{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:08:23Z","timestamp":1790842103606,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1038\/ajg.2012.52","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T13:48:17Z","timestamp":1335275297000},"page":"770-778","source":"Crossref","is-referenced-by-count":84,"title":["Cancer Risks for Relatives of Patients With Serrated Polyposis"],"prefix":"10.14309","volume":"107","author":[{"given":"Aung Ko","family":"Win","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhiannon J","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Sweet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy L","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"de la Chapelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M","family":"McKeone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Clendenning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally-Ann","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Pavluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Nagler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L","family":"Hopper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Gattas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Goldblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme K","family":"Suthers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry D","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Woodall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Greening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Gallinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melyssa","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Perrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael O","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Rosty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne P","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-22-20210210","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1053\/gast.1996.v110.pm8608884","article-title":"Serrated adenomatous polyposis in humans.","volume":"110","author":"Torlakovic","year":"1996","journal-title":"Gastroenterology"},{"key":"R3-22-20210210","first-page":"A4","article-title":"Hyperplastic polyposis: prevalence and cancer risk.","volume":"48","author":"Lockett","year":"2010","journal-title":"Gut"},{"key":"R4-22-20210210","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1136\/gut.2009.185884","article-title":"Increased colorectal cancer risk during follow-up in patients with hyperplastic polyposis syndrome: a multicentre cohort study.","volume":"59","author":"Boparai","year":"2010","journal-title":"Gut"},{"key":"R5-22-20210210","doi-asserted-by":"crossref","first-page":"e11636","DOI":"10.1371\/journal.pone.0011636","article-title":"Risk factors for colorectal cancer in patients with multiple serrated polyps: a cross-sectional case series from genetics clinics.","volume":"5","author":"Buchanan","year":"2010","journal-title":"PLoS ONE"},{"key":"R6-22-20210210","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/path.2187","article-title":"Molecular classification and genetic pathways in hyperplastic polyposis syndrome.","volume":"212","author":"Carvajal-Carmona","year":"2007","journal-title":"J Pathol"},{"key":"R7-22-20210210","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1007\/s10350-004-0709-6","article-title":"Hyperplastic polyposis and the risk of colorectal cancer.","volume":"47","author":"Hyman","year":"2004","journal-title":"Dis Colon Rectum"},{"key":"R8-22-20210210","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1111\/j.1572-0241.2004.30178.x","article-title":"Management of Portuguese patients with hyperplastic polyposis and screening of at-risk first-degree relatives: a contribution for future guidelines based on a clinical study.","volume":"99","author":"Lage","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"R9-22-20210210","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00000478-200102000-00005","article-title":"Hyperplastic polyposis: association with colorectal cancer.","volume":"25","author":"Leggett","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"R10-22-20210210","first-page":"U2827","article-title":"Hyperplastic polyposis in the New Zealand population: a condition associated with increased colorectal cancer risk and European ancestry.","volume":"120","author":"Yeoman","year":"2007","journal-title":"N Z Med J"},{"key":"R11-22-20210210","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/DCR.0b013e3181fd4c15","article-title":"Defining phenotypes and cancer risk in hyperplastic polyposis syndrome.","volume":"54","author":"Kalady","year":"2011","journal-title":"Dis Colon Rectum"},{"key":"R12-22-20210210","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00384-010-0907-8","article-title":"Phenotypic diversity in patients with multiple serrated polyps: a genetics clinic study.","volume":"25","author":"Buchanan","year":"2010","journal-title":"Int J Colorectal Dis"},{"key":"R13-22-20210210","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2006.03.046","article-title":"Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH.","volume":"131","author":"Chow","year":"2006","journal-title":"Gastroenterology"},{"key":"R14-22-20210210","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1111\/j.1572-0241.2004.30021.x","article-title":"Phenotypic characteristics and risk of cancer development in hyperplastic polyposis: case series and literature review.","volume":"99","author":"Ferrandez","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"R15-22-20210210","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2559.1980.tb02909.x","article-title":"Metaplastic polyps and polyposis of the colorectum.","volume":"4","author":"Williams","year":"1980","journal-title":"Histopathology"},{"key":"R16-22-20210210","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1136\/gut.2009.200741","article-title":"Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome.","volume":"59","author":"Boparai","year":"2010","journal-title":"Gut"},{"key":"R17-22-20210210","first-page":"81s","article-title":"Clinical diagnosis and management