{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:05:16Z","timestamp":1792670716148,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/ajg.2011.456","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T15:32:53Z","timestamp":1329233573000},"page":"418-427","source":"Crossref","is-referenced-by-count":121,"title":["Development of Ascites in Compensated Cirrhosis With Severe Portal Hypertension Treated With \u03b2-Blockers"],"prefix":"10.14309","volume":"107","author":[{"given":"Virginia","family":"Hern\u00e1ndez-Gea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Aracil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Colomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Garupera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Poca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Torras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Mi\u00f1ana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Guarner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e0ndid","family":"Villanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20210210","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","article-title":"Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies.","volume":"44","author":"DAmico","year":"2006","journal-title":"J Hepatol"},{"key":"R2-18-20210210","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/hep.23478","article-title":"Now there are many (stages) where before there was one: In search of pathophysiological classification of cirrhosis.","volume":"51","author":"Garcia-Tsao","year":"2010","journal-title":"Hepatology"},{"key":"R3-18-20210210","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1056\/NEJMoa044456","article-title":", for the Portal Hypertension Collaborative Group. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis.","volume":"353","author":"Groszmann","year":"2005","journal-title":"N Engl J Med"},{"key":"R4-18-20210210","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1053\/j.gastro.2007.05.024","article-title":"Hepatic venous pressure gardient predicts clinical descompensation in patients with compensated cirrhosis.","volume":"133","author":"Ripoll","year":"2007","journal-title":"Gastroenterology"},{"key":"R5-18-20210210","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1053\/j.gastro.2006.09.013","article-title":"Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review.","volume":"131","author":"DAmico","year":"2006","journal-title":"Gastroenterology"},{"key":"R6-18-20210210","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hep.1840070124","article-title":"Compensated cirrhosis: natural history and prognostic factors.","volume":"7","author":"Gines","year":"1987","journal-title":"Hepatology"},{"key":"R7-18-20210210","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/hep.21176","article-title":"The natural history of compensated cirrhosis due to hepatitis C virus: a 17-year cohort study of 214 patients.","volume":"43","author":"Sangiovanni","year":"2006","journal-title":"Hepatology"},{"key":"R8-18-20210210","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/hep.21103","article-title":"Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C.","volume":"43","author":"Sanyal","year":"2006","journal-title":"Hepatology"},{"key":"R9-18-20210210","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jhep.2004.01.017","article-title":"Maintenance of hemodynamic response to treatment for portal hypertension and influence on complications of cirrhosis.","volume":"40","author":"Villanueva","year":"2004","journal-title":"J Hepatol"},{"key":"R10-18-20210210","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1053\/jhep.2003.50133","article-title":"Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis.","volume":"37","author":"Abraldes","year":"2003","journal-title":"Hepatology"},{"key":"R11-18-20210210","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0016-5107(81)73224-3","article-title":"Prediction of variceal hemorrhage by esophageal endoscopy.","volume":"27","author":"Beppu","year":"1981","journal-title":"Gastrointest Endosc"},{"key":"R12-18-20210210","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1056\/NEJM198810133191505","article-title":"Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices.","volume":"319","year":"1988","journal-title":"N Engl J Med"},{"key":"R13-18-20210210","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/hep.510230122","article-title":"Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis.","volume":"23","author":"Arroyo","year":"1996","journal-title":"Hepatology"},{"key":"R14-18-20210210","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jhep.2005.05.009","article-title":"Evolving consensus in portal hypertension. Report of the Baveno III consensus workshop on methodology of diagnosis and therapy in portal hypertension.","volume":"43","author":"De Franchis","year":"2005","journal-title":"J Hepatol"},{"key":"R15-18-20210210","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1572-0241.2006.00453.x","article-title":"Pharmacological reduction of portal pressure and long-term risk of first variceal bleeding in patients with cirrhosis.","volume":"101","author":"Turnes","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"R16-18-20210210","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/0016-5085(95)90145-0","article-title":"Pattern of sodium handling and its consequences in patients with preascitic cirrhosis.","volume":"108","author":"Wong","year":"1995","journal-title":"Gastroenterology"},{"key":"R17-18-20210210","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/gut.49.6.847","article-title":"Sodium homeostasis in the chronic sodium loading in pre-ascitic cirrhosis.","volume":"49","author":"Wong","year":"2001","journal-title":"Gut"},{"key":"R18-18-20210210","doi-asserted-by":"crossref","first-page":"154","DOI":"10.7861\/clinmedicine.3-2-154","article-title":"The natural history and management of hepatorenal disorders: from pre-ascites to hepatorenal syndrome.","volume":"3","author":"Blendis","year":"2003","journal-title":"Clin Med"},{"key":"R19-18-20210210","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0140-6736(95)91740-3","article-title":"Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosis.","volume":"346","author":"Feu","year":"1995","journal-title":"Lancet"},{"key":"R20-18-20210210","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1056\/NEJMoa003223","article-title":"Endoscopic ligation compared with combined treatment with nadolol plus isosorbide mononitrate to prevent recurrent variceal bleeding.","volume":"345","author":"Villanueva","year":"2001","journal-title":"N Engl J Med"},{"key":"R21-18-20210210","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1053\/j.gastro.2009.03.048","article-title":"Acute hemodynamic response to beta-blockers and prediction of long-term outcome in primary prophylaxis of variceal bleeding.","volume":"137","author":"Villanueva","year":"2009","journal-title":"Gastroenterology"},{"key":"R22-18-20210210","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jhep.2009.04.015","article-title":"Prognostic value of acute hemodynamic response to i.v. propranolol in patients with cirrhosis and portal hypertension.","volume":"51","author":"La Mura","year":"2009","journal-title":"J Hepatol"},{"key":"R23-18-20210210","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/hep.21907","article-title":", and the Practice Guidelines Committee of the American Association for the Study of Liver Diseases, the Practice Parameters Committee of the American College of Gastroenterology. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis.","volume":"46","author":"Garcia-Tsao","year":"2007","journal-title":"Hepatology"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2011456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2011456","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2011456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201203000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:24:55Z","timestamp":1786544695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201203000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2011.456","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}