{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:44:20Z","timestamp":1791200660490,"version":"4.2.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1038\/ajg.2012.466","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T08:02:49Z","timestamp":1359446569000},"page":"376-382","source":"Crossref","is-referenced-by-count":139,"title":["Weight Loss and Reduction in Gastroesophageal Reflux. A Prospective Population-Based Cohort Study: The HUNT Study"],"prefix":"10.14309","volume":"108","author":[{"given":"Eivind","family":"Ness-Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lindam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Lagergren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Hveem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20210210","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.2004.051821","article-title":"Epidemiology of gastro-oesophageal reflux disease: a systematic review.","volume":"54","author":"Dent","year":"2005","journal-title":"Gut"},{"key":"R2-16-20210210","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1136\/gutjnl-2011-300715","article-title":"Changes in prevalence, incidence and spontaneous loss of gastro-oesophageal reflux symptoms: a prospective population-based cohort study, the HUNT study.","volume":"61","author":"Ness-Jensen","year":"2012","journal-title":"Gut"},{"key":"R3-16-20210210","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1111\/j.1365-2036.2006.02952.x","article-title":"Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general populationthe Kalixanda study.","volume":"23","author":"Ronkainen","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"R4-16-20210210","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1572-0241.2005.00343.x","article-title":"Gastroesophageal reflux symptoms and well-being in a random sample of the general population of a Swedish community.","volume":"101","author":"Wiklund","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"R5-16-20210210","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/j.1365-2036.2010.04471.x","article-title":"Meta-analysis: the association of oesophageal adenocarcinoma with symptoms of gastro-oesophageal reflux.","volume":"32","author":"Rubenstein","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"R6-16-20210210","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1056\/NEJM199903183401101","article-title":"Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma.","volume":"340","author":"Lagergren","year":"1999","journal-title":"N Engl J Med"},{"key":"R7-16-20210210","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0140-6736(90)90287-F","article-title":"Symptoms in gastro-oesophageal reflux disease.","volume":"335","author":"Klauser","year":"1990","journal-title":"Lancet"},{"key":"R9-16-20210210","first-page":"i","article-title":"Obesity: preventing and managing the global epidemic. Report of a WHO consultation.","volume":"894","year":"2000","journal-title":"World Health Organization Tech Rep Ser"},{"key":"R10-16-20210210","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/jama.290.1.66","article-title":"Obesity and estrogen as risk factors for gastroesophageal reflux symptoms.","volume":"290","author":"Nilsson","year":"2003","journal-title":"JAMA"},{"key":"R11-16-20210210","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7326\/0003-4819-143-3-200508020-00006","article-title":"Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications.","volume":"143","author":"Hampel","year":"2005","journal-title":"Ann Intern Med"},{"key":"R12-16-20210210","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1111\/j.1572-0241.2006.00849.x","article-title":"Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis.","volume":"101","author":"Corley","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"R13-16-20210210","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1001\/jama.288.14.1723","article-title":"Prevalence and trends in obesity among US adults, 1999-2000.","volume":"288","author":"Flegal","year":"2002","journal-title":"JAMA"},{"key":"R14-16-20210210","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.2009.2014","article-title":"Prevalence and trends in obesity among US adults, 1999-2008.","volume":"303","author":"Flegal","year":"2010","journal-title":"JAMA"},{"key":"R19-16-20210210","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/gut.45.2.172","article-title":"Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification.","volume":"45","author":"Lundell","year":"1999","journal-title":"Gut"},{"key":"R20-16-20210210","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1080\/003655202761020498","article-title":"Gastro-oesophageal reflux in obese subjects: influence of overweight, weight loss and chronic gastric balloon distension.","volume":"37","author":"Mathus-Vliegen","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"R21-16-20210210","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000075525","article-title":"Los function and obesity: the impact of untreated obesity, weight loss, and chronic gastric balloon distension.","volume":"68","author":"Mathus-Vliegen","year":"2003","journal-title":"Digestion"},{"key":"R23-16-20210210","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/003655299750026326","article-title":"Weight loss has an independent beneficial effect on symptoms of gastro-oesophageal reflux in patients who are overweight.","volume":"34","author":"Fraser-Moodie","year":"1999","journal-title":"Scand J Gastroenterol"},{"key":"R24-16-20210210","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s10620-005-9027-7","article-title":"A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms.","volume":"51","author":"Austin","year":"2006","journal-title":"Dig Dis Sci"},{"key":"R25-16-20210210","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1056\/NEJMoa054391","article-title":"Body-mass index and symptoms of gastroesophageal reflux in women.","volume":"354","author":"Jacobson","year":"2006","journal-title":"N Engl J Med"},{"key":"R26-16-20210210","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3109\/00365529609036885","article-title":"Gastroesophageal reflux in obese patients is not reduced by weight reduction.","volume":"31","author":"Kjellin","year":"1996","journal-title":"Scand J Gastroenterol"},{"key":"R27-16-20210210","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/j.1365-2982.2006.00816.x","article-title":"Relationship between upper gastrointestinal symptoms and changes in body weight in a population-based cohort.","volume":"18","author":"Cremonini","year":"2006","journal-title":"Neurogastroenterol Motil"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2012466.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2012466","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2012466.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201303000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:45:12Z","timestamp":1786542312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201303000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2012.466","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}