{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:24:38Z","timestamp":1786548278051,"version":"build-2736575974"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1038\/ajg.2016.466","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T08:03:36Z","timestamp":1476777816000},"page":"65-76","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis"],"prefix":"10.14309","volume":"112","author":[{"given":"Andrew J","family":"Irvine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Chey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20210210","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel disorders.","volume":"150","author":"Mearin","year":"2016","journal-title":"Gastroenterology"},{"key":"R2-17-20210210","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2007.04.005","article-title":"The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects.","volume":"133","author":"Kassinen","year":"2007","journal-title":"Gastroenterology"},{"key":"R3-17-20210210","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.gastro.2010.07.053","article-title":"Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome.","volume":"140","author":"Tillisch","year":"2011","journal-title":"Gastroenterology"},{"key":"R4-17-20210210","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/gut.14.2.125","article-title":"Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome.","volume":"14","author":"Ritchie","year":"1973","journal-title":"Gut"},{"key":"R5-17-20210210","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/ajg.2009.700","article-title":"Increased proteasome-mediated degradation of occludin in irritable bowel syndrome.","volume":"105","author":"Coeffier","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"R6-17-20210210","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s00535-013-0919-6","article-title":"Associations among gut permeability, inflammatory markers, and symptoms in patients with irritable bowel syndrome.","volume":"49","author":"Shulman","year":"2014","journal-title":"J Gastroenterol"},{"key":"R7-17-20210210","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2012.02.029","article-title":"Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis.","volume":"10","author":"Lovell","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R8-17-20210210","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1136\/gut.2007.119446","article-title":"Guidelines on the irritable bowel syndrome: mechanisms and practical management.","volume":"56","author":"Spiller","year":"2007","journal-title":"Gut"},{"key":"R11-17-20210210","doi-asserted-by":"crossref","first-page":"g1561","DOI":"10.1136\/bmj.g1561","article-title":"Coeliac disease.","volume":"348","author":"Mooney","year":"2014","journal-title":"BMJ"},{"key":"R12-17-20210210","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/ajg.2011.21","article-title":"Screening for celiac disease in a North American population: sequential serology and gastrointestinal symptoms.","volume":"106","author":"Katz","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"R13-17-20210210","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3109\/07853890.2010.505931","article-title":"The prevalence of celiac disease in Europe: results of a centralized, international mass screening project.","volume":"42","author":"Mustalahti","year":"2010","journal-title":"Ann Med"},{"key":"R14-17-20210210","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/ajg.2012.219","article-title":"The prevalence of celiac disease in the United States.","volume":"107","author":"Rubio-Tapia","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"R15-17-20210210","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/bmj.328.7435.322","article-title":"Undiagnosed coeliac disease at age seven: population based prospective birth cohort study.","volume":"328","author":"Bingley","year":"2004","journal-title":"BMJ"},{"key":"R16-17-20210210","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/S0140-6736(01)06581-3","article-title":"Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care.","volume":"358","author":"Sanders","year":"2001","journal-title":"Lancet"},{"key":"R17-17-20210210","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00042737-200304000-00012","article-title":"A primary care cross-sectional study of undiagnosed adult coeliac disease.","volume":"15","author":"Sanders","year":"2003","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R18-17-20210210","doi-asserted-by":"crossref","first-page":"e106478","DOI":"10.1371\/journal.pone.0106478","article-title":"The incidence of other gastroenterological disease following diagnosis of irritable bowel syndrome in the UK: a cohort study.","volume":"9","author":"Canavan","year":"2014","journal-title":"PLoS One"},{"key":"R19-17-20210210","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/archinternmed.2009.22","article-title":"Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis.","volume":"169","author":"Ford","year":"2009","journal-title":"Arch Intern Med"},{"key":"R20-17-20210210","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1365-2036.2004.01958.x","article-title":"Serological testing for coeliac disease in patients with symptoms of irritable bowel syndrome: a cost-effectiveness analysis.","volume":"19","author":"Mein","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"R21-17-20210210","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1053\/j.gastro.2004.03.012","article-title":"Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysis.","volume":"126","author":"Spiegel","year":"2004","journal-title":"Gastroenterology"},{"key":"R22-17-20210210","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s10198-012-0441-4","article-title":"Targeted screening for coeliac disease among irritable bowel syndrome patients: analysis of cost-effectiveness and value of information.","volume":"14","author":"Mohseninejad","year":"2013","journal-title":"Eur J Health Econ"},{"key":"R23-17-20210210","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","article-title":"ACG clinical guidelines: diagnosis and management of celiac