{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:52:39Z","timestamp":1786553559296,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1038\/ajg.2011.102","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T10:40:45Z","timestamp":1301395245000},"page":"1039-1047","source":"Crossref","is-referenced-by-count":122,"title":["Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease"],"prefix":"10.14309","volume":"106","author":[{"given":"Biljana","family":"Jovov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelia A","family":"Tobey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorka","family":"Djukic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid L M","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy C","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-7-20210210","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1572-0241.2003.04018.x","article-title":"Dilated intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium.","volume":"99","author":"Tobey","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"R3-7-20210210","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1172\/JCI110246","article-title":"Pathophysiology of acute acid injury in rabbit esophageal epithelium.","volume":"68","author":"Orlando","year":"1981","journal-title":"J Clin Invest"},{"key":"R5-7-20210210","first-page":"198","article-title":"Morphologic alterations in early acid-induced epithelial injury of the rabbit esophagus.","volume":"45","author":"Carney","year":"1981","journal-title":"Lab Invest"},{"key":"R7-7-20210210","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0016-5085(82)80069-3","article-title":"Esophageal potential difference measurements in esophageal disease.","volume":"83","author":"Orlando","year":"1982","journal-title":"Gastroenterology"},{"key":"R9-7-20210210","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1007\/s10620-005-2867-3","article-title":"Acid challenge to the human esophageal mucosa: effects on epithelial architecture in health and disease.","volume":"50","author":"Bove","year":"2005","journal-title":"Dig Dis Sci"},{"key":"R10-7-20210210","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1136\/gut.2007.141804","article-title":"Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces.","volume":"57","author":"Farre","year":"2008","journal-title":"Gut"},{"key":"R11-7-20210210","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1053\/gast.1996.v111.pm8898633","article-title":"Dilated intercellular spaces: a morphological feature of acid refluxdamaged human esophageal epithelium.","volume":"111","author":"Tobey","year":"1996","journal-title":"Gastroenterology"},{"key":"R12-7-20210210","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s004280050032","article-title":"Altered intercellular glycoconjugates and dilated intercellular spaces of esophageal epithelium in reflux disease.","volume":"436","author":"Solcia","year":"2000","journal-title":"Virchows Arch"},{"key":"R13-7-20210210","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1365-2036.2003.01713.x","article-title":"Dilated intercellular spaces as a marker of oesophageal damage: comparative results in gastro-oesophageal reflux disease with or without bile reflux.","volume":"18","author":"Calabrese","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"R14-7-20210210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000048833","article-title":"Dilated intercellular spaces as markers of reflux disease: histology, semiquantitative score and morphometry upon light microscopy.","volume":"64","author":"Villanacci","year":"2001","journal-title":"Digestion"},{"key":"R15-7-20210210","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/01.mpg.0000215312.78664.b9","article-title":"Dilated intercellular spaces: a major morphological feature of esophagitis.","volume":"42","author":"Ravelli","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R16-7-20210210","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1097\/00029330-200807020-00010","article-title":"Dilated intercellular spaces in gastroesophageal reflux disease patients and the changes of intercellular spaces after omeprazole treatment.","volume":"121","author":"Xue","year":"2008","journal-title":"Chin Med J (Engl)"},{"key":"R17-7-20210210","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1572-0241.2005.40476.x","article-title":"Reversibility of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment.","volume":"100","author":"Calabrese","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"R18-7-20210210","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bbamem.2007.07.012","article-title":"Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.","volume":"1778","author":"Hartsock","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"R19-7-20210210","doi-asserted-by":"crossref","first-page":"G1042","DOI":"10.1152\/ajpgi.00387.2003","article-title":"Calcium-switch technique and junctional permeability in native rabbit esophageal epithelium.","volume":"286","author":"Tobey","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R20-7-20210210","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1136\/gut.35.10.1343","article-title":"Cell adhesion molecules in oesophageal epithelium.","volume":"35","author":"Dobson","year":"1994","journal-title":"Gut"},{"key":"R21-7-20210210","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1007\/s10620-010-1215-4","article-title":"Lateral cell membranes and shunt resistance in rabbit esophageal epithelium.","volume":"55","author":"Tobey","year":"2010","journal-title":"Dig Dis Sci"},{"key":"R22-7-20210210","doi-asserted-by":"crossref","first-page":"G264","DOI":"10.1152\/ajpgi.00047.2007","article-title":"Electrical parameters and ion species for active transport in human esophageal stratified squamous epithelium and Barretts specialized columnar epithelium.","volume":"293","author":"Tobey","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R23-7-20210210","doi-asserted-by":"crossref","first-page":"G1106","DOI":"10.1152\/ajpgi.00158.2007","article-title":"Claudin-18: