{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:42:58Z","timestamp":1786545778697,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Gastroenterology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1038\/ajg.2013.169","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T07:57:39Z","timestamp":1370937459000},"page":"1566-1574","source":"Crossref","is-referenced-by-count":83,"title":["Efficacy of Pharmacological Therapies for the Treatment of Opioid-Induced Constipation: Systematic Review and Meta-Analysis"],"prefix":"10.14309","volume":"108","author":[{"given":"Alexander C","family":"Ford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren M","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S","family":"Schoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20190617","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/ajg.2011.164","volume":"106","author":"Suares","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"R2-9-20190617","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1572-0241.2003.07465.x","volume":"98","author":"Talley","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"R3-9-20190617","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0016-5085(88)90673-7","volume":"94","author":"Kaufman","year":"1988","journal-title":"Gastroenterology"},{"key":"R4-9-20190617","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1365-2036.2008.03689.x","volume":"27","author":"Cook","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"R5-9-20190617","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1526-4637.2008.00495.x","volume":"10","author":"Bell","year":"2009","journal-title":"Pain Med"},{"key":"R6-9-20190617","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5055\/jom.2009.0014","volume":"5","author":"Bell","year":"2009","journal-title":"J Opioid Manag"},{"key":"R9-9-20190617","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jpain.2010.11.008","volume":"12","author":"Michna","year":"2011","journal-title":"J Pain"},{"key":"R10-9-20190617","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1517\/14656560902796798","volume":"10","author":"Lowenstein","year":"2009","journal-title":"Expert Opin Pharmacother"},{"key":"R11-9-20190617","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jpain.2010.06.012","volume":"12","author":"Jansen","year":"2011","journal-title":"J Pain"},{"key":"R12-9-20190617","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/gut.2010.227132","volume":"60","author":"Ford","year":"2011","journal-title":"Gut"},{"key":"R14-9-20190617","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"R15-9-20190617","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"Higgins","year":"2003","journal-title":"Br Med J"},{"key":"R16-9-20190617","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"Egger","year":"1997","journal-title":"Br Med J"},{"key":"R17-9-20190617","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","volume":"343","author":"Sterne","year":"2011","journal-title":"Br Med J"},{"key":"R18-9-20190617","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1001\/jama.283.3.367","volume":"283","author":"Yuan","year":"2000","journal-title":"JAMA"},{"key":"R19-9-20190617","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1056\/NEJMoa0707377","volume":"358","author":"Thomas","year":"2008","journal-title":"N Engl J Med"},{"key":"R20-9-20190617","first-page":"39","volume":"7","author":"Slatkin","year":"2009","journal-title":"J Support Oncol"},{"key":"R21-9-20190617","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jhm.943","volume":"7","author":"Anissian","year":"2012","journal-title":"J Hosp Med"},{"key":"R23-9-20190617","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0885-3924(01)00369-4","volume":"23","author":"Liu","year":"2002","journal-title":"J Pain Symptom Manage"},{"key":"R24-9-20190617","first-page":"56","volume":"13","author":"Meissner","year":"2009","journal-title":"J Pain"},{"key":"R25-9-20190617","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1185\/03007990802584454","volume":"24","author":"Simpson","year":"2008","journal-title":"Curr Med Res Opin"},{"key":"R26-9-20190617","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jpain.2004.12.001","volume":"6","author":"Paulson","year":"2005","journal-title":"J Pain"},{"key":"R27-9-20190617","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.pain.2007.11.008","volume":"137","author":"Webster","year":"2008","journal-title":"Pain"},{"key":"R28-9-20190617","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jpain.2010.06.013","volume":"12","author":"Irving","year":"2011","journal-title":"J Pain"},{"key":"R31-9-20190617","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1007\/s10620-010-1229-y","volume":"55","author":"Sloots","year":"2010","journal-title":"Dig Dis Sci"},{"key":"R32-9-20190617","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1007\/s10620-009-1068-x","volume":"55","author":"Barish","year":"2010","journal-title":"Dig Dis Sci"},{"key":"R33-9-20190617","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/j.1365-2036.2007.03320.x","volume":"25","author":"Johanson","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"R34-9-20190617","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1572-0241.2007.01524.x","volume":"103","author":"Johanson","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"R35-9-20190617","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/bmj.323.7303.42","volume":"323","author":"Juni","year":"2001","journal-title":"Br Med J"},{"key":"R36-9-20190617","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3111\/13696998.2012.665279","volume":"15","author":"Dunlop","year":"2012","journal-title":"J Med Econ"},{"key":"R37-9-20190617","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cgh.2011.08.008","volume":"9","author":"Dorn","year":"2011","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2013169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2013169","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2013169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201310000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:46:26Z","timestamp":1786542386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201310000-00009"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":31,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1038\/ajg.2013.169","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}