{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:58:07Z","timestamp":1786546687509,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1038\/ajg.2015.118","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T08:07:03Z","timestamp":1430208423000},"page":"857-864","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein Level Predicts Liver Fibrosis and Prognosis in Primary Biliary Cirrhosis"],"prefix":"10.14309","volume":"110","author":[{"given":"Takeji","family":"Umemura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Joshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Usami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takefumi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiharu","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20210210","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis.","volume":"353","author":"Kaplan","year":"2005","journal-title":"N Engl J Med"},{"key":"R2-18-20210210","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0140-6736(10)61965-4","article-title":"Primary biliary cirrhosis.","volume":"377","author":"Selmi","year":"2011","journal-title":"Lancet"},{"key":"R3-18-20210210","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hep.22906","article-title":"Primary biliary cirrhosis.","volume":"50","author":"Lindor","year":"2009","journal-title":"Hepatology"},{"key":"R4-18-20210210","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1053\/jhep.2000.16602","article-title":"Practices of liver biopsy in France: results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF).","volume":"32","author":"Cadranel","year":"2000","journal-title":"Hepatology"},{"key":"R5-18-20210210","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1056\/NEJM200102153440706","article-title":"Liver biopsy.","volume":"344","author":"Bravo","year":"2001","journal-title":"N Engl J Med"},{"key":"R6-18-20210210","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1053\/cgh.2003.50014","article-title":"When is liver biopsy needed in the diagnosis of primary biliary cirrhosis?","volume":"1","author":"Zein","year":"2003","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R7-18-20210210","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/srep01065","article-title":"A serum sweet-doughnut protein facilitates fibrosis evaluation and therapy assessment in patients with viral hepatitis.","volume":"3","author":"Kuno","year":"2013","journal-title":"Sci Rep"},{"key":"R8-18-20210210","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1093\/emboj\/17.6.1606","article-title":"Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.","volume":"17","author":"Sasaki","year":"1998","journal-title":"EMBO J"},{"key":"R9-18-20210210","first-page":"4530","article-title":"Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion.","volume":"56","author":"Inohara","year":"1996","journal-title":"Cancer Res"},{"key":"R10-18-20210210","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00535-014-0946-y","article-title":"A novel serum marker, glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA-M2BP), for assessing liver fibrosis.","volume":"50","author":"Toshima","year":"2014","journal-title":"J Gastroenterol"},{"key":"R12-18-20210210","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/hep.27305","article-title":"Elevated serum levels of WFA -M2BP predict the development of hepatocellular carcinoma in hepatitis C patients.","volume":"60","author":"Yamasaki","year":"2014","journal-title":"Hepatology"},{"key":"R13-18-20210210","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","article-title":"A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C.","volume":"38","author":"Wai","year":"2003","journal-title":"Hepatology"},{"key":"R14-18-20210210","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIVHCV coinfection.","volume":"43","author":"Sterling","year":"2006","journal-title":"Hepatology"},{"key":"R15-18-20210210","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1053\/jhep.2002.36128","article-title":"Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model.","volume":"36","author":"Forns","year":"2002","journal-title":"Hepatology"},{"key":"R16-18-20210210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.1840100102","article-title":"Prognosis in primary biliary cirrhosis: model for decision making.","volume":"10","author":"Dickson","year":"1989","journal-title":"Hepatology"},{"key":"R17-18-20210210","doi-asserted-by":"crossref","first-page":"e100565","DOI":"10.1371\/journal.pone.0100565","article-title":"Human leukocyte antigen class II haplotypes affect clinical characteristics and progression of type 1 autoimmune hepatitis in Japan.","volume":"9","author":"Umemura","year":"2014","journal-title":"PLoS ONE"},{"key":"R18-18-20210210","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/hep.21700","article-title":"Immunoglobin G4-hepatopathy: association of immunoglobin G4-bearing plasma cells in liver with autoimmune pancreatitis.","volume":"46","author":"Umemura","year":"2007","journal-title":"Hepatology"},{"key":"R19-18-20210210","first-page":"1257","article-title":"Primary biliary cirrhosis.","volume":"60","author":"Scheuer","year":"1967","journal-title":"Proc R Soc Med"},{"key":"R20-18-20210210","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group.","volume":"24","author":"Bedossa","year":"1996","journal-title":"Hepatology"},{"key":"R21-18-20210210","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2559.2006.02537.x","article-title":"Proposal of a new staging and grading system of the liver for primary biliary