a dominant tight junction protein in Barretts esophagus and likely contributor to its acid resistance.","volume":"293","author":"Jovov","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R24-7-20210210","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0925-4773(02)00090-4","article-title":"E-cadherin is a survival factor for the lactating mouse mammary gland.","volume":"115","author":"Boussadia","year":"2002","journal-title":"Mech Dev"},{"key":"R25-7-20210210","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium.","volume":"106","author":"Rock","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"R26-7-20210210","doi-asserted-by":"crossref","first-page":"16626","DOI":"10.1073\/pnas.0808649105","article-title":"Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development.","volume":"105","author":"Que","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"R27-7-20210210","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1242\/dev.034629","article-title":"Multiple roles for Sox2 in the developing and adult mouse trachea.","volume":"136","author":"Que","year":"2009","journal-title":"Development"},{"key":"R28-7-20210210","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.modgep.2005.12.001","article-title":"Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns.","volume":"6","author":"Holmes","year":"2006","journal-title":"Gene Expr Patterns"},{"key":"R29-7-20210210","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1365-2133.1995.tb00720.x","article-title":"Soluble E-cadherin: a novel cutaneous disease marker.","volume":"132","author":"Matsuyoshi","year":"1995","journal-title":"Br J Dermatol"},{"key":"R30-7-20210210","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.2174\/138161209788682442","article-title":"ADAM10 as a therapeutic target for cancer and inflammation.","volume":"15","author":"Crawford","year":"2009","journal-title":"Curr Pharm Des"},{"key":"R31-7-20210210","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s10585-007-9104-8","article-title":"Soluble cadherins as cancer biomarkers.","volume":"24","author":"De Wever","year":"2007","journal-title":"Clin Exp Metastasis"},{"key":"R32-7-20210210","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/gut.48.6.808","article-title":"Soluble E-cadherin is a valid prognostic marker in gastric carcinoma.","volume":"48","author":"Chan","year":"2001","journal-title":"Gut"},{"key":"R33-7-20210210","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1002\/ijc.22219","article-title":"Soluble N-cadherin in human biological fluids.","volume":"119","author":"Derycke","year":"2006","journal-title":"Int J Cancer"},{"key":"R35-7-20210210","doi-asserted-by":"crossref","first-page":"9182","DOI":"10.1073\/pnas.0500918102","article-title":"ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.","volume":"102","author":"Maretzky","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"R36-7-20210210","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1038\/sj.jid.5701242","article-title":"ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.","volume":"128","author":"Maretzky","year":"2008","journal-title":"J Invest Dermatol"},{"key":"R37-7-20210210","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.trsl.2006.11.006","article-title":"Cleavage of E-cadherin: a mechanism for disruption of the intestinal epithelial barrier by Candida albicans.","volume":"149","author":"Frank","year":"2007","journal-title":"Transl Res"},{"key":"R38-7-20210210","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/emboj\/21.8.1948","article-title":"A presenilin-1gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.","volume":"21","author":"Marambaud","year":"2002","journal-title":"EMBO J"},{"key":"R39-7-20210210","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1074\/jbc.M006102200","article-title":"Cleavage and shedding of E-cadherin after induction of apoptosis.","volume":"276","author":"Steinhusen","year":"2001","journal-title":"J Biol Chem"},{"key":"R40-7-20210210","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1038\/sj.jid.5700865","article-title":"Tight junctionsadherens junctions: basic structure and function.","volume":"127","author":"Niessen","year":"2007","journal-title":"J Invest Dermatol"},{"key":"R41-7-20210210","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1053\/j.gastro.2004.08.014","article-title":"The pathogenesis of heartburn in nonerosive reflux disease: a unifying hypothesis.","volume":"128","author":"Barlow","year":"2005","journal-title":"Gastroenterology"},{"key":"R44-7-20210210","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1365-2559.2008.03187.x","article-title":"Comparison of histological parameters for the diagnosis of eosinophilic oesophagitis versus gastro-oesophageal reflux disease on oesophageal biopsy material.","volume":"53","author":"Mueller","year":"2008","journal-title":"Histopathology"},{"key":"R45-7-20210210","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1572-0241.2007.01594.x","article-title":"High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults.","volume":"103","author":"Rodrigo","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"R46-7-20210210","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1572-0241.2007.01179.x","article-title":"Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis.","volume":"102","author":"Spechler","year":"2007","journal-title":"Am J Gastroenterol"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2011102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2011102","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2011102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201106000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:35:51Z","timestamp":1786541751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201106000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2011.102","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}