disease.","volume":"108","author":"Rubio-Tapia","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"R24-17-20210210","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology.","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"R25-17-20210210","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.cgh.2015.05.014","article-title":"Evidence against routine testing of patients with functional gastrointestinal disorders for celiac disease: a population-based study.","volume":"13","author":"Choung","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R26-17-20210210","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1053\/j.gastro.2011.06.084","article-title":"The prevalence of celiac disease among patients with nonconstipated irritable bowel syndrome is similar to controls.","volume":"141","author":"Cash","year":"2011","journal-title":"Gastroenterology"},{"key":"R27-17-20210210","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/bmj.2.6138.653","article-title":"Towards positive diagnosis of the irritable bowel.","volume":"2","author":"Manning","year":"1978","journal-title":"BMJ"},{"key":"R28-17-20210210","first-page":"159","article-title":"Identification of sub-groups of functional gastrointestinal disorders.","volume":"3","author":"Drossman","year":"1990","journal-title":"Gastroenterology Int"},{"key":"R29-17-20210210","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders.","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"R31-17-20210210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0016-5085(84)90119-7","article-title":"A diagnostic score for the irritable bowel syndrome. Its value in the exclusion of organic disease.","volume":"87","author":"Kruis","year":"1984","journal-title":"Gastroenterology"},{"key":"R33-17-20210210","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis.","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"R34-17-20210210","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials.","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"R35-17-20210210","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test.","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"R36-17-20210210","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials.","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"key":"R37-17-20210210","first-page":"802","article-title":"Immunological profile of coeliac disease in a subgroup of patients with symptoms of irritable bowel syndrome.","volume":"86","author":"Elloumi","year":"2008","journal-title":"Tunis Med"},{"key":"R38-17-20210210","first-page":"192","article-title":"Prevalence of celiac disease in patients with irritable bowel syndrome.","volume":"13","author":"Emami","year":"2008","journal-title":"Govaresh"},{"key":"R39-17-20210210","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.3748\/wjg.15.5321","article-title":"Celiac disease in patients with presumed irritable bowel syndrome: a case-finding study.","volume":"15","author":"Jadallah","year":"2009","journal-title":"World J Gastroenterol"},{"key":"R40-17-20210210","first-page":"126","article-title":"Frequency of celiac disease and irritable bowel syndrome coexistance and its influence on the disease course.","volume":"66","author":"Zwolinska-Wcislo","year":"2009","journal-title":"Przegl Lek"},{"key":"R41-17-20210210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5001\/omj.2011.16","article-title":"Should we look for celiac disease in irritable bowel syndrome?","volume":"26","author":"Amiriani","year":"2011","journal-title":"Oman Med J"},{"key":"R42-17-20210210","doi-asserted-by":"crossref","first-page":"S309","DOI":"10.1016\/S0016-5085(10)61421-7","article-title":"Celiac disease rate increases in patients with irritable bowel syndrome-a community screen from West Virginia.","volume":"138","author":"Elitsur","year":"2010","journal-title":"Gastroenterology"},{"key":"R43-17-20210210","doi-asserted-by":"crossref","first-page":"S441","DOI":"10.1016\/S0016-5085(11)61810-6","article-title":"How prevalent is celiac disease in IBS-D type among South Indians?","volume":"140","author":"Balasubramanian","year":"2011","journal-title":"Gastroenterology"},{"key":"R44-17-20210210","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ajg.2012.03.003","article-title":"Coeliac disease in irritable bowel syndrome (Rome III) in Southeast Iran.","volume":"13","author":"Bakhshipour","year":"2012","journal-title":"Arab J Gastroenterol"},{"key":"R45-17-20210210","first-page":"839","article-title":"Celiac disease: serologic prevalence in patients with irritable bowel syndrome.","volume":"17","author":"Mehdi","year":"2012","journal-title":"J Res Med Sci"},{"key":"R47-17-20210210","first-page":"129","article-title":"Prevalence of celiac disease in patients with irritable bowel syndrome in Ardabil-Iran (2009-10).","volume":"14","author":"Houshiyar","year":"2013","journal-title":"J Gorgan Univ Med Sci"},{"key":"R49-17-20210210","first-page":"184","article-title":"Is it reasonable to perform serological tests for celiac disease in patients with irritable bowel syndrome?","volume":"8","author":"Respondek","year":"2013","journal-title":"Preglad Gastroenterol"},{"key":"R50-17-20210210","doi-asserted-by":"crossref","first-page":"R201","DOI":"10.1186\/ar4391","article-title":"Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study.","volume":"15","author":"Rodrigo","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"R51-17-20210210","first-page":"Gc01","article-title":"Celiac disease prevalence in the patients with irritable bowel syndrome in the Ilam province; a cross sectional study from Western Iran.","volume":"8","author":"Mahmoodi","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"R52-17-20210210","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.dld.2013.08.127","article-title":"Case-finding for coeliac disease in secondary care: a prospective multicentre UK study.","volume":"46","author":"Mooney","year":"2014","journal-title":"Dig Liver Dis"},{"key":"R53-17-20210210","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/1751-2980.12102","article-title":"Prevalence of celiac disease in Iranian patients with irritable bowel syndrome: a cross-sectional study.","volume":"15","author":"Shayesteh","year":"2014","journal-title":"J Dig Dis"},{"key":"R54-17-20210210","first-page":"319","article-title":"Prevalence of celiac disease in patients with irritable bowel