{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:21:26Z","timestamp":1786548086755,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1038\/ajg.2010.334","type":"journal-article","created":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T11:20:07Z","timestamp":1282648807000},"page":"2430-2436","source":"Crossref","is-referenced-by-count":59,"title":["Cardiovascular and Gastrointestinal Outcomes in Clopidogrel Users on Proton Pump Inhibitors: Results of a Large Dutch Cohort Study"],"prefix":"10.14309","volume":"105","author":[{"given":"Ofke S","family":"van Boxel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn G H","family":"van Oijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs P","family":"Hagenaars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J P M","family":"Smout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D","family":"Siersema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20-20210210","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.324.7329.71","article-title":"Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients.","volume":"324","year":"2002","journal-title":"BMJ"},{"key":"R3-20-20210210","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1001\/jama.282.21.2058","article-title":"Oral anticoagulant therapy in patients with coronary artery disease: a meta-analysis.","volume":"282","author":"Anand","year":"1999","journal-title":"JAMA"},{"key":"R4-20-20210210","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1056\/NEJMoa050522","article-title":"Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation.","volume":"352","author":"Sabatine","year":"2005","journal-title":"N Engl J Med"},{"key":"R5-20-20210210","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1056\/NEJMoa0808227","article-title":"Genetic determinants of response to clopidogrel and cardiovascular events.","volume":"360","author":"Simon","year":"2009","journal-title":"N Engl J Med"},{"key":"R6-20-20210210","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1093\/eurheartj\/ehn416","article-title":"WF, Bax J, Betriu A et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology.","volume":"29","year":"2008","journal-title":"Eur Heart J"},{"key":"R7-20-20210210","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jacc.2007.10.001","article-title":"2007 focused update of the ACCAHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of CardiologyAmerican Heart Association Task Force on Practice Guidelines.","volume":"51","author":"Antman","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"R8-20-20210210","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1161\/CIRCULATIONAHA.108.191087","article-title":"ACCFACGAHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents.","volume":"118","author":"Bhatt","year":"2008","journal-title":"Circulation"},{"key":"R9-20-20210210","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1160\/TH08-12-0808","article-title":"Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel.","volume":"101","author":"Sibbing","year":"2009","journal-title":"Thromb Haemost"},{"key":"R10-20-20210210","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1111\/j.1538-7836.2006.02162.x","article-title":"Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin.","volume":"4","author":"Gilard","year":"2006","journal-title":"J Thromb Haemost"},{"key":"R11-20-20210210","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jacc.2008.05.053","article-title":"Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors.","volume":"52","author":"Pezalla","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 3","key":"R12-20-20210210","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2036.1999.00022.x","article-title":"Review article: cytochrome P450 and the metabolism of proton pump inhibitorsemphasis on rabeprazole.","volume":"13","author":"Ishizaki","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"R13-20-20210210","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jacc.2007.06.064","article-title":"Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.","volume":"51","author":"Gilard","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"R14-20-20210210","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1001\/jama.2009.261","article-title":"Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome.","volume":"301","author":"Ho","year":"2009","journal-title":"JAMA"},{"key":"R15-20-20210210","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1503\/cmaj.082001","article-title":"A population-based study of the drug interaction between proton pump inhibitors and clopidogrel.","volume":"180","author":"Juurlink","year":"2009","journal-title":"CMAJ"},{"key":"R16-20-20210210","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0140-6736(09)61525-7","article-title":"Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials.","volume":"374","author":"ODonoghue","year":"2009","journal-title":"Lancet"},{"key":"R18-20-20210210","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1365-2036.2010.04247.x","article-title":"Meta-analysis: the effects of proton pump inhibitors on cardiovascular events and mortality in patients receiving clopidogrel.","volume":"31","author":"Kwok","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"R23-20-20210210","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1365-2036.2003.01769.x","article-title":"M, Moreno-Elola-Olaso C, Rey E et al. Symptoms of gastro-oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population.","volume":"19","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"R24-20-20210210","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1365-2036.2005.02426.x","article-title":"Risk factors for gastro-oesophageal reflux disease symptoms: a community study.","volume":"21","author":"Mohammed","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"R25-20-20210210","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7326\/0003-4819-143-3-200508020-00006","article-title":"Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications.","volume":"143","author":"Hampel","year":"2005","journal-title":"Ann Intern Med"},{"key":"R26-20-20210210","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1056\/NEJMoa042087","article-title":"Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.","volume":"352","author":"Chan","year":"2005","journal-title":"N Engl J Med"},{"key":"R27-20-20210210","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1572-0241.2006.01062.x","article-title":"Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants.","volume":"102","author":"Lanas","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"R28-20-20210210","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/sim.4780100409","article-title":"Channeling bias in the interpretation of drug effects.","volume":"10","author":"Petri","year":"1991","journal-title":"Stat Med"},{"key":"R29-20-20210210","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(96)09457-3","article-title":"A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee.","volume":"348","year":"1996","journal-title":"Lancet"},{"key":"R30-20-20210210","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa060989","article-title":"Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events.","volume":"354","author":"Bhatt","year":"2006","journal-title":"N Engl J Med"}],"updated-by":[{"DOI":"10.1038\/ajg.2010.391","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2010,11,3]],"date-time":"2010-11-03T00:00:00Z","timestamp":1288742400000}}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2010334.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2010334","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2010334.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201011000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:21:36Z","timestamp":1786544496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201011000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2010.334","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}