of hereditary colorectal cancer syndromes.","volume":"18","author":"Vasen","year":"2000","journal-title":"J Clin Oncol"},{"key":"R18-22-20210210","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/hmg\/10.7.721","article-title":"The ABC of APC.","volume":"10","author":"Fearnhead","year":"2001","journal-title":"Hum Mol Genet"},{"key":"R19-22-20210210","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/DCR.0b013e3181b5450c","article-title":"Is the phenotype mixed or mistaken? Hereditary nonpolyposis colorectal cancer and hyperplastic polyposis syndrome.","volume":"52","author":"Jarrar","year":"2009","journal-title":"Dis Colon Rectum"},{"key":"R20-22-20210210","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1158\/1055-9965.EPI-06-0359","article-title":"Somatic BRAF-V600E mutations in familial colorectal cancer.","volume":"15","author":"Vandrovcova","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R21-22-20210210","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1158\/1055-9965.EPI-07-0648","article-title":"Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer.","volume":"16","author":"Newcomb","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R22-22-20210210","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ncponc0248","article-title":"Serrated adenoma of the colorectum and the DNA-methylator phenotype.","volume":"2","author":"Jass","year":"2005","journal-title":"Nat Clin Pract Oncol"},{"key":"R24-22-20210210","first-page":"25","article-title":"Jackknife estimation.","volume":"4","author":"Gould","year":"1995","journal-title":"Stata Technical Bulletin"},{"key":"R28-22-20210210","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.cgh.2007.04.025","article-title":"A familial component to human rectal cancer, independent of colon cancer risk.","volume":"5","author":"Maul","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R29-22-20210210","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1158\/1055-9965.EPI-10-0055","article-title":"Increased cancer predisposition in family members of colorectal cancer patients harboring the p. V600E BRAF mutation: a population-based study.","volume":"19","author":"Wish","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R31-22-20210210","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10689-007-9166-4","article-title":"Pancreatic cancer and the FAMMM syndrome.","volume":"7","author":"Lynch","year":"2008","journal-title":"Fam Cancer"},{"key":"R32-22-20210210","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.yasu.2010.05.011","article-title":"Update on familial pancreatic cancer.","volume":"44","author":"Hruban","year":"2010","journal-title":"Adv Surg"},{"key":"R33-22-20210210","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/jnci\/djp466","article-title":"Importance of age of onset in pancreatic cancer kindreds.","volume":"102","author":"Brune","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"R34-22-20210210","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1159\/000320068","article-title":"Epidemiology of pancreatic cancer: an update.","volume":"28","author":"Maisonneuve","year":"2010","journal-title":"Dig Dis"},{"key":"R35-22-20210210","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/MCG.0b013e318207f3cf","article-title":"Risk factors for sessile serrated adenomas.","volume":"45","author":"Anderson","year":"2011","journal-title":"J Clin Gastroenterol"},{"key":"R36-22-20210210","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S1542-3565(04)00244-7","article-title":"Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach.","volume":"2","author":"Canto","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R37-22-20210210","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1136\/gut.2007.126870","article-title":"Serrated pathway colorectal cancer in the population: genetic consideration.","volume":"56","author":"Young","year":"2007","journal-title":"Gut"},{"key":"R39-22-20210210","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/ijc.25870","article-title":"Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer.","volume":"129","author":"Win","year":"2011","journal-title":"Int J Cancer"},{"key":"R40-22-20210210","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1136\/gut.2010.223826","article-title":"Estimates of familial risks from family data are biased when ascertainment of families is not independent of family history.","volume":"60","author":"Win","year":"2011","journal-title":"Gut"},{"key":"R41-22-20210210","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1365-2036.2010.04344.x","article-title":"Who needs colonoscopy to identify colorectal cancer? Bowel symptoms do not add substantially to age and other medical history.","volume":"32","author":"Adelstein","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"R42-22-20210210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1471-230X-11-65","article-title":"Most bowel cancer symptoms do not indicate colorectal cancer and polyps: a systematic review.","volume":"11","author":"Adelstein","year":"2011","journal-title":"BMC Gastroenterol"},{"key":"R43-22-20210210","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1463-1318.2009.01898.x","article-title":"Family history? The forgotten question in high-risk colorectal cancer patients.","volume":"11","author":"Foo","year":"2009","journal-title":"Colorectal Dis"},{"key":"R44-22-20210210","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1463-1318.2010.02219.x","article-title":"Importance of family history in colorectal cancer clinical practice.","volume":"12","author":"Perea","year":"2010","journal-title":"Colorectal Dis"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg201252.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg201252","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg201252.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201205000-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:25:11Z","timestamp":1786544711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201205000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2012.52","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}