cirrhosis.","volume":"49","author":"Hiramatsu","year":"2006","journal-title":"Histopathology"},{"key":"R22-18-20210210","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/prca.201300010","article-title":"Reconstruction of a robust glycodiagnostic agent supported by multiple lectin-assisted glycan profiling.","volume":"7","author":"Kuno","year":"2013","journal-title":"Proteomics Clin Appl"},{"key":"R23-18-20210210","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"R24-18-20210210","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1478-3231.2008.01722.x","article-title":"Serological markers for monitoring disease progression in noncirrhotic primary biliary cirrhosis on ursodeoxycholic acid therapy.","volume":"28","author":"Farkkila","year":"2008","journal-title":"Liver Int"},{"key":"R25-18-20210210","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3748\/wjg.15.591","article-title":"Biochemical markers for noninvasive assessment of disease stage in patients with primary biliary cirrhosis.","volume":"15","author":"Alempijevic","year":"2009","journal-title":"World J Gastroenterol"},{"key":"R26-18-20210210","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/hep.22517","article-title":"Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay.","volume":"48","author":"Mayo","year":"2008","journal-title":"Hepatology"},{"key":"R27-18-20210210","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/hep.21151","article-title":"Assessment of biliary fibrosis by transient elastography in patients with PBC and PSC.","volume":"43","author":"Corpechot","year":"2006","journal-title":"Hepatology"},{"key":"R28-18-20210210","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2036.2007.03585.x","article-title":"Transient elastography to assess hepatic fibrosis in primary biliary cirrhosis.","volume":"27","author":"Gomez-Dominguez","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"R29-18-20210210","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/hep.25599","article-title":"Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis.","volume":"56","author":"Corpechot","year":"2012","journal-title":"Hepatology"},{"key":"R30-18-20210210","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/hep.23425","article-title":"Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations.","volume":"51","author":"Castera","year":"2010","journal-title":"Hepatology"},{"key":"R31-18-20210210","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/hep.21472","article-title":"Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis.","volume":"45","author":"Nakamura","year":"2007","journal-title":"Hepatology"},{"key":"R32-18-20210210","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.24705","article-title":"Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis.","volume":"55","author":"Umemura","year":"2012","journal-title":"Hepatology"},{"key":"R33-18-20210210","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1053\/j.gastro.2014.08.029","article-title":"Levels of alkaline phosphatase and bilirubin are surrogate endpoints of outcomes of patients with primary biliary cirrhosis - an international follow-up study.","volume":"147","author":"Lammers","year":"2014","journal-title":"Gastroenterology"},{"key":"R34-18-20210210","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","article-title":"Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid.","volume":"130","author":"Pares","year":"2006","journal-title":"Gastroenterology"},{"key":"R35-18-20210210","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.22428","article-title":"Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis.","volume":"48","author":"Corpechot","year":"2008","journal-title":"Hepatology"},{"key":"R36-18-20210210","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1053\/j.gastro.2009.01.003","article-title":"Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid.","volume":"136","author":"Kuiper","year":"2009","journal-title":"Gastroenterology"},{"key":"R37-18-20210210","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1038\/ajg.2010.216","article-title":"Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosis.","volume":"105","author":"Kumagi","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"R38-18-20210210","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.jhep.2011.02.031","article-title":"Early primary biliary cirrhosis: biochemical response to treatment and prediction of long-term outcome.","volume":"55","author":"Corpechot","year":"2011","journal-title":"J Hepatol"},{"key":"R39-18-20210210","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jhep.2014.01.029","article-title":"Optimising risk stratification in primary biliary cirrhosis: ASTplatelet ratio index predicts outcome independent of ursodeoxycholic acid response.","volume":"60","author":"Trivedi","year":"2014","journal-title":"J Hepatol"},{"key":"R40-18-20210210","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/hep.26322","article-title":"Early biochemical response to ursodeoxycholic acid and long-term prognosis of primary biliary cirrhosis: results of a 14-year cohort study.","volume":"58","author":"Zhang","year":"2013","journal-title":"Hepatology"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2015118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2015118","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2015118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201506000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:01:07Z","timestamp":1786543267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201506000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2015.118","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}