syndrome in Kerman, Iran.","volume":"22","author":"Ahmadi","year":"2015","journal-title":"J Kerman Univ Med Sci"},{"key":"R55-17-20210210","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/1751-2980.12260","article-title":"Prevalence of celiac disease in Indian patients with irritable bowel syndrome and uninvestigated dyspepsia.","volume":"16","author":"Sharma","year":"2015","journal-title":"J Dig Dis"},{"key":"R56-17-20210210","doi-asserted-by":"crossref","first-page":"e1779","DOI":"10.1097\/MD.0000000000001779","article-title":"Serological screening for celiac disease in adult Chinese patients with diarrhea predominant irritable bowel syndrome.","volume":"94","author":"Wang","year":"2015","journal-title":"Medicine"},{"key":"R57-17-20210210","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/nmo.12799","article-title":"Prevalence of celiac disease and related antibodies in patients diagnosed with irritable bowel syndrome according to the Rome III criteria. A case-control study.","volume":"28","author":"Sanchez-Vargas","year":"2016","journal-title":"Neurogastroenterol Motil"},{"key":"R59-17-20210210","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/bmj.318.7177.164","article-title":"Coeliac disease in primary care: case finding study.","volume":"318","author":"Hin","year":"1999","journal-title":"BMJ"},{"key":"R60-17-20210210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/028134300750018990","article-title":"Endomysium antibodies are superior to gliadin antibodies in screening for coeliac disease in patients presenting supposed functional gastrointestinal symptoms.","volume":"18","author":"Agreus","year":"2000","journal-title":"Scand J Prim Health Care"},{"key":"R61-17-20210210","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1053\/gast.2001.29572","article-title":"Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome.","volume":"121","author":"Wahnschaffe","year":"2001","journal-title":"Gastroenterology"},{"key":"R63-17-20210210","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1365-2036.2003.01666.x","article-title":"Coeliac disease presenting with symptoms of irritable bowel syndrome.","volume":"18","author":"Shahbazkhani","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"R65-17-20210210","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4065\/79.4.476","article-title":"3rd, Murray JA, Zinsmeister AR et al. Celiac disease serology in irritable bowel syndrome and dyspepsia: a population-based case-control study.","volume":"79","author":"Locke","year":"2004","journal-title":"Mayo Clin Proc"},{"key":"R66-17-20210210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta10190","article-title":"Cognitive behavioural therapy in addition to antispasmodic therapy for irritable bowel syndrome in primary care: randomised controlled trial.","volume":"10","author":"Kennedy","year":"2006","journal-title":"Health Technol Assess"},{"key":"R67-17-20210210","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/gut.2006.112052","article-title":"Screening for coeliac disease in patients fulfilling the Rome II criteria for irritable bowel syndrome in a secondary care hospital in The Netherlands: a prospective observational study.","volume":"56","author":"van der Wouden","year":"2007","journal-title":"Gut"},{"key":"R68-17-20210210","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1111\/j.1572-0241.2007.01173.x","article-title":"Detection of celiac disease in primary care: a multicenter case-finding study in North America.","volume":"102","author":"Catassi","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"R69-17-20210210","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1007\/s10620-007-0082-0","article-title":"Association of gluten enteropathy and irritable bowel syndrome in adult Turkish population.","volume":"53","author":"Ozdil","year":"2008","journal-title":"Dig Dis Sci"},{"key":"R70-17-20210210","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.cgh.2016.04.032","article-title":"Ethnic variations in duodenal villous atrophy consistent with celiac disease in the United States.","volume":"14","author":"Krigel","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R71-17-20210210","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/ajg.2015.398","article-title":"Prevalence of adult celiac disease in India: regional variations and associations.","volume":"111","author":"Ramakrishna","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"R72-17-20210210","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/apt.12373","article-title":"Systematic review: worldwide variation in the frequency of coeliac disease and changes over time.","volume":"38","author":"Kang","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"R73-17-20210210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2036.2009.04110.x","article-title":"Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease.","volume":"31","author":"Lewis","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"R75-17-20210210","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/gut.46.1.78","article-title":"Irritable bowel syndrome in general practice: prevalence, characteristics, and referral.","volume":"46","author":"Thompson","year":"2000","journal-title":"Gut"},{"key":"R76-17-20210210","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/ajg.2013.105","article-title":"Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life.","volume":"108","author":"Bohn","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"R77-17-20210210","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/ajg.2012.236","article-title":"Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity.","volume":"107","author":"Carroccio","year":"2012","journal-title":"Am J Gastroenterol"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2016466.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2016466","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2016466.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201701000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:24:22Z","timestamp":1786544662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201701000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2016.466","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}