{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:29:34Z","timestamp":1788470974838,"version":"build-2803163510"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1038\/ajg.2013.97","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T07:59:30Z","timestamp":1365494370000},"page":"728-736","source":"Crossref","is-referenced-by-count":55,"title":["Dietary Proteins and Functional Gastrointestinal Disorders"],"prefix":"10.14309","volume":"108","author":[{"given":"Erica","family":"Boettcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila E","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20210210","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/gut.2007.137125","article-title":"Relationship between symptoms and ingestion of a meal in functional dyspepsia.","volume":"57","author":"Bisschops","year":"2008","journal-title":"Gut"},{"key":"R2-16-20210210","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000051878","article-title":"Food-related gastrointestinal symptoms in the irritable bowel syndrome.","volume":"63","author":"Simren","year":"2001","journal-title":"Digestion"},{"key":"R3-16-20210210","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/00075197-200111000-00013","article-title":"Nutritional issues in irritable bowel syndrome.","volume":"4","author":"Dunlop","year":"2001","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"R4-16-20210210","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.gtc.2010.12.012","article-title":"Food: the forgotten factor in the irritable bowel syndrome.","volume":"40","author":"Eswaran","year":"2011","journal-title":"Gastroenterol Clin North Am"},{"key":"R5-16-20210210","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1572-0241.2004.04003.x","article-title":"Diet, food intake, and disturbed physiology in the pathogenesis of symptoms in functional dyspepsia.","volume":"99","author":"Feinle-Bisset","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"R6-16-20210210","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/sj.ejcn.1602367","article-title":"Perceived food intolerance in subjects with irritable bowel syndromeetiology, prevalence and consequences.","volume":"60","author":"Monsbakken","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"R7-16-20210210","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.10.007","article-title":"Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel.","volume":"126","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"R8-16-20210210","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3390\/nu3050574","article-title":"Dietary proteins as determinants of metabolic and physiologic functions of the gastrointestinal tract.","volume":"3","author":"Jahan-Mihan","year":"2011","journal-title":"Nutrients"},{"key":"R9-16-20210210","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/0115426503018006461","article-title":"Gut immunology and the differential response to feeding and starvation.","volume":"18","author":"Jabbar","year":"2003","journal-title":"Nutr Clin Pract"},{"key":"R10-16-20210210","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2010.10.008","article-title":"Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report.","volume":"126","author":"Boyce","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"R11-16-20210210","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1053\/j.gastro.2004.08.015","article-title":"Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives.","volume":"128","author":"Bischoff","year":"2005","journal-title":"Gastroenterology"},{"key":"R12-16-20210210","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1053\/j.gastro.2006.10.004","article-title":"American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease.","volume":"131","author":"Rostom","year":"2006","journal-title":"Gastroenterology"},{"key":"R13-16-20210210","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1741-7015-10-13","article-title":"Spectrum of gluten-related disorders: consensus on new nomenclature and classification.","volume":"10","author":"Sapone","year":"2012","journal-title":"BMC Med"},{"key":"R14-16-20210210","doi-asserted-by":"crossref","first-page":"ITC5","DOI":"10.7326\/0003-4819-154-9-201105030-01005","article-title":"In the clinic. Celiac disease.","volume":"154","author":"Crowe","year":"2011","journal-title":"Ann Intern Med"},{"key":"R15-16-20210210","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000323930","article-title":"Environmental and lifestyle influences on disorders of the large and small intestine: implications for treatment.","volume":"29","author":"Hall","year":"2011","journal-title":"Dig Dis"},{"key":"R16-16-20210210","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrgastro.2010.2","article-title":"Mortality in celiac disease.","volume":"7","author":"Biagi","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"R17-16-20210210","first-page":"105","article-title":"Gluten-free diet and quality of life in patients with screen-detected celiac disease.","volume":"5","author":"Mustalahti","year":"2002","journal-title":"Eff Clin Pract"},{"key":"R18-16-20210210","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/gut.49.2.169","article-title":"Coeliac disease in the father affects the