"58","author":"Ismail-Beigi","year":"1970","journal-title":"Gastroenterology"},{"key":"R5-6-20210210","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0889-8553(21)00661-0","article-title":"Histology in the diagnosis of reflux esophagitis.","volume":"19","author":"Frierson","year":"1990","journal-title":"Gastroenterol Clin North Am"},{"key":"R6-6-20210210","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1053\/j.gastro.2009.07.055","article-title":"Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury.","volume":"137","author":"Souza","year":"2009","journal-title":"Gastroenterology"},{"key":"R7-6-20210210","doi-asserted-by":"crossref","first-page":"L566","DOI":"10.1152\/ajplung.00233.2002","article-title":"Pathophysiological roles of interleukin-8CXCL8 in pulmonary diseases.","volume":"284","author":"Mukaida","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"R8-6-20210210","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1136\/gut.50.4.451","article-title":"Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants.","volume":"50","author":"Fitzgerald","year":"2002","journal-title":"Gut"},{"key":"R9-6-20210210","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1572-0241.2003.07303.x","article-title":"Elevated levels of chemokines in esophageal mucosa of patients with reflux esophagitis.","volume":"98","author":"Isomoto","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"R10-6-20210210","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1001\/archsurg.142.6.554","article-title":"Reduction of interleukin 8 gene expression in reflux esophagitis and Barretts esophagus with antireflux surgery.","volume":"142","author":"Oh","year":"2007","journal-title":"Arch Surg"},{"key":"R11-6-20210210","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1572-0241.2004.04110.x","article-title":"Enhanced expression of interleukin-8 and activation of nuclear factor kappa-B in endoscopy-negative gastroesophageal reflux disease.","volume":"99","author":"Isomoto","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"R12-6-20210210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2036.2006.00049.x","article-title":"Molecular mechanisms involved in interleukin-8 production by normal human oesophageal epithelial cells.","volume":"24","author":"Yoshida","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"R13-6-20210210","first-page":"71","article-title":"Cytokine-induced neutrophil accumulation in the pathogenesis of acute reflux esophagitis in rats.","volume":"16","author":"Yamaguchi","year":"2005","journal-title":"Int J Mol Med"},{"key":"R14-6-20210210","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/72247","article-title":"Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.","volume":"6","author":"Steinhoff","year":"2000","journal-title":"Nat Med"},{"key":"R15-6-20210210","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1080\/00365520801942141","article-title":"Proteinase-activated receptor 2 (PAR-2) in gastrointestinal and pancreatic pathophysiology, inflammation and neoplasia.","volume":"43","author":"Soreide","year":"2008","journal-title":"Scand J Gastroenterol"},{"key":"R17-6-20210210","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/89945","article-title":"Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway.","volume":"7","author":"Vergnolle","year":"2001","journal-title":"Nat Med"},{"key":"R18-6-20210210","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1053\/gast.2002.32387","article-title":"Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats.","volume":"122","author":"Coelho","year":"2002","journal-title":"Gastroenterology"},{"key":"R19-6-20210210","first-page":"335","article-title":"Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells.","volume":"19","author":"Yoshida","year":"2007","journal-title":"Int J Mol Med"},{"key":"R21-6-20210210","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s10620-006-8024-9","article-title":"Trypsin activity and bile acid concentrations in the esophagus after distal gastrectomy.","volume":"51","author":"Kono","year":"2006","journal-title":"Dig Dis Sci"},{"key":"R22-6-20210210","first-page":"190","article-title":"The pH dependence of lipase and trypsin activity.","volume":"48","author":"Gerber","year":"1988","journal-title":"Dtsch Z Verdau Stoffwechselkr"},{"key":"R23-6-20210210","doi-asserted-by":"crossref","first-page":"31936","DOI":"10.1074\/jbc.M506338200","article-title":"Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.","volume":"280","author":"Jacob","year":"2005","journal-title":"J Biol Chem"},{"key":"R24-6-20210210","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.4049\/jimmunol.181.8.5702","article-title":"Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration.","volume":"181","author":"Chin","year":"2008","journal-title":"J Immunol"},{"key":"R25-6-20210210","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1053\/gast.2002.32978","article-title":"The burden of selected digestive diseases in the United States.","volume":"122","author":"Sandler","year":"2002","journal-title":"Gastroenterology"},{"key":"R26-6-20210210","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1053\/j.gastro.2008.08.044","article-title":"American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease.","volume":"135","author":"Kahrilas","year":"2008","journal-title":"Gastroenterology"},{"key":"R27-6-20210210","first-page":"2110","article-title":"Prolonged ambulatory pH monitoring in patients with persistent gastroesophageal reflux disease symptoms: testing while on therapy identifies the need for more aggressive anti-reflux therapy.","volume":"91","author":"Katzka","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"R28-6-20210210","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1007\/s10620-009-0951-9","article-title":"Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications.","volume":"54","author":"Kedika","year":"2009","journal-title":"Dig Dis Sci"},{"key":"R29-6-20210210","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.cgh.2009.08.003","article-title":"Surgery for gastroesophageal reflux disease: esophageal impedance to progress?","volume":"7","author":"Spechler","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"Suppl 2","key":"R30-6-20210210","first-page":"S33","article-title":"Proton pump inhibitor failure-what are the therapeutic options?","volume":"104","author":"Fass","year":"2009","journal-title":"Am J Gastroenterol"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2010272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2010272","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2010272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201009000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:34:33Z","timestamp":1786541673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201009000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2010.272","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}