{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:00:02Z","timestamp":1792155602189,"version":"4.4.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1038\/ajg.2015.139","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T10:28:34Z","timestamp":1432636114000},"page":"993-999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["Long-Term Prognostic Significance of Persisting Histological Activity Despite Biochemical Remission in Autoimmune Hepatitis"],"prefix":"10.14309","volume":"110","author":[{"given":"Harpreet K","family":"Dhaliwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S","family":"Hoeroldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha K","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"McFarlane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C E","family":"Underwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A","family":"Karajeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot","family":"Gleeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20210210","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/oxfordjournals.qjmed.a067264","article-title":"Controlled prospective trial of corticosteroid therapy in active chronic hepatitis.","volume":"40","author":"Cook","year":"1971","journal-title":"Q J Med"},{"key":"R2-14-20210210","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(73)92125-9","article-title":"Controlled trial of prednisone and azathioprine in active chronic hepatitis.","volume":"1","author":"Murray-Lyon","year":"1973","journal-title":"Lancet"},{"key":"R3-14-20210210","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0016-5085(19)33223-8","article-title":"Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis.","volume":"63","author":"Soloway","year":"1972","journal-title":"Gastroenterology"},{"key":"R4-14-20210210","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-2001-13708","article-title":"Long-term management and prognosis of autoimmune hepatitis (AIH): a single center experience.","volume":"39","author":"Kanzler","year":"2001","journal-title":"Z Gastroenterol"},{"key":"R5-14-20210210","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1053\/gast.1996.v110.pm8608895","article-title":"Prognosis of histological cirrhosis in type 1 autoimmune hepatitis.","volume":"110","author":"Roberts","year":"1996","journal-title":"Gastroenterology"},{"key":"R6-14-20210210","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1053\/j.gastro.2011.02.065","article-title":"Long-term outcomes of patients treated for autoimmune hepatitis at non-tertiary care centers.","volume":"140","author":"Hoeroldt","year":"2011","journal-title":"Gastroenterology"},{"key":"R7-14-20210210","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/00365520903555861","article-title":"Characteristics and long-term outcome of patients with autoimmune hepatitis related to the initial treatment response.","volume":"45","author":"Werner","year":"2010","journal-title":"Scand J Gastroenterol"},{"key":"R8-14-20210210","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jhep.2005.06.006","article-title":"Persistent normalization of serum alanine aminotransferase levels improves the prognosis of type 1 autoimmune hepatitis.","volume":"43","author":"Miyake","year":"2005","journal-title":"J Hepatol"},{"key":"R9-14-20210210","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1572-0241.2007.01153.x","article-title":"Improving the end point of corticosteroid therapy in type 1 autoimmune hepatitis to reduce the frequency of relapse.","volume":"102","author":"Montano-Loza","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"R10-14-20210210","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1136\/gut.2010.235259","article-title":"British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis.","volume":"60","author":"Gleeson","year":"2011","journal-title":"Gut"},{"key":"R11-14-20210210","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/hep.23584","article-title":"Diagnosis and management of autoimmune hepatitis.","volume":"51","author":"Manns","year":"2010","journal-title":"Hepatology"},{"key":"R12-14-20210210","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/MCG.0b013e318154af74","article-title":"Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis.","volume":"42","author":"Luth","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"R13-14-20210210","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0016-5085(81)90126-8","article-title":"Laboratory assessment of severe chronic active liver disease during and after corticosteroid therapy: correlation of serum transaminase and gamma globulin levels with histologic features.","volume":"80","author":"Czaja","year":"1981","journal-title":"Gastroenterology"},{"key":"R14-14-20210210","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/hep.20235","article-title":"Progressive fibrosis during corticosteroid therapy of autoimmune hepatitis.","volume":"39","author":"Czaja","year":"2004","journal-title":"Hepatology"},{"key":"R15-14-20210210","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jhep.2004.01.009","article-title":"Decreased fibrosis during corticosteroid therapy of autoimmune hepatitis.","volume":"40","author":"Czaja","year":"2004","journal-title":"J Hepatol"},{"key":"R16-14-20210210","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0168-8278(05)80005-4","article-title":"Survival and histological resolution of fibrosis in patients with autoimmune chronic active hepatitis.","volume":"18","author":"Schvarcz","year":"1993","journal-title":"J Hepatol"},{"key":"R17-14-20210210","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis.","volume":"31","author":"Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"R18-14-20210210","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis.","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"R19-14-20210210","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1037\/h0026256","article-title":"Weighted kappa: nominal scale agreement provision for scaled disagreement or partial credit.","volume":"70","author":"Cohen","year":"1968","journal-title":"Psychol Bull"},{"key":"R20-14-20210210","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data.","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"R23-14-20210210","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/j.1572-0241.2004.30457.x","article-title":"Factors predicting relapse and poor outcome in type I autoimmune hepatitis: role of cirrhosis development, patterns of transaminases during remission and plasma cell activity in the liver biopsy.","volume":"99","author":"Verma","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"R24-14-20210210","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.cgh.2008.08.018","article-title":"Effects of serum aspartate aminotransferase levels in patients with autoimmune hepatitis influence disease course and outcome.","volume":"6","author":"Al-Chalabi","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R25-14-20210210","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJM199510123331502","article-title":"Azathioprine for long-term maintenance of remission in autoimmune hepatitis.","volume":"333","author":"Johnson","year":"1995","journal-title":"N Engl J Med"},{"key":"R26-14-20210210","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/hep.1840080414","article-title":"Maintenance of remission in autoimmune chronic active hepatitis with azathioprine after corticosteroid withdrawal.","volume":"8","author":"Stellon","year":"1988","journal-title":"Hepatology"},{"key":"R27-14-20210210","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10620-005-2472-5","article-title":"Impact of immunosuppressive treatment on liver fibrosis in autoimmune hepatitis.","volume":"50","author":"Mohamadnejad","year":"2005","journal-title":"Dig Dis Sci"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2015139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2015139","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2015139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201507000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:09:53Z","timestamp":1786547393000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201507000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2015.139","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}