newborn.","volume":"49","author":"Ludvigsson","year":"2001","journal-title":"Gut"},{"key":"R19-16-20210210","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms.","volume":"62","author":"Ludvigsson","year":"2012","journal-title":"Gut"},{"key":"R20-16-20210210","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12016-010-8223-1","article-title":"Cutting-edge issues in celiac disease and in gluten intolerance.","volume":"42","author":"Bizzaro","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"R21-16-20210210","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1159\/000321196","article-title":"Occurrence of nonceliac gluten sensitivity in patients with allergic disease.","volume":"155","author":"Massari","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"key":"R22-16-20210210","doi-asserted-by":"crossref","first-page":"309","DOI":"10.7326\/0003-4819-156-4-201202210-00010","article-title":"Nonceliac gluten sensitivity: sense or sensibility?","volume":"156","author":"Di Sabatino","year":"2012","journal-title":"Ann Intern Med"},{"key":"R23-16-20210210","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/MCG.0b013e3182372541","article-title":"Serological tests in gluten sensitivity (nonceliac gluten intolerance).","volume":"46","author":"Volta","year":"2012","journal-title":"J Clin Gastroenterology"},{"key":"R24-16-20210210","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1038\/ajg.2009.188","article-title":"Between celiac disease and irritable bowel syndrome: the no mans land of gluten sensitivity.","volume":"104","author":"Verdu","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"R25-16-20210210","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1053\/j.gastro.2012.01.020","article-title":"Irritable bowel syndrome and gluten sensitivity without celiac disease: separating the wheat from the chaff.","volume":"142","author":"Ferch","year":"2012","journal-title":"Gastroenterology"},{"key":"R26-16-20210210","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1053\/j.gastro.2008.11.040","article-title":"Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study.","volume":"136","author":"Kurppa","year":"2009","journal-title":"Gastroenterology"},{"key":"R27-16-20210210","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2036.2006.02997.x","article-title":"Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease.","volume":"24","author":"Salmi","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"R28-16-20210210","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.dld.2009.04.004","article-title":"Diagnostic methods beyond conventional histology in coeliac disease diagnosis.","volume":"42","author":"Salmi","year":"2010","journal-title":"Dig Liver Dis"},{"key":"R29-16-20210210","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1023\/A:1010729207320","article-title":"Celiac disease without villous atrophy: revision of criteria called for.","volume":"46","author":"Kaukinen","year":"2001","journal-title":"Dig Dis Sci"},{"key":"R30-16-20210210","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1053\/gast.2001.29572","article-title":"Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome.","volume":"121","author":"Wahnschaffe","year":"2001","journal-title":"Gastroenterology"},{"key":"R31-16-20210210","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.cgh.2007.03.021","article-title":"Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome.","volume":"5","author":"Wahnschaffe","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R32-16-20210210","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.gastro.2006.11.039","article-title":"Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome.","volume":"132","author":"Barbara","year":"2007","journal-title":"Gastroenterology"},{"key":"R33-16-20210210","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/gut.2007.140210","article-title":"Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity.","volume":"57","author":"Gecse","year":"2008","journal-title":"Gut"},{"key":"R34-16-20210210","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/gut.2007.140806","article-title":"Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators.","volume":"58","author":"Piche","year":"2009","journal-title":"Gut"},{"key":"R35-16-20210210","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000260087","article-title":"Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease.","volume":"152","author":"Sapone","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"key":"R36-16-20210210","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1741-7015-9-23","article-title":"Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity.","volume":"9","author":"Sapone","year":"2011","journal-title":"BMC Med"},{"key":"R37-16-20210210","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/S0021-9258(17)30243-0","article-title":"Opioid peptides derived from food proteins. The exorphins.","volume":"254","author":"Zioudrou","year":"1979","journal-title":"J Biol Chem"},{"key":"R38-16-20210210","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-2000-12557","article-title":"Junctional complexes in the early mammalian embryo.","volume":"18","author":"Fleming","year":"2000","journal-title":"Semin Reprod Med"},{"key":"R39-16-20210210","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1083\/jcb.101.6.2124","article-title":"Occluding junction structure-function relationships in a cultured epithelial monolayer.","volume":"101","author":"Madara","year":"1985","journal-title":"J Cell Biol"},{"key":"R40-16-20210210","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/labinvest.3700050","article-title":"A porous defense: the leaky epithelial barrier in intestinal disease.","volume":"84","author":"Clayburgh","year":"2004","journal-title":"Lab Invest"},{"key":"R41-16-20210210","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.addr.2003.10.045","article-title":"Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins.","volume":"56","author":"Fasano","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"R42-16-20210210","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/S0140-6736(00)02169-3","article-title":"Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease.","volume":"355","author":"Fasano","year":"2000","journal-title":"Lancet"},{"key":"R43-16-20210210","first-page":"254","article-title":"Structural abnormalities of jejunal epithelial cell membranes in celiac sprue.","volume":"43","author":"Madara","year":"1980","journal-title":"Lab Invest"},{"key":"R44-16-20210210","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/physrev.00003.2008","article-title":"Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.","volume":"91","author":"Fasano","year":"2011","journal-title":"Physiol Rev"},{"key":"R45-16-20210210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.0105-2896.2005.00294.x","article-title":"Innate and adaptive immunity: the yin and yang of celiac disease.","volume":"206","author":"Jabri","year":"2005","journal-title":"Immunol Rev"},{"key":"R46-16-20210210","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/gut.52.2.218","article-title":"Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function.","volume":"52","author":"Clemente","year":"2003","journal-title":"Gut"},{"key":"R47-16-20210210","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000324456","article-title":"Lower expression of tight junction protein 1 gene and increased FOXP3 expression in the small bowel mucosa in coeliac disease and associated type 1 diabetes mellitus.","volume":"156","author":"Vorobjova","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"key":"R48-16-20210210","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/gutjnl-2011-300123","article-title":"Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease.","volume":"61","author":"Schumann","year":"2012","journal-title":"Gut"},{"key":"R49-16-20210210","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1136\/gut.34.3.354","article-title":"Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease.","volume":"34","author":"van Elburg","year":"1993","journal-title":"Gut"},{"key":"R50-16-20210210","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1572-0241.2006.00672.x","article-title":"Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes.","volume":"101","author":"Dunlop","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"R51-16-20210210","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/gut.47.6.804","article-title":"Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome.","volume":"47","author":"Spiller","year":"2000","journal-title":"Gut"},{"key":"R52-16-20210210","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/j.1365-2036.2004.02284.x","article-title":"Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario.","volume":"20","author":"Marshall","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"R53-16-20210210","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/ajg.2012.236","article-title":"Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity.","volume":"107","author":"Carroccio","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"R54-16-20210210","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/ajg.2010.487","article-title":"Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial.","volume":"106","author":"Biesiekierski","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"R55-16-20210210","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0140-6736(82)92782-9","article-title":"Food intolerance: a major factor in the pathogenesis of irritable bowel syndrome.","volume":"2","author":"Jones","year":"1982","journal-title":"Lancet"},{"key":"R56-16-20210210","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1111\/j.1572-0241.1998.00531.x","article-title":"Are adverse food reactions linked to irritable bowel syndrome?","volume":"93","author":"Niec","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"R57-16-20210210","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cgh.2009.11.010","article-title":"A cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome.","volume":"8","author":"Carroccio","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R58-16-20210210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12519-012-0332-x","article-title":"Diagnosis and management of cows milk protein allergy in infants.","volume":"8","author":"De Greef","year":"2012","journal-title":"World J Pediatr"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg201397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg201397","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg201397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201305000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:45:56Z","timestamp":1786542356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201305000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2013.97","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}